Social Isolation and Mortality in Ischemic Heart Disease

ABSTRACT The effects of psychosocial and clinical factors on mortality in ischemic heart disease (IHD) were examined in a 10-year follow-up of 150 middle-aged men. Three groups of men were included: men with clinically manifest IHD, men with risk factors and healthy men. Psychosocial factors were assessed by means of standardized questionnaires. They comprised educational level, social class, marital status and a comprehensive assessment of the daily rounds of life of these men. Furthermore, a subjective rating of the own general health status was obtained. The clinical investigation included a standard physical examination, fasting serum lipids, glucose and urate, a frontal and sagittal chest X-ray and a 24-hour ambulatory ECG monitoring. During follow-up 37 men died, 20 of them from IHD. Non-survivors were descriminated from survivors by the following factors: older age, lower education, lower social class, higher systolic blood pressure, increased ventricular irritability and cardiac enlargement. Furthermore, a relative social isolation as indicated by a low social activity level and a poor self-rated general health status was characteristic of non-survivors. In multivariate analyses three factors emerged as the equally strong predictors of mortality, both from all causes and from IHD: social isolation, a poor self-rated health status and ventricular irritability. The psychosocial mortality predictors were independent of and of similar strength as the clinical predictors.     

Predictors for functional decline among nondisabled older Japanese living in a community during a 3-year follow-up

OBJECTIVES: To examine predictors for functional decline in basic activities of daily living (BADL) as well as predictors for decline in instrumental activities of daily living (IADL) among nondisabled older Japanese people living in a community during a 3-year interval from 1992 to 1995. DESIGN: A prospective cohort study. SETTING: A community-based environment. PARTICIPANTS: A total of 583 men and women aged 65 to 89 at baseline who were independent in both BADL and IADL. MEASUREMENTS: Independent variables regarding various factors potentially associated with functional decline were obtained from an interview survey and medical examinations at baseline. Dependent variables were functional status in BADL and IADL obtained at the time of the 3-year follow-up. RESULTS: During the 3-year follow-up, significant predictors for functional decline in BADL and only IADL decline included (1) age of > or = 75, (2) less hand-grip strength, and (3) a history of hospitalization during the past 1 year. In addition, having poor intellectual activities and having poor social roles were identified as significant predictors for functional decline in only IADL during the 3-year follow-up. Furthermore, not having the habit of taking a walk was identified as a significant predictor of functional decline in BADL during the 3-year interval. CONCLUSION: Having a high level hand-grip strength, good intellectual activities, and good social roles are strongly associated with remaining independence in IADL for the nondisabled Japanese persons aged > or = 65.     

Walking speed as a good predictor for maintenance of I-ADL among the rural community elderly in Japan: A 5-year follow-up study from TMIG-LISA

Background   A population-based prospective cohort study was undertaken to examine the predictors of functional decline in instrumental activities of daily living (I-ADL) among non-disabled older Japanese subjects living in a rural community during a five-year interval from 1992 to 1997.
Methods   The subjects consisted of 624 men and women aged from 65–89 years and independent in I-ADL at baseline, who could be completely followed for five years. Independent variables were various physical factors potentially associated with higher level of functional capacity obtained from an interview survey and medical examinations at baseline. Dependent variables were functional status in I-ADL obtained at the time of the 5-year follow-up.
Results   Significant predictors of functional decline in I-ADL during a 5-year follow-up period included: (1) older age; (2) higher blood pressure; and (3) lower maximum walking speed at baseline. Among these predictor, the maximum walking speed is likely to the strongest predictor for the decline in I-ADL.
Conclusion   The ability to walk faster in the old age is strongly associated with independence in the other I-ADL, and walking speed should be modified by the lifestyle to strengthen muscles of the lower extremities in daily life.     

