经胸与经食管超声心动图对心脏人工瓣膜的对比研究

４７例心脏人工机械瓣膜置换术后的病人，经胸超声心动图（ＴＴＥ）和经食管超声心动图（ＴＥＥ）对比研究显示，低估二尖瓣置换后人工瓣膜返流程度的分级和返流的发生率；主动脉瓣和二尖瓣置换的病人，ＴＴＥ探查人工二尖瓣返流的效果硬差。ＴＥＥ能较容易地探查人工二尖瓣瓣周漏。揭示对人工二尖瓣的评价，ＴＥＥ比ＴＴＥ能提供更多更可靠的信息，毫无疑问这是由于ＴＴＥ检查时人工瓣膜材料的声衰减和血流掩盖的影响，但我们的经验揭示，在评价主动脉瓣置换人工瓣膜时，ＴＥＥ并不优于ＴＴＥ。     

Left-side approach to the mitral valve

BACKGROUND AND AIM OF THE STUDY: The standard, minimally invasive surgical approach to the mitral valve is usually accomplished from the right side, through a longitudinal incision posterior and parallel to the interatrial groove. The left-side approach should perhaps be reconsidered for its suitable exposure of the mitral valve. METHODS: Eleven consecutive patients underwent mitral valve surgery via a left lateral minithoracotomy, with cardiopulmonary bypass performed through the left femoral artery and vein. The left internal mammary artery was used as a coronary graft in one patient. Cardioplegic solution was delivered through the ascending aorta. After direct aorta cross-clamping, mitral surgeries were performed, including mechanical and bioprosthetic implants, redo operations, annuloplasties and repairs. RESULTS: An excellent view of the mitral valve was obtained in all cases, with optimal vision of the whole annulus, chordae tendineae, papillary muscles and aortic valve possible. Exposure of the mitral valve was superior to that achieved with the standard approach from the right, notably with a wider angle of vision and greater flexibility of movement available. Moreover, mitral valve structures were closer to the operator, making the procedure easier to perform. CONCLUSION: The left-side approach to the mitral valve offers excellent vision and exposure of the valve. Although awaiting additional cases to validate results, in the absence of major complications we recommend this technique.     

Retrograde percutaneous aortic valve implantation for critical aortic stenosis.

Recently, a prosthetic aortic valve has been implanted percutaneously in several patients using an antegrade transseptal approach. This has been shown to be feasible and associated with dramatic hemodynamic improvement. We report a retrograde implantation of a percutaneous heart valve (PHV) in an 84-year-old man with critical aortic stenosis and refractory congestive heart failure after difficulties encountered with an initial antegrade approach. While attempting antegrade transseptal implantation of a PHV, the anterior leaflet of the mitral valve was tethered by the guidewire resulting in severe mitral regurgitation and pulseless electrical activity. Cardiac resuscitation was successful. Utilizing a retrograde approach, the PHV was successfully implanted in a stable position below the coronary ostia and well above the mitral valve leaflets. The aortic valve area increased from 0.55 to 1.7 cm2 with only mild paravalvular aortic regurgitation. Despite marked improvement in aortic valve function, the patient died secondary to guidewire-induced mitral valve anterior leaflet laceration, severe mitral regurgitation, and cardiogenic shock. Retrograde implantation of a PHV can be successfully performed with substantial increase in aortic valve area and an acceptable degree of aortic regurgitation. Although the retrograde approach may be associated with greater risk of vascular access site complications, it may be considerably safer by avoiding potential guidewire injury to the mitral valve. Further refinements in technique may establish the retrograde approach as the preferred means of PHV implantation in nonsurgical patients with critical aortic stenosis.     

Percutaneous mitral valve repair: a feasibility study in an ovine model of acute ischemic mitral regurgitation.

Annuloplasty is the cornerstone of surgical mitral valve repair. A percutaneous transvenous catheter-based approach for mitral valve repair was tested by placing a novel annuloplasty device in the coronary sinus of sheep with acute ischemic mitral regurgitation. Mitral regurgitation was reduced from 3-4+ to 0-1+ in all animals (P < 0.03). The annuloplasty functioned by reducing septal-lateral mitral annular diameter (30 +/- 2.1 mm preinsertion vs. 24 +/- 1.7 mm postinsertion; P < 0.03). These preliminary experiments demonstrate that percutaneous mitral annuloplasty is feasible. Further study is necessary to demonstrate long-term safety and efficacy of this novel approach.     

