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1.
Mendoza-Pinto C García-Carrasco M Sandoval-Cruz H Escárcega RO Jiménez-Hernández M Etchegaray-Morales I Soto-Vega E Muñoz-Guarneros M López-Colombo A Delezé-Hinojosa M Cervera R 《Clinical rheumatology》2009,28(1):65-70
The aim of this study was to determine the prevalence and risk factors for low bone mineral density (BMD) in women with systemic
lupus erythematosus (SLE). A cross-sectional study was conducted among 100 pre-menopausal patients with SLE. Patients were
evaluated using a questionnaire about the following variables: age, disease duration, disease activity, chronic disease damage,
cumulative corticosteroid dose, and history of fracture. Lumbar spine and hip measurements of BMD were performed by dual absorptiometry.
Univariate and multivariate statistical analyses were used to assess the relationship between risk factors and BMD. The mean
age was 32.8 ± 8.7 years, and the median duration of SLE was 73.2 ± 65 months. The mean cumulative corticosteroid dose was
20.0 ± 21.3 g. The mean BMD was 1.09 ± .18 g/cm2 in the lumbar spine and 1.0 ± .14 g/cm2 in the hip. Osteopenia was present in 40% of patients and osteoporosis in 5%. In the multiple regression analysis, low BMD
in the lumbar spine was associated with chronic disease damage and low body mass index (BMI). Low BMD in the hip was associated
with cumulative corticosteroid dose and low BMI. Chronic disease damage, low BMI, and cumulative corticosteroid dose are risks
factors for low BMD in pre-menopausal SLE patients. Osteopenia was found in 40% of patients, while osteoporosis was found
in only 5%. 相似文献
2.
Rossi M Mosca M Tani C Franzoni F Santoro G Bombardieri S 《Clinical rheumatology》2008,27(12):1485-1488
A number of studies based on conventional ultrasound scanning (CUS) gave contrasting results about the occurrence of early
atherosclerosis in patients with systemic lupus erythematosus (SLE), while no study on early arterial sclerosis in the same
patients are available. Recently, information on early arterial sclerosis can be provided by the integrated backscatter (IBS)
analysis which reflects the collagen and calcium content within the vascular wall. In order to evaluate if atherosis and/or
sclerosis of carotid arteries are early features of SLE, we performed carotid CUS and IBS analysis in 16 SLE patients (15
females; aged 37 ± 10 years), free from clinically evident cardiovascular diseases and cardiovascular risk factors, with the
only exception of five patients who had arterial hypertension. The same investigations were performed in 16 sex- and age-matched
healthy control subjects. No statistically significant difference was observed either in carotid corrected IBS values or in
carotid intima–media thickness (IMT) values between SLE patients and control subjects (−17.9 ± 2.5 dB vs −19.0 ± 1.7 dB, p = 0.14; 0.66 ± 0.08 mm vs 0.62 ± 0.13 mm, p = 0.35, respectively). The little sub-group of hypertensive SLE patients exhibited a significantly higher carotid corrected
IBS mean value compared to control subjects (−16.4 ± 3.1 dB vs −19.0 ± 1.7 dB, p = 0.026), while it did not significantly differ in carotid IMT value from control group (0.67 ± 0.09 mm vs 0.62 ± 0.13 mm,
respectively; p = 0.86). These findings show that neither atherosis nor sclerosis of carotid arteries are early features of SLE patients
free from cardiovascular risk factors. Further studies are needed to clearly demonstrate that early carotid sclerosis affects
hypertensive SLE patients. 相似文献
3.
Parasar Ghosh Amresh Kumar Sudeep Kumar Amita Aggarwal Nakul Sinha Ramnath Misra 《Clinical rheumatology》2009,28(11):1259-1265
Patients with systemic lupus erythematosus (SLE), especially Asian Indians, are at increased risk of developing premature
atherosclerosis. To find out the prevalence and predictors of carotid intima-medial thickness (IMT) and brachial artery flow-mediated
dilatation (FMD). Endothelial dysfunction was assessed by FMD in brachial artery and IMT was measured in common carotid artery
in SLE patients and healthy controls. Sixty SLE patients (mean age 31 ± 9 years) and 38 healthy controls (mean age 34 ± 6 years)
were included. The IMT was higher in SLE patients as compared to controls (0.49 ± 0.08 mm vs. 0.39 ± 0.05 mm, p < 0.0001). SLE and damage were independent predictors of abnormal IMT. FMD was impaired in SLE patients compared to controls
(9.97% vs. 18.97%, p < 0.00001). None of the classical cardiovascular risk factors were predictors of FMD or abnormal IMT. Indian patients with
SLE have higher prevalence of subclinical atherosclerosis and endothelial dysfunction. Presence of damage was associated with
abnormal IMT in SLE patients. 相似文献
4.
