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1.
Nelson LG Gonzalez R Haines K Gallagher SF Murr MM 《The American surgeon》2005,71(11):950-3; discussion 953-4
Symptoms of gastroesophageal reflux disease (GERD) are frequent in patients with clinically significant obesity and are reported to improve after Roux-en-Y gastric bypass (RYGB). The purpose of this study is to determine timing and duration of improvement of GERD symptoms in patients undergoing RYGB. Prospectively collected data from patients who underwent RYGB from January 1998 to August 2004 were analyzed. Patients answered a standardized questionnaire pre- and postoperatively inquiring about frequency of GERD symptoms (none, one episode/ week, one episode/day, more than one episode/day) and medication use. Of 606 patients undergoing RYGB, 239 patients (39%) reported GERD symptoms preoperatively (mean age 43 +/- 1 years; body mass index 51 +/- 1 kg/m2). Of these, 89 per cent of patients reported improved at 3 months post-op and 94 per cent of patients 9 months post-op (P < 0.001). Medication usage decreased from 30 per cent to 3 per cent by 3 months and 5 per cent beyond 9 months (P < 0.001). Percentage of excess weight loss was 18 +/- 1 per cent and 75 +/- 2 per cent at 3 and 9 months, respectively. Symptoms of GERD significantly improve and use of antireflux medications is reduced after RYGB independent of weight loss. RYGB may be the treatment of choice for GERD in obese patients. 相似文献
2.
Background Morbid obesity is associated with gastroesophageal reflux disease (GERD), which, in most cases, completely resolves after
Roux-en-Y gastric bypass (RYGB). Patients with persistent or recurrent symptoms have limited surgical options. This study
sought to evaluate the application of the Stretta procedure for patients with refractory GERD.
Methods The medical records of all patients who underwent Stretta for refractory GERD after RYGB were reviewed. Demographic, preoperative,
and postoperative reflux data were collected. Data are presented as mean ± standard error of the mean. The t-test was used for comparison purposes.
Results Of 369 patients, 7 received Stretta 27 ± 6 months after RYGB. All were women with a mean age of 49 ± 2 years. All the patients
had experienced prebypass GERD symptoms for a duration of 45 ± 8 months. The mean prebypass body mass index was 45 ± 2 kg/m2, and this was reduced to 29 ± 2 kg/m2 after laparoscopic RYGB (p < 0.001). Before Stretta, all patients underwent a 48-h Bravo pH study, which demonstrated reflux with a mean fraction time
of 7% ± 2% for pH lower than 4. After Stretta, five patients had complete resolution of their symptoms, with normalization
of pH studies (mean fraction time of 3% ± 0% for pH < 4). The follow-up period after Stretta was 20 ± 2 months. One patient
did not have adequate relief of symptoms after Stretta, and one patient was lost to follow-up evaluation.
Conclusion Stretta is a valid option in the treatment of persistent GERD for patients who have undergone gastric bypass. Further study
is required to evaluate the long-term efficacy of this procedure. 相似文献
3.
Laparoscopic Roux-en-Y gastric bypass for recalcitrant gastroesophageal reflux disease in morbidly obese patients. 总被引:4,自引:0,他引:4
Yaron Perry Anita P Courcoulas Hiran C Fernando Percival O Buenaventura James S McCaughan James D Luketich 《JSLS, Journal of the Society of Laparoendoscopic Surgeons》2004,8(1):19-23
BACKGROUND AND OBJECTIVES: Gastroesophageal reflux disease (GERD) is commonly associated with morbid obesity (MO). Antireflux surgery has a higher failure rate in MO and addresses only one of the comorbidities present. This paper reviews the results of laparoscopic Roux-en-Y gastric bypass (LRYGBP) performed for recalcitrant GERD in MO. METHODS: Patients with recalcitrant GERD and a body mass index (BMI)>35 undergoing LRYGBP were included. LRYGB included crural repair, creation of a small gastric pouch (30 mL), and intestinal bypass (150 to 180 cm). All patients were followed in clinic and by telephone. RESULTS: From February 1999 to April 2001, 57 patients (51 F, 6 M) with a mean age of 43 (range, 22 to 67) and a median BMI of 43 underwent LRYGBP. Hiatal hernia or esophagitis, or both, were present in 48, Barrett's in 2. LRYGBP was possible in 52 patients; 5 required open conversion. The median hospital stay was 3 days. Complications included 1 leak, 1 pulmonary emboli, 2 reoperations for internal roux limb hernia, and 7 gastrojejunal strictures. At a mean follow-up of 18 months (range, 3 to 30), all patients report improvement or no symptoms of GERD and a mean weight loss of 40 kg (range, 16 to 70). Quality of life scores (SF-36) were above national norms for physical and mental components (median 55, norms=50). GERD-health related quality of life median score was <1 (scale, 0 to 45, 0=asymptomatic, 45=worse). CONCLUSION: LRYGBP was effective for recalcitrant GERD in MO. LRYGBP also led to weight loss and improvement in other comorbidites. Surgeons with minimally invasive expertise should consider LRYGBP for treatment of GERD in the morbidly obese. 相似文献
4.
