内固定手术治疗跟骨关节内移位骨折49例临床体会

目的:探讨切开复位内固定手术治疗跟骨关节内移位骨折的临床疗效。方法:对49例56足跟骨关节内移位骨折行切开复位钢针或钛板内固定手术,按Sanders骨折分型,Ⅱ型22足,Ⅲ型28足,Ⅳ型6足。结果:全部病例均随访11个月～2年,平均16个月,按Maryland足部评分系统评估:优28足,良22足,可4足,差2足,优良率86.2%。结论:切开复位内固定治疗跟骨关节内移位骨折疗效满意,钢针内固定适合于轻度移位的SandersⅡ型骨折,Ⅲ型、Ⅳ型骨折更适合钛板内固定手术治疗。治疗效果与手术时机、皮肤软组织损伤程度、骨折类型、复位质量、术后功能锻炼有关。     

跟骨关节内骨折17例手术治疗

目的:探讨跟骨关节内骨折内固定手术方法和治疗效果。方法:跟骨关节内骨折17例18足,采用跟骨外侧可延伸的L形切口,切开复位可塑性钛板内固定治疗。结果:所有患者均获6~20个月随访。根据Maryland足部功能评分标准,优10足,良6足,可2足,优良率为88.9%。结论:切开复位可塑性钛板内固定是治疗跟骨关节内骨折的可靠方法。     

跟骨关节内骨折的手术治疗

目的：探讨切开复位钛板内固定治疗跟骨关节内骨折的临床疗效。方法：对22例31足跟骨关节内骨折患者术前详细检查,手术切开复位后采用钛板内固定,术后早期x线复查复位效果,术后随访12～36个月,采用Kerr跟骨骨折百分评分系统评价手术治疗效果。结果：x线检查结果显示术后早期31足全部获得良好复位,随访后疗效评价：优19足,良7足,可4足,差1足,优良率83．8％（26／31o结论：手术切开复位,结合钛板内固定,治疗跟骨关节内骨折,可取得满意疗效,值得临床推广使用。     

切开复位钛板内固定治疗跟骨关节内骨折

目的 探讨跟骨关节内骨折切开复位解剖钛板内固定的手术方法及其可行性.方法 2005年4月～2007年11月期间采用切开复位解剖钛板内固定加自体骨移植术治疗34例39足跟骨关节内骨折,手术恢复跟骨后关节面的平整、跟骨的宽度、高度、长度以及B(o)hler's角和Gissane's角,常规植骨,放置解剖型钛板.根据Sanders分型:Ⅱ型11足,Ⅲ型21足,Ⅳ型7足.结果 本组34例39足全部获得随访,随访时间6～30个月,平均21个月,所有患者骨折均愈合.X线片提示:B(o)hler's角和Gissane's角均恢复至正常范围,跟骨的宽度、高度、长度基本恢复正常.按Maryland方法评价术后功能:优21足,良14足,可4足,优良率89.7%.结论 切开复位钛板内固定治疗跟骨关节内骨折效果良好.     

跟骨骨折内固定术疗效分析

目的 探讨切开复位可塑形钛板内固定治疗跟骨关节内骨折的临床疗效.方法 自2004年1月至2008年12月,应用可塑形钛板治疗Sanders Ⅱ～Ⅳ型跟骨骨折31例34足,其中Ⅱ型7足,Ⅲ型19足,Ⅳ型8足.结果 随访6～36个月,平均14个月,采用Maryland足功能评分标准,优14足,良14足,可6足,优良率82.4%.结论 应用可塑形钛板治疗跟骨关节内骨折获得良好效果,但需要恰当选择手术时机并注意预防并发症.     

