纳米载银磷酸锆抗菌聚氨酯的抗菌性能****

背景：聚氨酯材料具有优异的物理和化学性能,良好的生物相容性和抗凝血性能,且易加工成形,但聚氨酯制造的人工器官容易受到细菌等微生物的入侵。 目的：观察纳米载银无机抗菌剂对聚氨酯抗菌性能的影响。 方法：将纳米载银无机抗菌剂RHA-2,按0%(空白对照组),0.5%,1%,1.5%,2%,2.5%,5%比例添加到聚氨酯中。采用薄膜密着法检测抗菌聚氨酯对金黄色葡萄球菌、大肠杆菌的抑菌作用,并分析比较抗菌剂添加比例与聚氨酯抗菌性能的相关性。 结果与结论：添加纳米载银无机抗菌剂的聚氨酯对金黄色葡萄球菌、大肠杆菌具有良好的抑菌作用。抗菌剂添加比例0.5%~5%组对金黄色葡萄球菌的抑菌率分别为80.23%,91.32%,95.23%,99.19%,99.87%,99.93%,对大肠杆菌的抑菌率分别为76.70%,86.96%,92.92%,95.43%,99.34%,99.87%,显示抗菌性能随抗菌剂添加比例的上升而明显提高。表明纳米载银无机抗菌剂的添加赋予了聚氨酯优异的抗菌性能,且从抗菌角度出发,推荐纳米载银无机抗菌剂在聚氨酯中的添加比例不应低于1.5%。     

银纳米颗粒及载银抗菌涂层的研究与进展

BACKGROUND: Current numerous studies have confirmed that silver nanoparticles have been extensively applied due to their good anti-bacterial performances.     

纳米载银磷酸锆抗菌聚氨酯的细胞毒性检测

背景：聚氨酯是一种研究热门的医用高分子材料,并在许多人工器官和医疗装置中发挥着至关重要的作用。 目的：制备并观察纳米载银磷酸锆抗菌聚氨酯生物材料对L929细胞增殖活性的影响及细胞毒性反应。 方法：采用MTT法检测各组抗菌聚氨酯对传代培养小鼠成纤维细胞L929的细胞毒性,L929细胞接种于96孔板,随机分为3组进行培养,实验组用抗菌聚氨酯浸提液处理,阳性对照组用苯酚溶液,阴性对照组用高密度聚乙烯浸提液,于24,48,72 h后在倒置相差显微镜下观察细胞形态,通过MTT比色法检测各组细胞的相对增殖率,并评价材料的细胞毒性。 结果与结论：实验组作用于小鼠成纤维细胞24,48,72 h后,相对增殖率分别为94.3%~97.9%,94.5%~99.8%和90.8%~96.3%,材料细胞毒性评级为Ⅰ级。提示添加低浓度纳米载银无机抗菌剂RHA-2(添加比例<5%)的热塑性聚氨酯,无细胞毒性,符合医用生物材料安全标准。     