5.
A canine model of gastroesophageal reflux disease (GERD) 总被引:2,自引:0,他引:2
McMahon RL Ali A Chekan EG Clary EM Garcia-Oria MJ Fina MC McRae RL Ko A Gandsas A Pappas TN Eubanks WS 《Surgical endoscopy》2002,16(1):67-74
BACKGROUND: Although a variety of antireflux procedures and medications are used to treat gastroesophageal reflux disease (GERD), reliable large-animal models of GERD that can be used to objectively compare the efficacy of these treatments are lacking. METHODS: Esophageal manometry and 24-h gastroesophageal pH monitoring with event data were performed in 18 mongrel dogs with a cervical esophagopexy. We then calculated a modified DeMeester score: The Duke Canine reflux score (DCR). Thereafter, the animals underwent a 4-cm anterior distal esophageal myotomy, incision of the left diaphragmatic crus, and intrathoracic gastric cardiopexy. Postoperative 24-h pH and manometry were obtained 2 weeks later. RESULTS: The postoperative 24-h pH results showed a significant increase in the mean DCR score (5.9 +/- 4.5 vs 84.9 +/- 56.1, p < 0.0002), and manometry indicated a significant decrease in mean lower esophageal sphincter (LES) pressure (7.1 +/- 2.9 vs 3.2 +/- 2.5 mmHg, p < 0.0001). CONCLUSION: This technique reliably creates a canine model of GERD. 相似文献
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7.
E. Eypasch E. Neugebauer F. Fischer H. Troidl A. L. Blum D. Collet A. Cuschieri B. Dallemagne H. Feussner K.-H. Fuchs H. Glise C. K. Kum T. Lerut L. Lundell H. E. Myrvold A. Peracchia H. Petersen J. J. B. van Lanschot 《Surgical endoscopy》1997,11(5):413-426
Background: Laparoscopic antireflux surgery is currently a growing field in endoscopic surgery. The purpose of the Consensus Development
Conference was to summarize the state of the art of laparoscopic antireflux operations in June 1996.
Methods: Thirteen internationally known experts in gastroesophageal reflux disease were contacted by the conference organization team
and asked to participate in a Consensus Development Conference. Selection of the experts was based on clinical expertise,
academic activity, community influence, and geographical location. According to the criteria for technology assessment, the
experts had to weigh the current evidence on the basis of published results in the literature. A preconsensus document was
prepared and distributed by the conference organization team. During the E.A.E.S. conference, a consensus document was prepared
in three phases: closed discussion in the expert group, public discussion during the conference, and final closed discussion
by the experts.
Results: Consensus statements were achieved on various aspects of gastroesophageal reflux disease and current laparoscopic treatment
with respect to indication for operation, technical details of laparoscopic procedures, failure of operative treatment, and
complete postoperative follow-up evaluation. The strength of evidence in favor of laparoscopic antireflux procedures was based
mainly on type II studies. A majority of the experts (6/10) concluded in an overall assessment that laparoscopic antireflux
procedures were better than open procedures.
Conclusions: Further detailed studies in the future with careful outcome assessment are necessary to underline the consensus that laparoscopic
antireflux operations can be recommended.
Received: 29 November 1996/Accepted: 14 December 1996 相似文献
8.