Differences between older men and women in the self-rated health-mortality relationship

PURPOSE: The aims of this study were to examine differences between older men and women: (a) in the ability of self-rated health to predict mortality, (b) in the effect of different follow-up periods on the self-rated health mortality relationship, and (c) in the relative importance of self-rated health and self-rated change in health in predicting mortality. DESIGN AND METHODS: By using data from the Nottingham Longitudinal Study of Activity and Ageing, the author assessed relationships between self-rated health and self-rated change in health and 4- and 12-year mortality in separate unadjusted and adjusted Cox proportional hazards regression models in men and women. RESULTS: The differences between men and women in the hazard ratios for poor self-rated health were not significant, although there were differences in the explanatory factors. The relationship between self-rated health and short-term and long-term mortality was explained by age and health among men. The relationship between self-rated health and short-term mortality was explained by age, physical and mental health, and physical activity among women. The relationship between self-rated health and long-term mortality was explained by age, physical health, and physical activity among women. The relationship between self-rated change in health and short-term mortality was explained by age among men and women. The relationship between self-rated change in health and long-term mortality was explained by age and physical health among men and women. Social engagement was an independent predictor of short- and long-term mortality among men and women in this study. IMPLICATIONS: The finding that low self-rated health was not an independent predictor of mortality among men or women, contrary to many, but not all, previous studies, may be related to differences in study design and/or across cultures. Further research investigating relationships between self-rated health and mortality and potential explanatory variables should analyze men and women separately and should consider the length of follow-up period. The benefits of individual physical and social activities in reducing mortality merit further investigation.     

Risk factors for 6-year mortality by gender in a Japanese elderly population

The aim of this study is to examine gender differences in the factors associated with 6-year mortality among 784 elderly residents (mean age=73 years) in Japan from 1995 (baseline) to 2001. Survival status during 6 years of follow-up was confirmed by either inquiries of older participants or family members or data from official death certificates, or both in 2001. Information on variables associated with mortality was elicited by using a face-to-face interview at baseline (1995). Results of longitudinal analyses showed that self-rated health (SRH) was not an independent predictor of mortality among men or women after adjustment of the other factors. Instead of SRH, having much feeling of usefulness among men and being married among women were significantly associated with increased mortality risk, suggesting that these findings may play an important role in enhancing survival in the elderly.     

Self-rated health and its association with all-cause mortality of older adults in Poland: The PolSenior project

ObjectivesPredictive effect of self-rated health (SRH) on mortality in older adults has been observed. The purpose of the study was to analyze this association in Poles aged 65+.MethodsData were obtained from the nationwide, multidisciplinary PolSenior project, conducted in a representative sample of older population. The study group comprised 4049 respondents (48.0% women) without significant cognitive deficit. SRH was measured using Visual Analog Scale. The analysis included selected socio-economic, health status and life-style factors. Mortality data were retrieved from the state registry.ResultsDuring 5-year period, 414 women (21.4%) and 672 men (31.8%) have died, including 17.5% of women and 26.6% of men with good, 21.6% and 32.9% with fair, 36.2% and 55.3% with poor SRH, respectively. Kaplan-Meier survival curves for SRH revealed significant differences for both genders. Univariate Cox regression analysis revealed significant hazard ratios (HRs) for mortality among women and men with poor compared to good SRH [2.48 (1.83–3.37); 2.62 (2.04–3.36), respectively] and those with fair compared to good SRH [1.29 (1.03–1.60); 1.29 (1.10–1.52), respectively]. Age-adjusted HRs for mortality were significant between groups with poor and good SRH [women: 1.98 (1.46–2.68), men: 2.06 (1.60–2.64)]. Multivariate Cox proportional hazard regression model including revealed significant HRs for mortality between women with poor and good SRH [1.67 (1.06–2.64)].ConclusionsSRH was associated with mortality in both genders. After adjustment for age, this relationship was maintained in respondents with poor compared to good SRH. Inclusion of potential confounders demonstrated that SRH was an independent predictor of mortality only in women.     

Self-rated life expectancy as a predictor of mortality: evidence from the HRS and AHEAD surveys