This study describes the characteristics of severe systemic lupus erythematosus (SLE) patients who visited the emergency department
of the Shanghai Renji Hospital, and the aim is to identify the causes, the outcome, and the prognostic factors. SLE patients
who visited the emergency department between January 2007 and August 2010, and who were subsequently hospitalized or who died
in emergency department, were included in this retrospective study. Of the total 131 SLE emergency events, overall mortality
was 16.8%. Older age (≥45 years), longer duration of disease, presence of pulmonary hypertension, renal insufficiency, and
invasive infections are risk factors. Higher organ damage index (SLICC, 3.86 ± 2.14 vs. 0.93 ± 1.14, p < 0.001) but relatively lower disease activity (SLEDAI, 11.5 ± 7.7 vs. 16.5 ± 9.0, p = 0.015) were the characteristics of the deceased when compared with the survivors. Recent-onset (duration of disease ≤3 months)
SLE accounts for 32.1% of the patients in emergency, and this group showed a distinctive pattern of younger age with higher
frequencies of neuropsychiatric and hematologic manifestations. A good short-term outcome with a 95.2% survival rate can be
observed in such patients. Older age, longer disease duration and cumulative damage of vital organs determine the short-term
outcome of severe SLE in the emergency department. Recognizing disease patterns and objective prognostic parameters may help
physicians to provide better care, based on a risk-fitted approach, for the SLE patients in emergencies. 相似文献
5.
Risk factors for cardiovascular disease and endothelin-1 levels in Takayasu arteritis patients 总被引:1,自引:0,他引:1
Alexandre Wagner Silva de Souza Henrique Ataíde Mariz Edgard Torres Reis Neto Anne Elizabeth Diniz Arraes Neusa Pereira da Silva Emília Inoue Sato 《Clinical rheumatology》2009,28(4):379-383
The objective of this study was to evaluate traditional risk factors for cardiovascular disease (CVD) and endothelin-1 (ET-1)
levels in Takayasu arteritis (TA) patients. Twenty-two TA patients and 37 controls were evaluated. TA patients had a higher
prevalence of hypertension (63.6% vs. 21.6%, p = 0.001) and higher levels of triglycerides (129.5 mg/dL ± 70.8 vs. 88.4 mg/dL ± 60.8, p = 0.017) than controls. Mean number of CVD risk factors was 1.64 ± 1.22 in TA patients and 1.03 ± 1.44 among controls, p = 0.030. More TA patients presented at least one CVD risk factor when compared to controls (77.2% vs. 51.3%, p = 0.048). ET-1 levels were higher in patients than in controls (1.49 pg/mL ± 0.45 vs. 1.27 pg/mL ± 0.32, p = 0.034), however no significant difference was found between patients with active and inactive disease. In this study, TA
patients presented a higher prevalence of hypertension, higher levels of triglycerides, and ET-1 than controls. 相似文献
6.
N. Abildgaard K. Brixen J. E. Kristensen T. Vejlgaard P. Charles J. L. Nielsen 《European journal of haematology》1996,57(5):370-376
Abstract: To evaluate the use of dual energy X-ray absorptiometry (DXA) in multiple myeloma (MM) we performed a prospective study of 34 patients with newly diagnosed MM. Most patients had advanced disease and all but two patients had osteolytic bone destructions and/or pathological fractures. Bone mineral content (BMC) and bone mineral density (BMD) of the lumbar spine (L1–L4) and hip were measured using a Hologic QDR-1000 scanner. Collapsed vertebrae were not excluded from analysis. Data from 289 healthy Danish volunteers aged 21–79 yr were used for calculation of Z-scores. Lumbar spine BMC (Z-score –0.46±0.23, p=0.05) and lumbar spine BMD (Z-score –0.56±0.23, p=0.02) were significantly reduced in MM patients, whereas no reduction was seen in hip BMC or BMD. Collapsed vertebrae had marked reduced BMD (Z-score –1.34±0.22, p<0.001), as had non-fractured vertebrae in the same individuals (Z-score –1.42±0.25, p<0.001). Lumbar spine BMD correlated with radiologically assessed bone morbidity (r –0.37, p=0.03) and stronger with the incidence of vertebral fractures (r –0.64, p<0.001). Thus, osteopenia of the back is common in multiple myeloma and correlates with an increased incidence of fractures. DXA may identify subjects with increased risk of vertebral fractures for more intensive chemotherapeutic or anti-resorptive treatment. 相似文献
7.
