Total hip arthroplasty in Paget's disease. A follow-up note

In eighty patients who were seen with Paget's disease of the hip between 1969 and 1982, symptomatic coxarthrosis led to total hip arthroplasty in ninety-one hips. The long-term clinical and radiographic results were analyzed by use of the Mayo Clinic hip-scoring system. The cases of the forty-six patients (fifty-two hips) who had been operated on before 1975 were analyzed ten years after the arthroplasty. In this group, the incidence of aseptic loosening that required revision was approximately 15 per cent; radiographic evidence of loosening was evident in approximately 30 per cent of the femoral components and approximately 14 per cent of the acetabular components. Actuarial analysis comparing these forty-six patients with our over-all experience of total hip arthroplasty during the same period of time in 7,222 hips of patients who did not have Paget's disease revealed an increase of slight statistical significance in the incidence of revision for aseptic loosening in the patients who had Paget's disease. However, the over-all result was good or excellent in 74 per cent of these patients, suggesting that replacement of the hip using cemented components remains an acceptable form of treatment for degenerative coxarthrosis secondary to Paget's disease.     

Total hip arthroplasty revision using the press-fit CLS Spotorno cementless stem

A retrospective study of uncemented femoral revision for loosening after total hip arthroplasty was conducted for the period 1987-1998. The study included 24 hips in 22 patients (7 men, 15 women). The revision procedure consisted of the replacement of the loose hip prosthesis using the CLS (Protek) press-fit stem. Patients were followed for a mean duration of 4.5 years. The mean interval between the primary operation and the revision was 10 years (range 2-16 years). Using the Merle D'Aubigné hip score and radiographic findings, a favorable outcome was noted in 20 hips. We suggest that the femoral revision procedure using the uncemented Spotorno stem is a very useful method of correction of loosening after total hip replacement.     

The impact of infection after total hip arthroplasty on hospital and surgeon resource utilization

BACKGROUND: Deep infection following total hip arthroplasty is a devastating complication for the patient and a costly one for patients, surgeons, hospitals, and payers. The purpose of this study was to compare revision total hip arthroplasty for infection, revision total hip arthroplasty for aseptic loosening, and primary total hip arthroplasty with respect to their impact on hospital and surgeon resource utilization and referral patterns to a tertiary-care hospital. METHODS: Clinical, demographic, and economic data were obtained for twenty-five consecutive patients with an infection after a total hip replacement who underwent a two-stage revision arthroplasty (Group 1) performed by one of two surgeons, between March 2001 and December 2002, at a single institution. Similar data were collected during the same time-period for a cohort of twenty-five consecutive patients who underwent revision of both components because of aseptic loosening (Group 2) and twenty-five consecutive patients who underwent a primary hip arthroplasty (Group 3). Quantitative and categorical variables were compared among the groups. Referral patterns were examined by reviewing the primary diagnosis for all patients referred to our institution for a revision total hip arthroplasty during a five-year period. RESULTS: Revision procedures for infection were associated with longer operative time, more blood loss, and a higher number of complications compared with revisions for aseptic loosening or primary total hip arthroplasty (p < 0.02 for all). Revisions for infection were also associated with a higher total number of hospitalizations, total number of days in the hospital, total number of operations, total hospital costs, total outpatient visits, and total outpatient charges during the twelve-month period following the index procedure (p < 0.001 for all). The incidence of referrals to our institution for a diagnosis of infection following total hip arthroplasty increased significantly over a five-year period (Spearman rank correlation, 1.0; p = 0.0083), while referral rates for revision for causes other than infection remained relatively constant (Spearman rank correlation, 0.500; p = 0.3910). CONCLUSIONS: The treatment of patients with an infection after a total hip arthroplasty is associated with significantly greater hospital and physician resource utilization compared with the treatment of patients who have a revision because of aseptic loosening or who have a primary total hip arthroplasty. We believe that the lack of incremental reimbursement associated with these procedures results in strong financial disincentives for physicians and hospitals to provide treatment for patients with an infection after a total hip arthroplasty.     