数字化载银羟基磷灰石人工骨抗菌性及生物相容性

背景：载银珊瑚羟基磷灰石作为一种新型抗菌植骨材料,受到越来越多的关注,作为植入物需与人体具有良好的生物相容性。 目的：观察数字化载银珊瑚羟基磷灰石人工骨材料的抗菌性及生物相容性。 方法：将珊瑚羟基磷灰石粉末浸泡于不同浓度的硝酸银溶液,制备出不同含银量的载银羟基磷灰石,再将其与聚乳酸混合,并通过选择性激光烧结快速成形制备出具有特殊形状的数字化载银抗菌人工骨材料。 结果与结论：连续光源原子吸收光谱仪测定珊瑚羟基磷灰石浸泡于10^-2,10^-3,10^-4,10^-5 mol/L AgNO₃中制备的载银人工骨中Ag+的含量分别为2.31×10^-1%,3.18×10^-2%,6.75×10^-3%,6.05×10^-4%。体外抑菌圈实验表明浸泡10^-2 mol/L AgNO₃中制备的载银人工骨材料对金黄色葡萄球菌和大肠杆菌的抑菌圈直径分别为(13.00±1.52)mm 及(12.30±1.65)mm;浸泡10^-3 mol/L AgNO₃中制备的载银人工骨材料分别为(11.50±0.73) mm及(11.00±0.46) mm。浸泡10^-4,10^-5 mol/L AgNO₃载银人工骨材料对两种细菌均无抑菌圈产生。细胞毒性试验结果表明100%浸泡10^-2,10^-3,10^-4,10^-5 mol/L AgNO₃的载银珊瑚羟基磷灰石人工骨材料的细胞毒性分别为3级、1级、0级、0级。急性全身毒性试验表明浸泡10^-3 mol/L AgNO₃中的人工骨浸提液对小鼠无明显的急性毒性反应,具有良好的安全性。结果表明浸泡10^-3 mol/L AgNO₃中的载银珊瑚羟基磷灰石人工骨在体外对金黄色葡萄球菌及大肠杆菌有明显抗菌作用,且具有良好的生物相容性及安全性。     

新型银纳米颗粒涂层薄膜材料的制备与抗菌性研究

目的制备银纳米颗粒涂层薄膜材料并检测其抗菌性。方法利用脉冲激光沉积法（PLD）将银-二氧化硅薄膜种植在衬底硅片表面,根据不同的激光脉冲沉积速率制备3组薄膜材料样品,其银与二氧化硅的含量比分别为1：3（TypeA）、1：1（TypeB）、3：1（TypeC）设为实验组,纯硅片设为对照组。使用扫描电子显微镜（SEM）、能量色散光谱仪（EDS）、原子力显微镜（AFM）对实验组样品进行物理表征,选用临床标准菌株金黄色葡萄球菌和大肠杆菌作为实验菌株进行样品体外抗菌试验。结果制备的3种样品TypeA、TypeB和TypeC应用EDS测定银纳米颗粒的含量分别为19．29％、65．32％、77．18％。SEM显示,实验组样品中银纳米颗粒镶嵌于二氧化硅的骨架结构中,结构清晰。AFM显示3种样品TypeA、TypeB和TypeC表面粗糙度良好,银纳米颗粒的大小分别为10．8、11．9和12．9nm。抗菌实验显示,接种大肠杆菌的培养基中3种样品TypeA、TypeB和TypeC的抑菌环直径分别为11、15、16mm,接种金黄色葡萄球菌的培养基中3种样品的抑菌环直径分别为15、16、17mm,所制备的银纳米颗粒涂层薄膜材料均显示出抑菌作用;对照组没有出现抑菌环。结论应用PLD方法制备银纳米颗粒抗菌薄膜材料简单易行,且材料具有良好的抑菌作用。     

载银珊瑚羟基磷灰石人工骨的机械性能及修复桡骨大段污染性骨缺损

背景：国内外学者在抗菌骨移植材料的基础实验和临床实践方面进行了大量的研究,取得了一定的进展。目的：通过体外力学实验检测抗菌性载银珊瑚羟基磷灰石人工骨的机械性能,并通过动物实验检测其修复大段污染性骨缺损的能力。方法：利用压缩试验及三点弯曲试验评价载银珊瑚羟基磷灰石、珊瑚羟基磷灰石与珊瑚的力学性能。将36只新西兰大白兔随机分为4组,均制作右侧大段污染性桡骨缺损模型,其中3组分别植入载银珊瑚羟基磷灰石、珊瑚羟基磷灰石与原位自体骨,另1组不植入任何材料(对照)。术后2,6,10周处死动物并取材,通过大体观察、影像学检查、组织学检查观察比较各组骨缺损修复情况,通过细菌学检查评估各组抗菌情况。结果与结论：载银珊瑚羟基磷灰石、珊瑚羟基磷灰石与珊瑚的力学性能无差异。术后10周时,X射线及组织学观察结果显示,载银珊瑚羟基磷灰石骨缺损内为成熟的骨组织,骨组织中有大量的骨陷窝和成熟的骨细胞,可见哈弗氏系统,材料大部分降解,只有少量残留,骨髓腔有部分再通,骨缺损修复效果与自体骨组相似,优于珊瑚羟基磷灰石组与对照组。细菌学检查显示载银珊瑚羟基磷灰石具有良好的抗菌能力。表明载银珊瑚羟基磷灰石具有较好的力学性能及抗菌性能,可用于修复大段污染性骨缺损。 中国组织工程研究杂志出版内容重点：生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程     

