共查询到20条相似文献,搜索用时 11 毫秒
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Surgical resection of colorectal liver metastases 总被引:7,自引:0,他引:7
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Monteiro A Arce N Bernardo J Eugénio L Antunes MJ 《The Annals of thoracic surgery》2004,77(2):431-437
BACKGROUND: One of the main characteristics of malignant tumors is the capability to disseminate, giving rise to local or distant metastases. Pulmonary metastases occur in almost 30% of all oncology patients, and secondary lung tumors are more frequent than primary ones. Surgical resection of metastases is now a well-established procedure, but the results vary with the histologic type of the primary tumor. We wished to identify factors affecting late survival after pulmonary metastasectomy for epithelial tumors. METHODS: We have reviewed retrospectively data for 78 patients who underwent 101 curative resections of epithelial pulmonary metastases between January 1988 and December 2000 at our department. Potential prognostic factors affecting late survival, namely histology of the primary tumor, disease-free interval, number and size of resected lung metastases, involvement of lymph nodes, use of nonsurgical adjuvant therapy, and relapse of pulmonary metastases, were investigated. RESULTS: There was no operative mortality, and the postoperative course was uneventful in 91.1% of the procedures. The mean disease-free interval was 48.2 +/- 59.8 months, and the mean follow-up after the first pulmonary metastasectomy was 40.8 +/- 31.5 months. Mean overall survival was 81.0 +/- 10.0 months, and 5-year and 10-year survival rates were 47.4% and 37.7%, respectively. By univariate and multivariate analyses, the disease-free interval and the prognostic grouping system proposed by the International Registry of Lung Metastases were found to significantly influence the long-term survival. Presence of symptoms also showed an important influence. CONCLUSIONS: Resection of epithelial pulmonary metastases is safe and effective, and is associated with very low perioperative morbidity and mortality and a reasonable 5-year and 10-year survival. In the present study, the disease-free interval influenced significantly the long-term survival. Our results did not differ significantly from (and in many cases compared favorably with) those described in the literature. 相似文献
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H Hashimoto F Inada T Takamura S Yachiku Y Kubo 《Hinyokika kiyo. Acta urologica Japonica》1984,30(10):1387-1392
Four patients (2 with renal cell carcinoma, 1 with testicular embryonal carcinoma, 1 with testicular seminoma) underwent surgical resection for pulmonary metastases. Three patients except one with renal cell carcinoma are still alive without disease at 1, 2.3 and 2.3 years, respectively. Surgical resection of metastatic pulmonary sarcoma or carcinoma is now the accepted method of treatment. As chemo- and radio-therapy are often ineffective for metastatic genitourinary cancers, our current policy is to employ surgical treatment provided that the operability is assessed carefully. 相似文献
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B Nordlinger M A Quilichini R Parc L Hannoun E Delva C Huguet 《International surgery》1987,72(2):70-72
Surgical resection is currently the only potentially curative treatment in some selected patients with colo-rectal liver metastases (LM). Unfortunately only a minority of patients are candidates for resection. Only solitary or unilobar LM that can be removed by partial liver resection, are considered to be resectable. The second condition for the resection of LM is that the primary cancer must be resected. The third condition for resection is that the patient must be able to undergo a major liver resection if it is necessary. Small metastases which do not exceed 5 cm, and appear on the surface of the liver can be removed by a simple wedge resection. If the tumor is larger than 5 cm, or if multiple unilobar nodules are discovered, a major liver resection becomes necessary. Hospital mortality does not exceed 5% in most published series. Five year survivals are very rare when histologically proven colo-rectal LM are left in place. After surgical resection of LM, five year survival rates are close to 25% and range from 18% to 52%. Surgical resection is of benefit to approximately one fourth of the patients, who survive five years or more, but three fourths of the patients have early recurrences. None of the studied criteria can predict which patients will benefit from surgical resection of LM. In order to try to reduce the rate of early recurrences adjuvant chemotherapy has been proposed. No positive data have yet been obtained. 相似文献
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Surgical resection of brain metastases from lung cancer 总被引:1,自引:0,他引:1
Summary The role of surgical resection for brain metastases is evolving. The most common primary for brain metastases is lung; in the US in 1992, for example, there were nearly 40,000 deaths with symptomatic brain metastases from lung cancer.We reviewed a series of 25 consecutive patients with non small cell lung cancer (NSCLC) undergoing open resection of one or moresymptomatic brain metastases to consider the role of open resection. Twenty-three of the 28 resected lesions were 3 cm or greater in diameter; 19 were solid and nine cystic. Surgical adjuncts included (where indicated): stereotactic biopsy, cyst drainage, and craniotomy; intra-operative ultrasound; and intra-operative evoked potential mapping of the sensorimotor area. Six patients underwent thoracotomy for resection of the lung primary (in all but one case, prior to craniotomy). Except for two patients who had had whole brain radiation therapy (WBXRT) prior to referral to Neurosurgery, all patients underwent WBXRT (30 to 60 Gy) postoperatively.The mean survival from date of craniotomy was 13.1 months, with