Prosthetic hip joint infection caused by Listeria monocytogenes

The authors report an unusual case of prosthetic hip joint infection caused by Listeria monocytogenes. The patient, an 87-year-old lady who had undergone a right total hip replacement 10 years previously, presented with pain and restriction of hip motion three weeks after an episode of abdominal pain. Aspiration of the joint yielded a dark fluid, from which Listeria Monocytogenes type 4-b was isolated. Blood cultures remained negative. After prolonged antibiotic therapy, symptoms gradually resolved. A few months later, pain recurred with radiological signs of loosening of the femoral component. One-stage revision arthroplasty was performed combined with antibiotic treatment. The patient remains asymptomatic at one year follow-up. Laboratory data and x-ray control are normal. Prosthetic hip joint infection with Listeria monocytogenes is uncommon; few cases have been reported. The literature review shows that prolonged antibiotic therapy alone may be used in patients for whom removal of the prosthesis is not desirable, although revision arthroplasty or prosthesis removal remains necessary in the other cases.     

One-stage cementless revision arthroplasty for infected hip replacements

We hypothesised that one-stage cementless revision hip arthroplasty may have advantages and a role in the treatment of selected patients with an infected hip replacement. We retrospectively reviewed all patients with an infected hip replacement treated with one-stage revision using cementless implants. Twelve patients were reviewed and followed up for at least three years (average: 7.2 years, range: 3.3–11.3 years) postoperatively. One recurrence of infection and one aseptic stem loosening were detected during follow-up. Grafted bone, which was used in eight patients, appeared to have united to host bone in all patients. The success rate of treatment was 83.3% when infection recurrence or component loosening were regarded as failure. One-stage revision hip arthroplasty using cementless implants appears to have a role in the treatment of carefully selected patients with an infected hip replacement if meticulous débridement is performed and appropriate antibiotics are properly used.     

Revision arthroplasty of the hip joint

Summary During the period 1974–1983, 768 total hip arthroplasties were performed at the Surgical Hospital, University Central Hospital in Helsinki. Brunswik prostheses were used until 1980, and after this the operations were routinely performed with Lubinus prostheses. Additionally, from 1977 to 1981 Wagner and Freeman resurfacing prostheses were used in 107 cases. Of all these patients, 44 (5.7%) needed revision arthroplasty. The average interval between the primary operation and revision arthroplasty was 3.7 years and the follow-up period after the second operation averaged 2.9 years. The patients who underwent revision arthroplasty were compared with a matched control group. In the revision group, radiographs revealed that the medial cement packing was complete in 28% of the hips, this being the case in 78% of the controls (P < 0.001). Also, the cement tip packing was more often incomplete in the revision hips than in the controls (P < 0.01). Regarding the lateral cement packing there was no statistical difference between the two groups. The revision rate of the resurfacing prostheses was 14.9%, compared with 7.8% of the Brunswik prostheses which were inserted at the same time. At the follow-up, the patients with revised hips had less pain than before the primary operation (P < 0.001) and their mobility was similarly improved. We conclude that adequate medial and tip cement packing must be emphasized in the primary arthroplasty. Resurfacing prostheses have a relatively high loosening tendency. Revision arthroplasty is the treatment of aseptic loosening after total hip replacement and it gives good clinical results.Aseptic loosening is the most common long-term complication after total hip replacement surgery. Clinical loosening rates are mostly judged by the number of patients who have been reoperated on, this probably leading to somewhat low figures. Reports on prosthesis loosening usually concern cemented prostheses, and both analyses based on radiographical evidence and revision rates have been published [1, 3, 4, 10, 12, 14]. It appears that most of the prostheses, at least as concerns femoral components, loosen during the first 5 years, and the numbers increase only slowly between 5 and 10 years postoperatively [16, 17].A certain proportion of prostheses will loosen even when the most progressive operative methods are used, and revision arthroplasties of the hip joint are part of the routine of orthopedic departments. We have analyzed our total hip revision arthroplasties, focusing on the factors leading to prosthesis loosening and on the outcome of hip revision operations.     

