Brandt-Daroff习服法联合倍他司汀治疗良性阵发性位置性眩晕复位后残余症状的疗效分析

目的　观察Brandt-Daroff习服法,以及联合倍他司汀治疗良性阵发性位置性眩晕（BPPV）复位后残余症状的疗效。方法　纳入2017年3月～2019年3月收治BPPV复位成功患者,将其中复位后仍存在残余头晕患者75例随机分3个组,对照组（倍他司汀治疗）、训练组（Brandt-Daroff习服法）和联合组（Brandt-Daroff习服法联合倍他司汀）,每组25例。对所有患者治疗后残余症状持续时间,治疗前后的眩晕残障量表（dizziness handicap inventory,DHI）进行评分比较。结果　治疗前各组患者的基线资料及DHI评分差异无统计学意义（P＞0.05）。治疗后,联合组残余症状持续时间低于对照组和训练组（P＜0.05）,对照组和训练组之间差异无统计学意义（P＞0.05）;治疗7天后,联合组DHI评分低于训练组及对照组（P 均＜0.05）,训练组和对照组比较差异无统计学意义（P＞0.05）;治疗28天后,联合组DHI评分均低于对照组和训练组（P 均＜0.001）,训练组评分低于对照组,差异具有统计学意义（P＜0.001）。结论  Brandt-Daroff习服法联合倍他司汀能显著减轻BPPV成功耳石复位后残余的头晕症状,单用Brandt-Daroff习服法和常规内科药物倍他司汀有相似疗效。     

不同方案治疗良性阵发性位置性眩晕的疗效分析

目的比较分析不同治疗方案治疗良性阵发性位置性眩晕的疗效。方法回顾性分析189例BPPV患者,根据治疗方案分成4组。组1(56例)为手法复位加甲磺酸倍他司汀口服,组2(55例)为手法复位加银杏叶提取物静脉滴注,组3(40例)为SRM-IV前庭功能治疗系统复位加甲磺酸倍他司汀口服,组4(38例)为SRM-IV前庭功能治疗系统复位加银杏叶提取物静脉滴注。比较分析各组的治愈时间及治疗效果。结果治愈时间组间差异有显著性统计学意义(P<0.05),组2治疗时间最短(6.58±2.05天);治疗效果组间差异有统计学意义(P<0.05),组2痊愈率最高,组2及组4有效率优于其他2组。结论结果分析显示,手法复位或机械复位基础上辅以药物治疗BPPV,都可以获得较好疗效。     

前庭康复训练联合药物治疗对良性阵发性位置性眩晕复位后残余症状的疗效分析

目的分析前庭康复训练联合药物治疗对良性阵发性位置性眩晕（BPPV）患者复位后残余症状的改善情况。方法选取2013年6月—2016年2月确诊为BPPV且行手法复位成功患者66例,根据随机数字表法,将患者平均分为药物组、前庭康复组和联合组,每组各22例。比较患者治疗前后的眩晕残障程度量表（DHI）和医院焦虑抑郁量表（HADS）评分情况;治疗结束后随访6个月,并记录各组患者复发率。结果治疗2、4、6周时,联合组DHI评分均明显低于前庭康复组和药物组,差异具有统计学意义（P＜0.05）。治疗6周后,联合组HADS T评分明显低于前庭康复组和药物组,差异均具有统计学意义（P均＜0.05）;联合组复发率低于药物组（χ2=3.511,P<0.05）和前庭康复组（χ2=2.387,P<0.05）,差异均具有统计学意义（P均<0.05）。结论对BPPV且行手法复位成功患者在药物治疗的同时辅以前庭康复训练,可有效改善BPPV患者的残余症状,并且降低了眩晕复发率,改善患者焦虑和抑郁状态,疗效显著。     

