共查询到20条相似文献,搜索用时 15 毫秒
1.
Background
Granulosa cell tumors (GCTs) are relatively rare and are subtypes of the sex-cord stromal neoplasms. Methylation induced silencing in the promoters of genes such as tumor suppressor genes, DNA repair genes and pro-apoptotic genes is recognised as a critical factor in cancer development. 相似文献2.
Olga A Patutina Nadezda L Mironova Nelly A Popova Vasily I Kaledin Valery P Nikolin Valentin V Vlassov Marina A Zenkova 《BMC cancer》2010,10(1):204
Background
One of the main obstacles for successful cancer polychemotherapy is multiple drug resistance phenotype (MDR) acquired by tumor cells. Currently, RNA interference represents a perspective strategy to overcome MDR via silencing the genes involved in development of this deleterious phenotype (genes of ABC transporters, antiapoptotic genes, etc.). 相似文献3.
Helena Zientek-Targosz Dimiter Kunnev Lesleyann Hawthorn Mikhail Venkov Sei-Ichi Matsui Richard T Cheney Yuri Ionov 《Molecular cancer》2008,7(1):51
Background
Widely accepted somatic mutation theory of carcinogenesis states that mutations in oncogenes and tumor suppressor genes in genomes of somatic cells is the cause of neoplastic transformation. Identifying frequent mutations in cancer cells suggests the involvement of mutant genes in carcinogenesis. 相似文献4.
Pia Fernberg Ellen T. Chang Kristina Duvefelt Henrik Hjalgrim Sandra Eloranta Karina Meden Sørensen Anna Porwit Keith Humphreys Mads Melbye Karin Ekström Smedby 《Cancer causes & control : CCC》2010,21(5):759-769
Background
Tumor necrosis factor (TNF) and interleukin 10 (IL10) are promising candidate susceptibility genes for non-Hodgkin lymphoma (NHL). Chromosomal translocation breakpoint genes are of interest, given their documented involvement in lymphoma progression. 相似文献5.
Silke G?tze Valeska Feldhaus Thilo Traska Marietta Wolter Guido Reifenberger Andrea Tannapfel Cornelius Kuhnen Dirk Martin Oliver Müller Sonja Sievers 《BMC cancer》2009,9(1):447
Background
Cancer cells display widespread changes in DNA methylation that may lead to genetic instability by global hypomethylation and aberrant silencing of tumor suppressor genes by focal hypermethylation. In turn, altered DNA methylation patterns have been used to identify putative tumor suppressor genes. 相似文献6.
Background
Numerous factors that contribute to malignant glioma invasion have been identified, but the upstream genes coordinating this process are poorly known. 相似文献7.
Helena Carén Anna Djos Maria Nethander Rose-Marie Sjöberg Per Kogner Camilla Enström Staffan Nilsson Tommy Martinsson 《BMC cancer》2011,11(1):66
Background
Epigenetic mechanisms such as DNA methylation and histone modifications are important regulators of gene expression and are frequently involved in silencing tumor suppressor genes. 相似文献8.
Background
Insertional mutagenesis screens in the mouse are an acknowledged approach to identify genes involved in the pathogenesis of cancer. The potential of these screens to identify genes causally involved in tumorigenesis is not only limited to the murine host, but many of these genes have also been proven to be involved in the oncogenic process in man. 相似文献9.
Jinyun Chen Carol J. Etzel Christopher I. Amos Qing Zhang Nancy Viscofsky Noralane M. Lindor Patrick M. Lynch Marsha L. Frazier 《Cancer causes & control : CCC》2009,20(9):1769-1777
Purpose
Lynch syndrome is an autosomal dominant syndrome of familial malignancies resulting from germ line mutations in DNA mismatch repair (MMR) genes. Our goal was to take a pathway-based approach to investigate the influence of polymorphisms in cell cycle-related genes on age of onset for Lynch syndrome using a tree model. 相似文献10.
Priscilla D Negraes Francine P Favaro João Lauro V Camargo Maria Luiza CS Oliveira José Goldberg Cláudia A Rainho Daisy MF Salvadori 《BMC cancer》2008,8(1):238
Background
Epigenetic alterations are a hallmark of human cancer. In this study, we aimed to investigate whether aberrant DNA methylation of cancer-associated genes is related to urinary bladder cancer recurrence. 相似文献11.
Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response,involving LBP,CD14 and STAT3
下载免费PDF全文
![点击此处可从《Breast cancer research : BCR》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Introduction
Involution of the mammary gland is a complex process of controlled apoptosis and tissue remodelling. The aim of the project was to identify genes that are specifically involved in this process. 相似文献12.