BACKGROUND: An extensive literature has demonstrated that self-ratings of health predict mortality, even after controlling for more objective measures of health, health habits and sociodemographic characteristics. We examine the role of a related concept, self-rated life expectancy, in predicting mortality. OBJECTIVE: To assess whether self-rated life expectancy predicts mortality after controlling for measures of health, self-rated health, and sociodemographic characteristics. METHODS: Using data from the 1992 Health and Retirement Survey (HRS), the 1993 Asset and Health Dynamics Among the Oldest Old (AHEAD) survey, and the second Tracker file (2.0), Cox proportional hazard models were estimated to assess whether self-rated life expectancy predicts mortality, after adjusting for self-rated health and several potential confounders that might otherwise explain this relationship. The AHEAD sample included 2,102 men and 3,160 women. During the 2 years of follow-up, 9% (n = 185) of the men died and 5% (n = 166) of the women died. The HRS sample was comprised of 4,090 men and 4,885 women. Four percent (n = 164) of the men died and 2% (n = 99) of the women died in the 3 years of follow-up. RESULTS: In the older, AHEAD sample, both self-rated life expectancy (p < 0.01) and self-rated health (p < 0.05) predicted mortality for both men and women, even when the two measures were included in the model together. In the younger, HRS sample, self-rated life expectancy was not significantly associated with mortality when self-rated health was included in the model. CONCLUSION: Our findings suggest that, although self-rated life expectancy and self-rated health may be conceptually related, they have independent empirical effects on mortality.     

Functional transitions and active life expectancy for older Japanese living in a community

We examined functional transitions in both the activities of daily living (ADL), and instrumental activities of daily living (IADL), over a 1-year interval among older Japanese living in a community, then estimated their physically active life expectancy (PALE) and instrumentally active life expectancy (IALE). In 1992, all residents aged 65 or older who lived in Saku City, Nagano, Japan, were followed-up over the 1-year interval. A self-administrated questionnaire, which involved age, sex, five ADL items, and five IADL items, was used for each survey in both 1992 and 1993. Of the baseline cohort (n=10,098), we received 9533 analyzable questionnaires at the follow-up survey in 1993. During the follow-up, 92 and 87% of subjects who were initially independent in ADL and IADL remained independent, respectively. PALE for men and women were estimated to be 16.0 and 18.9 at 65 years of age, respectively. IALE for men and for women were estimated to be 12.8 and 14.6 at the age of 65, respectively. Proportions of the PALE to total life expectancy (TLE) at any age did not greatly differ between men and women; however, men had a slightly larger proportion of IALE to TLE at any given age than women.     

Ten-year mortality and glucose tolerance status in an elderly Finnish population

The aim of this study was to determine the 10-year mortality rate of an elderly population aged 70 years or over (n=379) with reference to glucose tolerance status, taking into account other determinants of excess mortality. The baseline examination during 1991-1992 included a postal questionnaire, a physical examination and a 2h OGTT, which was classified according to both the 1985 WHO criteria and the 1999 WHO criteria. Follow-up was continued until death or until 31 December 2001. 66% of men and 51% of women died within 10 years. In men, the cumulative mortalities were 84% for previously diagnosed diabetes, 67% for undiagnosed diabetes, 67% for impaired glucose tolerance (IGT) and 60% for normal glucose tolerance (NGT). The corresponding percentages for women were 76, 52, 49, and 40%. Male gender, poor self-rated health and previously diagnosed diabetes were the most powerful predictors of mortality. When adjustments were made for age, gender, BMI, cardiovascular disease, hypertension, physical exercise and self-rated health, the estimated relative mortality rate was 2.0 (95% CI 1.5-2.7) among previously diagnosed diabetic subjects, 1.3 (CI 0.8-2.2) among undiagnosed diabetic subjects and 1.1 (0.8-1.5) among IGT subjects compared to NGT subjects. These relative mortalities were higher in women than in men. When abnormal glucose tolerance was pooled into one category, the OR for excess mortality was 1.4 (95% CI 1.1-1.9).     

Gender differences in correlates of mental health among elderly Koreans

OBJECTIVE: . This study examined the differential impact of social roles and socioeconomic resources on the mental health of Korean men and women aged 65 years or older. METHODS: The study sample was a weighted population of 930 people (905 survey samples) aged 65 years or older who had responded to the health behavior survey of the 2001 Korean National Health and Nutrition Examination Survey. RESULTS: We observed striking gender differences in the correlates of poor mental health. Living alone was significantly associated with depressive symptoms and suicidal ideation in men but not in women. Living in a multigenerational family without a spouse and having a lower household income were significantly associated with poor mental health in both men and women. DISCUSSION: We discuss the intriguing evidence of gender differences in the correlates of mental health within the context of traditional Asian society and suggest further research on social components of gender differences in mental health across diverse cultures.     