分析昂丹司琼配合倍他司汀在前庭神经元炎引起眩晕患者中的疗效

目的 研究前庭神经元炎引起眩晕症患者行昂丹司琼+倍他司汀治疗的效果。方法 数据取自我院2022年4月-2021年4月收治的80例前庭神经元炎引起眩晕症患者，“随机取样法”分单一组(倍他司汀，n=40)、联用组(倍他司汀+昂丹司琼，n=40)，两组疗效比较。结果 用药前分析眩晕障碍程度、氧化应激性无差异，用药后分析不良反应无差异，P>0.05；用药后相比单一组，联用组DHI评分更低；SOD、GSH-Px指标更高，MDA、ET-1指标更低；联用组有效率(95.00%)高于单一组(75.00%)，χ²=4.132;P=0.042,P<0.05(具有统计学意义)。结论 昂丹司琼+倍他司汀治疗前庭神经元炎引起眩晕症患者可改善眩晕障碍、减轻氧化应激性，达到预期疗效、减少副作用，值得推崇。     

倍他司汀联合利多卡因对良性阵发性位置性眩晕患者管石复位治疗成功后残余头晕的疗效观察

目的观察倍他司汀联合利多卡因对良性阵发性位置性眩晕患者管石复位治疗成功后残余头晕的临床疗效。方法抽取本院2017年1月~2019年6月接诊的良性阵发性位置性眩晕管石复位治疗成功后残余头晕患者60例作为研究对象。按照就诊时间,将60例患者平均分为对照组和研究组,每组30例。对照组患者接受倍他司汀单一用药治疗,研究组患者接受倍他司汀联合利多卡因治疗。分别比较两组患者的临床疗效。结果研究组临床治疗有效率为93.33%,明显高于对照组的70.00%,组间存在统计学意义,P<0.05。结论对良性阵发性位置性眩晕管石复位治疗成功后残余头晕患者采取倍他司汀联合利多卡因治疗效果显著,不仅能缓解头晕症状,还能改善患者的生活质量,值得在临床上应用和推广。     

中药辅助良性阵发性位置性眩晕复位治疗效果的观察

目的观察良性阵发性位置性眩晕复位治疗辅以中药治疗的临床效果。方法选择2017年1~7月在北京中医医院耳鼻咽喉科治疗的52例BPPV患者,随机分为观察组(26例)和对照组(26例)。两组患者均采用前庭功能诊疗系统进行复位治疗,同时观察组辅以中医辨证治疗,对照组则辅以西药治疗,比较两组患者治疗后1周和1个月时的有效率。结果治疗后1周,两组病例的有效率差异无统计学意义(χ~2=0.340,P0.05);治疗后1个月,观察组有效率则明显高于对照组(χ~2=4.127,P0.05)。结论良性阵发性位置性眩晕复位治疗辅以中药治疗可有效提高其临床治疗效果。     

甲磺酸倍他司汀对良性阵发性位置性眩晕位置试验眼震的影响CSCD

目的探讨甲磺酸倍他司汀对良性阵发性位置性眩晕(BPPV)位置试验眼震的影响。方法2022年1~6月就诊的头晕患者并且予BPPV位置试验检查,其中61例检查前24h内仅口服过甲磺酸倍他司汀治疗,199例检查前24h内口服其他药物或者多种药物联合治疗。观察其停药前、后BPPV位置试验眼震变化情况:检查前24h内有用药史者,先予第1次BPPV位置试验,记录眼震情况;若第1次位置试验为阴性,嘱其停药24h后再予第2次BPPV位置试验,记录眼震情况;若第1次位置试验为阳性,予手法复位治疗,1h后复查,若复位效果欠佳,嘱其停药24h后再予第2次BPPV位置试验,记录眼震情况。位置试验眼震均通过视频眼罩观察。结果检查前24h内仅口服过甲磺酸倍他司汀的患者中,第1次BPPV位置试验眼震阳性者占16.39%(10/61),停药24h后第2次BPPV位置试验眼震阳性者占49.02%(25/51),停药前、后BPPV位置试验眼震阳性率有显著统计学差异(x2=8.89,P=0.003)。第1次位置试验眼震阳性者中,有5例(50%)在停药24h后第2次位置试验中眼震强弱程度发生变化,导致定位患侧半规管发生变化:2例左水平半规管BPPV修正为右水平半规管BPPV;1例左水平半规管帽型BPPV修正为右水平半规管帽型BPPV;2例水平半规管帽型BPPV,从第1次位置试验无法根据眼震强弱程度辨别患侧,到第2次位置试验可以根据眼震强弱程度明确患侧。结论甲磺酸倍他司汀对BPPV位置试验的精确性有一定影响,主要表现为抑制患者发病时原有的眼震,建议停药24h后再做位置试验,有助于BPPV精准诊疗。     