髋关节置换术后早期失败原因的回顾性分析

目的探讨髋关节置换术后早期失败的原因和特点。方法对1995年1月至2009年1月本组收治的342例初次髋关节置换（THA）失败患者进行回顾性分析,将这些失败的患者分为早期失败组（初次髋关节置换术后〈5年内失败组）和晚期失败组（初次髋关节置换术后〉5年失败组）,再对早期失败组患者的翻修原因进行分析。结果以髋关节翻修作为终止点,42．1％（144／342）的患者在初次THA术后5年内进行翻修,在早期失败的两个主要原因中,31．2％是因为无菌性松动,24．3％是因为髋关节脱位。结论THA术后早期的失败原因是无菌性松动和髋关节脱位。外科医师要提高手术技术,以避免THA术后的早期失败。     

Revision arthroplasty of the hip joint. A retrospective analysis

During the period 1974-1983, 768 total hip arthroplasties were performed at the Surgical Hospital, University Central Hospital in Helsinki. Brunswik prostheses were used until 1980, and after this the operations were routinely performed with Lubinus prostheses. Additionally, from 1977 to 1981 Wagner and Freeman resurfacing prostheses were used in 107 cases. Of all these patients, 44 (5.7%) needed revision arthroplasty. The average interval between the primary operation and revision arthroplasty was 3.7 years and the follow-up period after the second operation averaged 2.9 years. The patients who underwent revision arthroplasty were compared with a matched control group. In the revision group, radiographs revealed that the medial cement packing was complete in 28% of the hips, this being the case in 78% of the controls (P less than 0.001). Also, the cement tip packing was more often incomplete in the revision hips than in the controls (P less than 0.01). Regarding the lateral cement packing there was no statistical difference between the two groups. The revision rate of the resurfacing prostheses was 14.9%, compared with 7.8% of the Brunswik prostheses which were inserted at the same time. At the follow-up, the patients with revised hips had less pain than before the primary operation (P less than 0.001) and their mobility was similarly improved. We conclude that adequate medial and tip cement packing must be emphasized in the primary arthroplasty. Resurfacing prostheses have a relatively high loosening tendency. Revision arthroplasty is the treatment of aseptic loosening after total hip replacement and it gives good clinical results. Aseptic loosening is the most common long-term complication after total hip replacement surgery.(ABSTRACT TRUNCATED AT 250 WORDS)     

Bilateral femoral fracture at the site of bilateral hip prostheses. A case report]

Fracture of the femoral shaft after hip arthroplasty is a serious problem. In most cases, minimal trauma is responsible for the fracture. Predisposing factors include severe osteoporosis, loosening of the prosthetic stem and perforations of the cortex. The incidence in our patient material in 2.3% after total hip arthroplasty and 2.9% after revision. Operative treatment may consist in osteosynthesis with compression plates, screws, or cerclage wires with or without revision of the arthroplasty. We give a case report covering treatment and 2-year follow-up for a bilateral proximal femoral fracture in a 72-year-old farmer with bilateral total hip replacements. Both fractures were treated similarly, with replacement of the femoral components by a cementless Wagner revision stem prosthesis and cerclage wiring of the fragments. No classic osteosynthesis was required to manage the fractures.     

Proximal femoral osteotomy as an adjunct in cementless revision total hip arthroplasty

Cementless total hip replacement techniques are increasingly used in revision arthroplasty. A major challenge is to achieve implant stability in a femur distorted by a failed arthroplasty. Five patients with aseptic loosening of cemented primary or revision total hip replacements complicated by significant proximal femoral disease, four with marked angular deformity of the femur and one with a subtrochanteric nonunion, were treated successfully with cementless revision arthroplasty combined with proximal femoral osteotomy. At follow-up examination, all femoral and trochanteric osteotomies had healed and D'Aubigne and Postel scores for pain, function, and range of motion had improved. All porous prostheses demonstrated radiographic features consistent with bone ingrowth fixation. No progressive stress shielding has been observed. Concomitant femoral osteotomy to correct anatomic deformity, in association with cementless total hip arthroplasty, results in union of the osteotomy and restoration of hip function.     

Secondary total hip replacement after fractures of the femoral neck

We studied the rate of revision in 84 consecutive total hip replacements performed for failed osteosynthesis of femoral neck fractures and compared it with that for primary arthroplasty for osteoarthritis. The age and sex adjusted risk of prosthetic failure was 2.5 times higher after failure of fixation, but all the excess risk was in patients over 70 years of age. There were radiographic signs of loosening of the femoral component at five to 12 years after secondary arthroplasty in six of 33 survivors. In general, the results of secondary replacement were no worse than those obtained after primary arthroplasty for femoral neck fracture. We consider that internal fixation should be the primary procedure: total hip replacement is a safe secondary procedure when osteosynthesis fails.     