Effects of cognitive function on functional decline among community-dwelling non-disabled older Japanese

This study examined whether cognitive impairment, falls, and urinary incontinence (UI) were independent predictors of functional decline using a 2-year observation of a non-disabled older Japanese cohort living in a community from 1999 to 2001. A total of 139 men and 214 women aged 70-94 years at the baseline who were independent in both activities of daily living (ADL) and instrumental activities of daily living (IADL) were analyzed in this study. Independent variables, such as cognitive impairment, falls, UI, and other possible factors associated with functional decline were obtained from an interview survey at the baseline. A dependent variable was functional status in ADL and IADL obtained at the time of the 2-year follow-up. During the 2-year follow-up, cognitive function was a significant predictor for both IADL dependence and ADL and/or IADL dependence. Using a group of subjects with Mini Mental State Examination (MMSE) scores of 30-27 points as a reference group, a significant correlation was identified between lower MMSE scores and an increased odds ratio for functional decline. Lower cognitive function was a significant predictor of functional decline, even among those older Japanese whose cognitive function was deemed to be within the normal range.     

Determinants of changes in self-rated health among Finnish war veterans: results from the Veteran Project 1992 and 2004 surveys

Self-rated health is a strong predictor of mortality, morbidity, future functional capacity and the quality of life. Measures of self-rated health have been collected fairly regularly since the 1980s, but few of them focus on self-rated health among the elderly war veterans. The aim of this study was to examine changes in self-rated health among Finnish war veterans from 1992 to 2004 and to analyze the independent determinants associated with changes in veterans' self-rated health. The study population was 4999 veterans living in Finland, who participated in data collection of both the Veteran Project 1992 and 2004. Logistic regression models were used to identify independent predictors for changes in self-rated health. Analyses were conducted separately for men with and without disability and for women. During the follow-up, self-rated health improved or remained unchanged among 88.8% of the men without disability, 90.5% of the men with disability and 87.9% of the women. Determinants for declined self-rated health were a new cardiovascular disease (CVD) among all veteran groups, increased walking difficulties among men without disability and women, a new neurological disease and institutionalization among men without disability, and a new musculoskeletal disease among men with disability. In conclusion, the majority of veterans rated their health improved or unchanged during the follow-up. The importance of mobility impairments and cardiovascular, musculoskeletal and neurological diseases as the predictors of declined self-rated health were confirmed.     

Predictors of mortality in the old-old in Israel: the Cross-sectional and Longitudinal Aging Study

OBJECTIVES: To examine whether well-known predictors of mortality change their predictive power over time, being reduced or even reversed in the old-old. DESIGN: A multidimensional survey of the Cross-Sectional and Longitudinal Aging Study conducted from 1989 to 1992 with follow-up of mortality after 6, 8, 10, and 12 years since 1989. SETTING: Israel. PARTICIPANTS: Participants (N=1,369) were drawn from a national sample of the Jewish Israeli population aged 75 to 94. MEASUREMENTS: Data included sociodemographic factors and measures of health, physical condition, cognitive performance, and depression. RESULTS: The results showed that age, sex, disability, self-rated health, and marital status predicted mortality and that their predictive power changed over 9 years. CONCLUSION: In the old-old, predictors of mortality changed over time, and their predictive effect eventually diminished. The predictors found to be most significant (age, sex, disability, and self-rated health) support the common cause theory.     