Percutaneous Retrograde Closure of Mitral Paravalvular Leak in Patients With Mechanical Aortic Valve Prostheses

Mechanical aortic valve prostheses are considered a limiting factor when contemplating percutaneous closure of mitral paravalvular leaks using a retrograde approach. However, transfemoral artery access and a retrograde approach have advantages over a trans-septal anterograde approach when the paravalvular defect is large with a significant gradient or when the defect is medial to the mitral valve. We describe a novel technique of mitral paravalvular leak closure in the presence of a mechanical aortic valve prosthesis, which we performed successfully in 3 patients. The technique uses a retrograde approach and arteriovenous wire loop.     

Acquired Lutembacher syndrome or mitral stenosis and acquired atrial septal defect after transseptal mitral valvuloplasty

Critical mitral stenosis in selected patients may be treated successfully with percutaneous mitral valvuloplasty. Complications of this procedure, particularly an atrial septal defect following transseptal approach, are generally of minor clinical significance. We describe a woman who initially underwent a successful percutaneous double-balloon mitral valvuloplasty via the transseptal approach. Three months later she presented with right-sided heart failure. Color Doppler echocardiography and cardiac catheterization demonstrated an atrial septal defect (ASD) as well as restenosis of the mitral valve. We conclude that significant ASDs may occur following transseptal mitral valvuloplasty with appearance of right ventricular failure and that color Doppler imaging aids in the diagnosis of this new variant of the classical Lutembacher syndrome.     

Newer advances in the diagnosis and treatment of mitral stenosis

There have been significant changes in presentation, diagnosis, and therapy of patients with mitral stenosis. Both the prevalence of mitral stenosis, as well as the type of patient now with mitral stenosis, have changed significantly over the past few decades. In patients with mitral stenosis two-dimensional and Doppler echocardiography have become the diagnostic modalities of choice. The advent of percutaneous mitral balloon valvotomy now provides a nonsurgical approach for the treatment of selected patients with mitral stenosis.     

Minimally invasive mitral valve surgery is associated with a low rate of complications

Minimally invasive mitral valve surgery is generally performed through a right minithoracotomy, in contrast to the traditional full median sternotomy approach. Minimally invasive mitral valve surgery is performed with increasing frequency, and by reducing surgical trauma, several observational studies suggest potential benefits with decreased bleeding and postoperative pain, reduced incidence of sternal wound infections, reduced length of hospital stay and shortened recovery period after surgery. In this review, we present an overview of mitral valve surgery, summarize the available evidence regarding the minimally invasive approach and report our experiences from introducing a minimally invasive mitral valve surgery programme at the Karolinska University Hospital in Stockholm, Sweden.     

Reduction of left ventricular outflow tract obstruction with transcatheter mitral valve repair

Many patients with severe mitral regurgitation cannot undergo conventional mitral valve surgery due to prohibitive surgical risk and are candidates for transcatheter repair with an edge‐to‐edge technique. Prior reports suggest efficacy with this approach for mitral regurgitation due to hypertrophic cardiomyopathy with left ventricular outflow obstruction. We present a case report of transcatheter mitral valve repair for posterior leaflet prolapse with concomitant left ventricular outflow tract obstruction due to systolic anterior motion of the mitral valve in the absence of hypertrophic cardiomyopathy.     

First report of a simultaneous transcatheter mitral valve‐in‐valve and aortic valve replacement in a left ventricular assist device patient

Transcatheter aortic valve replacement is standard of care for patients with severe aortic stenosis at high risk for surgical aortic valve replacement. Although not intended for treatment of primary aortic insufficiency, several transcatheter aortic valve prostheses have been used to treat patients with severe aortic insufficiency (AI), including patients with left ventricular assist devices (LVAD), in whom significant AI is not uncommon. Similarly, transcatheter valve replacements have been used for valve‐in‐valve treatment, in the pulmonary, aortic, and mitral positions, either via a retrograde femoral approach or antegrade transseptal approach (mitral valve‐in‐valve). In this case report, we report an LVAD patient with severe aortic insufficiency and severe bioprosthetic mitral prosthetic stenosis, in whom we successfully performed transfemoral aortic valve replacement and transfemoral mitral valve‐in‐valve replacement via a transseptal approach. © 2017 Wiley Periodicals, Inc.     