跟骨肽板内固定治疗跟骨关节内骨折

目的探讨跟骨钛板内固定治疗跟骨关节内骨折的疗效。方法对25例（30足）行切开复位,跟骨钛板螺丝内固定治疗,必要时植骨。结果随访时间6～25个月,所有患者均可正常行走,参照Maryland足部评分系统评定,优20足,良8足,尚可2足。结论跟骨外侧入路切开复位跟骨钛板螺丝内固定是治疗关节内骨折的有效方法。     

Ⅲ型跟骨解剖钛板内固定治疗跟骨关节内骨折体会

目的 探讨跟骨关节内骨折手术切开复位采用跟骨Ⅲ型解剖钛板内固定治疗的手术时机、手术要点及临床疗效.方法 对62例72足跟骨关节内骨折采取手术切开复位和跟骨Ⅲ型解剖钛板内固定,以及围手术期常规治疗、护理.结果 优52例,良10例,可8例,差2例.优良率86.1%.手术后X片跟骨的高度、宽度、长度和Bhler角均得到良好的恢复.结果 切开复位Ⅲ型跟骨解剖钛板内固定治疗跟骨关节内骨折疗效确切,是治疗跟骨关节内骨折的良好方法之一.     

切开复位Y形钛板内固定治疗跟骨关节面塌陷性骨折

目的:探讨Y形钛板内固定治疗跟骨关节面塌陷性骨折的临床疗效。方法:收集2009年7月至2012年6月项城市中医院采用切开复位Y形钛板内固定治疗跟骨关节面塌陷性骨折30例(32足),按照Sanders分型,Ⅱ型20例22足,Ⅲ型8例8足,Ⅳ型2例2足。结果:术后随访8～20个月,平均12个月,全部骨折均获骨性愈合,愈合时间8～16周,切口部分皮肤坏死1例1足,经换药后自行愈合,无钢板外露及感染病例。按照Maryland足部评分系统评分:优11足,良19足,可2足,优良率93.7%。结论:对跟骨关节面塌陷性骨折,行切开复位Y形接骨板内固定疗效确切,是一种实用有效的内固定方法。     

跟骨关节内骨折22例治疗分析

目的:探讨跟骨关节内骨折治疗经验和效果。方法:跟骨关节内骨折22例(25足),左足10例,右足9例,双足3例。Essex-Lopresti分型Ⅰ型:舌形骨折6足;Ⅱ型:中央压缩骨折15足;Ⅲ型:严重粉碎性骨折4足。采用单纯石膏固定2足,均为Ⅰ型无移位骨折。闭合撬拨复位司氏针内固定 石膏固定4足,为Ⅰ型移位骨折。切开复位斯氏针内固定 植骨术2足,为Ⅱ型骨折。切开复位跟骨钢板内固定 植骨术16足,其中Ⅱ型骨折12足,Ⅲ型骨折4足。患者放弃手术治疗1足。其中自体髂骨移植10足,同种异体骨条移植8足。结果:放弃手术治疗1例(1足)失随访,单纯石膏固定1例(2足)功能完全恢复,20例(22足)获得随访,时间为2￣18个月,平均5个月,其中2例已取出内固定。按Letournel标准评定:优良15足,可6足,差1足。和术前对比,B$hler角平均改善30(°15￣°38)°。出现切口皮缘部分坏死2例,经换药后愈合;切口皮肤坏死,钢板部分外露1例,经3个多月换药,切口基本愈合。结论:跟骨关节内骨折的预后对患者的生活能力影响非常大,其治疗关键在于关节的解剖复位和坚强的固定。认为对于移位明显的跟骨关节内骨折,手术治疗是必要的。     

手术治疗跟骨关节内骨折的疗效与体会

目的 探讨手术治疗跟骨关节内骨折的疗效.方法 对55例(63足)以SandersⅡ～Ⅳ型为主的跟骨关节内骨折,行跟骨外侧人路,切开复位钛板螺丝钉固定,必要时行植骨术(10足).结果 55例(63足)患者平均随访23.5个月,参照MarylaRCl food score评分标准.疗效为优40足,良21足,可2足,优良率为6.8%.其中钛板松动1足,钛板断裂l足,手术切口皮缘坏死2足,换药后自愈.结论 跟骨外侧人路切开复位钛板螺钉内固定,是治疗跟骨关节内骨折的有效方法.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.