Laparoscopic Roux-en-Y gastric bypass for severe gastroesophageal reflux after vertical banded gastroplasty 总被引:4,自引:0,他引:4
Background: Vertical banded gastroplasty (VBG) is sometimes associated with complications such as pouch obstruction, dilatation,
and gastroesophageal reflux. This occasionally requires surgical revision, in many cases to a Roux-en-Y gastric bypass (RYGBP).
Case Report: A 47-year-old woman with severe obesity developed severe symptoms of stenosis of the pouch outlet and gastroesophageal
reflux 15 years after VBG. Laparoscopic conversion to a RYGBP was performed. At 9-month follow-up, she lost an additional
32 kg and had complete resolution of her reflux. Conclusion: In this patient, laparoscopic re-operative RYGBP produced additional
weight loss, and improved gastroesophageal reflux that occurred many years after having a VBG. Laparoscopic conversion of
a VBG to RYGBP is feasible, and may confer the benefits of other minimally invasive abdominal procedures to this high-risk
patient group. 相似文献
9.
Kaufman JA Houghland JE Quiroga E Cahill M Pellegrini CA Oelschlager BK 《Surgical endoscopy》2006,20(12):1824-1830
A strong link exists between gastroesophageal reflux disease (GERD) and airway diseases. Surgical therapy has been recommended
as it is more effective than medical therapy in the short term, but there is little data on the effectiveness of surgery long-term.
We analyzed the long-term response of GERD-related airway disease after laparoscopic anti-reflux surgery (LARS).
Methods In 2004, we contacted 128 patients with airway symptoms and GERD who underwent laparoscopic antireflux surgery (LARS) between
12/1993 and 12/2002. At median follow-up of 53 months (19–110 mo) we studied the effects on symptoms, esophageal acid exposure,
and medication use and we analyzed the data to determine predictors of successful resolution of airway symptoms.
Results Cough, hoarseness, wheezing, sore throat, and dyspnea improved in 65-75% of patients. Heartburn improved in 91 % (105/116)
of patients and regurgitation in 92% (90/98). The response rate for airway symptoms was the same in patients with and without
heartburn. Almost every patient took proton pump inhibitors (PPIs) preoperatively (99%, 127/128) and 61% (n = 78) were taking double or triple dose. Postoperatively, 33% (n = 45) of patients were using daily anti-acid therapy but no one was on double dose. The only factor that predicted a successful
surgical outcome was the presence of abnormal reflux in the pharynx as determined by 24-hour pharyngeal pH monitoring. One
hundred eleven (87%) patients rated their results as excellent (n = 78, 57%) or good (n = 33, 24%).
Conclusion LARS provides an effective and durable barrier to reflux, and in so doing improves GERD-related airway symptoms in ∼70% of
patients and improves typical GERD symptoms in ∼90% of patients. Pharyngeal pH monitoring identifies those patients more likely
to benefit from LARS, but better diagnostic tools are needed to improve the response of airway symptoms to that of typical
esophageal symptoms. 相似文献
10.
11.
Robot-assisted laparoscopic Roux-en-Y gastric bypass 总被引:2,自引:0,他引:2
Background Robotic surgery promises to extend the capabilities of the minimally invasive surgeon. The aim of this study was to examine the feasibility of robotic surgery in the setting of laparoscopic gastric bypass.Methods The Zeus robotic surgical system was used in 50 laparoscopic gastric bypass procedures. The learning curve was staged to add complexity to the robotic tasks as experience grew. Robotic setup time, robotic operative time, total operative time, and operative outcomes were tracked prospectively.Results We observed a significant decrease in the robotic setup time. Our robotic learning curve demonstrated decreased operative time, even as more complex tasks were accomplished. Total operative time also decreased significantly over the series. There were no complications in our series that could be attributed to the robotic technique.Conclusions Robot-assisted laparoscopic Roux-en-Y gastric bypass is safe. The steadiness and extra degrees of freedom of surgical robotic systems may improve the accuracy of laparoscopic tasks. The learning curve for robot-assisted laparoscopic Roux-en-Y gastric bypass is significant but manageable.Presented at the annual meeting of the Society of American Gastrointesinal Endoscopic Surgeons (SAGES), Denver, CO, USA, 1 April 2004 相似文献
12.