Transjugular approach for transcatheter closure of mitral paraprosthetic leak

Transcatheter closure of mitral paraprosthetic leak (PPL) using femoral antegrade transseptal or retrograde approach is often unsuccessful when the involved part of the mitral annulus is difficult to access or when the left atrium is large. We report the successful use of jugular venous approach to perform transseptal antegrade PPL closure in a 49‐year‐old male with mitral PPL located in the anteromedial part of the annulus. This technique could serve as a useful alternative in patients in whom transcatheter closure of mitral PPL is technically difficult. © 2009 Wiley‐Liss, Inc.     

Robotic mitral surgery: current and future roles

PURPOSE OF REVIEW: Cardiac surgery, like other surgical fields, is evolving to a more minimally invasive approach. Robotic technology now allows complex mitral valve repairs to be carried out via small incisions with complete avoidance of a sternotomy. The purpose of this review is to assess the current role of robotics in the repair of the mitral valve, and to speculate as to what advances may be forthcoming. RECENT FINDINGS: Several groups have now confirmed that complex mitral valve repairs can be carried out robotically with early results comparable to open repair. SUMMARY: Endoscopic mitral repair has become a reality. With further technological advancements and continued clinical experience, this may become the standard approach for mitral valvuloplasty.     

Contemporary Management of Ischemic Mitral Regurgitation: A Review

Ischemic mitral regurgitation occurs relatively frequently in patients with coronary artery disease and is associated with an increased long-term risk. The pathophysiology of ischemic mitral regurgitation is vexing and poses both diagnostic and therapeutic challenges, leading to the need for a comprehensive, multidisciplinary approach. The management is largely focused on medical therapy, and for those eligible, coronary revascularization or cardiac resynchronization therapy may be considered. In select patients, mitral valve surgery or catheter-based therapy may be undertaken with careful consideration of the underlying pathophysiology, surgical risk, and expected long-term outcomes. The appropriate evaluation of patients with ischemic mitral regurgitation involves a careful multidisciplinary approach that carefully considers symptomatology, the etiology and severity of the mitral regurgitation, and the assessment of comorbidities and operative risk to individualize the care of these patients.     

左房顶人路二尖瓣手术的临床应用

目的 探讨二尖瓣手术左房顶入路的可行性及安全性.方法 纳入2011年8月～2012年3月行二尖瓣手术患者46例,其中选取左房顶入路者纳入左房顶组（n=23）,其他入路（房间隔或房间沟入路）者纳入对照组（n=23）,比较两组患者手术视野显露程度和手术效果.结果 两组病例均一次手术成功,左房顶组二尖瓣显露满意（可显露二尖瓣全貌）占60.87%,一般显露（可显露二尖瓣大部分）占34.78%,均未在术中扩大切口或变更手术入路,左房顶组和对照组平均体外循环时间[（80±21）min vs.（86±27）min]、平均主动脉阻断时间[（50±14）min vs.（60±17）min]、术后平均住院时间[（11±4）d vs.（12±4）d]、术后24小时胸腔引流量[（311±63）ml vs.（276±78）ml]均无统计学差异（P＞0.05）,两组院内和随访期间不良事件发生率无统计学差异（P＞0.05）.结论 左房项入路行二尖瓣手术是一种较为安全可行的手术方式,近期效果切确,远期预后需进一步随访.     

Mitral valve reoperation through the left atrial appendage in a patient with mesocardia

We report the case of a patient with mesocardia, mitral restenosis, and mitral regurgitation. He had undergone an open mitral valvotomy 4 years earlier and, therefore, presented us with a problematic approach to the mitral valve. In such cases, access to the mitral valve is almost impossible due to the position of the valve, which is more posterior and to the left of a normal valve, and due to adhesions from the previous surgery We approached the mitral valve through the left atrial appendage and replaced the mitral valve with a mechanical prosthesis.     

Transcatheter edge-to-edge mitral valve repair for annuloplasty ring dehiscence: The peri-ring approach

Recurrent severe primary mitral regurgitation from annuloplasty ring dehiscence is very rare and is associated with adverse outcomes. We present a case where transcatheter edge-to-edge mitral repair with MitraClip was used in high surgical risk patient using a peri-ring approach due to unfavorable anatomy for a conventional intra-ring approach.     

Measurement of mitral regurgitation by Doppler echocardiography.