Perceived age as a predictor of old age mortality: a 13-year prospective study

OBJECTIVES: To examine whether in older people perceived age is associated with risk of total mortality independent of chronological age. DESIGN: Prospective population-based study (Evergreen project) with mortality surveillance for 13 years after the baseline. SETTING: Face-to-face interview among community-dwelling residents of the city of Jyv?skyl?, Finland. SUBJECTS: 395 men and 770 women aged 65-84 years at baseline. MEASURES: Perceived physical age and perceived mental age were rated either as younger, the same or older in comparison with subject's chronological age. Death dates were received from the official register of the province of Central Finland. Confounders used were chronological age, education in years, number of long-term illnesses, self-rated health, depression score (Beck's 13-item depression scale), and cognitive status. RESULTS: Mortality rates per 1,000 person-years from the older to younger perceived physical age category were 99, 65 and 59 in men, and 81, 54 and 36 in women. In the perceived mental age categories, correspondingly, mortality rates were 139, 63 and 64 in men, and 82, 55 and 44 in women. The fully adjusted relative risk (RR) of death over 13 years with the perceived younger physical age category as referent was 1.42 (95% CI 1.00-2.02) in the older category and 1.28 (1.03-1.60) in the same age category (P=0.049). The crude RR of mortality for perceived mental age categories was 1.56 (1.09-2.23) in the older and 1.10 (0.92-1.31) in the same age as compared with the younger category (P=0.046). Adding cognitive status into the model diminished the predictive value of the model (P=0.545). CONCLUSIONS: Perceived age predicted worsening of health as described as mortality. Perceived age may indicate general well-being and faith in the future, potentially reflecting changes in health.     

Predictors of mortality in 2,249 nonagenarians--the Danish 1905-Cohort Survey

OBJECTIVES: : To elucidate whether well-known predictions of mortality are reduced or even reversed, or whether mortality is a stochastic process in the oldest old. DESIGN: : A multidimensional survey of the Danish 1905 cohort conducted in 1998 with follow-up of vital status after 15 months. SETTING: : Denmark. PARTICIPANTS: : All Danes born in 1905, irrespective of physical and mental status were approached. Two thousand two hundred sixty-two persons of 3,600 participated in this survey. MEASUREMENTS: : Professional interviewers collected data concerning sociodemographic factors, smoking, alcohol consumption, body mass index, physical and cognitive performance, and health during a visit at the participant's residency. Cox regression models were used to evaluate predictors of mortality. RESULTS: : Five hundred seventy-nine (25.7%) of the 2,249 participants eligible for the analysis died during the 15 months follow-up. Multivariate analyses showed that marital status, education, smoking, obesity, consumption of alcohol, and number of self-reported diseases were not associated with mortality. Disability and cognitive impairment were significant risk factors in men and women. In addition poor self-rated health was associated with an increase in mortality in women. CONCLUSION: : In the oldest old, several known predictors of mortality, such as sociodemographic factors, smoking, and obesity, have lost their importance, but a high disability level, poor physical and cognitive performance, and self-rated health (women only), predict mortality, which shows that mortality in the oldest old is not a stochastic process.     

Self-rated current and future health independently predict subsequent mortality in an aging population

BACKGROUND: Self-rated current health is an independent, robust predictor of subsequent mortality in older adults. Investigators hypothesize that individuals likely take into account their future health when reporting their current health. However, few have measured and examined self-rated future health in relation to mortality. METHODS: We investigate the effect of three self-rated health measures on 10-year mortality in 2091 men and women in an aging cohort: (i) self-rated current health, (ii) self-rated future health (1 year in the future), and (iii) a combined measure of current and future health. Vital status at follow-up year 10 was the outcome. We used data from SPPARCS (Study of Physical Performance and Age-Related Changes in Sonomans), a population-based, census-sampled, study of the epidemiology of aging, health, and functioning. RESULTS: Compared to those reporting their future health as better/same, participants reporting their future health as worse or unknown (don't know) experienced elevated 10-year mortality (adjusted rate ratio [RR]=1.6, 95% confidence interval [CI], 1.2-2.1, p=.01), after adjustment for self-rated current health and other relevant covariates. The combined measure of current and future health also contributed important information. Compared to the referent (the best combination, current health excellent/good and future health better/same), participants reporting the worst combination, fair/poor current health and worse/unknown future health, experienced the highest 10-year mortality in the cohort (adjusted RR=3.2, 95% CI, 2.2-4.7, p=.00). CONCLUSIONS: Self-rated future health is an independent, robust predictor of mortality. It is as predictive of subsequent mortality in older adults as the standard measure of self-rated current health. Furthermore, a measure that combines self-reports of current health with future health was most useful in the identification of older adults with the highest mortality rates. Thus, the combined measure of current and future health may be most useful in practice, in distinguishing the differential mortality rates among persons reporting fair or poor self-rated current overall health.     