视频头脉冲试验与BPPV复位治疗后残余症状关系

目的 回顾性分析视频头脉冲试验（Video head impulse test,vHIT）与良性阵发性位置性眩晕（Benign paroxysmal positional vertigo,BPPV）复位治疗后残余症状持续时间关系。方法 回顾辽宁中医药大学附属医院就诊诊断为BPPV并经复位治疗后治愈患者共152例,按vHIT回报正常与否分为正常组（n=49）与异常组（n=103）,对比两组间复位治疗次数、残余症状持续时间。其次将所有病例按不同责任半规管及不同类型进行分析与比较。再对所有病例年龄、复位治疗次数、残余症状持续时间之间相关性进行两两分析。另外对同时具有冷热试验结果的27例进行分析。结果 正常组与异常组间复位治疗次数差异无统计学意义（P=0.370）。正常组残余症状持续时间（15.37±21.74d）小于异常组（19.57±16.70d）,组间差异有统计学意义（P=0.008）。不同类型及不同责任半规管BPPV中,后管复位次数最少（P=0.021）,水平管嵴顶结石症残余症状持续时间最短（P<0.001）。全部样本中年龄与复位治疗次数之间不相关（P=0.198）,年龄与残余症...     

单纯手法复位与合并药物治疗良性阵发性位置性眩晕的疗效比较

目的:比较单纯手法复位与合并药物治疗良性阵发性位置性眩晕(BPPV)的疗效及复发情况。方法:对84例BPPV患者采取随机对照方法进行临床研究,对照组42例予单纯手法复位,治疗组42例在手法复位的基础上口服甲磺酸倍他司汀片、盐酸氟桂利嗪、金纳多滴剂。7d、28d后进行疗效评定,观察半年的复发情况。结果:治疗7d后,治疗组痊愈率为78.57%,总有效率为92.86%,均高于对照组(分别为50.00%和80.95%,P<0.05);治疗28d后,治疗组痊愈率为80.95%,总有效率为95.24%,与对照组(分别为71.43%和90.48%)比较无差异(P>0.05);随访半年,治疗组3例(7.14%)复发,对照组7例(16.67%)复发,两组差异有统计学意义(P<0.05)。结论:复位法治疗BPPV有效、简便、安全,可作为首选的治疗方法,配合药物综合治疗近期能缓解症状,缩短治愈时间。     

动态平衡仪在良性阵发性位置性眩晕患者平衡功能评价及康复治疗中的应用价值

目的 探讨动态平衡仪在良性阵发性位置性眩晕(benign paroxysmal positional vertigo,BPPV)患者平衡功能评价及康复治疗中的应用价值.方法 回顾性分析2007年5月至2008年12月48例后半规管BPPV患者的临床资料.所有患者分别于Epley法复位前后行动静态平衡仪及冷热试验检查,并对结果进行分析比较.对于复位后眼震消失但仍有平衡障碍的患者采用动态平衡仪进行平衡康复训练,3周后再行动态平衡仪检查.结果 48例BPPV患者,Epley法复位前,冷热试验异常12例,占25.O%;静态平衡仪异常16例,占33.3%;动态平衡仪异常34例,占70.8%.经统计分析,动态平衡仪异常率高于冷热试验及静态平衡仪,差异具有统计学意义(χ2值分别为4.84和7.88,P值均＜O.05).Epley法复位治疗后,冷热试验异常7例,静态平衡仪异常4例,动态平衡仪异常8例.复位治疗后动态及静态平衡仪测试结果异常率明显降低,差异具有统计学意义(χ2值分别为24.04和1O.08,P值均＜0.05);而冷热试验结果无明显变化,治疗前后差异无统计学意义(χ2=3.2,P＞0.05).运用动态平衡仪对复位治疗后仍有平衡障碍的8例患者进行平衡康复训练,3周后所有患者平衡不稳感均消失,复查动态平衡仪结果均正常.结论 动态平衡仪可定量分析姿势平衡状态,有助于全面评价BPPV患者的平衡功能;BPPV患者多伴有平衡功能的降低,Epley法复位治疗可改善大部分患者的平衡功能,但并非所有患者平衡功能均恢复正常.运用动态平衡仪进行平衡康复训练对于已行耳石复位但仍有平衡障碍的患者有益.     