银纳米颗粒对神经元的毒性研究

目的 研究不同浓度的银纳米颗粒对神经元毒性的剂量-效应关系,探索银纳米颗粒对神经元的毒性机理.方法 首先培养一种活性好、生长状态优良的原代神经元,将不同浓度（2.5～500μg/mL）的银纳米颗粒加入神经元中作用24h后,通过MTT法计算细胞增殖率,并分析不同浓度的银纳米颗粒对神经元毒性的剂量-效应关系.结果 在25～250μg/mL范围内,细胞数量与形态呈现不同的变化,银纳米颗粒浓度与细胞增殖率呈负相关.结论 在25～250μg/mL的浓度范围内,银纳米颗粒对神经元细胞的毒性呈剂量-效应关系.     

含银介孔二氧化硅-壳聚糖复合材料的制备与性能研究

目的探讨含银介孔二氧化硅-壳聚糖复合材料(Ag/MSN-Chi)的制备方法及其微观表征、细胞毒性、吸水性能、抗菌性能及止血性能。 方法以正硅酸乙酯为前驱体，十六烷基三甲基溴化铵为致孔剂，采用离子交换法在介孔二氧化硅纳米粒子(MSN)中引入银离子，制备出具有抗菌作用的新型有序的含银介孔二氧化硅纳米粒子(Ag/MSN)材料。再利用烷基化壳聚糖负载Ag/MSN，制备出Ag/MSN-Chi。根据所用材料不同将实验分为实验组和空白对照组，实验组又分为3个亚组：MSN组、Ag/MSN组、Ag/MSN-Chi组，空白组为不加任何材料的阳性对照。计算MSN和Ag/MSN的比表面积、孔容、孔径和Ag/MSN与Ag/MSN-Chi的电荷。并通过吸水实验、体外凝血实验、抗菌实验对MSN、Ag/MSN和Ag/MSN-Chi的细胞毒性、吸水性能、止血性能及抗菌性能进行评价，计算细胞相对存活率、吸水率、凝血酶原时间(PT)、凝血活酶时间(APTT)及抑菌率。取健康成年新西兰大白兔18只，随机分成3组：对照组(采用医用纱布处理)、Ag/MSN组(采用Ag/MSN处理)、Ag/MSN-Chi组(采用Ag/MSN-Chi处理)，每组6只，建立肝创伤出血模型，计算止血时间。数据比较采用方差分析和t检验。 结果MSN的比表面积为(523.8±12.4) m²/g、孔容为(1.2±0.4) m³/g、孔径为(3.5±0.9) nm；Ag/MSN的比表面积为(521.6±11.7) m²/g、孔容为(1.15±0.5) m³/g、孔径为(3.6±0.7) nm，2种材料的比表面积、孔容、孔径比较差异均无统计学意义(t＝0.224、0.135、0.015，P值均大于0.05)。经测量，Ag/MSN的Zeta电位为－19.7 mV，Ag/MSN-Chi的Zeta电位为10.27 mV，表明Ag/MSN表面电荷从负值变为正值。Ag/MSN-Chi组、Ag/MSN组和MSN组与小鼠成肌细胞共培养1、4、7 d的细胞相对存活率比较，差异均无统计学意义(F＝2.61、4.72、3.52, P值均大于0.05)。Ag/MSN组吸水率分别与MSN组和Ag/MSN-Chi组比较，差异均无统计学意义(t＝0.482、1.159，P值均大于0.05)。经检测，Ag/MSN-Chi组、Ag/MSN组、MSN组和空白对照组的PT比较，差异无统计学意义(F＝10.28，P>0.05)；Ag/MSN-Chi组、Ag/MSN组、MSN组和空白对照组APTT分别为(20.9±2.1)、(28.5±3.4)、(31.4±2.6)、(38.7±2.5) s，4组比较差异有统计学意义(F＝8.70，P<0.05)；Ag/MSN-Chi组、Ag/MSN组、MSN组APTT分别与空白对照组比较，差异均有统计学意义(t＝9.443、4.186、3.506，P值均小于0.05)；Ag/MSN-Chi组APTT与Ag/MSN组比较，差异有统计学意义(t＝3.294，P<0.05)。MSN组在培养0.5、2、4、6、24 h 5个时间点抑菌率比较差异无统计学意义(F＝5.437，P>0.05)；培养0.5 h，Ag/MSN组和Ag/MSN-Chi组抑菌率分别为(99.7±5.2)%、(97.1±5.4)%，与培养0.5 h MSN组抑菌率(11.2±5.8)%比较，差异均有统计学意义(t＝19.678、18.775, P值均小于0.05)；培养24 h，Ag/MSN组和Ag/MSN-Chi组抑菌率分别为(73.2±5.1)%和(72.9±6.9)%，与MSN组(11.8±5.7)%比较，差异均有统计学意义(t＝13.904、11.825, P值均小于0.05)。Ag/MSN-Chi组、Ag/MSN组和对照组止血时间分别为(12.3±1.5)、(17.2±3.4)、(28.1±3.8) s，3组比较差异有统计学意义(F＝5.892，P<0.05)；Ag/MSN-Chi组和Ag/MSN组止血时间分别与对照组比较，差异均有统计学意义(t＝9.473、5.236, P值均小于0.05)；且Ag/MSN-Chi组与Ag/MSN组止血时间比较，差异有统计学意义(t＝3.230，P<0.05)。 结论Ag/MSN-Chi在不增加细胞毒性的基础上具有有较好的吸水性能、止血性能及抗菌性能。     