two patients still alive at ten and seventeen months post-cra-niotomy. Survival comparisons which were significantly different included (1) lung surgery versus no lung surgery (25.7 months versus 9.1 months, P < 0.001), and (2) metachronous presentation of the lung primary and brain metastasis versus synchronous presentation (17.6 months versus 9.5 months, ). Survival comparisons which werenot significantly different included single versus multiple metastases, complete versus incomplete resection, adeno-carcinoma versus large or squamous or cell histology, supratentorial versus infratentorial location, solid versus cystic metastasis, and age 60 years versus > 60 years.These results, when compared with the literature on brain metastases, suggest that aggressive resection of symptomatic metastases from lung cancer (even if multiple) can improve functional survival over conservative management, and that small, asymptomatic lesions are well-controlled by WBXRT. They also confirm the previous finding that surgical treatment of both the lung primary and the brain metastases may afford the greatest period of functional survival for these patients. 相似文献
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Background : Isolated pulmonary metastases from colorectal cancer are rare. The present study reports on the 15‐year experience of the Royal Prince Alfred Unit and discusses means of improving survival outcomes. Methods : This was a retrospective review, over a 15‐year period, of 41 patients who had resectable pulmonary metastases of colorectal origin. Results : Most were asymptomatic at the time of diagnosis. Seventy‐two per cent had solitary metastases. The most common procedure performed was a lobectomy. Median follow up was 21 months. Five‐year survival was 24%. There were no significant prognostic indicators except for the ability to achieve clear surgical margins. Conclusion : Morbidity and mortality have not altered significantly over time. But an improved selection process such as the use of preoperative positron emission tomography will potentially improve survival outcomes. 相似文献
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Extra-axial cavernous hemangiomas involving the dural sinuses 总被引:17,自引:0,他引:17
Extra-axial cavernous hemangiomas are rare lesions previously associated with unacceptable mortality and morbidity rates that precluded surgical resection. The authors analyze the clinical presentation, surgical results, and histology of eight intrasinus cavernous hemangiomas: six located in the cavernous sinus, one in the petrosal sinus, and one in the torcula. Magnetic resonance imaging is the best radiographic test for surgical planning. Successful tumor removal was achieved in six cases with no mortality and low morbidity. In the remaining two patients, only subtotal resection was achieved because of massive hemorrhage in one and the misdiagnosis of a pituitary adenoma leading to a transsphenoidal approach in the other. For hemangiomas arising within the cavernous sinus, extradural removal of the sphenoid bone facilitated preservation of the neurovascular structures. Since the clinical and histological characteristics of these lesions are distinct from intra-axial cavernous hemangiomas, a more appropriate term may be "sinus cavernoma" to indicate that these lesions are primarily intrasinus in origin. 相似文献
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Shohachi Suzuki Satoshi Nakamura Hideto Ochiai Hiroyuki Konno Shozo Baba Satoshi Baba Kenzo Yasui 《Journal of Hepato-Biliary-Pancreatic Surgery》1997,4(1):103-112
The optimal treatment for recurrent lesions after hepatectomy for colorectal liver metastases is controversial. We report the outcome of aggressive surgery for recurrent disease after the initial hepatectomy and the influence on quality of life of such treatment. Forty-five (70%) of the 64 surviving patients developed recurrence after the initial hepatectomy for liver metastases. The determinants of hepatic recurrence were the distribution and the number of liver metastases. Twenty-eight (62%) of patients with recurrence underwent resection. A second hepatectomy was performed in 20 patients, and a third hepatectomy was done in 5 patients. Ten patients with pulmonary metastasis underwent partial lung resection on 14 occasions, while resection of brain metastases was performed in 3 patients on 5 occasions. There were no operative deaths after resection of recurrent disease. The morbidity rate was 28% after repeat hepatectomy, 21% after pulmonary resection, and 0% after resection of brain metastasis. The Karnofsky performance status (PS) after the last surgery was not significantly different from that after the initial hepatectomy. The 3- and 5-year survival rates after the second hepatectomy were 54% and 14%, respectively. The 3-and 5-year survival rates of the patients undergoing resection of extrahepatic recurrence were both 17%. The survival rate after resection of recurrent disease (n=28) was significantly better than that of patients (n=17) with unresectable recurrence (P < 0.05). For the 66 patients with colorectal liver metastases, the 5-year survival rate after initial hepatectomy was 50%. The distribution and the number of liver metastases and the presence of extrahepatic disease, as single factors, significantly affected prognosis after the initial hepatectomy. Multivariate analysis revealed that only the presence of extrahepatic metastasis and a disease-free interval of less than 6 months were independent predictors of survival after the initial and second hepatectomy, respectively. It is concluded that aggressive surgery is an effective strategy for selected patients with recurrence after initial hepatectomy. Careful selection of candidates for repeat surgery will yield increased clinical benefit, including long-term survival. 相似文献
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Infratentorial tumors and the dural venous sinuses 总被引:2,自引:0,他引:2