Min-A Seol In-Sun Chu Mi-Jin Lee Goung-Ran Yu Xiang-Dan Cui Baik-Hwan Cho Eun-Kyung Ahn Sun-Hee Leem In-Hee Kim Dae-Ghon Kim 《BMC cancer》2011,11(1):78
Background
The molecular mechanisms of CC (cholangiocarcinoma) oncogenesis and progression are poorly understood. This study aimed to determine the genome-wide expression of genes related to CC oncogenesis and sarcomatous transdifferentiation. 相似文献13.
Yanyuan Wu Monica Alvarez Dennis J Slamon Phillip Koeffler Jaydutt V Vadgama 《BMC cancer》2010,10(1):32
Background
Epigenetic changes associated with promoter DNA methylation results in silencing of several tumor suppressor genes that lead to increased risk for tumor formation and for progression of the cancer. 相似文献14.
Jian Jiang Jun Liang Ruyong Yao Qingfang Li Shanai Song Yingying Sun 《临床肿瘤与癌症研究(英文版)》2009,6(5):328-336
OBJECTIVE To investigate whether polymorphisms in ERCC1, XPD, XPG, XRCC1 genes are associated with clinical outcomes in advanced gastric cancer (AGC) patients treated with oxaliplatinbased chemotherapy. METHODS The genetic polymorphisms in ERCCI, XPD, XPG, XRCC1 were determined in 94 advanced gastric cancer patients treated with oxaliplatin-based chemotherapy, using TaqMan-MGB probes. The clinical response of 60 patients with stage IV disease, time to progression (TTP) and overall survival (OS) of 94 patients were evaluated. RESULTS The overall disease control rate (CR + PR + SD) of the 60 patients in stage IV was 70% (42/60). Patients with XRCC1 399 G/G, XPG 46 C/C genotypes showed enhanced response to the oxaliplatin-based chemotherapy compared to those with other genotypes (P 〈 0.05). The median OS and TTP of the patients were 5.5 months and 9.0 months, respectively. Among the 4 types of polymorphisms in the study, XRCC1 399 G/A + A/A, XPG 46 C/T + T/T genotypes were regarded to be associated with chemoresistance and poor survival (P 〈 0.05). Combination analysis of the 2 polymorphisms using the Kaplan-Meier method revealed that the TTP and OS of the patients with a number of risk genotypes were significantly shortened (P 〈 0.05). No significant association was found between the genotypes of the XPD codon 751, the ERCC1 codon 118 and the clinical outcome (P 〉 0.05). CONCLUSION Testing for XRCC1 399, XPG 46 polymorphisms may allow identification of the gastric cancer patients who will benefit from oxaliplatin-based chemotherapy. Specific polymorphisms may influence clinical outcomes of AGC patients. Selecting specific chemotherapy based on pretreatment genotyping represents an innovative strategy that warrants prospective studies. 相似文献
15.
Ya-Sian Chang Kun-Tu Yeh Tien-Jye Chang Connie Chai Hsiu-Chin Lu Nicholas C Hsu Jan-Gowth Chang 《BMC cancer》2009,9(1):179
Background
RAS genes acquire the most common somatic gain-of-function mutations in human cancer, and almost all of these mutations are located at codons 12, 13, 61, and 146. 相似文献16.
17.
Olafur Andri Stefansson Jon Gunnlaugur Jonasson Oskar Thor Johannsson Kristrun Olafsdottir Margret Steinarsdottir Sigridur Valgeirsdottir Jorunn Erla Eyfjord 《Breast cancer research : BCR》2009,11(4):R47-14
Introduction
Germline mutations in the BRCA1 and BRCA2 genes account for a considerable fraction of familial predisposition to breast cancer. Somatic mutations in BRCA1 and BRCA2 have not been found and the involvement of these genes in sporadic tumour development therefore remains unclear. 相似文献18.
19.
Background
The role of genes involved in the control of progression from the G1 to the S phase of the cell cycle in melanoma tumors in not fully known. The aim of our study was to analyse mutations in TP53, CDKN1A, CDKN2A, and CDKN2B genes in melanoma tumors and melanoma cell lines 相似文献20.
Jack X Yu Anieta M Sieuwerts Yi Zhang John WM Martens Marcel Smid Jan GM Klijn Yixin Wang John A Foekens 《BMC cancer》2007,7(1):182