Efficacy and safety of Buyang Huanwu decoction(补阳还五汤)for diabetic peripheral neuropathy:a systematic review and Meta-analysis

OBJECTIVE: To evaluate the efficacy and safety of Buyang Huanwu decoction(BYHWD) in treating diabetic peripheral neuropathy(DPN). METHODS: Eight electronic databases, including China National Knowledge Infrastructure Database, Wanfang Database, China Science and Technology Journal Database, Chinese Biomedical Literature Database, Cochrane Library, Embase, Web of Science, and PubM ed, were searched for randomized controlled trials(RCTs) of BYHWD to treat DPN. We identified all RCTs related to BYH...     

Effect of supplementing Qi and promoting blood circulation therapy on left ventricular remodeling: a systematic review and Meta-analysis

OBJECTIVE: To evaluate the effectiveness of an adjuvant therapy from Traditional Chinese Medicine for supplementing Qi and promoting blood circulation(CMSQPBC) on left ventricular remodeling in patients after myocardial infarction(MI).METHODS: Randomized controlled trials were identified in the Cochrane Library, Embase, Web of Science, PubMed, China National Knowledge Infrastructure Database, Chinese Biomedical Literature Database, China Science and Technology Journal Database, Wanfang databases...     

Effectiveness of redcore lotion in patients with vulvovaginal candidiasis: a systematic review and Meta-analysis

OBJECTIVE:To summarize and evaluate the effectiveness and safety of Redcore lotion on treating vulvovaginal candidiasis(VVC) using a systematic review and Meta-analysis of randomized controlled trials. METHODS:A systematic literature search was performed in five English and three Chinese electronic databases up to October 2019. Randomized controlled trials in the treatment for VVC were included; only studies which compared the effectiveness and safety of Redcore lotion plus miconazole with micon...     

ABSTRACTS FROM ORIGINAL ARTICLES

Tneoretical research of Chinese balance moxibustion，The reinforcing and reducing theory of the acupuncture and moxibustion，The outline of the acupuncture cosmetology，Clinical observation of acupuncture treatment on 116 cases of obesity disease complicated with hypertension，Clinical study on dongated needle therapy for deglutition disorders at the chronic stage of apoplexy……     

Study on the Biological Basis of Hypertension and Syndrome with Liver-Fire Hyperactivity Based on Data Mining Technology

Objective: To construct gene co-occurrence network of hypertension and liver-fire hyperactivity syndrome, to investigate the biological basis of hypertension and liver-fire hyperactivity syndrome and the characteristics of the molecular network from gene level. Materials and Methods: Applying GenCLip 2.0 online platform to retrieve the up-to-date literature referred to essential hypertension from PubMed database, cluster the abnormal expression of essential hypertension-related genes and analyze their function, combining Kyoto encyclopedia of genes and genomes-pathway analysis to investigate the closely related genes and the signaling molecules. Based on the genes closely related to hypertension, standard diagnostic symptoms of liver?fire hyperactivity were used as keywords to conduct hypertension liver?fire hyperactivity?related gene cluster analysis. Results: The top 1000 genes of essential hypertension were retrieved from GenCLip 2.0 online platform, which mainly clustered in the regulation of ambulatory blood pressure, regulation of renin-angiotensin-aldosterone system (RAAS), and sympathetic nervous system activity, as well as endothelial dysfunction; the closely related genes of hypertension with liver?fire hyperactivity are related to RAAS, gene REN, angiotensin converting enzyme, angiotensinogen, and cytochrome P450 family CYP2D6. Conclusion: A combination of literature mining and data mining can construct the gene network of hypertension and the syndrome-related genes, which provides a new method for the study of the biological basis of hypertension from the genetic level.     

Effects of Traditional Chinese Medicine on the survival of patients with stage Ⅰ gastric cancer and high-risk factors: a real-world retrospective study

OBJECTIVE: To investigate the benefits of Traditional Chinese Medicine(TCM) therapy for improving the survival of patients with stage I gastric cancer(GC) and high-risk factors in a real-world setting. METHODS: The clinical data of patients who were diagnosed with stage I GC from March 1, 2012 to October 31, 2020 were collected. Prognostic analysis was performed to explore the high-risk factors that affected the survival of the patients. A Cox multivariate regression model was used to compare th...     