Worawit Louthrenoo Nuntana Kasitanon Ramjai Wichainun Suparaporn Wangkaew Waraporn Sukitawut Shoji Kuwata Fujio Takeuchi 《Clinical rheumatology》2010,29(3):241-246
This study was performed to determine the prevalence of anti-agalactosyl IgG antibodies in Thai patients with RA, systemic
lupus erythematosus (SLE) and systemic sclerosis (SSc), and determine the sensitivity and specificity of anti-agalactosyl
IgG antibodies in the diagnosis of RA in comparison with IgM-rheumatoid factor (IgM-RF) and anti-cyclic citrullinated peptide
(anti-CCP) antibodies. Serum samples were obtained from 100 patients with RA, 50 cases of SLE, 50 cases of SSc, and 100 healthy
controls and analyzed for the presence of anti-agalactosyl IgG antibodies, IgM-RF and anti-CCP antibodies. A serum value greater
than mean + 2 standard deviation of normal value of anti-agalactosyl IgG antibodies and anti-CCP antibodies was considered
positive. The prevalence of anti-agalactosyl IgG antibodies in RA, SLE, and SSc patients was 88.0%, 14.0%, and 12.0%, respectively.
The serum level of anti-agalactosyl IgG antibodies in patients with RA (227.10 ± 353.64 AU/mL) was significantly higher than
those in SLE (11.84 ± 52.04 AU/mL), SSc (18.85 ± 99.60 AU/mL), and healthy controls (2.14 ± 1.97 AU/mL), (p < 0.001). There was a good correlation between the log serum level of anti-agalactosyl IgG antibodies and IgM-RF (r = 0.92, p < 0.001), anti-CCP antibodies and IgM-RF (r = 0.49, p < 0.001), and anti-agalactosyl IgG antibodies and anti-CCP antibodies (r = 0.55, p < 0.001). The sensitivity and specificity in the diagnosis of RA was 88.00% and 96.00% for anti-agalactosyl IgG antibodies,
90.00% and 99.00% for anti-CCP antibodies, and 91.00% and 95.00% for IgM-RF, respectively. The serum level of anti-agalactosyl
IgG antibodies was significantly higher in RA than in SLE, SSc, and healthy controls. There was a good correlation between
serum levels of anti-agalactosyl IgG antibodies, anti-CCP antibodies, and IgM-RF. These three tests had comparable sensitivity
and specificity. 相似文献
8.
Anselm Mak Jia Qing Lim Yang Liu Alicia Ai-cia Cheak Roger Chun-man Ho 《Rheumatology international》2013,33(2):299-307
This study aimed at comparing the FRAX® 10-year fracture risk between SLE patients and demographically- and anthropometrically matched healthy individuals. Consecutive SLE patients aged ≥40 were analyzed for the FRAX® 10-year probability of major osteoporotic and hip fractures and their risk was compared with healthy controls matched for age, gender and body mass index. Potential determinants associated with higher 10-year fracture probability in the SLE patients were studied by regression models. Ninety subjects (45 SLE patients and 45 healthy controls) were studied. While the bone mineral density (BMD) of the lumbar spine and dominant hip was comparable between the two groups, the FRAX® 10-year probability of major and hip fractures was significantly higher in SLE patients. Significantly more SLE patients had high 10-year fracture risk as defined by the National Osteoporosis Foundation compared with healthy controls (16 vs. 2 %, p = 0.026). After controlling for glucocorticoid use and premature menopause which were significant univariate risk factors, the difference in the 10-year fracture risk became insignificant. Amongst SLE patients, increasing age, lower hip BMD and cumulative glucocorticoid dose independently predicted higher 10-year major fracture risk while higher anti-dsDNA level independently predicted higher hip fracture risk in addition to age and lower hip BMD. Chronic glucocorticoid use and premature menopause led to higher 10-year probability of major osteoporotic and hip fractures in SLE patients compared with their healthy counterparts although their BMD was comparable. Advanced age, lower hip BMD, cumulative glucocorticoid and higher anti-dsDNA level independently predicted higher 10-year fracture risk amongst SLE patients. 相似文献
9.