Poor health in the Korean older population: Age effect or adverse socioeconomic position

The objective of this study was to examine the impact of socioeconomic status and age on poor health among elderly people. Data were taken from the 2006 baseline survey of the Korean Longitudinal Study of Aging (KLoSA). We compared self-rated poor health, depressive symptoms, chronic disease, and disability in middle-aged (age 45-64), old (age 65-74), and very old (age 75-105) individuals. Logistic regression models were used to assess the effect of a poor social environment on health. Elderly Koreans generally had poor socioeconomic status and reported a high prevalence of poor health compared with middle-aged people. Respondents aged 65-74 years old and those aged 75+ were approximately three and four times more likely, respectively, to report self-rated poor health than middle-aged people. These differences were reduced by 41-71% after controlling for education, employment, and income. Elderly persons were also more likely to report depression, chronic disease, or disability, and the differences between age groups were reduced after adjustment for socioeconomic status, but to a lesser extent than was self-rated poor health. Our results indicate that a substantial portion of the gap in health status between middle-aged and older Koreans may be accounted for by the typically low socioeconomic status of elderly people. Income security and health-related interventions are required to improve the health of the elderly cohort who are confronted with the synergistic effects of aging and low socioeconomic status on health.     

Tiredness in daily activities: a subjective measure for the identification of frailty among non-disabled community-living older adults

The objective of this study was to determine whether the responses to questions about tiredness in daily activities is an early subjective sign of frailty indicating older community-living adults at increased risk for disability and mortality. Tiredness in daily activities as measured by the Mob-T Scale, maximal power in sustained work, and comorbid diseases were assessed together with sociodemographic variables in a sample of 705 non-disabled, 70-year old men and women surveyed in 1984. Vital status of members was determined prospectively over the next 15 years. Onset of disability was measured at 5-, 10-, and 15-year follow-up. Onset of disability among non-disabled 70-year old men and women was strongly related to tiredness in daily activities at 5- and 10-year follow-up. Scores on the Mob-T Scale were significantly associated with mortality during the aggregate 15-year follow-up period. Multiple stepwise regression analyses not only indicated that tiredness in daily activities is a strong independent predictor of both disability and mortality, but also that tiredness mediates the effects of comorbidity and maximal power in sustained work on disability/mortality. Self-reported tiredness in daily activities is suggested as a basis for identifying vulnerable frail subsets of older adults requiring targeted strategies for prevention.     

Predictors of five-year mortality in older Canadians: the Canadian Study of Health and Aging.

OBJECTIVE: Based on the Canadian Study of Health and Aging (CSHA), to determine the importance of cognitive status, sociodemographic factors, functional status, and other health related factors as predictors of 5-year overall mortality in older Canadians. DESIGN, SETTING AND PARTICIPANTS: Two partially overlapping groups from the Canadian Study of Health and Aging (1991) were identified: (1) older people living in the community (n = 8949) who had a screening interview (larger sample, fewer variables) and (2) older people who underwent an extensive clinical examination (smaller sample, more objective variables; n = 2914). Deaths in the subsequent 5 years were determined from death certificates and interviews with the caregivers. Multivariate logistic regression models, with death within 5 years as the outcome, were developed separately for men and women. Predictor variables were introduced in the following groups: sociodemographic factors, physical and cognitive status, and physical illnesses and life style factors. Parallel models were developed for the screening sample and for the clinical sample. RESULTS AND DISCUSSION: Five-year mortality ranged from 10.0% (women aged 65-74 living in the community) to 88.1% (men aged 85 and older living in institutions). Multivariate models showed that the odds of death within 5 years increased with age. This effect remained after adjustment for all other variables. Odds of death increased with institutionalization and with increasing cognitive and physical impairment. Although vision and hearing problems and the presence of heart disease, stroke, and diabetes were all strongly related to 5-year mortality in univariate, unadjusted analyses, their contributions were minimal in the multivariate analyses. Increased Body Mass Index was associated with lower mortality in both univariate and multivariate analyses. CONCLUSIONS: This population-based study supported the importance of gender, age, functional status, cognition, and health status in predicting 5-year mortality, and after accounting for cognitive status, physical status, and specific disease variables, the difference in mortality between older people in the community and in institutions was reduced. Knowledge about survival and prognosis is important not only for the planning of long-term facilities and home care, but it can also be helpful for clinical decision-making and for family and caregivers.