Filiform needle acupuncture for allergic rhinitis: A systematic review and meta-analysis

Background: Filiform needle acupuncture(FNA), the most classical and widely applied acupuncture method based on traditional Chinese medicine theory, has shown a promising effect in the treatment of allergic rhinitis(AR).Objective: To evaluate the efficacy, safety, cost-effectiveness, and patient preference of FNA in the treatment of AR by comparing FNA with sham acupuncture, no treatment, and conventional medication.Search strategy: Eight electronic databases were systematically searched from in...     

Effectiveness and safety of traditional Chinese medical therapy for cancer-related fatigue: a systematic review and Meta-analysis of randomized controlled trials

OBJECTIVE: To assess the effectiveness and safety of traditional Chinese medical therapy for cancer-related fatigue.METHODS: We systematically searched eight electronic databases up to June 2017 for randomized clinical trials of traditional Chinese medical therapy for cancer-related fatigue. Two authors independently extracted data and assessed the risk bias of the included trials using the Cochrane Handbook.Data were analyzed by Rev Man 5.2 software.RESULTS: A total of 23 trials involving 1832 ...     

Mechanism underlying Fanmugua(Fructus Caricae)leaf multicomponent synergistic therapy for anemia: data mining based on hematopoietic network

OBJECTIVE: To investigate the underlying mechanism of Fanmugua(Fructus Caricae) Leaf(CPL) multicomponent synergistic therapy for anemia. METHODS: The components were identified in the literature. Six databases were searched for targets of CPL. Enrichment analysis was used to determine the targets associated with anemia and in bone marrow. Based on the Kyoto Encyclopedia of Genes and Genomes database, pathways and targets related to hematopoiesis were obtained. The key targets were obtained by pr...     

EFFECTS OF ELECTROACUPUNCTURE AND MASSAGE IN REDUCING THE RECURRENCE RATE OF EXTERNAL HUMERAL EPICONDYLITIS

Objective: To compare the therapeutic effect of shock-wave and combination therapy of electroacupuncture, massage and shock-wave on external humeral epicondylitis in patients at a specified time, and to find out a way which can make the curative effect last longer.Methods: We randomly divided 86 patients into group I(43 cases) and group II(43 cases).Three drop-outs occurred in each group.Patients in group I received the combination therapy of electroacupuncture, massage and shock-wave, while patients in group II received shock-wave.We used Grip Strength Index Score(GSIS), Mayo Elbow Performance Score(MEPS), visual analog scale(VAS) and the total effective rate to assess joint function, pain intensity and curative effect.We compared the overall outcome in both groups before treatment and at 0, 6, 12 and 24 months after treatment to find out a way which can make the curative effect last longer.Results: Following treatment, we obtained the following results in group I and group II at the 12 th month after treatment: the GSIS was 83.58±6.15 and 62.21±7.62; MEPS was 80.02±7.01 and 66.12±5.73; VAS score was 4.78±1.65 and 6.64±1.58; and the total effective rate was 80.0% and 12.5%.Compared to the group II, group I had better joint function and curative effect, and lower pain intensity(P0.01).There was no difference with t test in VAS, GSIS, and MEPS at 0, 6, and 24 months after treatment(P0.05) between the two groups, indicating their comparability.Conclusion: Electroacupuncture, massage and shock-wave can make the curative effect last longer or delay the recurrence of the disease.     

Safflower yellow injection combined with conventional therapy in treating unstable angina pectoris： a meta-analysis