Survival analysis of T-28 hip arthroplasty with clinical implications

Seventeen years after its introduction, the T-28 and its successor (the TR-28) have proved to be a successful arthroplasty system, with very low long-term socket and femoral loosening rates, especially in older patients. The 10-year revision rate for aseptic loosening of the socket is only 2 per cent. This form of conventional cemented total hip replacement has provided pain relief and improved function in many individuals who have exhausted nonoperative treatment alternatives. Although there are still unsolved long-term problems for the young active patients, cemented hip arthroplasty continues to play an important role in joint replacement, and remains the treatment of choice in older and relatively inactive patients.     

人工髋关节置换术后翻修病例分析

目的分析人工髋关节置换术后翻修的原因,评价全髋翻修术的临床效果。方法本组33例34髋。初次关节置换类型:全髋置换21例,双杯髋关节置换1例,人工股骨头置换11例。翻修原因:无菌性松动23例24髋,髋臼位置不良1例1髋,股骨头置换后髋臼磨损5例5髋,感染4例4髋。翻修距初次手术时间:1年以内5髋,1～2年1髋,5～10年18髋,10～13年10髋。翻修假体类型:非骨水泥型假体20髋,混合型假体7髋,骨水泥型假体7髋。结果平均随访3.5年。1例术后半年发生股骨柄松动进行再翻修,其余病例假体保留,优良率为82.4%。结论翻修的最常见原因为无菌性松动,人工股骨头置换时髋臼磨损也是翻修原因之一,对较年轻的股骨颈骨折患者,如行假体置换,最好采用全髋关节置换。翻修术采用非骨水泥型假体较好。     

The hip-spine relationship and its effect on total hip arthroplasty outcomes: What do the databases show?

The number of patients with degenerative disorders of both the hip and spine is increasing, as is our understanding of hip-spine interactions. Much of the work elucidating the effects of the interplay between the spine and hip joint, specifically as it relates to total hip arthroplasty, has come from database research. Database studies have demonstrated that patients with lumbar spinal pathology undergoing subsequent total hip arthroplasty are at increased risk for adverse outcomes including dislocation, aseptic loosening, fracture, lower patient reported outcome measures, and revision when compared to replacement patients without spinal disease.     

Assessment of Five Interleukins in Human Synovial Fluid as Possible Markers for Aseptic Loosening of Hip Arthroplasty

One of the most important factors that seems to be involved in total hip replacement is periprosthetic osteolysis. As it is well documented that several interleukins (ILs) are triggered in periprosthetic osteolysis, this article investigates the role of five ILs in primary and replacement total hip arthroplasty, understanding if one of them can also predict hip implant loosening, secondary surgery, and prosthesis breakage. The levels of IL-1α, 1β, 6, 8, and 10 in synovial fluid were examined, using a high sensitivity enzyme-linked immunosorbent assay (ELISA) test kit (Pierce Biotechnology, Inc., Rockford, IL, USA) to determine whether these cytokines could be used as markers of enhanced periprosthetic osteolysis, leading to aseptic loosening of total/partial hip arthroplasty or revision surgery. Synovial fluid was harvested from 23 patients undergoing primary total hip arthroplasty and 35 patients undergoing total/partial hip revision due to aseptic loosening. In the revision group, four cases had suffered a prosthesis fracture and five were second revisions. ILs 6 and 8 were significantly higher in the revisions (305 and 817 pg/mL) compared with the primary arthroplasties (151 and 151 pg/mL), including cases with prosthesis fracture and those requiring a second revision. IL-10 levels were lower (not significantly) in second revision samples compared with those of revision samples. IL-1β levels were significantly higher in prosthesis fracture samples compared with those of all the other revision samples. No statistically significant differences in IL levels were found between osteoarthritis samples and those of other diseases. These results are a step forward to elucidating the complex network of events that are involved in loosening of hip implants.     