Ti－6A1—4V医用钛合金表面载银涂层的制备和抗菌性能研究

目的通过两步微弧氧化法在医用Ti－6Al－4V表面制备载银多孔涂层．研究其抗菌性能。方法选用医用Ti－6A1—4V,在其表面先采用250V低电压微弧氧化法制备TiO：预涂层,然后将样品浸入到浓度1mol／L的AgNO,溶液浸泡2h．再经紫外光照射3．5h,以实现银颗粒在预涂层上的固定．最后在含银（浓度O．2mol/L）电解液中经过350V正向电压的二次微弧氧化处理制备出载银多孔涂层。利用扫描电子显微镜和能量分散谱仪对涂层表面形貌、载银量进行了表征,并通过金黄色葡萄球菌检验了涂层的抗菌性能。结果Ti-6Al-4V表面预涂层呈多孔状,孔洞呈火山口形,平均孔径0．71μm,而载银涂层表面平均孔径约为1．57μm。银颗粒分布在微孔表面和孔洞内壁,涂层平均银含量约为8％。抗菌试验结果显示．当载银涂层与细菌的接触1d后,对金黄色葡萄球菌的杀菌率均达到96．94％．7d后抑菌率仍达到71-27％。结论通过两步微弧氧化法可在医用Ti-6A1—4V钛合金表面制备出具有良好抗菌活性的载银涂层。     

