开放与腔镜肾癌根治术对机体创伤应激反应影响的比较

目的探讨开放手术与后腹腔镜下肾癌根治术对患者白细胞、血清皮质醇、甲状腺素及C反应蛋白（CRP）的影响,比较机体对两种不同手术方式的创伤应激反应。方法选择行后腹腔镜肾癌根治术患者24例和开放手术患者26例,分别于术前、术后1d、3d、6d抽取静脉血测定白细胞数、血清皮质醇、甲状腺素（FT3、FT4）及C反应蛋白CRP含量进行对比研究。结果术后第1天腹腔镜组和开放手术组的白细胞数、血清皮质醇、CRP含量均较术前增加（P〈0．05）,血清FT3、FT4含量较术前降低（P〈0．05）,但后腹腔镜组和开放手术组间对比没有显著性差异（P〉0．05）。术后第3天,后腹腔镜组和开放手术组的各项指标均开始缓慢恢复,组间对比有显著性差异（P〈0．05）。术后第6d,后腹腔镜组除白细胞数外的所有指标均恢复术前水平,而开放手术组的各项指标未能恢复术前水平（P〈0．05）。结论开放手术与后腹腔镜肾脏肾癌根治术在术后第1d对机体造成的创伤应激反应没有差异,但后腹腔镜组的机体恢复速度快于开放手术组。     

腹腔镜腹膜后与开放性肾癌根治术治疗局限性肾癌的对比分析

目的:探讨腹腔镜腹膜后与开放肾癌根治术治疗局限性肾癌的临床疗效.方法:纳入2018年8月至2019年8月收治的72例局限性肾癌患者,按手术方式分为两组,对照组(n=36)行开放性肾癌根治术,观察组(n=36)行腹腔镜腹膜后肾癌根治术.对比分析两组治疗效果.结果:观察组术中出血量、手术时间、肿瘤根治性优于对照组,差异有统...     

胸腔镜手术对肺癌患者术后感染及疼痛应激相关指标的影响

目的 探究肺癌手术对患者术后感染及疼痛应激相关指标的影响。方法 以2016年3月至2021年1月在本院就诊的肺癌患者72例为研究对象,其中常规开胸手术32例为对照组,胸腔镜微创手术40例为观察组,检测患者手术前后的血清IL-6、IL-1β、NO、NPY、5-HT和PGE2的表达水平,比较两组患者手术前后的VAS评分、术后感染情况及并发症的发生情况。结果 观察组患者的术后感染率和并发症发生率低于对照组,差异有统计学意义（P<0.05）;观察组与对照组患者术前的血清IL-6、IL-1β、NO、NPY、5-HT、PGE2表达水平和VAS评分间的差异无统计学意义（P>0.05）;观察组患者术后上述相关指标均低于对照组,差异均有统计学意义（P<0.05）。结论 胸腔镜微创手术能够显著降低肺癌患者术后疼痛及相关指标表达水平,有利于术后感染控制,降低并发症发生率。     

后腹腔镜下与开放手术治疗局限性肾癌的比较

目的行后腹腔镜下肾癌根治术与开放性肾癌根治术总结比较。方法分析后腹腔镜下肾癌根治术（治疗组）28例、开放性肾癌根治术（对照组）30例临床资料,总结治疗效果。结果两组病例年龄、性别、肿瘤大小、分期、手术时间、生存率无明显差异。术中出血量、住院时间、术后进食时间、术后恢复正常活动时间、术后下床时间、肠功能恢复时间、术后并发症等方面,治疗组优于对照组,差异有统计学意义（P〈0.05）。结论后腹腔镜下肾癌根治术较开放性肾癌根治术具有安全性高、创伤小、术后恢复快、并发症少等优点,临床应用前景广泛。     

腹腔镜与传统开放远端胃癌D_2根治术对胃癌患者的近期疗效比较

比较腹腔镜与传统开放远端胃癌D2根治术对胃癌患者的近期疗效。2011年1月—2014年8月,胃癌患者138例随机分成观察组及对照组各69例,对照组给予传统的开放性远端胃癌D2根治术,观察组给予腹腔镜辅助的D2根治术,随访2年,比较两组的近期疗效。结果显示,观察组术中出血量、手术时间、术后排气时间、胃肠功能的恢复时间以及住院时间均优于对照组(P0.05)。治疗后观察组的CRP、IL-6及TNF-α水平均明显低于对照组,IL-10水平明显高于对照组(P0.05)。观察组1年生存率、2年生存率、1年和2年复发率与对照组差异无统计学意义(P0.05)。观察组的并发症发生率低于对照组(P0.05)。结果表明,腹腔镜胃癌D2根治术具有较好的近期疗效及安全性,有效降低患者的机体炎症反应。     