OBJECTIVE:To evaluate the clinical efficacy of safflower yellow injection combined with conventional therapy in treating unstable angina pectoris.METHODS:We searched online databases:Chinese journal full-text database,China National Knowledge Infrastructure,Wanfang database,Chinese journal full-text database,Pubmed,ScienceDirect,Embase,and the Cochrane Library with manual-screening of relevant literature.Eligible randomized controlled trials(RCT)on angina pectoris were included.We conducted meta-analysis using the RevMan 5.1 software from The Cochrane Collaboration.We treated the relief rate of angina symptoms and electrocardiograph(ECG)as evaluation.RESULTS:Seven articles,including in 1134 patients,were enrolled after the evaluation.Therewas no significant heterogeneity among the studies(χ2=1.08,df=6,P=0.98,I2=0%).The safflower yellow injection with conventional therapy has a higher effective rate than the control group in relieving the symptoms of angina pectoris[odds ratio(OR)=2.95,95%(CI)(1.81,4.81)]and improving ischemic ECG[OR=2.85,95%CI(1.67,4.86)].The difference was statistically significant in the"80 mg dosage"and"100 mg dosage"subgroups(P0.05)for improving clinical symptoms and ECG.The funnel graphic was nearly symmetrical.Sensitivity analysis suggested that the results were stable.CONCLUSION:Safflower yellow injection as an adjunct therapy with conventional drugs shows advantages in easing the clinical symptoms of unstable angina and improving ECG over basic therapy alone.However,the conclusions should be interpreted with care until more high-quality RCTs are reported.2013 JTCM.All rights reserved.     

Effect of Yinian Jiangya Yin on primary hypertension in early stage--a clinical observation on 40 patients

Objective： To observe the effect of Yinian Jiangya Yin （Decoction for lowering blood pressure to prolong life） on patients with early hypertension and its mechanism on the function of vascular endotheliocytes. Methods： The 79 patients with early primary hypertension belonging to the TCM syndrome of stagnation of phlegm and blood stasis in meridians and hyperactivity of the liver-yang were randomly divided into a treatment group of 40 patients treated with Yinian Jiangya Yin and a control group of 39 patients treated with Tianma Gouteng Yin （Decoction of Gastrodia and Uncaria）. The changes in score of TCM syndrome and in blood pressure before and after treatment were observed in the two groups. The contents of nitrogen monoxide （NO） and endothelin （ET） in serum after treatment were determined. Results： There was a statistical difference （P〈0.05） in score of TCM syndrome, effect of lowering blood pressure, and the contents of ET and NO in serum after treatment between the two groups. Conclusion： The effect of Yinian Jiangya Yin on improving TCM syndrome of patients with primary hypertension in early stage and on lowering blood pressure may be related to its regulating the imbalanced condition between ET and NO for restoring the function of endothelium-dependent vasodilation.     

早期乳腺癌保乳术及中药疗效评价

Objective To investigate the indication, methods and therapeutic effects of breast-conserving surgery in mammary cancer of early stage. Methods A retrospective study on 28 cases of Ⅰ and Ⅱ stage of breast-conserving surgery was underwent. Results Breast-conserving surgery does not destroy the appearance symmetry of breast, and maintains a low baldness rate. The recurrence rate in 5 years after surgery is 5.3%, and the 5 years' survival rate is 100%. Conclusion Breast-conserving surgery combined with the hinese herbal medicine therapy is an effective and safe way to treat mammary cancer in a early stage.     

Effect of Medical Qigong Therapy on Distress, Fatigue, and Quality of Life in Head and Neck Cancer Patients Undergoing Intensity‑Modulated Radiation Therapy: A Single Arm Clinical Trial

Background: Cancer of Head and Neck (HNC) is the 2nd common cancer in India leading to around 8% of the global cancer mortality. Intensity?modulated radiation therapy (IMRT) is advanced method minimizing exposure of radiation to adjacent normal structures but is associated with higher fatigue indirectly elevating distresslevels. Medical Qigong (MQ), a meditative mind therapy has numerous health benefits. The purpose of the current study was to investigate effect of MQ therapy on distress, fatigue, and quality of life in HNC patients undergoing IMRT. Materials and Methods: This experimentalstudy was conducted on 16 Hospitalized HNC subjects undergoing IMRT aged 18–65 years. All the subjects performed Qigong Walk Cycle for 5 weekdays for 4 weeks from initiation of IMRT. Scores of Brief Fatigue Inventory (BFI), 6 min walk distance (6MWD), Functional Assessment of Cancer Therapy-Head and Neck (FACT-HN) were documented at the baseline and at end of 4th week and compared. Results: IBM SPSS Statistics version 23.0; Indian version of Windows was used for statistical analysis. The 16 HNC subjects majorly rural residents (62.5%) of mean age group 47.68 ± 10.25 years with tobacco chewing as prevalent habit (94%) with maximum cases recorded in stage III of the disease. The pre and post test score comparison of serum cortisol, BFI and 6MWD found high statistical significance with P = 0.001 while that of the total and all components of FACT HN was found to be significant with P ≤ 0.05. Conclusion: MQ therapy was effective in managing the levels of distress and fatigue thereby improving quality of life of all HNC subjects.     