Mazzoccoli G Fontana A Grilli M Dagostino MP Copetti M Pellegrini F Vendemiale G 《Age (Dordrecht, Netherlands)》2012,34(3):751-760
Arterial and venous thrombosis have always been regarded as different pathologies and epidemiological studies have examined
the association between venous thrombosis and indicators of atherosclerosis and/or arterial thromboembolic events. We measured
the flow-mediated dilation (FMD), a well-known marker of arterial endothelial dysfunction, in young–middle-aged and old-aged
patients with and without unprovoked deep venous thrombosis (DVT). The aim of this study was to investigate whether DVT was
a significant predictor for impaired FMD, considering all the patients and young–middle-aged (age < 65 years) and old-aged
(age ≥ 65 years) patients separately. FMD was measured in the brachial artery on a population of 120 subjects with the same
atherosclerosis risk factors, 68 male and 52 female, 70 young–middle-aged subjects (mean age ± SD 49.5 ± 10.5 years) and 50
old-aged subjects (76.2 ± 7.7 years). Patients with DVT showed a significant decrease of FMD compared to patients without
DVT (6.8 ± 5.5% vs. 10.9 ± 3.5%, p < 0.001). Moreover, old-aged patients showed a significant decrease of FMD compared to the young–middle-aged subjects (7.4 ± 4.1%
vs. 9.8 ± 5.3%, p = 0.005). In the whole study population, DVT was strongly associated with FMD (risk factors adjusted β = −4.14, p < 0.001). A significant interaction between age and the presence of DVT on predicting FMD was found (p = 0.003) suggesting a differential behavior of DVT as predictor of FMD. In young–middle-aged group, multivariate model confirmed
that DVT was the most significant predictor of continuous FMD (β = −6.06, p < 0.001). On the contrary, DVT was no more a predictor of FMD in the old age group (β = −0.73, p=0.556). Furthermore, old-aged patients without DVT showed a statistically significant decrease of FMD compared to the young–middle-aged
subjects without DVT (8.2±2.1% vs. 12.6±2.7%, p<0.001) and old-aged patients with DVT showed a not statistically significant decrease of the FMD compared to the young–middle-aged
patients with DVT (6.7±5.3% vs. 6.8±5.7%, p = 0.932). In conclusion, young–middle-aged patients with spontaneous DVT show an impaired FMD, whereas this impairment in
old-aged subjects is evident independently from the presence or absence of DVT. Aging per se may be associated with physiologic
abnormalities in the systemic arteries and with endothelial dysfunction. 相似文献
10.
F. Piarulli G. Sartore A. Ceriello E. Ragazzi R. Reitano L. Nollino C. Cosma D. Fedele A. Lapolla 《Diabetologia》2009,52(7):1419-1425
Aims/hypothesis This study examined the relationship, if any, between glucose-induced oxidative stress, antioxidant status and microalbuminuria
in patients with type 2 diabetes.
Methods The study involved 99 consecutive type 2 diabetic patients (57 men, 42 women). Patients with persistent microalbuminuria were
identified and the following variables evaluated: fasting plasma glucose, HbA1c, malonyldialdehyde (MDA), pentosidine, AGE, the total radical-trapping antioxidant parameter (TRAP), vitamin E, creatinine,
estimated GFR and lipid profile.
Results Patients were divided into two groups, i.e. 37 individuals without microalbuminuria (AER <20 μg/min) and 62 with microalbuminuria
(AER ≥20 μg/min). The following variables were significantly higher in patients with microalbuminuria than in those without
microalbuminuria (mean ± SD): fasting plasma glucose 9.41 ± 2.88 vs 8.19 ± 1.93 mmol/l, p < 0.05; HbA1c 7.97 ± 1.51 vs 7.39 ± 1.03%, p < 0.05; MDA 1.18 ± 0.35 vs 1.02 ± 0.29 μmol/l, p < 0.05; pentosidine 98.5 ± 24.6 vs 82.9 ± 20.9 pmol/ml, p < 0.005; and AGE 13.2 ± 4.8 vs 10.6 ± 3.8 μg/mg protein, p < 0.01. However, vitamin E and TRAP did not differ between the two groups. Serum creatinine values and estimated GFR were
similar in the two groups. Only in patients with microalbuminuria were significant linear correlations seen between AER and
both oxidation (HbA1c
r = 0.33, p < 0.01; MDA r = 0.59, p < 0.001; pentosidine r = 0.48, p < 0.001; and AGE r = 0.44, p < 0.001) and antioxidation variables (vitamin E r = −0.55, p < 0.001; TRAP r = −0.49, p < 0.001). Considering all variables together, multiple regression revealed a correlation between microalbuminuria and vitamin
E, TRAP, HbA1c and MDA, but not pentosidine or AGE.
Conclusions/interpretation Our data suggest that microalbuminuria in type 2 diabetic patients might be promoted by an insufficient counter-regulation
of the antioxidant system in the event of increased glyco-oxidation/glycation. 相似文献
11.