全身麻醉联合硬膜外阻滞对腹腔镜结肠癌根治术患者POCD的影响

目的:观察全身麻醉联合硬膜外阻滞对腹腔镜结肠癌根治术患者术后认知功能障碍(POCD)的影响,并分析影响患者POCD发生的因素。方法:以接受腹腔镜结肠癌根治术的80例患者为研究对象,并随机分为对照组和观察组,每组各40例,其中对照组给予全身麻醉,观察组给予全身麻醉+硬膜外阻滞。观察两组患者术后POCD的发生率,比较两组患者简易智力状况检查法(MMSE)评分、镇静镇痛评分及POCD发生率,比较两组患者S-100β、IL-6和TNF-α水平。分析影响POCD发生的因素。结果:两组患者手术前的MMSE得分无明显差别(P0.05),观察组患者手术后1 h和术后1 d的MMSE得分高于对照组(P0.05),发生POCD的例数少于对照组(P0.05),两组患者在术后7 d时的MMSE评分和发生POCD的例数无明显差别(P0.05);两组患者手术前的VAS和Ramsay评分无明显差别(P0.05),术后1 h、术后1 d和术2 d,观察组患者的VAS评分低于对照组(P0.05),Ramsay评分高于对照组(P0.05);手术前两组患者的S-100β、IL-6和TNF-α水平无明显差别(P0.05),术后1 d时,两组患者的上述指标水平均增高(P0.05),但观察组低于对照组(P0.05)。VAS评分、Ramsay评分、麻醉方式、S-100β、IL-6和TNF-α是影响患者发生POCD的危险因素(P0.05)。结论:全身麻醉联合硬膜外阻滞腹腔镜结肠癌根治术可降低患者术后早期发生POCD的概率,可能与该种麻醉方式镇静镇痛效果较好,并可调节相关细胞因子水平有关。     

后腹腔镜下与开放性肾癌根治术治疗局限性肾癌的比较

目的对比腹膜后腹腔镜肾癌根治术与开放性肾癌根治术治疗局限性肾癌的临床疗效。方法回顾分析2010年1月至2013年6月我院收治的局限性肾癌患者65例,其中行后腹腔镜下肾癌根治术35例,开放性肾癌根治术30例,比较两组的一般临床资料和疗效指标的差别。结果两组患者的年龄、BMI、肿瘤位置、肿瘤大小、手术时间差异无统计学意义（P〉0．05）,而手术出血量、术后拔除引流管时间、术后下床活动时间、术后住院时间等方面后腹腔镜下手术优于开放性手术,差异有统计学意义（P〈0．05）。结论与开放肾癌根治术相比,后腹腔镜下肾癌根治术具有出血少、术后恢复快的优点,是一种安全、有效的治疗方法,可作为局限性肾癌的首选治疗方法。     

超声引导阻滞麻醉在胸腔镜肺癌根治术后镇痛中的研究

目的探讨超声引导下前锯肌平面阻滞麻醉(SAPB)在胸腔镜肺癌根治术后镇痛效果。方法选取2017年1月至2018年12月本院行胸腔镜肺癌根治术患者160例,随机数表法分为观察组(n=80)和对照组(n=80)。观察组给予SAPB干预,对照组给予生理盐水干预。记录两组患者术后2、6、12、24小时静息、咳嗽时视觉模拟评分(VAS)以及白细胞介素-6(IL-6)、白细胞介素-10(IL-10)浓度,镇痛按压次数以及输注总量。结果观察组静息时术后2、6、12、24小时疼痛VAS评分小于对照组,差异具有统计学意义(P0.05);观察组咳嗽时术后2、6、12、24小时疼痛VAS疼痛评分小于对照组,差异具有统计学意义(P0.05)。两组患者术后2、6、12、24小时血清IL-6、IL-10表达水平均升高,观察组IL-6浓度低于对照组,差异具有统计学意义(P0.05);IL-10浓度高于对照组,差异具有统计学意义(P0.05)。观察组术后24小时内按压次数、输注总量均少于对照组(P0.05)。结论 SAPB能够为胸腔镜肺癌根治术患者提供良好的术后镇痛,减轻患者炎性反应,减少术后镇痛药量的使用,值得临床推广使用。     