In an attempt to develop a new approach to the non-invasive measurement of mitral regurgitation, Doppler echocardiography and left ventriculography were performed in 20 patients without valvar heart disease (group A) and in 30 patients with pure mitral regurgitation (group B). Volumetric flows through the aortic and the mitral orifices were determined by Doppler echocardiography. Aortic flow (AF) was calculated as the product of the aortic orifice area and the systolic velocity integral. The mitral flow (MF) was calculated as the product of the corrected mitral orifice area and the diastolic velocity integral. The mitral regurgitant fraction (RF) was calculated as RF = 1 - AF/MF. In group A aortic and mitral flow were very similar and the difference between the two did not differ significantly from zero. In group B the mitral flow was significantly larger than the aortic flow. There was a good correlation (r = 0.82) between the regurgitant fraction determined by Doppler echocardiography and the regurgitant grades determined by left ventriculography. The regurgitant fraction increased significantly with each grade of severity. These results show that Doppler echocardiography can be used to give a reliable measure of both aortic and mitral flow. This technique is a new and promising approach to the non-invasive measurement of mitral regurgitation.     

Functional ischemic mitral regurgitation: an open debate

Functional ischemic mitral regurgitation is a complex disorder with a poor prognosis. Although the underlying anatomical and pathophysiological mechanisms are not entirely clear, it is known that postinfarction left ventricular remodeling is the most significant factor in the development of this mitral valve lesion. Echocardiography and magnetic resonance imaging have made significant contributions to clarifying the many mechanisms that progressively worsen mitral regurgitation. There is still controversy about the best surgical approach, particularly with regard to whether to replace or repair the valve, the type and size of prosthesis to be used in mitral annuloplasty, the durability of repair, valve-related complications, and medium-term survival. The early recurrence (< or =6 months) of mitral regurgitation after surgery has been reported in 17%-29% of patients. Better understanding of the origin and evolution of functional ischemic mitral regurgitation is necessary to enable the adoption of a more effective surgical approach to this enigmatic valvular disease.     

Percutaneous valve repair for mitral regurgitation using the Carillon Mitral Contour System. Description of the method and case report

Mitral regurgitation may result from left ventricular dilatation and cause progression of heart failure. Percutaneous techniques for mitral valve repair are under development. Techniques utilizing a trans-coronary venous approach exploit the anatomical relationship between the mitral annulus and the venous system of the heart. The coronary sinus, great cardiac vein and the origin of the anterior interventricular vein surround the posterior mitral annulus. This enables percutaneous approaches to annuloplasty for mitral regurgitation. Devices can be implanted into the coronary veins that modify the shape and size of the mitral annulus. We present a case of ischaemic mitral regurgitation successfully treated by use of a percutaneous approach, the Carillon Mitral Contour System. Significant reduction of the mitral regurgitation jet was observed. The patient was discharged 4 days after the procedure. During the follow-up visits, the patient showed an improved general condition and increased exercise capacity. Procedural steps are shown in detail and the current status of the coronary sinus based technique is discussed. Percutaneous techniques for mitral valve repair may be an attractive alternative to cardiac surgery in heart failure patients with secondary mitral regurgitation. The Carillon Mitral Contour System is under ongoing clinical evaluation in the AMADEUS trial.     

Measurement of mitral regurgitation by Doppler echocardiography

In an attempt to develop a new approach to the non-invasive measurement of mitral regurgitation, Doppler echocardiography and left ventriculography were performed in 20 patients without valvar heart disease (group A) and in 30 patients with pure mitral regurgitation (group B). Volumetric flows through the aortic and the mitral orifices were determined by Doppler echocardiography. Aortic flow (AF) was calculated as the product of the aortic orifice area and the systolic velocity integral. The mitral flow (MF) was calculated as the product of the corrected mitral orifice area and the diastolic velocity integral. The mitral regurgitant fraction (RF) was calculated as RF = 1 - AF/MF. In group A aortic and mitral flow were very similar and the difference between the two did not differ significantly from zero. In group B the mitral flow was significantly larger than the aortic flow. There was a good correlation (r = 0.82) between the regurgitant fraction determined by Doppler echocardiography and the regurgitant grades determined by left ventriculography. The regurgitant fraction increased significantly with each grade of severity. These results show that Doppler echocardiography can be used to give a reliable measure of both aortic and mitral flow. This technique is a new and promising approach to the non-invasive measurement of mitral regurgitation.