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《检验医学与临床》2017,(3)
目的探讨分析高分辨磁共振(HR-MRI)管壁成像技术在颅内动脉瘤破裂风险评估中的可行性。方法将该院60例经三维数字减影血管造影(DSA)技术诊断为颅内动脉瘤破裂患者分为瘤壁强化组(24例)和瘤壁未强化组(36例),所有研究对象在术前行HR-MRI管壁成像检查,观察瘤壁强化与颅内动脉瘤破裂的关系,进而探究HR-MRI成像技术在颅内动脉瘤破裂风险评估中的可行性。结果所有研究对象HR-MRI管壁成像检查显示颅内动脉瘤破裂的有41例,准确率为68.33%;瘤壁未强化组中瘤体破裂的比例(9.80%)明显低于瘤壁强化组(18.42%),差异有统计学意义(χ~2=1.39,P0.05);2组患者中有子囊与无子囊患者例数,SR2与SR≥2患者例数比较,差异均有统计学意义(χ~2=5.62、9.26,P0.05)。结论 HR-MRI成像技术对颅内动脉瘤破裂有少许的漏诊率,但成像结果显示瘤体破裂的风险与瘤壁强化有明显关系,影响瘤壁强化的因素包括瘤体有无子囊及瘤体体率等动脉瘤形态学特征。 相似文献
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目的 探讨CT血管造影(CTA)与高分辨磁共振血管壁成像(HR-MRI)评估颅内动脉瘤破裂风险的临床价值.方法 选取2019年1月至2020年12月我院收治的189例颅内动脉瘤患者作为研究对象,入院后均行数字减影血管造影(DSA)、CTA、HR-MRI检查,检测患者动脉瘤破裂情况,并根据诊断结果将患者分为破裂组(n=5... 相似文献
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Yue W 《Interventional neuroradiology》2011,17(4):420-424
We report the clinical and angiographic results of endovascular treatment of unruptured intracranial aneurysms. Over a three-year period, 80 unruptured aneurysms in 74 patients were electively treated with endovascular management. One aneurysm was diagnosed during investigations for a second ruptured aneurysm, 54 aneurysms were incidentally discovered, 18 aneurysms presented with symptoms of mass effect and seven aneurysms presented with symptoms of brain stem ischemia. Mean size of the 80 unruptured aneurysms was 12.5±8.0 mm (range, 2-39 mm). Thirty-six aneurysms (45%) were small (<10 mm), 38 aneurysms (47.5%) were large (10-25 mm), and six aneurysms (7.5%) were giant (25-39 mm). Forty-eight wide-necked aneurysms (60%) were coiled with the aid of a supporting device. The mortality rate was 1.25%, and the overall morbidity was 1.25%. Of these, one of the patients suffered a stroke, leading to severe disability (1.25%). In one patient, the aneurysm ruptured during treatment, resulting in death. Initial aneurysm occlusion was complete (100%) in 76.25% aneurysms, nearly complete (90%-98%) in 10% aneurysms and incomplete (60%-85%) in 13.75% aneurysms. Follow-up angiography was available in 67 patients with 73 treated aneurysms (91.25%) from one to 36 months (mean 9.3 months); partial reopening occurred in 7.5%, mainly large and giant aneurysms (5.5%). Additional coiling was performed in four aneurysms. There were no complications in additional treatments. At 14.1-month clinical follow-up (range, 2 to 36 months), mRS score was 0 in 78.75% patients, 1 in 10% patients, 2 in 8.75% and 3 in 1.25%. There was no aneurysmal rupture during the follow-up period. Endovascular treatment of unruptured intracranial aneurysms has low procedural mortality and morbidity rates. 相似文献
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【目的】探讨与颅内动脉瘤(IA)破裂相关的危险因素。【方法】回顾性分析167例经数字减影血管造影(DSA)确诊的IA患者资料,分为破裂IA(A组)和未破裂IA(B组),比较两组动脉瘤的位置、大小以及患者的血压、血糖、颅内血管粥样硬化情况。【结果】位于大脑前、后交通动脉以及左侧椎动脉的动脉瘤在B组所占比例大;两组动脉瘤的平均直径无显著性差异;高血压、颅内血管粥样硬化可能为动脉瘤破裂的高危因素,而血糖对动脉瘤的破裂无明显影响。【结论】IA的破裂可能与动脉瘤的位置及患者的血压、颅内血管粥样硬化有关。 相似文献
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Dylan Noblett Lotfi Hacein-Bey Ben Waldau Jordan Ziegler Brian Dahlin Jennifer Chang 《Interventional neuroradiology》2021,27(1):75