加速康复外科在老年局部进展期胃癌腹腔镜D2根治术中的应用

目的 探讨加速康复外科(ERAS)对老年局部进展期胃癌(LAGC)腹腔镜D₂根治术患者炎症反应及术后恢复的影响。方法 将拟行腹腔镜胃癌D₂根治术的患者按随机数字表法分为ERAS组和对照组。比较2组患者干预前后的白介素-6(IL-6)、IL-8、肿瘤坏死因子-α(TNF-α)、超敏C-反应蛋白(hs-CRP)等炎性反应指标水平,以及视觉模拟评分法(VAS)评分。记录术后胃肠功能和并发症情况。结果 干预前2组患者的炎性反应指标水平差异均无统计学意义(P>0.05);干预后ERAS组患者的各项炎性反应指标水平均低于对照组,术后肠鸣音恢复时间、肛门排气时间、首次排便时间均短于对照组,VAS评分和并发症发生率均低于对照组。以上差异均有统计学意义(P<0.05)。结论 ERAS应用于老年LAGC腹腔镜胃癌D₂根治术患者的围术期,能减轻机体的炎症反应和缓解疼痛程度,有助于促进患者胃肠功能恢复和降低并发症风险。     

结直肠癌NOSE术对患者氧化应激、免疫功能及机体微炎症的影响

目的探讨腹腔镜结直肠癌标本经自然腔道取出手术(natural orifice specimen extraction,NOSE)对结直肠癌患者氧化应激、免疫功能及机体微炎症的影响。方法选取2014年1月~2015年12月我院收治的120例结直肠癌患者,根据随机数字表法将患者分为观察组及对照组,各60例,分别行NOSE结直肠癌根治术和传统腹腔镜结直肠癌根治术治疗。比较两组患者术中出血量、手术时间、术后第1 d VAS评分、术后排气时间及术后住院时间等围手术期指标。于手术前(T1)、术后第3 d(T2)、术后第7d(T3)测定患者氧化应激指标(SOD、MDA)、微炎症因子(CRP、TNF-α、IL-6、IL-10)、免疫功能(NK细胞活性、CD3+、CD4+、CD4+/CD8+、Ig G、Ig M、Ig A)并进行比较。结果观察组术后第1 d VAS评分明显低于对照组,术后排气时间、术后住院时间均短于对照组,差异均有统计学意义(P0.05),而两组患者术中出血量、手术时间比较均无统计学差异(P0.05)。两组患者T2、T3时SOD均明显低于T1时,并且T3时SOD明显高于T2时;T2、T3时MAD、CRP、TNF-α、IL-6均明显高于T1时,IL-10明显低于T1时,且T3时MDA、CRP、TNF-α、IL-6均明显低于T2时,IL-10明显高于T2时(P0.05)。两组患者T2、T3时CD3+、CD4+、Ig M、Ig A均明显低于T1时,且T3时CD3+、CD4+、Ig M、Ig A含量均明显高于T2时(P0.05)。两组患者间T1时各项指标比较均无统计学差异(P0.05);观察组T2、T3时SOD、IL-10、CD3+、CD4+、Ig M均明显高于对照组,MAD、CRP、TNF-α、IL-6均明显低于对照组(P0.05)。结论相对于传统腹腔镜结直肠癌根治术,NOSE结直肠癌根治术可有效减轻氧化应激反应,减少微炎症因子的释放,对机体免疫功能的影响更小。     

腹腔镜下行保留肾单位的肾肿瘤切除术对患者氧化应激反应以及红细胞糖代谢的影响

目的 分析腹腔镜下行保留肾单位肾肿瘤切除术对患者氧化应激反应以及红细胞糖代谢的影响.方法 选择接受手术治疗的肾肿瘤患者作为研究对象,按照手术方式不同分为观察组(腹腔镜手术)及对照组(开放性手术).检测分析两组患者的围术期氧化应激反应、红细胞糖代谢水平、微炎症水平等差异.结果 观察组患者接受腹腔镜手术治疗后的丙二醛(MDA)、皮质醇(Cor)水平低于对照组,谷胱甘太(GSH)、超氧化物歧化酶(SOD)水平高于对照组患者(P＜0.05);观察组患者的术后磷酸果糖激酶(PEK)水平高于对照组,红细胞6-磷酸葡萄糖胱氢酶(G-6PD)及醛糖还原酶(AR)水平低于对照组患者(P＜0.05);观察组患者的术后C反应蛋白(CRP)、IL-6、TNF-α水平低于对照组患者(P＜0.05).结论 腹腔镜下手术可以有效减少手术过程中的氧化应激反应,优化红细胞糖代谢,降低全身炎症反应,相较于开放性手术具有更多优势.     