Rostom S Allali F Bennani L Abouqal R Hajjaj-Hassouni N 《Rheumatology international》2012,32(4):971-980
Vertebral fractures are the hallmark of osteoporosis, responsible for increased back pain, impairment of mobility and functional
limitations. These factors have an impact on patients’ health-related quality of life (QOL). The aim of this study was to
evaluate the prevalence of vertebral fractures in Moroccan postmenopausal women and to assess their QOL, using an Arabic validated
version of QUALEFFO. The study recruited 347 postmenopausal women in obvious good health. We excluded women who had used a
drug or who had chronic diseases affecting bone metabolism. All patients had density measurements and spinal radiography.
Each vertebral body (T4–L5) was graded using the semiquantitative method of Genant. The mean age was 60 years. Forty-six percent
of patients had at least one vertebral fracture. The prevalence ranged from 31% in patients 50–55 years to 69% in patients
65 years and older. Patients with vertebral fractures were older (61.6 ± 8 vs 57 ± 7 years, P < 0.001), had more frequent history of nonvertebral fractures, and had spine and hip BMD values significantly lower (P < 0.001) than patients without vertebral fractures. In multivariate analysis, older age and a history of nonvertebral fractures
were the two independent clinical factors of vertebral fractures. The number of fractures was a determinant of a low QOL,
as indicated by an increased score in physical function, social function, mental function, and general health [for all (P < 0.05)]. Patients with higher grades of vertebral deformities, i.e., more severe fractures, had low QOL in these four domains.
Patient with thoracolumbar fractures had a worse general health than patients with thoracic or lumbar fractures. We found
a high prevalence of vertebral fractures probably explained by socioeconomic factors in Morocco. QOL, assessed by an osteoporosis-specific
instrument, is decreased in postmenopausal women as a function of both the number and the severity of the vertebral fractures.
Treating women with prevalent fractures may avoid a further decrease in their quality of life. 相似文献
12.
Dhanunjaya Lakkireddy George Nadzam Atul Verma Subramanya Prasad Kay Ryschon Luigi Di Biase Mohammed Khan David Burkhardt Robert Schweikert Andrea Natale 《Journal of interventional cardiac electrophysiology》2009,24(2):105-112
Background Pulmonary vein antral isolation (PVAI) is an effective treatment for atrial fibrillation and involves prolonged procedure
and fluoroscopy times. This study assesses the impact of a comprehensive radiation safety program on patient and operator
radiation exposure during PVAI.
Methods and Results We evaluated a comprehensive radiation safety program including: (1) verbal reinforcement of previous fluoroscopy times (2)
effective collimation (3) minimizing source-intensifier distance and (4) effective lead shield use. Exposure doses in 41 consecutive
patients without (group-I, n = 21) and with (group-II, n = 20) the use of radiation safety program were assessed. PVAI was done using intracardiac echo (ICE) guided roving circular
mapping catheter. A 3-dimensional mapping system was used in 27% cases for additional guidance. Operator and patient exposure
was measured during the PVAI. The age, gender, body mass index and AF duration were similar in both of the groups. The total
procedure (166 ± 56 vs 178 ± 38 min, p = 0.54) and fluoroscopy times (74 ± 24 vs 70 ± 20 min, p = 0.72) were comparable. Group-II had significantly lower dose area product (234 ± 120 vs 548 ± 363 Gy cm2, p = 0.03) compared to group-I. The mean operator exposure was reduced by half and mean patient peak skin dose by three to ten
times with comprehensive radiation safety program. None of the patients were noted to have radiation related skin injuries.
Additional lifetime cancer risk was significantly lower in group-II patients (0.08 vs 0.2%, p < 0.001) than group-I.
Conclusions Implementation of a comprehensive radiation safety program described above significantly decreases the radiation exposure
to the patient as well as the operator. 相似文献
13.
Ramírez Pérez E Clark P Wacher NH Cardiel MH del Pilar Diez García M 《Clinical rheumatology》2008,27(2):151-161
Measuring quality of life (QOL) is important, but to date, questionnaires to measure QOL in Mexican patients with osteoporosis
(OP) have not been validated. A study was carried out to culturally adapt and validate the Quality of Life Questionnaire of
the European Foundation for Osteoporosis (QUALEFFO) in a Mexican population. Interviews were performed with 160 women, 80
patients with at least one vertebral fracture, and 80 patients with OP as determined by the World Health Organization criteria.