纳米载银抗菌剂与四针状氧化锌抗白色念珠菌的性能

背景：口腔修复材料室温固化甲基丙烯酸甲酯的表面结构疏松多孔,极易附着各种细菌、微生物导致患者义齿性口炎的发生,所以在甲基丙烯酸甲酯中加入抗菌剂成为国内外学者研究的热点。 目的：比较加入纳米载银抗菌剂与四针状氧化锌抗菌剂后,室温固化甲基丙烯酸甲酯对白色念珠菌的抗菌活性。 方法：采用对倍稀释法测定纳米载银抗菌剂与四针状氧化锌抗菌剂对白色念珠菌的最小杀菌浓度。将纳米磷酸锆载银抗菌粉体与四针状氧化锌抗菌剂分别以0%,1%,2%,3%的质量比加入到室温固化甲基丙烯酸甲酯粉剂中,检测各组试件对白色念珠菌的抗菌率。 结果与结论：纳米载银抗菌剂对白色念珠菌的最小杀菌浓度为 40 g/L,四针状氧化锌抗菌剂对白色念珠菌的最小杀菌浓度为25 g/L。未加入纳米载银抗菌剂或四针状氧化锌抗菌剂的甲基丙烯酸甲酯几乎无抗菌活性,加入两种抗菌剂后其抗菌活性明显增加,随着加入抗菌剂质量比的增加,抗菌活性逐渐增强;当抗菌剂质量比增加到3%时,加入纳米载银抗菌剂的甲基丙烯酸甲酯抗菌率为92.23%,加入四针状氧化锌抗菌剂的甲基丙烯酸甲酯抗菌率为98.23%。表明纳米载银抗菌剂与四针状氧化锌抗菌剂对白色念珠菌均有抗菌效果,且四针状氧化锌抗菌剂比纳米载银系抗菌剂抗菌效果好。     

Non‐Volatile Glycerin Gel Enhanced by Sub‐5 nm Particles with Super Elasticity,Recoverability, and High Temperature Resistance

A gel material that can be applied to industry needs to fulfill two requirements: excellent mechanical properties and high temperature resistance. Previous research developed a hydrogel enhanced by sub‐5 nm particles, with excellent mechanical properties. While its application in the open environment is still limited by the volatilization of inner moisture, in this research, a non‐volatile gel (NV gel) enhanced by 5‐nm spherulites is manufactured. The NV gel remains stable after staying at 90 °C for 24 h. Meanwhile, being enhanced by sub‐5 nm nanospherulites, the NV gel shows good mechanical properties: with 200 ppm nanoparticle content, the tensile strength reaches 814 kPa and the compressive stress is 173.41 MPa at a recoverable 99% strain. The high temperature resistance is characterized by thermogravimetric analysis (TGA) and mechanical testing after thermal treatment. Transmission electron microscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, time of flight secondary ion mass spectrometry, and thermogravimetric analysis are used to evaluate the microstructure of NV gel. Possessing non‐volatile and good mechanical properties at the same time, this NV gel becomes very suitable for fulfilling the application requirement as an engineering material.     

Polycyanurate Thermoset Networks with High Thermal,Mechanical, and Hydrolytic Stability Based on Liquid Multifunctional Cyanate Ester Monomers with Bisphenol A and AF Units

Two cyanate ester monomers (CEMs) based on oligomeric aryl ether (OAE) derivatives of bisphenol AF and bisphenol A, with multiple reactive cyanate groups, were developed as technologically highly relevant thermosets. These CEMs are liquids processable at room temperature and can be crosslinked by cyclotrimerization of the cyanate groups to form extended polycyanurate (PC) networks at lower temperatures (<265 °C) than many existing CEMs. The cured PCs have high T_gs (>280 °C), with excellent thermal, mechanical, and dielectric properties. PC nanorods with diameters of 65 or 380 nm could be moulded in porous alumina templates from the OAE‐CEMs. The high aspect ratio nanorods with a length in the order of 100 µm were hydrolytically stable upon extended exposure to boiling water.