前庭康复对老年良性阵发性位置性眩晕患者后遗头晕的疗效

目的 探讨前庭康复训练对老年良性阵发性位置性眩晕(BPPV)患者后遗头晕的疗效。 方法 选择BPPV患者耳石成功复位治疗眼震消失3 d仍后遗头晕患者86例,按照随机表法分为观察组43例与对照组43例。对照组采用甲磺酸倍他司汀治疗,观察组在对照组基础上结合前庭康复训练,两组疗程均为7 d。比较两组治疗疗效、治疗前后BBS评分、VSI评分及DHI量表评分。 结果 观察组总有效率(95.35%)高于对照组(72.09%)(P<0.05)。观察组治疗前BBS评分为7.39±1.24,治疗后为49.81±4.56;对照组治疗前BBS评分为7.61±1.27,治疗后为39.62±3.21,观察组治疗后高于对照组(P<0.05)。观察组治疗前VSI评分为32.78±2.41,治疗后为24.87±3.28;对照组治疗前VSI评分为32.54±2.39,治疗后为28.46±2.80,观察组治疗后低于对照组(P<0.05)。观察组治疗前DHI量表总分为76.44±6.57,治疗后为30.81±3.24;对照组治疗前DHI量表总分为76.36±5.82,治疗后为42.36±4.67,观察组治疗后低于对照组(P<0.05)。 结论 前庭康复训练对老年BPPV患者后遗头晕疗效显著。     

前庭功能诊治系统SRM-Ⅳ在良性阵发性位置性眩晕中的应用

目的观察全自动前庭功能诊治系统（SRM-Ⅳ）诊治良性阵发性位置性眩晕的临床效果。方法回顾分析了56例良性阵发性位置性眩晕患者,其中36例采用SRM-Ⅳ进行诊断和治疗,20例采用手法诊治,对其疗效进行比较。结果采用SRM-Ⅳ治疗的患者中第1次治疗后有32例患者（89%）治愈,4例患者经过第2次治疗痊愈;采用手法复位的患者中第1次治疗后有17例患者（85%）治愈,3例患者经过第2次治疗痊愈。应用χ2检验二者的差异没有统计学意义。结论应用全自动前庭功能诊治系统诊治良性阵发性位置性眩晕临床效果可靠,弥补了手法复位的缺陷,效果直观,可重复性强。     

Vestibular rehabilitation therapy in combination with transcranial direct current stimulation (tDCS) for treatment of chronic vestibular dysfunction in the elderly: a double-blind randomized controlled trial

IntroductionDizziness and imbalance are common dysfunctions in the elderly. Vestibular rehabilitation therapy is an effective method to alleviate chronic dizziness in patients with vestibular dysfunction. Transcranial direct current stimulation has reportedly improved balance function in patients with vestibular dysfunction.ObjectiveThis study was conducted to investigate the therapeutic efficacy of vestibular rehabilitation combined with transcranial direct current stimulation in elderly patients with vestibular dysfunction.MethodsIn a double-blinded randomized controlled trial, 36 elderly patients with chronic vestibular dysfunction were randomly assigned to either vestibular rehabilitation and transcranial direct current stimulation (n = 18) or vestibular rehabilitation alone (n = 18) group. The transcranial stimulation protocol consisted of multisession bifrontal electrical stimulation of the dorsolateral prefrontal cortex (2 mA intensity and 20 min duration), followed by rehabilitation exercises. The vestibular rehabilitation protocol consisted of habituation and adaptation exercises combined with gait exercises during a three week period. The primary outcome of this study was the dizziness handicap inventory score, and the secondary outcomes were activities-specific balance confidence and Beck anxiety inventory scores.ResultsFor the dizziness handicap score, the repeated-measures analysis of variance showed a significant main effect of “time”, “stimulation” and stimulation × time interaction effect. There was a significant reduction in the overall dizziness handicap score with “time” for both the groups, which was more pronounced in the vestibular rehabilitation and electrical stimulation group. In terms of activities-specific balance confidence change scores, we found a significant main effect of “time” and “stimulation” main factors, but this effect for stimulation × time interaction was not significant. For the Beck anxiety score, we observed a significant main effect of “time”, but no evidence for the main effect of the “stimulation” factor.ConclusionBifrontal transcranial direct current stimulation in combination with vestibular rehabilitation therapy is a promising approach to improve chronic vestibular symptoms in the elderly.     