Several cultural modifications were made to the Spanish version of the QUALEFFO. Content validity was assessed by a group
of experts, and a pilot study was undertaken. At the same time, the Spanish version of the Short Form 36 (Medical Outcomes
Study) was applied. The mean age of patients was 71.9 ± 11.1. The QOL questionnaire showed a test–retest reproducibility (R
i = 0.94) and internal consistency (α = 0.92), while social function scored low (α = 0.46). Concurrent validity was significant (r = −0.837, p < 0.001). Significant differences were found between the two groups for pain (p < 0.05), physical function (p < 0.01), social function (p < 0.01), mental function (p < 0.05), and number of fractures (p < 0.001). Discriminatory characteristics between the groups were significant for physical (p < 0.001), social (p < 0.001), and mental (p < 0.02) function. The cultural adaptation of the QUALEFFO was consistent, homogenous, and discriminative. It also showed
deterioration in the QOL group of Mexicans with vertebral fractures. The QUALEFFO can be used in a Mexican population to measure
the QOL in patients with vertebral fractures after some cultural modifications to take into account local sensibilities. 相似文献
14.
Fadoua Allali Samira Rostom Loubna Bennani Redouane Abouqal Najia Hajjaj-Hassouni 《Clinical rheumatology》2010,29(11):1269-1275
The objectives of this study are (1) to evaluate whether the prevalence of osteoporosis and peripheral fractures might be
influenced by the educational level and (2) to develop a simple algorithm using a tree-based approach with education level
and other easily collected clinical data that allow clinicians to classify women into varying levels of osteoporosis risk.
A total number of 356 women with a mean age of 58.9 ± 7.7 years were included in this study. Patients were separated into
four groups according to school educational level; group 1, no education (n = 98 patients); group 2, elementary level (n = 57 patients); group 3, secondary level (n = 138 patients) and group 4, university level (n = 66 patients). We observed dose–response linear relations between educational level and mean bone mineral density (BMD).
The mean BMDs of education group 1 (10.39% (lumbar spine), 10.8% (trochanter), 16.8% (wrist), and 8.8% (femoral neck)) were
lower compared with those of group IV (p < 0.05). Twelve percent of patient had peripheral fractures. The prevalence of peripheral fractures increased with lowered
educational levels. Logistic regression analysis revealed a significant independent increase in the risk of peripheral fracture
in patients with no formal education (odds ratio, 5.68; 95% , 1.16–27.64) after adjustment for age, BMI and spine BMD. Using
the classification tree, four predictors were identified as the most important determinant for osteoporosis risk: the level
of education, physical activity, age >62 years and BMI <30 kg/m2. This algorithm correctly classified 74% of the women with osteoporosis. Based on the area under the receiver–operator characteristic
curves, the accuracy of the Classification and Regression Tree (CART) model was 0.79. Our findings suggested that a lower
level of education was associated with significantly lower BMDs at the lumbar spine and the hip sites, and with higher prevalence
of osteoporosis at these sites in a dose–response manner, even after controlling for the strong confounders. On the other
hand, our CART algorithm based on four clinical variables may help to estimate the risk of osteoporosis in a health care system
with limited resources. 相似文献
15.
Sun LY Zhou KX Feng XB Zhang HY Ding XQ Jin O Lu LW Lau CS Hou YY Fan LM 《Clinical rheumatology》2007,26(12):2073-2079
Defects of hematopoietic stem cells (HSCs) have been suggested to contribute to the development of systemic lupus erythematosus
(SLE). The aim of this study was to investigate the phenotypic characteristics of bone marrow (BM) CD34+ cells in patients with SLE and its relationship with SLE disease activity. Ten SLE patients and 10 healthy subjects were
recruited and their BM CD34+ cells were analyzed by flow cytometric analysis with CD45/SSC gating for the expression of CD90, CD95, CD117, CD123, CD164,
CD166, FAS-L, and HLA-DR. The percentage of BM CD34+ cells was significantly decreased in active SLE patients (1.48 ± 0.41%, n = 7) compared to the healthy controls (2.31 ± 0.75%, n = 10, p < 0.01), but no significant difference was found between the inactive patients (2.04 ± 0.44%, n = 3) and the controls. The expression of CD95, CD123, and CD166 on BM CD34+ cells were significantly increased in SLE patients (48.31 ± 10.59%, 44.9 ± 21.5%, 30.9 ± 19.54%, respectively, n = 10) when compared with the control subjects (24.33 ± 11.1%, 19.5 ± 4.4%, 10.7 ± 5.5%, respectively, n = 10, p < 0.05). The increased CD123 expression was negatively correlated with the number of peripheral white blood cells (r = −0.700, p < 0.05, n = 10). The percentage of CD166 expression was found significantly correlated with the index of SLE disease activity (r = 0.472, p < 0.05, n = 10) and 24 h proteinuria (r = 0.558, p < 0.05, n = 10), but negatively correlated with serum C3 level (r = −0.712, p < 0.01, n = 10). Our study found that the surface marker expression of CD95, CD123, and CD166 on BM CD34+ cells were significantly increased in patients. This supports the hypothesis that there are abnormalities of the HSC in SLE.