     

The Effect of High Pressure Air or Oxygen with and without Carbon Dioxide Added on the Catecholamine Levels of Rat Brain

The noradrenaline and dopamine levels in brain have been studied biochemically after exposure of rats to pure oxygen, oxygen and carbon dioxide, air, air and carbon dioxide at increased pressure up to 6 to 7 ata. After exposure to air with or without carbon dioxide added the catecholamine levels were unchanged, except for a tendency to decreased levels after about 5 hrs exposure to air without carbon dioxide at 7 ata. The behaviour of the rats during the exposure was unchanged. After exposure to oxygen decreased noradrenaline levels were found. Also the dopamine levels seemed to be decreased, but with carbon dioxide added to the oxygen the dopamine levels appeared to increase. During the oxygen exposure most rats developed convulsions. The onset of the convulsive state appeared earlier in rats exposed to oxygen with carbon dioxide added. The effects on the catecholamine levels are discussed with respect to e.g. the convulsions. Some symptoms at exposure to these gases at high pressure are suggested being due to effects on catecholamine or monoamine containing neurons in the brain.     

Ultrastructural and Cytochemical Changes in the Respiratory Compartment of the Lungs in Rats after Combined Treatment with Fine Silicon Dioxide Powder and Uridine

Electron microscopy and cytochemical study of alveolar tissue of rat lungs were performed at the early stage after intratracheal treatment with fine silicon dioxide powder. The preparation was administered to animals receiving or not receiving intravenous injection of uridine. Dust particles permeated the cytoplasm, mitochondria, and nuclei of cells in the air-blood barrier of the alveoli. Uridine decreased the severity of dust-induced damage to cells and increased intracellular glycogen content.     

Curing Reaction of Benzoxazine Under High Pressure and the Effect on Thermal Resistance of Polybenzoxazine

Two benzoxazine monomers, bisphenol A/aniline type benzoxazine (BA‐a) and bisphenol A/tert‐butylamine type benzoxazine (BA‐tb), are prepared with high purity. Their curing behaviors and cure kinetics are studied by high pressure differential scanning calorimetry (HP DSC) at normal pressure and high pressure, respectively. Meanwhile, the apparent activation energy (E _a) is calculated by Kissinger and Ozawa methods. The results show that the curing reaction temperature and E _a of BA‐a are little influenced by high pressure, but for BA‐tb, its curing reaction temperature and E _a increase greatly. FTIR is used to analyze the difference in the hydrogen bonds in cross‐linking structures of cured BA‐a and BA‐tb. Also, molecular simulations are used to figure out the effect of the high pressure on chemical structures. It is found that the content of hydrogen bonds in polybenzoxazines cured at high pressure increases, resulting in the decrease of cross‐linking densities. Moreover, DSC and thermogravimetric analysis tests are carried out to study the thermal resistance of these polybenzoxazines, and the results indicate that their glass transition temperatures (T _gs) and thermal stability decrease after curing at high pressure.     

Effect of High Temperature on Walking among Residents of Rural and Urban Communities

PurposeThis study aimed to establish the association between high temperature and walking among residents of rural and urban areas.Materials and MethodsThis cross-sectional study used data from the Korea Meteorological Administration and the 2018 Community Health Survey to confirm the association between temperature and walking practice. The dependent variable was walking practice. Walking practice was considered if the participants walked for more than 30 minutes a day or more than 5 days a week. The independent variable was the daily maximum temperature (℃) for the preceding 7 days, calculated from the survey date of each participant. A multilevel analysis was conducted to simultaneously consider the individual- and neighborhood-level variables that could affect determining the association between daily maximum temperatures and walking practice.ResultsWhen the daily maximum temperature increased by 1℃, the odds ratio of walking practice decreased to 0.95 (95% confidence interval 0.94–0.97) in rural areas. In contrast, it decreased to 0.98 (95% confidence interval 0.97–1.00) in urban areas, considering both individual- and neighborhood-level factors. Individual- and neighborhood-level determinants of walking practice in rural areas, including educational attainment, marital status, driving a car, subjective health, depression, and meeting neighbors and friends, were confirmed.ConclusionThis study confirmed that increased temperature led to more decrease in physical activity levels in rural areas than in urban areas. Physical and environmental approaches to avoid heat are needed to maintain and promote physical activity, since temperatures can reduce physical activity during the hot summer months.     