Bertucci W White S Yadegar J Patel K Han SH Blocker O Frickel D Kadell B Mehran A Gracia C Dutson E 《The American surgeon》2006,72(10):862-864
Routine early postoperative upper gastroesophageal imaging (UGI) is often used in laparoscopic Roux-en-Y gastric bypass (LRYGB) procedures to confirm anastomotic patency and to exclude leaks. The aim of our study was to assess the usefulness of this practice. From January 2003 to November 2004, 322 LRYGB cases were performed using linear staplers for the gastrojejunostomy and jejuno-jejunostomy anastomoses. As part of our protocol, all patients received a Gastrograffin (Mallinkrodt, Inc., St Louis, Missouri) UGI on postoperative Day 1. The same radiological techniques were used and the same radiological team reviewed all films. Abnormal films were identified. In addition, patient demographics, time to discharge, and complications were collected and analyzed in a prospective database. There were no anastomotic leaks or obstructions. However, 42 of 322 (13%) studies demonstrated delayed gastric emptying. There were no statistically significant differences between patients with normal and delayed UGI studies. Routine UGI studies did not contribute significantly to patient care, and its routine use was subsequently abandoned. 相似文献
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14.
J. Esteban Varela Marcelo W. Hinojosa Ninh T. Nguyen 《Surgery for obesity and related diseases》2009,5(2):139-143
BackgroundGastroesophageal reflux disease (GERD) is commonly associated with morbid obesity. Laparoscopic fundoplication is a standard surgical treatment for GERD, and laparoscopic gastric bypass has been shown to effectively resolve GERD symptoms in the morbidly obese. We sought to compare the in-hospital outcomes of morbidly obese patients who underwent laparoscopic fundoplication for the treatment of GERD versus laparoscopic gastric bypass for the treatment of morbid obesity and related conditions, including GERD, at U.S. academic medical centers.MethodsUsing the “International Classification of Diseases, 9th Revision” procedural and diagnoses codes for morbidly obese patients with GERD, we obtained data from the University HealthSystem Consortium database for all patients who underwent laparoscopic fundoplication or laparoscopic gastric bypass from October 2004 to December 2007 (n = 27,264). The outcome measures included the patient demographics, length of stay, in-hospital overall complications, mortality, risk-adjusted mortality ratio (observed to expected mortality), and hospital costs.ResultsCompared with the patients who underwent laparoscopic gastric bypass, those who underwent laparoscopic fundoplication had a lower severity of illness score (P <.05). The overall in-hospital complications were significantly lower in the laparoscopic gastric bypass group (P <.05). The mean length of stay, observed mortality, risk-adjusted mortality, and hospital costs were comparable between the 2 treatment groups.ConclusionLaparoscopic gastric bypass is as safe as laparoscopic fundoplication for the treatment of GERD in the morbidly obese. Hence, morbidly obese patients with GERD should be referred for bariatric surgery evaluation and offered laparoscopic gastric bypass as a surgical option. 相似文献
15.
Background Gastrojejunal strictures following laparoscopic Roux-en-Y gastric bypass (LRYGBP) present with dysphagia, nausea, and vomiting. Diagnosis is made by endoscopy and/or radiographic studies. Therapeutic options include endoscopic dilation and surgical revision.Methods Of 369 LRYGBP performed, 19 patients developed anastomotic stricture (5.1%). One additional patient was referred from another facility. Pneumatic balloons were used for initial dilation in all patients. Savary-Gilliard bougies were used for some of the subsequent dilations.Results Flexible endoscopy was diagnostic in all 20 patients allowing dilation in 18 (90%). Two patients did not undergo endoscopic dilation because of anastomotic obstruction and ulcer. The median time to stricture development was 32 days (range: 17–85). Most patients (78%) required more than two dilations. The complication rate was 1.6% (one case of microperforation). At a mean follow-up of 21 months, all patients were symptom-free.Conclusions Gastrojejunostomy stricture following LRYGBP is associated with substantial morbidity and patient dissatisfaction. Based on our experience, we propose a clinical grading system and present our strategy for managing gastrojejunal strictures.Presented as a poster of distinction at the 12th Congress of the European Association of Endoscopic Surgery, Barcelona, Spain, June 2004 相似文献
16.