Since CD166 and CD123 correlated with the overall lupus activity, their role as a biomarker of inflammatory disease activity
also requires further study. 相似文献
16.
Bone loss in patients with rheumatoid arthritis (RA) varies at different skeletal sites. The aim of the study was to evaluate
whether bone mineral density (BMD) of the forearm is significantly different in patients with RA and controls and may correlate
to BMD or other parameters of inflammation or bone resorption. We included 421 patients (357 women: mean age 58.4 ± 12.87 years
and 64 men: mean age 56.11 ± 12.80 years) with RA in the study. BMD values of the ultradistal forearm (0.381 ± 0.052 g/cm2) and middistal forearm (0.519 ± 0.091 g/cm2) were significantly (p < 0.01) lower in women with RA than controls (0.395 ± 0.043 and 0.535 ± 0.052 g/cm2, respectively). In contrast, there was no difference in bone density at the lumbar spine (women 0.921 ± 0.l570 g/cm2, men 0.941 ± 0.144 g/cm2) or hip (women 08.11 ± 0.140 g/cm2, men 0.895 ± 0.143 g/cm2) in patients with RA in comparison to controls (lumbar spine: women 0.930 ± 0.146 g/cm2; men 0.960 ± 0.146 g/cm2; hip: women 0.820 ± 0.122 g/cm2; men 0.899 ± 0.144/cm2). Patients with increased inflammatory activity (elevated C-reactive protein) presented with significantly lower BMD of the
hip (0.7533 ± 0.144 versus 0.825 ± 0.138 g/cm2) and ultradistal forearm (0.366 ± 0.09 versus 0.390 ± 0.07 g/cm2). This was not the case for the lumbar spine. BMD of the forearm is precise and, in contrast to BMD of the lumbar spine,
significantly lower in patients with RA. It is related to inflammatory activity, grip strength, and treatment with glucocorticoids
in patients with RA. 相似文献
17.
Spangler L Scholes D Brunner RL Robbins J Reed SD Newton KM Melville JL Lacroix AZ 《Journal of general internal medicine》2008,23(5):567-574
Background Osteoporosis and depression may be associated through common physiologic systems or risk factors.
Objective To assess the associations between depressive symptoms (Burnam’s scale) or antidepressant use and bone outcomes.
Design Prospective cohort study.
Participants A total of 93,676 postmenopausal women (50 to 79 years old) enrolled in the Women’s Health Initiative Observational Study.
Measurements Self-reported fractures (n = 14,982) (hip [adjudicated], spine, wrist, and “other”). Analyses included 82,410 women with complete information followed
on average for 7.4 years. Bone mineral density (BMD) of the hip (n = 4539), spine (n = 4417), and whole body (n = 4502) was measured at baseline and 3 years in women enrolled at 3 densitometry study sites.
Results Overall, there were no statistically significant associations between depressive symptoms or antidepressant therapy and 3-year
change in BMD. In a subset of women not using antidepressants, there was a significant difference in whole-body BMD change
between women with and without depressive symptoms (P = .05). Depressive symptoms (hazard ratio [HR] 1.08; 95% CI = 1.02 to 1.14) and antidepressant therapy (HR = 1.22; CI = 1.15
to 1.30) independently increased risk of any fracture, the majority of which occurred at “other” anatomic sites. Antidepressant
therapy increased the risk of spine fracture (HR = 1.36; CI = 1.14 to 1.63). No associations were observed between depressive
symptoms or antidepressant therapy and hip or wrist fracture.
Conclusion In this study of postmenopausal women, average age 64, we observed minimal association between depressive symptoms and 3-year
changes in either BMD or fracture risk. Antidepressant use was not associated with changes in BMD, but was associated with
increased risk of fractures at the spine and “other ” anatomic sites. 相似文献
18.
The objective of our study was to elucidate serum levels of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP),
and C-type natriuretic peptide (CNP) in Behcet’s disease (BD) patients with active and inactive period. The multicenter study
included 53 patients with active (n = 28) and inactive (n = 25) BD (mean age, 34.3 ± 9 years; 15 men and 38 women) satisfying the International Study Group criteria and 26 healthy
controls (mean age, 34.4 ± 6.1 years; seven men and 19 women) matched for age and gender from a similar ethnic background.
