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Hypoglycemic and hypolipidemic effects of the total triterpene acid fraction from Folium Eriobotryae
H. Lü J. Chen W.L. Li B.R. Ren J.L. Wu H.Y. Kang H.Q. Zhang A. Adams N. De Kimpe 《Journal of ethnopharmacology》2009
For seeking the good natural material to develop new agent to treat diabetes, the total triterpene acid (TTA) fraction extracted from Folium Eriobotryae [leaves of Eriobotrya japonica (Thunb.) Lindl.] was evaluated for its hypoglycemic and hypolipidemic potential through normal, alloxan and streptozotocin-induced diabetic mice administered with graded oral doses (100, 200, 300 mg/(kg day)) for 7 or 14 days. The results showed that a dose of 300 mg/kg of TTA is the most effective dose to cause significant (p < 0.01) hypoglycemic and/or hypolipidemic effects on normal, alloxan and streptozotocin-induced diabetic mice. This dose also significantly (p < 0.01) lowered the glycosylated serum protein (GSP), total cholesterol (TC) and triglyceride (TG) level in severely diabetic mice. Furthermore, TTA increased the superoxide dismutase activity (SOD) and the serum insulin level of diabetic mice. These evidences indicated that the total triperpene acid fraction from Folium Eriobotryae has a high anti-diabetic potential along with a good hypolipidemic profile. 相似文献
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目的探讨韭菜总黄酮的提取、鉴别及对羟自由基的清除作用,以充分利用韭菜植物资源,避免资源的浪费。方法采用超声波乙醇浸提法从韭菜中提取黄酮类物质,对所提取的黄酮类物质进行验证,并用分光光度法测定含量,用韭菜总黄酮对羟自由基清除作用进行试验。结果测得样品中总黄酮的含量C=0.1950mg/ml,回收率为100%,其纯度和产率均较高。结论该方法采用全物理过程,无任何污染,是提取韭菜黄酮类物质的有效途径。韭菜总黄酮提取液对Fenton体系产生的·OH自由基有很好的清除作用。 相似文献