Yves Borbély Dino Kröll Philipp C. Nett Peter Moreno Radu Tutuian Johannes Lenglinger 《Surgery for obesity and related diseases》2018,14(6):764-768
Background
Roux-en-Y gastric bypass (RYGB) is considered the gold standard in treatment of morbid obesity and gastroesophageal reflux disease (GERD). Resolution of GERD symptoms is reported to be approximately 85% to 90%.Objective
To evaluate patients with persistent GERD symptoms after RYGB and to identify contributing factors.Setting
University hospital, cross-sectional study.Methods
Data of patients evaluated for persistent GERD with a history of RYGB between January 2012 and December 2015 were reviewed. GERD was assessed with questionnaires, endoscopy, 24-hour pH-impendance manometry, and barium swallow.Results
Of 47 patients, 44 (93.6%) presented with typical GERD, 18 (38.3%) with obstruction, 8 (17%) with pulmonary symptoms, and 21 (44.7%) with pain. The interval between RYGB and evaluation was a median of 3.8 years (range .8–12.6); median patient age was 36.5 years (19.1–67.2). Median body mass index was 30.3 kg/m2 (20.3–47.2). Pouch gastric fistulas were seen in 2 (5.1%), enlarged pouches in 5 (10.6%), and hiatal hernias in 25 patients (53.2%). Twelve (23.4%) had esophagitis>Los Angeles (LA) grade B. Manometry was performed in 45 (95.7%) and off–proton pump inhibitor 24-hour pH-impedance-metry in 44 patients (94.6%). Seventeen patients (37.8%) had esophageal hypomotility or aperistalsis; hypotensive lower esophageal sphincter was seen in 26 patients (57.8%). Increased esophageal acid exposure (>4% pH<4) was found in 27 (61.4%), an increased number of reflux episodes (>53) in 30 patients (68.2%). Symptoms were deemed as functional in 6 (12.8%).Conclusion
The evaluation for persistent GERD after RYGB revealed a high percentage of hiatal hernias, hypotensive lower esophageal sphincter, and severe esophageal motility disorders. These findings might have an influence on hiatal hernia closure concomitant with RYGB and the role of pH manometry in the preoperative bariatric assessment. 相似文献17.
Conversion of laparoscopic Roux-en-Y gastric bypass 总被引:3,自引:0,他引:3
BACKGROUND: To determine the incidence and causes of conversion from a laparoscopic to an open gastric bypass for morbid obesity, we reviewed the experience of our bariatric center. METHODS: We performed a retrospective review of the records of consecutive patients undergoing laparoscopic Roux-en-Y gastric bypass at our center. RESULTS: In all, 1,236 consecutive patients with body mass indes (BMI) from 35 to 82 were approached laparoscopically. In 97%, bypasses were completed laparoscopically and in 3% (40 patients), a conversion was required to complete the procedure. Older age and male sex were greater in the converted group, whereas BMI was not different nor was the proportion of super obese patients. The cause of conversion was technical in 80%, bleeding in 10%, and a massive liver in 10%. CONCLUSIONS: Our risk of conversion was generally low, but increased in older patients and males. In 33% of patients, conversions could have been avoided with technical lessons learned by experience. 相似文献
18.
Al Harakeh AB 《The Surgical clinics of North America》2011,91(6):1225-37, viii
Despite the well-documented safety of laparoscopic RYGB, several short-term and long-term complications, with varying degrees of morbidity and mortality risk, are known to occur. Bariatric surgeons, all too familiar with these complications, should be knowledgeable in risk-reduction strategies to minimize the incidence of complication occurrence and recurrence. Bariatric and nonbariatric surgeons who evaluate and treat abdominal pain should be familiar with these complications to facilitate early recognition and intervention, thereby minimizing the associated morbidity and mortality. 相似文献
19.
Morbid obesity represents a challenge to healthcare as the underlying source of numerous risks and significant expenditure. Gastric bypass surgery has been validated as a means of significant and reproducible reduction in weight. In the laparoscopic era, the minimally invasive approach has been applied to this procedure with promising results. In our technique, we divide the stomach to create a small gastric pouch drained by a retrocolic, retrogastric Roux-en-Y alimentary jejunal limb. The gastrojejunostomy is performed in 2 layers, an inner stapled layer and an outer sutured layer. We, like other groups, have found that laparoscopic gastric bypass provides similar efficacy to open gastric bypass, but offers improved patient acceptance, quality of life, and significantly less wound complications. 相似文献