成人腹股沟疝开放及腹腔镜术后炎性反应及并发症比较

目的探讨开放式以及腹腔镜手术方式对成人腹股沟疝患者炎性反应及相关并发症的影响差异。 方法选择2020年1月至2021年12月,在安徽省皖南康复医院·芜湖市第五人民医院完成腹股沟疝手术的60例患者的数据资料,进行回顾性分析。依手术方法分为对照组和观察组,各30例。对照组采用开放无张力疝修补术,观察组采用腹腔镜经腹腹膜前疝修补术（TAPP）。对比2组患者的手术耗时、失血量、切口长度、肛门排气时间、总住院时间、总医疗费用、切口疼痛持续时间、术后12 h疼痛程度、术后并发症指标。对比2组患者术前以及术后48 h的血清炎性反应指标[C反应蛋白（CRP）,白介素-6、降钙素原]。 结果观察组的失血量、切口长度、肛门排气时间、总住院时间低于对照组,观察组的总医疗费用高于对照组（P<0.05）。2组手术耗时差异无统计学意义（P>0.05）。观察组切口疼痛时间、术后VAS评分均低于对照组（P<0.05）。2组患者术后并发症发生率差异无统计学意义（P>0.05）。术后48 h,2组患者的血清CRP、白介素-6、降钙素原均增高（P<0.05）,观察组患者的CRP、白介素-6、降钙素原水平低于对照组（P<0.05）。 结论腹腔镜经腹腹膜前疝修补术组织创伤程度低,术后恢复速度快,疼痛感低,安全性良好,有利于控制术后的炎性反应水平。     

Comparison of surgical stress between laparoscopy and open surgery in the field of urology by measurement of humoral mediators

BACKGROUND: Recently, laparoscopic procedures have become more common in urological surgery, and are suggested to be less stressful compared with open surgery; however, little data on objective evaluation of surgical stress after laparoscopic surgery are available. The objective of this study was to compare surgical stress between laparoscopic and open surgery in the field of urology by measurement of humoral mediators. METHODS: Blood samples were obtained from 25 patients who underwent laparoscopic surgery (laparoscopic radical prostatectomy, 10; retroperitoneoscopic nephrectomy or nephroureterectomy, seven; laparoscopic adrenalectomy, five; and hand-assisted laparoscopic radical nephrectomy, three) and 10 who underwent open surgery (retropubic radical prostatectomy, four; radical cystectomy, three; and radical nephrectomy, three), 48 h before surgery, during surgery, and 24, 48 and 96 h after surgery. Serum levels of interleukin (IL)-6, IL-10 and granulocytic elastase in these samples were measured, and the results were analyzed with respect to several clinical factors. RESULTS: In both groups, IL-6 and granulocytic elastase levels increased during surgery and reached maximum levels 24 h after surgery; the increase in granulocytic elastase tended to be prolonged compared with that of IL-6. Changes in IL-10 levels in the open surgery group were similar to those of IL-6 and granulocytic elastase levels, whereas IL-10 levels in the laparoscopic surgery group reached a maximum level during surgery and then decreased to the same level as at 48 h before surgery, on the first postoperative day. The maximum levels of these three mediators in the laparoscopic surgery group were significantly lower than those in the open surgery group. IL-6 was closely associated with the interval of fasting and duration of hospitalization after surgery. CONCLUSION: Although the present study was based on retrospective and non-randomized analysis, the findings suggest that serum levels of IL-6, IL-10 and granulocytic elastase are useful as objective markers of surgical stress, and that laparoscopic surgery is markedly less stressful than open surgery.     

Why is urological laparoscopy minimally invasive?