用于提高非接触体温测量精度的恒低温环境系统的设计与实现

目前非接触体温测量已成为研究体温测量方向的热点问题.普遍采用的非接触体温测量的方法是红外辐射法,即用热电堆传感器把人体辐射的红外线能量转化成电信号,但热电堆传感器易受到环境温度影响.提出一种适合于红外传感器的恒低温环境系统的设计方案,可以避免环境温度变化对红外传感器输出信号的影响,且可以增加输出信号的信噪比.采用半导体制冷片(TEC)作为控温的执行器件,利用单片机输出的脉冲宽度调制(PWM)信号对半导体制冷片进行控制,采用PID算法控制调节PWM的占空比.当控温基线在0 ℃时,温度波动小于0.05℃.     

外泌体miR-27a/b与单纯性肥胖儿童胰岛素抵抗、血脂代谢和生长发育的关系

目的 检测循环血外泌体miR-27a、miR-27b表达与单纯性肥胖儿童胰岛素抵抗、血脂代谢和生长发育的关系.方法 共纳入了120例年龄在6～15岁之间在我院儿保科体检的儿童,包括60例诊断为单纯性肥胖者作为肥胖组和60例非肥胖儿童作为正常对照组.进行人体测量(包括身高、体重、腰围等),采集血样,提取血清外泌体,采用实...     

硝酸银对乳糜瘘作用的微循环研究

本文对硝酸银经肾盂灌注后,对乳糜瘘的作用作了研究。认为乳糜尿的病因存在丝虫感染之外的未明因素;提出2.5％硝酸银是临床治愈乳糜尿的最佳浓度;结合动物实验结果,着重对肾盂淋巴痿的微循环转归机理作了论证。     

Effect of Hedan Tablets on Body Weight and Insulin Resistance in Patients with Metabolic Syndrome

IntroductionApart from their recognized lipid-lowering effect, Hedan tablets, a mixture of Chinese herbal medicines, have demonstrated a certain weight-loss effect in clinical practice. The aim of this randomized, double-blind, placebo-controlled study was to verify the effect of Hedan tablets on body weight (BW) and insulin resistance (IR) in patients with metabolic syndrome (MetS).MethodsA total of 62 eligible patients with MetS were divided into two groups: the treatment group (Hedan tablets at 4.38 g/day tid) and the control group (placebo treatment). Both groups attended follow-ups at 8, 16, and 24 weeks during the process. The parameters of the assessment include lipid level, BW, triglyceride (TG) to high-density lipoprotein cholesterol (HDLc) ratio (TG/HDLc), homeostasis model assessment for IR (HOMA-IR) index, and adiponectin.ResultsPatients in the treatment group showed a significant decrease in BW compared to those in the control group (−4.47 vs. 0.06 kg) after 8 weeks of treatment. A significant decrease in body mass index (BMI) was also observed in the treatment group after 16 weeks of treatment (−1.79 vs. −0.03 kg/m²). In the treatment group, 20 out of 31 (64.5%) patients lost 5–10% BW and 4 out of 31 (12.9%) patients lost over 10% BW after 24 weeks of treatment. Although there were no significant changes in the patients'' HOMA-IR, the treatment group showed a significant reduction in TG/HDLc (−0.98 vs. −0.19) after 8 weeks of treatment and a significant increase in adiponectin (6.87 vs. −0.43) after 16 weeks of treatment.Discussion/ConclusionThe Hedan tablets significantly improve BW, BMI, TG/HDLc, and adiponectin in patients with MetS. Thus, Hedan tablets may be used as an adjunct to existing MetS management methods.