BackgroundAneurysmal subarachnoid hemorrhage (SAH) is the most common cause of nontraumatic SAH. Current guidelines generally recommend observation for unruptured intracranial aneurysms smaller than 7 mm, for those are considered at low risk for spontaneous rupture according to available scoring systems.ObjectiveWe observed a tendency for SAH in small intracranial aneurysms in patients who are methamphetamine users. A retrospective, single center study to characterize the size and location of ruptured and unruptured intracranial aneurysms in methamphetamine users was performed.Materials and methodsClinical characteristics and patient data were collected via retrospective chart review of patients with intracranial aneurysms and a history of methamphetamine use with a specific focus on aneurysm size and location.ResultsA total of 62 patients were identified with at least one intracranial aneurysm and a history of methamphetamine use, yielding 73 intracranial aneurysms (n = 73). The mean largest diameter of unruptured aneurysms (n = 44) was 5.1 mm (median 4.5, SD 2.5 mm), smaller than for ruptured aneurysms (n = 29) with a mean diameter of 6.3 mm (median 5.5, SD 2.5 mm). Aneurysms measuring less than 7 mm presented with SAH in 36.5%. With regard to location, 28% (n = 42) of anterior circulation aneurysms less than 7 mm presented with rupture, in contrast to 70% (n = 10) of posterior circulation aneurysms which were found to be ruptured.ConclusionsMethamphetamine use may be considered a significant risk factor for aneurysmal SAH at a smaller aneurysm size than for other patients. These patients may benefit from a lower threshold for intervention and/or aggressive imaging and clinical follow-up. 相似文献
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目的通过量化分析前交通支动脉瘤形态学特征,并预测其破裂风险。方法本研究回顾性地分析了2015年1月~2019年12月收治的246例前交通支动脉瘤患者的头部CT血管造影资料,记录下动脉瘤的形态学特征,再对其形态学特征进行赋值量化(1、2、3分),寻找动脉瘤破裂风险界值。结果(1)发生于偏侧的前交通支动脉瘤共计186个(破裂151个,81.18%),中间位置动脉瘤89个(破裂38个,42.70%)。(2)已破裂动脉瘤的瘤体长径、瘤体长径/瘤颈宽径(AR)、瘤体宽径/瘤颈宽径(BN)与未破裂动脉瘤相比,均具有统计学差异(均P<0.05)。(3)有子囊结构者破裂率(89.26%)高于无子囊者(44.16%)。(4)前交通支动脉瘤总分越高,其破裂率亦越高;总分为11分或以上破裂风险高(P<0.01)。结论CTA形态学特征量化分析可评估前交通支动脉瘤破裂风险。 相似文献
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目的研究高分辨率磁共振成像(high-resolution magnetic resonance imaging,HR-MRI)在颅内动脉瘤测量中的应用价值,并与三维数字减影血管造影(three-dimensional DSA,3D-DSA)、三维时间飞跃法磁共振血管成像(threedimensional time of fl ight MRA,3D-TOF MRA)作对比。材料与方法选取2013年10月至2015年3月我院神经外科诊断为颅内动脉瘤的患者25例。患者首先行3D-TOF MRA及HR-MRI扫描,并于1周内行DSA检查。分别在3D-TOF MRA、HR-MRI和3D-DSA图像上测量动脉瘤的宽径,采用配对t检验两两比较3D-TOF MRA、HR-MRI与3D-DSA在测量颅内动脉瘤宽径方面的差异。P0.05为差异有统计学意义。结果 HR-MRI与3D-DSA、HR-MRI与3D-TOF MRA在测量颅内动脉瘤宽径方面的差异[平均差值分别为(3.16±2.66)mm、(5.15±4.89)mm]均有统计学意义(P10.05,P20.05),3D-DSA与3D-TOF MRA在测量颅内动脉瘤宽径方面的差异[平均差值为(2.53±5.18)mm]无统计学意义(P30.05)。结论 HRMRI与3D-DSA、HR-MRI与3D-TOF MRA在显示颅内动脉瘤宽径方面有差异,可能HR-MRI能更准确地显示颅内动脉瘤实际大小,具有较高的临床应用价值。 相似文献
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BackgroundIntracranial aneurysms are arterial anomalies affecting 2% to 3% of the general population in the world and these ruptures are associated with a high mortality. Some risk factors, such as age, gender, smoking, alcohol, hypertension and familial history are associated with the number of aneurysms and their size. In addition, inflammatory processes within the blood vessels of the brain can activate matrix metalloproteinase-9 (MMP-9), which degrades various components of the extracellular matrix, such as elastin. Thereby, this work has aimed at evaluating the relationship between plasma MMP-9 levels and the risk factors that are associated with intracranial aneurysm, as well as