Objectives
This study attempted to evaluate clinical outcomes and long-term cost-effectiveness of an intervention involving Community Health Workers (CHW's, a.k.a. promotoras de salud in Spanish) in assisting Mexican-American diabetes type-2 patients with controlling their condition. The intervention has been carried out in Hidalgo County, TX which is situated on the U.S.–Mexico border.Study design
The design of the study is experimental. The sample (n = 30) was recruited from Mexican–American diabetes patients aged 30 or above. The intervention group received monthly visits from CHW's, while the control group did not.Methods
Incremental lifetime health outcomes and related expenditures were calculated using the CDC Diabetes Cost-Effectiveness Model (DCEM) which is a probabilistic computer simulation model of disease progression and cost-effectiveness for type 2 diabetes patients. The DCEM allows projection of lifetime healthcare costs and Quality-Adjusted Life-Years (QALYs).Results
The intervention group showed a significant improvement in glycemic control and cholesterol management after two years of intervention. The intervention is expected to reduce long-term complications, resulting in an increase in residual life-years and quality-adjusted life-years. The incremental cost-effectiveness ratio has been estimated to be $13,810, which is below the level of comparable studies.Conclusions
Intervention has a substantial impact on the medical costs of type 2 diabetes treatment. The estimates presented in this model may be used to analyse the cost-effectiveness of interventions involving CHW's for type 2 diabetes. 相似文献Background
Emerging experimental studies suggest that parabens could affect metabolism by altering the microbiome or signaling pathways involved in adipocyte differentiation. While human exposure to parabens is widespread, epidemiologic studies assessing the role of these chemicals on adiposity measures are scarce.Objective
We examined associations of parabens with adiposity measures among adults and children in the U.S. general population.Methods
We conducted covariate-adjusted linear and logistic regression models to examine associations between urinary biomarker concentrations of four parabens (butyl-BP, ethyl-EP, methyl-MP, and propyl paraben-PP) and measures of adiposity (obesity; body mass index, BMI or BMI z-score; and waist circumference) among 4730 adults (2007–2014) and 1324 children (2007–2012), participating in the National Health and Nutrition Examination Survey. We also assessed heterogeneity of associations by gender.Results
We generally observed significant inverse associations between adiposity measures and paraben biomarker concentrations among adults (BP, EP, MP, PP) and children (MP). For example, adjusted prevalence odds ratios (95% confidence intervals, CI) for obesity per a ten-fold increase in MP concentrations were 0.64 (95% CI: 0.55, 0.73) for adults and 0.71(95% CI: 0.52, 0.95) for children. Strength of inverse associations typically increased monotonically with increasing paraben exposure quartiles; and, in general, inverse associations were more pronounced among females. Associations remained when controlling for other phenolic compounds previously linked with adiposity measures.Conclusions
In this cross-sectional study of adiposity measures and parabens, we observed consistent inverse associations in a representative sample of U.S adults and children. Further studies are warranted to confirm our findings, examine the potential role of paraben sequestration in adipose tissue, and elucidate mechanisms by which parabens could alter metabolism. 相似文献Objective
Distracted driving is an increasingly deadly threat to road safety. This study documents trends in and characteristics of pedestrian, bicycle rider, and other victim deaths caused by distracted drivers on U.S. public roads.Methods
We obtained data from the Fatality Analysis Reporting System database from 2005 to 2010 on every crash that resulted in at least one fatality within 30 days occurring on public roads in the U.S. Following the definition used by the National Highway Traffic Safety Administration, we identified distracted driving based on whether police investigators determined that a driver had been using a technological device, including a cell phone, onboard navigation system, computer, fax machine, two-way radio, or head-up display, or had been engaged in inattentive or careless activities.Results