Assessment of sensory organization testing in benign paroxysmal positional vertigo patients before and after repositioning manoeuvre

Introduction and objectiveBenign paroxysmal positioning vertigo is considered the most common disorder of the peripheral vestibular system. After successful physical manoeuvres for BPPV, a number of patients complain of non-positional sustained imbalance of variable duration called residual dizziness lasting for several days. The objective of this study was to compare the posturographic changes before and one week after successful repositioning manoeuvres in patients with idiopathic BPPV.Materials and methodsThis study was a case–control study, where the first group was composed of 20 patients with confirmed BPPV diagnosis regardless of the affected canal or pathology. Twenty age and gender matched normal subjects constituted the control group. The sensory organization test was performed before and one week after a repositioning manoeuvre in BPPV patients.ResultsAll 20 BPPV patients, except 6 who had no significant improvement of symptoms even after disappearance of classic vertigo and nystagmus, had substantial improvement in sensory scores after CRPs in the antero-posterior visual and vestibular scores and the medio-lateral visual and global scores. All antero-posterior and medio-lateral scores before and after CRPs, except for the AP preferential score, were considerably poorer in BPPV patients than healthy subjects. The 6 patients, who showed no improvement after CRPs, presented with a history of non-specific symptoms i.e., light-headedness or sense of floating.ConclusionsSensory organization test might have a role in the assessment of residual dizziness in patients with BPPV after CRPs.     

Danhong enhances recovery from residual dizziness after successful repositioning treatment in patients with benign paroxysmal positional vertigo

ObjectivesAlthough the repositioning maneuvers are usually very effective in patients with BPPV, some patients still complain residual dizziness. Danhong injection (DHI), a traditional Chinese medicine, can effectively dilate blood vessels and improve microcirculation, and has been proven to be effective in improving cervical vertigo and posterior circulation ischemic vertigo. The aim of this study was to evaluate the effects of DHI on residual dizziness after successful repositioning treatment in patients with BPPV.MethodsEighty-six patients with BPPV were randomized into two treatment groups, DHI group and non DHI group. The DHI group received the same repositioning treatment as the non-DHI group, with the addition of DHI therapy. The durations of residual dizziness of DHI group and non-DHI group were compared. In addition, the scores of the dizziness handicap inventory of these two groups were calculated.ResultsThe durations of residual dizziness of DHI group were shorter than that of non-DHI group. There were no significant differences in the scores of dizziness handicap inventory in the first week between these two groups, and there were much significant differences in the second, the fourth, the sixth and eighth weeks.ConclusionsThe results demonstrate that DHI can significantly improve the residual dizziness after successful repositioning treatment in patients with BPPV.     

