单导管射频消融治疗频发房颤的预激综合征

采用单导管射频消支治疗１２例预激综合征（ＷＰＷ）。１２例中８例有反复快速性房颤史,３例须用同步直流以电复律,１例伴有晕厥。旁路分别为左侧８条,右后间隔２条,右后侧及右前间隔各１条,右侧者有１工存１条左侧隐匿旁路。全部旁践一次消融成功。术中未诱发房颤。随访５～１７月未见复发。     

右侧和间隔房室旁路射频消融的初步体会

用导管射频消融右侧和间隔房室旁路１３例，其中左后间隔旁路８例，显性及隐性各４例；右后间隔显性旁路２例，右前间隔显性旁路１例；右后侧显性旁路２例。全部病例消融成功，随访０．５～８个月，均未见复发。     

右侧和间隔房室旁路射频消融的初步体会

用导管射频消融右侧和间隔房室旁路１３例，其中左后间隔旁路８例，显性及隐性各４例；右后间隔显性旁路２例，右前间隔显性旁路１例；右后侧显性旁路２例。全部病例消融成功，随访０．５－８个月，均未见复发。     

经导管射频消融术治疗阵发性室上性心动过速26例

用射频消融术治疗２６例阵发性室上性心动过速患者，其中房室旁路１７例（显性Ａ型预激综合征５例、隐匿性左侧旁路１０例、Ｂ型预激综合征２例），共有房室旁路１８条，其中左侧壁１０条、左后间隔６条、右后间隔２条。９例房室结双径路患者均采用下位法阻断慢径。全部病例均消融成功（１００％）。无并发症。随访２～１２周均未复发。     

经导管射频消融术治疗发性室上性心动过速26例

用射频消融术治疗２６例阵发性室上性心动过速患者，其中房室旁路１７例（显性Ａ型预激综合征５例、隐匿性左侧旁路１０例、Ｂ型预激综合征２例），共有房室旁路１８条，其中左侧壁１０条、左后间隔６条、右后间隔２条。９例房室结双径路患者均采用下位法阻断慢径。全部病例均消融成功（１００％）。无并发症。随访２￣１２周均未复发。     

间隔旁路射频消融15例分析

目的： 总结１５ 例间隔旁路的射频消融结果。方法： 将间隔旁路区分为前间隔旁路,左、右中间隔旁路以及左、右后间隔旁路; 然后对不同部位旁路的射频消融方法进行分析。结果： 前间隔旁路１ 例、左中间隔旁路１ 例、右中间隔旁路２ 例、左后间隔旁路６ 例及右后间隔旁路５ 例。所有病例均一次消融成功, 均未发生房室传导阻滞; ２ 例左后间隔旁路在冠状静脉窦内消融成功。随访２ 个月～３８ 个月, 无心动过速复发。结论： 射频导管消融术是阻断间隔旁路的安全有效的方法。     

射频消融治疗阵发性室上性心动过速

本文总结了 6 4例阵发性室上性心动过速的射频消融治疗 ,其中房室折返性心动过速 (AVRT) 4 4例 ,包括左前侧壁旁路 13例 ,左侧游离壁旁路 15例 ,左后侧壁旁路 2例 ,左后间隔旁路 8例。右后间隔旁路 4例 ,右后壁旁路 2例 ;房室结折返性心动过速 (AVNRT) 2 0例 ;既有旁路 ,又有双径路 1例 ;两条旁路 1例。以导管射频消融阻断旁路及改良房室结构 ,成功率98 4% ,1例出现Ⅲ°房室传导阻滞 ,1例复发 ,再次射频消融后治愈。     

前后位影像条件完成射频消融术10例

目的:总结前后位影像条件完成射频消融术的成功经验。方法:常规穿刺血管,就位电极,利用前后位影像,采取下位法消融双径路,对右后间隔旁路以冠状窦口为标志,在三尖瓣环上标测电位;对左侧旁路采取逆行电极、消融电极与靶点心肌同向协调运动,测示靶点电位,同时记录操作时程及并发症和随访情况。结果:消融11条旁路,双径路4条,右后间隔旁路1条,左侧旁路6条,1例术后4h复发,再次原靶点消融成功。1例术后出现完全右束支阻滞,随访2～14个月无复发。操作时程3.0 8±0 .37h。结论:利用前后位影像完全可以开展此项技术,成功率高,不延长操作时程。     

射频消融治疗房室折返性心动过速16例分析

目的:房室折返性心动过速(AVRT)是临床实践中常见的心律失常,本文报道对其进行标测及射频导管消融(RFCA)的经验。方法:16例患者(男性9例,女性7例),平均年龄(40.1±10.7)岁,对全部患者进行了心内电生理检查,在标测到的逆行心房最早激动部位进行射频导管消融。结果:16例患者中,11例为隐匿性左侧旁路,1例为隐匿性右后间隔旁路,4例为B型预激综合征。隐匿性左侧旁路中,左后间隔旁路3例,左前旁路5例,左后旁路3例。B型预激综合征中3例为右前游离壁旁路,1例为右后游离壁旁路。B型预激综合征右前游离壁旁路影像学有效消融靶点为:左前斜位45°,右房室环9点处。右后游离壁旁路影像学有效消融靶点为:左前斜位45°,右房室环7点处。所有患者均获得成功,无并发症。结论:RFCA术治疗AVRT有效、安全。     

经导管射频消融治疗阵发性室上性心动过速的初步体会

经导管射频消融治疗９例预激综合征和３例房室结双径路所致室上性心动过速患者。９例预激综合征共９条旁道；左前壁２条，右侧壁３条，左后间隔，右前壁，右后间隔，右前间隔各１条。除１例右前壁上，其余８条旁道均消融成功。３例房室结以径路患者，２例阻断慢径路，１例阻断快径路。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.