The rate of fatalities per 10 billion vehicle miles traveled increased from 116.1 in 2005 to 168.6 in 2010 for pedestrians and from 18.7 in 2005 to 24.6 in 2010 for bicyclists. Pedestrian victims of distracted driving crashes were disproportionately male, 25–64 years of age, and non-Hispanic white. They were also more likely to die at nighttime, be struck by a distracted driver outside of a marked crosswalk, and be in a metro location. Bicycling victims of distracted crashes were disproportionately male, non-Hispanic white, and struck by a distracted driver outside of a crosswalk. Compared with pedestrians, bicyclists were less likely to be hit in early morning.Conclusions
Distracted drivers are the cause of an increasing share of fatalities found among pedestrians and bicycle riders. Policies are needed to protect pedestrians and bicycle riders as they cross intersections or travel on roadways.Mounting evidence links the use of electronic devices with increased traffic deaths and injuries.1–4 Even though traffic deaths are declining, deaths from distracted driving are rising, with one study attributing much of this increase to texting volume, which surpassed 100 billion monthly text messages in 2008.5 However, there are many potential causes of distraction other than electronic devices that threaten roadway safety. Most of this research has examined aggregate fatalities and injuries from distracted driving crashes, but little is known about the characteristics of victims killed in these crashes despite extensive research on predictors of pedestrian injuries.6–11 Policy makers and advocacy organizations need greater understanding of the characteristics of victims who are most at risk from distracted drivers.In this study, we report the number of pedestrians, bicyclists, and motorist victims who died from distracted driving-related motor vehicle crashes from 2005 to 2010, and describe the victims'' characteristics. We identified a distracted driving-related crash according to whether a driver had been using a technological device, including a cell phone, onboard navigation system, computer, fax machine, two-way radio, or head-up display, or had been engaged in inattentive or careless activities. 相似文献Objective
We used a recent source of nationally representative population data on tuberculosis (TB) infection to characterize concordance between the tuberculin skin test (TST) and the QuantiFERON®-TB Gold In-Tube (QFT-GIT) blood test for immigrants in the United States.Methods
We used TB screening data from the 2011–2012 National Health and Nutrition Examination Survey to examine concordance between the TST and QFT-GIT—an interferon-gamma release assay (IGRA) blood test—for 7,097 U.S. natives, naturalized citizens, and noncitizens.Results
Consistent with prior findings, one in five immigrants in the survey was identified with latent TB infection (LTBI), a rate 14 times higher than for U.S. natives. We also found higher rates of discordant TST/IGRA results among immigrants than among U.S. natives. Unadjusted discordance between TST and IGRA was 3% among U.S. natives (weighted N=5,684,274 of 191,179,213) but ranged up to 19% for noncitizens (weighted N=3,722,960 of 19,377,147). Adjusting for age, sex, and race/ethnicity, noncitizens had more than nine times the odds of having a positive TST result but negative QFT-GIT result compared with U.S. natives.Conclusions
Our findings suggest that whether and how either of these tests should be deployed is highly context sensitive. Significant discordance in test results when used among immigrants raises the possibility of missed opportunities for harm reduction in this already at-risk population. However, we found little distinction between the tests in terms of diagnostic outcome when used in a U.S. native population, suggesting little benefit to the adoption and use of the QFT-GIT test in place of TST on the basis of test performance alone for this population.Although systematic public health efforts during the last 60 years have produced dramatic reductions in domestic tuberculosis (TB) incidence, prevalence, and fatalities, TB remains a major public health threat to global populations, with serious health and economic consequences, especially TB that is resistant to treatment.1–6 One focus of public health efforts to control TB in the United States has been to screen immigrants for active TB by collecting a medical history, conducting a physical examination, and performing a chest radiography for all visa applicants aged ≥15 years.7–9 Still, many immigrants, especially from high-burden regions, enter the United States in apparent health but carrying latent TB infection (LTBI) from some prior TB exposure. As a result, nearly two-thirds of new TB cases in the United States occur among the foreign-born.1 LTBI may not be promptly identified and treated for immigrants in part because of well-documented barriers to health-care access for this population and also because of the complexity of diagnosing LTBI and effectively evaluating the risks and benefits of its