A case of a case of mild cognitive impairment--diagnostic uncertainties

In the paper a case of mild cognitive impairment is presented. It is interesting because of its atypical psychopathological picture. The primary disorder is accompanied with symptoms of depression and anxiety. A course of diagnosis and treatment are outlined.     

Patient case study: in the case of Miss Christine

Young stroke survivors often return to the community for ongoing recovery and reintegration. Their needs are somewhat different than their older counterparts, and they can be easily lost in the complex health care system of specialty and primary care services. This young woman and her outpatient rehabilitation providers exemplify some problems encountered and the persistent, caring, and successful work that teams can accomplish to maximize ongoing recovery.     

A case of juvenile metachromatic leukodystrophy--the third case in Japan

We report here a case of juvenile metachromatic leukodystrophy. The patient is an 8-year-old boy with motor and mental deterioration, which began at about age 3. He has also suffered from astatic seizures since age 8. Arylsulfatase A activity in the patient was markedly decreased in peripheral leukocytes, cultured fibroblasts and urine. Sulfatide was detected in urine from the patient by thin-layer chromatography. Peripheral motor and sensory nerve conduction velocities were markedly reduced. Computerized tomography of the brain showed low density areas in the periventricular white matter which were not enhanced by intravenous contrast material. His parents' arylsulfatase A activities were about half those of normal controls. This is the third case of juvenile metachromatic leukodystrophy in Japan.     

Alexander's disease: a case report of a biopsy proven case

A case of infantile onset Alexander's disease in a two and a half year old male child is presented, who had progressively increasing macrencephaly since birth. A frontal lobe biopsy revealed collections of Rosenthal fibres in the subpial and perivascular areas with diffuse dysmyelination and presence of reactive astrocytes. The Rosenthal fibres were immunoreactive for glial fibrillary acidic protein and ubiquitin. Electron microscopic examination showed the Rosenthal fibres as intra-astrocytic and extracellular granular osmiphilic collections.     

A case of hematomyelia

The authors report haematomyelia developing in a 43-year-old man following a slight spinal trauma. The clinical course was severe but the prognosis was good.