Comparison of the Digital Point Pressure and Massage on Meridians with Acupuncture

Professor ZHANG Tao, a national-noted TCM physician in Guanganmen Hospital, China Academy of Chinese Medical Sciences, has rich experience in the treatment of orthopedic and traumatic diseases. The author fortunately had a chance to work with Professor ZHANG during his advanced studies in 1999, and used the digital point pressure and massage on meridians in clinic and obtained a very satisfactory result.12 The digital point pressuremassage on meridians is also termed as the ＂finger needle＂ therapy, ＂finger pressure＂ therapy and ＂digital point pressure＂ therapy. Through many years＇ study on the basic theory of ancient classics and the clinical practice, the author has had a further understanding of the digital point pressure and massage on meridians and thought that profound TCM theories are worth carrying on and developing. The following is the comparison of the digital point pressure and massage on meridians with acupuncture.     

Efficacy of Buzhong Yiqi decoction(补中益气汤)on benign prostatic hyperplasia and its possible mechanism

OBJECTIVE: To explored the mechanism of Buzhong Yigi decoction(补中益气汤 BZYQD) in inhibiting prostatic cell proliferation effect. METHODS: The compounds of BZYQD consisted with eight herbs were searched in TCMSP databases and the putative targets of BZYQD were collected in Drugbank database. Then, “Benign prostatic hyperplasia”(BPH) was used to find the targets based on the Gene Cards, Online Mendelian Inheritance in Man(OMIM) and Therapeutic Target Database(TTD) databases, and they were further us...     

Effectiveness of Chinese herbal medicine combined with conventional medicine on acute exacerbation of chronic obstructive pulmonary disease: a systematic review and Meta-analysis

OBJECTIVE: To systematically evaluate the efficacy and safety of Chinese herbal medicine(CHM) combined with conventional Western Medicine(CWM) on acute exacerbation of chronic obstructive pulmonary disease(AECOPD) based on high-quality randomized placebocontrolled trials. METHODS: We searched PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure Database, Chinese Biomedical Literature Database, China Science and Technology Journal Database, and Wanfang databases for randomize...     

The Potential Effects and Use of Chinese Herbal Medicine Pine Pollen (Pinus pollen): A Bibliometric Analysis of Pharmacological and Clinical Studies

The objectives of this study are to conduct a comprehensive literature search and bibliometric analysis to identify the breadth and volume of pharmacological and clinical studies on pine pollen (Pinus pollen) and to identify the potential effects and the use of pine pollen. Three Chinese electronic databases and two English electronic databases were searched for pharmacological and clinical studies on pine pollen. Data were extracted and analyzed and included publication year, authors,study type, pharmacological research topics or clinical diseases/conditions, usage and type of preparation, authors’ conclusions, and adverse effects. Of 239 publications identified, 180 were pharmacological studies, 37 were clinical trials, and 22 were reviews. Numbers of publications increased particularly from 2004 onward. The top 10 most frequent topics in pharmacological studies were immune regulation, antisenility, antioxidation, liver protection, inhibiting prostate hyperplasia, inhibiting tumor cell proliferation, lowering blood glucose, lowering blood lipids, antifatigue, and improving intestinal function. The top 10 most frequent clinical diseasestreated or where pine pollen was used as an adjuvant were bedsores, diaper dermatitis, hyperlipidemia, oral mucositis, eczema, hyperplasia of prostate, hypertension, prostatitis, type 2 diabetes mellitus, and radiodermatitis. Eight trialsreported no adverse events associated with pine pollen, one reported mild gastrointestinal reactions, but symptoms disappeared without special management. There have been an increasing number of publications on pine pollen during the past 20 years. Pharmacological studies have shown many potential benefits, and clinical studies have indicated some positive effects when it is either used as a single herb or as an adjuvant to treat disease. Its use as a topical agent, especially for skin diseases, was notable.