treatment.10The current mainstay of TB risk evaluation—the tuberculin skin test (TST)—has many limitations, including a requirement for two health worker visits up to 72 hours apart, inability to distinguish LTBI from active TB, subjective interpretation of test results, and the test being subject to confounding by other infections or bacille Calmette-Guérin (BCG) immunization.7,8,11–13 A new generation of diagnostic tests, Interferon Gamma-Release Assays (IGRAs), shows promise as an effective screening method for LTBI in part because these tests may have fewer limitations than TSTs; they have reduced confounding by immune response and less subjectivity in interpreting results, and are based on more specific markers.11,12 The IGRA requires only one health-care visit during which a blood sample is drawn. Laboratory results for the IGRA can be available within 24 hours.13However, much remains unknown about the efficacy of IGRAs relative to TSTs, and without a gold standard diagnostic, the Centers for Disease Control and Prevention (CDC) recommends screening for TB using either the TST or IGRA, but not both.13 TSTs cost less than IGRAs, which may be an important consideration for public health departments.14–18 Other disadvantages of IGRAs are that blood samples must be collected, transported to a laboratory, and processed shortly after collection.13 More importantly, growing evidence suggests that IGRA and TST results may be widely discordant when used among immigrants or other special groups relative to a U.S. native or more generalized U.S. population. One study of 279 immigrants to Italy found only a 70.9% concordance between these tests.19 A separate study of 132 U.S. visa applicants from Vietnam with culture-confirmed TB found a lack of concordance for 16 tested applicants.20 A study of 604 newly arrived refugees in Decatur, Georgia, documented that one in four had discordant test results between TST and QuantiFERON®-TB Gold In-Tube (QFT-GIT, QIAGEN, Hilden, Germany).21 This lack of concordance—in combination with CDC recommendations against using both tests for TB screening—may result in substantial numbers of immigrants receiving inaccurate test results when being initially screened for TB.To our knowledge, no nationally representative study of concordance between the TST and IGRA for immigrants in the United States has been conducted. We used a well-established source of nationally representative population data on TB infection to characterize concordance between the TST and the IGRA for immigrants in the United States. 相似文献Since the emergence of the COVID-19 pandemic, there has been an increasing body of research focused on the effects that measures like stay-at-home orders and social distancing are having on other aspects of health, including mental health and sexual health. Currently, there are limited extant data on the effects of the pandemic on sexual and gender minorities. Between April 15, 2020, and May 15, 2020, we invited participants in an ongoing U.S. national cohort study (Together 5000) to complete a cross-sectional online survey about the pandemic, and its effects on mental and sexual health and well-being (n?=?3991). Nearly all (97.7%) were living in an area where they were told they should only leave their homes for essentials. Most (70.1%) reported reducing their number of sex partners as a result of the pandemic. Among the 789 participants prescribed HIV pre-exposure prophylaxis (PrEP), 29.9% said they stopped taking their PrEP entirely, and 14.2% started selectively skipping doses. For those who had been taking PrEP, discontinuing PrEP was associated with having no new sex partners (β?=?0.90, 95% CI 0.40–1.40). Among the 152 HIV-positive participants, 30.9% said they were unable to maintain an HIV-related medical appointment because of the pandemic and 13.8% said they had been unable to retrieve HIV medications. Additionally, 35.3% of participants were experiencing moderate to severe anxiety because of the pandemic and 36.7% reported symptoms of depression. In a multivariable logistic regression, reporting a new sex partner in the prior 30 days was significantly associated with being aged 30 or older (vs. not, AOR?=?1.21), being Black (AOR?=?1.79) or Latinx (AOR?=?1.40, vs. white), and being unsure if they had been in close contact with someone diagnosed with COVID-19 (AOR?=?1.32, vs. no contact). It was unassociated with COVID-19-induced anxiety, depression, or knowing someone hospitalized with COVID-19. The pandemic has caused disruptions in sexual behavior (partner reduction) as well as difficulties navigating PrEP and HIV care continua. Findings will guide more comprehensive public health responses to optimize HIV prevention and treatment in the era of COVID-19.
相似文献