investigating the aneurysm statuses (ruptured and unruptured) and comparing them with the control volunteers.MethodsBetween August 2014 to June 2016, blood samples were collected from 282 patients (204 ruptured and 78 unruptured saccular intracranial aneurysms) and 286 control volunteers. The MMP-9 plasma levels were measured by ELISA. Statistical analyzes were performed with SPSS software when using parametric or nonparametric tests, after the normality tests.ResultsHigher levels of MMP-9 were found in the aneurysm groups as a whole and when they were stratified by rupture status, then compared with the control group (p < 0.0001). When stratifying them by diameter, those smaller than 7 mm presented high levels of MMP-9 (p < 0.0001), especially in the ruptured ones. As for risk factors, hypertension and smoking were the most important. However, hypertension was mostly associated with the ruptured aneurysms (p < 0.0001).ConclusionsHigh levels of MMP-9 were found in smaller ruptured and unruptured intracranial aneurysms (<7 mm) with strongest statistical associations than other sizes, especially when associated with smoking and hypertension. 相似文献
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目的 探讨未破裂颅内动脉瘤发生破裂的危险因素.方法 回顾性分析承德医学院附属医院2008年1月至2010年5月确诊为颅内动脉瘤的患者,依据动脉瘤是否破裂分为破裂组(n=326)和未破裂组(n=90),收集患者临床资料及动脉瘤特征相关资料.结果 对两组临床资料和颅内动脉瘤特征的各变量单因素分析筛选后进行logistic回归分析,结果显示,吸烟史[优势比(OR)=18.226,95%可信区间(CI)=4.427~75.033]、动脉瘤家族史(OR=14.334,95%CI=3.171~64.786)、后交通动脉瘸(OR=4.265,95%CI=1.643~11.072)、中等动脉瘤(OR=5.641,95%CI=2.332~13.641)发生动脉瘤破裂风险高.结论 吸烟史、动脉瘤家族史、中等动脉瘤、后交通动脉瘤均是未破裂颅内动脉瘤发生破裂的危险因素. 相似文献
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目的 探讨血清胱抑素C(serum cystatin C, CysC)、纤维蛋白原(fibrinogen, FBG)和C 反应蛋白(C reactive protein, CRP)水平与颅内动脉瘤发生及破裂的关系。方法 选取颅内动脉瘤患者100例分为破裂组(n=54)和未破裂组(n=46),50例健康体检者为对照组。收集患者血液和脑脊液并检测血清CysC、FBG和CRP的含量。结果 颅内动脉瘤患者中饮酒、吸烟、高血压和动脉粥样硬化比例明显高于对照组,且破裂组年龄≥60岁、男性、饮酒、吸烟、糖尿病、高血压及动脉粥样硬化占比更高,差异具有统计学意义 (p<0.05)。与对照组相比,颅内动脉瘤患者血液和脑脊液内CysC、FBG和CRP 含量显著升高(P<0.05)。结论 颅内动脉瘤患者血液和脑脊液内CysC、FBG和CRP 含量异常升高,且CysC、FBG和CRP 含量与颅内动脉瘤破裂有关。 相似文献
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It is estimated that approximately 10 to 15 million Americans have intracranial aneurysms. Intracranial aneurysms are classified as either unruptured or ruptured. Advances in knowledge and technology are enhancing diagnosis, management, and outcomes associated with unruptured intracranial aneurysms. Optimal outcomes are achieved when aneurysms are treated before they rupture. If the aneurysm ruptures, the mortality rate ranges from 30% to 60%. A review of evidence regarding aneurysms, including the pathogenesis, risk factors, treatment options, and outcomes, is presented. Treatment options addressed include surgical clipping, endovascular coiling, or watchful waiting. Current evidence supports aggressive treatment for patients with previously ruptured aneurysms, large or symptomatic aneurysms, a family history of aneurysm rupture, a long life expectancy, and aneurysms demonstrating growth. Factors that favor watchful waiting include aneurysms that are small or located in the anterior circulation and in patients with a short life expectancy or comorbid medical conditions. Nurses are in an ideal position to use evidence and outcomes to provide accurate and current information on how to reduce the risks for rupture and evaluate treatment options. 相似文献