甲磺酸倍他司汀治疗内耳缺血相关性眩晕的疗效研究

目的通过观察良性阵发性位置性眩晕（benign positional paroxysrnal vertigo，BPPV）、后循环缺血（posterior circulation ischemia，PCI）、偏头痛性眩晕（migrainousvertigo，MV）、青少年良性眩晕在服用不同剂量的甲磺酸倍他司汀后的临床表现，了解甲磺酸倍他司汀治疗内耳缺血性眩晕的疗效。方法BPPV、PCI、MV各30例，分成2组。组一：甲磺酸倍他司汀6mg，3／日：组二：甲磺酸倍他司汀12mg，3／El，治疗均为期1个月。观察量-效关系。青少年良性阵发性眩晕25例不分组，甲磺酸倍他司汀6mg3／19，服药治疗1月。分别观察治疗前后高刺激听性脑干测听（auditory brainstem response，ABR）和眩晕残障程度（dizziness handicap inventory，DHI）的变化。结果四类眩晕治疗后症状减轻，高刺激ABR和DHI均有改善，而眼动异常变化不明显。连续用药1个月后，BPPV、PCI、MV三类患者12mg，3／日方案疗效优于6mg，3／日方案。青少年良性眩晕6mg，3/日方案也获得满意疗效。结论甲磺酸倍他司汀对良性阵发性位置性眩晕、后循环缺血、偏头痛性眩晕和青少年良性眩晕等与内耳低灌注有关的眩晕有较好的治疗作用，并表现出量效关系，12mg，3/日方案疗效优于6mg，3／日方案。     

Effect of treatment with betahistine dihydrochloride on the postural stability in patients with different duration of benign paroxysmal positional vertigo

The effect of betahistine dihydrochloride on the postural stability after repositioning Epley's maneuver (EM) in patients with BPPV was evaluated by static posturography in open and closed eyes conditions. Ninety patients were divided into four groups by duration (less and above 60 days of BPPV) and by treatment (with and without treatment with betahistine). The investigation was made one hour after the positive Dix-Hallpike test, 10 and 20 days after the treatment with EM. "Sway velocity" (SV) was calculated to evaluate postural stability. The results show dependence between efficacy of treatment with betahistine applied after EM and duration of BPPV. Betahistine normalized postural stability of patients with duration of BPPV less than 60 days after 10 days of treatment and had less effect on patients with duration of BPPV above 60 days. We assume that after removing the otoconia betahistine plays an important role for improving blood flow in the inner ear. The short presence of otoconia didn't damage sensory receptor, and restoring the normal function of motion-sensitive hairs cells and stabilizing the posture was observed.     

Repeated canalith repositioning procedure in BPPV: Effects on recurrence and dizziness prevention

Purpose

To evaluate whether a repeated canalith repositioning procedure (CRP) influences the residual symptoms and the rate of recurrence of benign paroxysmal positional vertigo (BPPV) in patients with post-CRP dizziness.

Residual dizziness after successful repositioning maneuvers for idiopathic benign paroxysmal positional vertigo in the elderly

Even after successful repositioning maneuvers for benign paroxysmal positional vertigo (BPPV), some patients report dizziness lasting for a certain period afterwards. We studied the prevalence and clinical factors associated with residual dizziness in a sample of elderly patients. Sixty outpatients over 65 years of age, affected by idiopathic BPPV were recruited; the exclusion criterion was a history of previous episodes of vertigo, including positional. The patients were asked to describe their self-perceived anxiety for vertigo on a Visual Analogue Scale (VAS) and successively treated with appropriate maneuvers till resolution of nystagmus. Data concerning the demographic and clinical features of BPPV were collected. Patients were followed until complete resolution of subjective dizziness and imbalance without positional nystagmus. Data about residual dizziness were collected from the second day from resolution of BPPV. Clinical and demographic factors related to residual dizziness were analyzed. Twenty-two subjects (37%) reported residual dizziness. In these subjects, the mean duration of residual dizziness was 13.4 ± 7.5 days. No association was observed between residual dizziness and gender, involved canal and the number of repositioning maneuvers before resolution. On the other hand, age older than 72 years, symptom duration greater than 9 days and VAS scale for anxiety greater than 10/100 were associated with an increased risk of residual dizziness. The odds ratio were respectively 6.5 (age—residual dizziness, Confidence Interval 95%), 6.5 (duration of vertigo—residual dizziness, Confidence Interval 95%) and 15.5 (anxiety levels—residual dizziness, Confidence Interval 95%). Longer symptom duration before diagnosis was associated with higher anxiety levels. The results underline the necessity for an early and correct diagnosis of BPPV, especially in the elderly.