M E Kinal 《Journal of neurosurgery》1966,25(4):395-401
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A case of axillary sweat gland carcinoma which metastasised to both lungs six years after resection of the primary lesion is described. The lesions were resected and three years later two further pulmonary metastases were resected. 相似文献
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Shah SA Haddad R Al-Sukhni W Kim RD Greig PD Grant DR Taylor BR Langer B Gallinger S Wei AC 《Journal of the American College of Surgeons》2006,202(3):468-475
BACKGROUND: Patients with hepatic and pulmonary metastases from colorectal cancer (CRC) may benefit from aggressive surgical therapy. We examined the longterm outcomes of patients who underwent both lung and liver resections for colorectal metastases over a 10-year period. STUDY DESIGN: Four hundred twenty-three hepatectomies were performed for metastatic CRC between 1992 and 2002 at two university-affiliated hospitals. Patients who underwent both lung and liver resections for metastatic CRC were studied. Demographic, perioperative, and survival data were evaluated by retrospective chart review. Disease-free survival (DFS) and overall survival (OS) were evaluated by Kaplan-Meier analysis and survival curves were compared using the log-rank test. RESULTS: Thirty-nine patients underwent both lung and liver resections for metastatic CRC. Eleven patients (28%) underwent staged liver and lung metastasectomy from synchronously identified metastases. Twenty-eight patients (72%) underwent sequential metastasectomy because of recurrent disease. The median disease-free and overall survivals after initial metastasectomy were 19.8 and 87 months, respectively. Serial metastasectomy was common in this patient population. The mean number of metastasectomies performed was 2.6 per patient (range 1 to 4). There was no difference in overall survival for patients with synchronous versus metachronous presentation of liver and lung metastases (p=0.45). The site of first recurrence after initial metastasectomy was, most commonly, the lung (n=19, 49%), followed by the liver (n=8, 21%). Nineteen patients (49%) underwent subsequent resections for recurrences. Seven patients (18%) underwent 2 or more liver resections for recurrent disease, and 12 (31%) underwent multiple lung resections. CONCLUSIONS: An aggressive multidisciplinary surgical approach should be undertaken for recurrent CRC metastases. In selected patients, serial metastasectomy for recurrent metastatic disease is safe and results in excellent longterm survival after CRC resection. 相似文献
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Hiroki Hirabayashi Jun Takahashi Hiroyuki Kato Sohei Ebara Hideto Takahashi 《European spine journal》2009,18(Z2):232-235
Meningiomas of the spine occur in the thoracic spine in approximately 80%, followed in frequency by the cervical and lumbar
regions. The treatment of spinal meningiomas is complete surgical resection. As intraspinal meningiomas are almost always
adherent to the dura, extensive dural resection or diathermic treatment of the dural attachment is usually performed to prevent
tumor recurrence. The authors present the case of lumbar spinal meningioma in 82-year-old woman. Successful resection with
preservation of the dura mater using the technique of Saito et al. (Spine 26:1805-1808, 2001) is described: After lumbar laminectomy a small incision was made in the surface of the spinal dura. The dura mater was separated
into its inner and outer layers, and the tumor was resected with inner layer alone, preserving the outer layer. The outer
layer is simply closed to achieve a watertight seal. The pathologic diagnosis was metaplastic (osseous) meningioma. Almost
full recovery of the neurologic deficit was attained. Neither complication nor tumor recurrence has occurred in the 5 years
since surgery. Dural preservation during surgical resection of spinal meningioma obviates the need for dural reconstruction
and should reduce surgical morbidity. However, the patient should be followed long-term to watch for recurrence. 相似文献
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Management of combat wounds of the dural venous sinuses 总被引:1,自引:0,他引:1
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Kanzaki R Higashiyama M Fujiwara A Tokunaga T Maeda J Okami J Tomita Y Kodama K 《Surgery today》2011,41(7):995-998
Meningiomas rarely metastasize, and little information on pulmonary metastasectomy from meningioma has been documented. We
herein report a case of a potentially curative resection for meningioma that metastasized to the lung. A 67-year-old woman
was admitted to our hospital because of two masses in the right lung. In 1993, when the patient was 52 years old, she underwent
a craniotomy for an atypical meningioma. The meningioma recurred once in the local site and was re-excised in 1997. In 2008,
a screening chest X-ray detected two lung nodules in the right lung field. A computed tomographic scan demonstrated round
masses with sharp borders, in the right S2 (2.2 cm in diameter) and S4 (1.1 cm in diameter) regions. A whole-body [18F]2-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography/CT examination revealed intense focal FDG uptake (maximum standard uptake value
[SUVmax] = 6.9) in the larger mass, and weak FDG uptake (SUVmax = 2.3) in the smaller mass. A wedge resection of S2 and a middle lobectomy of the right lung were performed, and the final
diagnosis was pulmonary metastases from an intracranial meningioma. The patient is presently doing well 20 months after the
surgery without any signs of recurrence. Our case demonstrates that surgery should be considered when pulmonary metastases
are deemed completely resectable by a preoperative radiological examination, and that a good clinical outcome can be achieved. 相似文献
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