Serum natriuretic peptides levels were determined by enzyme immunoassay kit. Mean serum ANP concentrations in the active patients
(4.01 ± 1.21 ng/ml) were significantly lower than in the healthy controls (5.76 ± 1.99 ng/ml, p = 0.004). Mean serum BNP levels were found to be significantly higher in both the active (6.19 ± 2.97 ng/ml) and inactive
(6.49 ± 2.88 ng/ml) BD groups compared with the control group (3.82 ± 1.1 ng/ml, p = 0.004 and p = 0.001, respectively). Mean serum CNP concentrations in the active patients (0.49 ± 0.12 ng/ml) were significantly lower
than in the inactive patients (0.65 ± 0.2 ng/ml, p = 0.017) and the healthy controls (0.8 ± 0.27 ng/ml, p < 0.001). Our results suggest that changes in natriuretic peptide levels may be associated with vasculitis that play role
in the etiopathogenesis of the BD. 相似文献
19.
Mazziotti G Mancini T Mormando M De Menis E Bianchi A Doga M Porcelli T Vescovi PP De Marinis L Giustina A 《Pituitary》2011,14(4):299-306
Hyperprolactinemia may cause bone loss but data on fractures are scanty. The aim of this study was to evaluate the prevalence
of vertebral fractures in women with prolactin (PRL)-secreting adenoma. In this cross-sectional study, 78 women (median age
45.5 years, range: 20–81) with PRL-secreting pituitary adenoma (66 with microadenoma and 12 with macroadenoma) and 156 control
subjects, with normal PRL values and with comparable age to patients with hyperprolactinemia, were evaluated for vertebral
fractures by a morphometric approach and for bone mineral density (BMD) by a dual-energy X-ray absorptiometry at lumbar spine.
Vertebral fractures were shown in 25 patients with PRL-secreting adenoma (32.6%) and in 20 controls (12.8%, P < 0.001). Fractured patients were significantly older (P < 0.001) and had lower BMD T-score (P < 0.001), longer duration of disease (P < 0.001), higher serum PRL (P = 0.004) and lower serum IGF-I (P < 0.001) values as compared to patients who did not fracture. The prevalence of vertebral fractures was significantly (P < 0.001) higher in post-menopausal women with PRL-secreting adenoma as compared to pre-menopausal patients. Fractures occurred
more frequently (P = 0.01) in patients with untreated hyperprolactinemia versus patients treated with cabergoline. Logistic regression analysis
demonstrated that duration of disease maintained a significant correlation with vertebral fractures (odds ratio 1.16, C.I.
95% 1.02–1.33) even after correction for age, menopausal status, treatment with cabergoline, BMD, serum IGF-I and serum PRL
values. Hyperprolactinemia is associated with high prevalence of radiological vertebral fractures in women with PRL-secreting
adenoma. 相似文献
20.
Lappa V Dontas IA Trovas G Constantelou E Galanos A Lyritis GP 《Clinical rheumatology》2007,26(7):1067-1073
The association between quantitative ultrasound (QUS) and bone turnover in postmenopausal women of different ages is an area
of continuous investigation. The aim of this study was to investigate the relationship of ultrasound parameters [broadband
ultrasound attenuation (BUA) and speed of sound (SOS)] to bone mineral density (BMD) and biochemical markers of bone turnover
in three age groups of postmenopausal women. One hundred and twenty-three postmenopausal Caucasian women were divided into
three groups according to their age: group A, range 44–54 years, mean age (±SD) 48.3 ± 2.3; group B, range 55–65 years, mean
age 59.4 ± 2.1; and group C, range 66–77 years, mean age 68.2 ± 3.1. Ultrasound parameters were measured by the DTU-one imaging
ultrasonometer in the calcaneus. BMD was assessed by dual-energy X-ray absorptiometry (DEXA) at the lumbar spine, femoral
neck, and trochanter. Bone turnover was assessed by serum bone-specific alkaline phosphatase (BAP), urinary excretion of free
deoxypyridinoline, N-telopeptides (NTX), and C-telopeptide breakdown products of type I collagen (CTX). QUS and BMD were significantly
correlated in all sites, except hip BMD in group A. The most significant correlation was observed between BUA and femoral
neck BMD in group C (r = 0.626, p < 0.01). BUA correlated significantly with BAP, NTX, and CTX (r = −0.434, −0.511, −0.478, respectively; p < 0.01), and SOS with BAP and NTX (r = −0.351 and −0.356, respectively; p < 0.05) only in group C. In groups A and B, ultrasound parameters did not correlate significantly to biochemical markers.
Ultrasound parameters were better correlated to hip BMD and to biochemical markers of bone turnover in elderly postmenopausal
women. These ultrasound measurements could be used as a screening test for bone status, either in nonambulatory third aged
women or in those living in rural areas where attending medical centers with DEXA equipment and biochemical laboratories is
difficult. 相似文献