Severe metallosis-related osteolysis as a cause of failure after total knee replacement

BackgroundMetallosis is a syndrome of metal-induced synovitis caused by friction between two metal surfaces. In contrast to the hip joint after resurfacing arthroplasty or metal-on-metal (MoM) total hip replacement, metallosis of the knee is extremely rare.MaterialsWe describe 4 patients who underwent revision total knee replacement because of disabling pain and implant loosening after a mean time of 21 (range: 13–30) years of knee replacement surgery. They were all females with a mean age of 79 (range: 75–82) years. Septic loosening was excluded through microbiological examination and synovial fluid analysis.ResultsDirect metal-on-metal contact at the tibiofemoral interface was confirmed intraoperatively in all cases. All knees showed severe metallosis with advanced osteolysis and pseudotumor formation. In one knee there was a complete fracture of the tibial tray. All patients had a one-stage revision surgery with implant removal, profound synovectomy and implantation of a constrained modular revision knee system. Long modular stems with offset adapters, wedges and/or blocks were used in all cases.ConclusionMetallosis-associated osteolysis should be suspected in cases with radiologically evident polyethylene wear after knee replacement. Recognizing that revision arthroplasty is very technically demanding in such cases, surgeons should have a back-up with modular revision components and a ready access to reconstructive options at this revision setting.     

Aseptic loosening of total hip replacement presenting as an anterior thigh mass

Aseptic loosening is one of the commonest complications of total hip replacement that can cause pain and instability. The chronic inflammatory response to the wear debris from the polyethylene or metal can cause osteolysis and implant failure. We report a case of aseptic loosening of the hip, presented with a swelling over the anterior thigh without any pain or instability in the joint. This mass was a foreign body granuloma formed secondary to the polyethylene wear debris due to the instability of the polyethylene in the metal shell. The patient underwent successful revision hip arthroplasty after the removal of the foreign body granuloma.     

Patient activity, sports participation, and impact loading on the durability of cemented total hip replacements

Patients with either cemented surface replacements or cemented stemmed hip prostheses and who regularly participate in sporting activities or heavy labor after total joint arthroplasty are at twice the long-term risk of requiring revision surgery for loosening as patients who are less active. For patients with surface replacement total hip arthroplasty (THA), the adverse effects of activity are greatest in patients with preoperative diagnoses other than osteoarthritis, and were seen by the sixth year postsurgery. For patients with conventional stemmed prostheses, the effects of patient activity are not seen until about ten years postsurgery. For resurfacing THA for osteoarthritis, the long-term of loosening is primarily in patients who participate in high impact activities.     

人工全髋关节置换翻修术术前假体松动的回顾性研究

目的通过对48例人工全髋关节置换翻修术术前资料的系统回顾性研究,评价采取不同固定方法的假体的临床疗效。方法笔者对行髋关节置换的48例实行了全髋翻修术,并对全部病例进行了术前X线评价及术中假体松动情况调查,并做χ2检验,判断不同假体固定方式对假体寿命的影响。结果早、中期假体松动主要为非骨水泥型假体。骨水泥固定的假体与非骨水泥固定的假体远期均存在很高的松动下沉率,以骨水泥臼的松动为多数。髋臼侧骨溶解发生率以Ⅰ区为高,股骨柄侧骨溶解发生率以股骨近端为最高。结论人工全髋关节置换术中生物性固定初期并不十分牢固。人工全髋关节置换术中骨水泥固定假体松动主要发生在远期,并且以髋臼侧骨水泥松动为主。     

Artificial hip replacement in young patients with hip dysplasia--long-term outcome after 10 years

PURPOSE: The experience gained in three decades of hip arthroplasty includes observations on patients with congenital dysplasia of the hip (CDH) under 20 years of age. A study dealing with hip arthroplasty in patients with osteoarthritis following CDH in such young age is not known in the literature. In the present study we report about a long-term follow-up of 41 total hip arthroplasties which were performed using bone-cement in 29 patients from 1966 to 1995. METHODS: The evaluation of this retrospective study was performed with an questionnaire and a clinical and radiological investigation (Harris hip score, Sutherland activity score). RESULTS: 18 patients with 27 THR (62%) were evaluated clinically and radiologically after a mean duration of follow-up of 10 years and 8 months. Seven additional THR had been revised in the meantime. Kaplan-Meier survival analysis showed a survival rate after 10 years of 64%. Acetabular loosening occurred three times as often as femoral loosening (overall revision rate 41.2%). CONCLUSION: The overall loosening rate of total hip replacement of young patients is significantly elevated. These findings suggest that total hip replacement in young patients with dysplastic hips should be considered most carefully. Implantation of a hip prosthesis is only justified in special cases where alternative procedures are contra-indicated or unacceptable.