OBJECTIVES: Laparoscopic procedures have been developed and established with the view that a similar operative effect can be achieved with less traumatization, especially as far as systemic stress response is concerned. We report a prospective, controlled, nonrandomized animal and patient study to determine the systemic response to laparoscopic and open surgical procedures. METHODS: In the animal study, 26 female pigs underwent either a laparoscopic bilateral varix ligation followed by bilateral nephrectomy (group I), sole introduction of trocars (group II) or sole establishment of an open surgical approach (group III). In the patient study, 145 patients underwent various laparoscopic procedures (nephrectomy, renal cyst marsupialization, varix ligation), open surgical procedures (nephrectomy, inguinal orchiectomy) or extracorporeal shockwave lithotripsy (ESWL). The serum parameters interleukin (IL)-6, IL-10 and C-reactive protein (CRP) were measured before, during and after the operative procedure. RESULTS: In animals and patients, laparoscopy resulted in significantly lower serum levels of CRP during and after the operative procedure. Animals in group I showed a 5-fold elevation, in group II a 3-fold elevation and in group III a 9-fold elevation of CRP. In patients, the increase of CRP was twice as high after open unilateral nephrectomy than after laparoscopic unilateral or bilateral nephrectomy. IL-6 showed less marked elevation during laparoscopy, ESWL and minor operative procedures like laparoscopic varix ligation or inguinal orchiectomy when compared to an open unilateral nephrectomy. The parameter IL-10 showed no significant differences among the patient groups. CONCLUSIONS: The extent of the acute phase reaction to the operative trauma correlates much more convincingly to the approach than to the extent of the procedure. Only larger operations like nephrectomy trigger a systemic acute phase reaction, which can be limited by the laparoscopic access. For minor operative procedures like varix ligation or exploration of cryptorchidism, laparoscopy offers technical advantages rather than minimal invasiveness.     

羟考酮对腹腔镜胆囊切除术患者拔管期应激反应、术后疼痛的影响分析

目的分析羟考酮对腹腔镜胆囊切除术患者拔管期应激反应、术后疼痛的影响分析。方法收集行腹腔镜胆囊切除术治疗的患者120例,ASA分级为Ⅰ~Ⅱ级,根据随机数字表法分为4组(每组30例),A、B、C组分别于术前15min静脉注射0.1mg/kg、0.15mg/kg、0.2mg/kg的羟考酮,D组静脉注射相同剂量的生理盐水。比较4组患者术后VAS评分、Ramsay镇静评分和炎性因子水平,并比较4组患者静脉注射羟考酮即刻(T1)、拔管即刻(T2)及拔管后5(T3)、10min(T4)的平均动脉压(MAP)、心率(HR)、血清肾上腺素(E)、皮质醇(Cor)水平。结果 C组拔管时间、苏醒时间明显高于A组、B组和D组(P0.05);B组、C组T2、T3时刻MAP、HR均明显低于A组和D组(P0.05);B组、C组T2、T3、T4时刻血清E、Cor水平明显低于A组和D组(P0.05);B组、C组术后1、2、6h的VAS评分明显低于A组和D组(P0.05);C组术后1、2、6h的Ramsay评分明显高于A组、B组和D组(P0.05);D组术后6、12h血IL-6水平均明显高于A组、B组和C组,术后6、12、24h血IL-10水平均明显高于A组、B组和C组(P0.05);B组、C组术后6、12h血IL-6水平均明显低于A组,IL-10水平均明显高于A组(P0.05);C组恶心呕吐、嗜睡、头晕发生率明显高于A组、B组和D组(P0.05)。结论腹腔镜胆囊切除术患者术前15min静脉注射0.15mg/kg的羟考酮,可更加有效减轻拔管期应激反应,改善了术后疼痛和炎症反应,且未增加不良反应的发生和拔管时间、苏醒时间,值得临床重视。     

Immunohumoral response during laparoscopic and open living donor nephrectomy: an experimental model

Measurement of interleukins (IL) and C-reactive protein (CRP) have demonstrated that a laparoscopic approach may induce less surgical stress than an open approach. The potential influence of this observation in living donor nephrectomy has scarcely been analyzed. The aim of the study was to analyze the immunohumoral response induced by laparoscopic versus open donor nephrectomy in an experimental model. Twenty pigs underwent left nephrectomy, 10 by laparoscopy and 10 by an open approach. In both groups the following parameters were measured: CRP, IL-2, IL-10, tumour necrosis factor alpha (TNF alpha), and endothelin-1 (ET-1). The determinations were done at different times: basal, immediately as well as on the first, third, fifth, and seventh days after the procedure. A comparative analysis between groups demonstrated a significant increases among the open group in the following markers: CRP (1.44 +/- 0.88 vs 1.32 +/- 0.14 mg/dL, P = .046); TNF alpha (131.14 +/- 41.37 vs 57.19 +/- 23.71 pg/mL; P > .001); and ET-1 (0.91 +/- 0.49 vs 0.56 +/- 0.5 fmol/mL; P = .001). The laparoscopic group showed higher levels of IL-2 than the open group. In conclusion, open donor nephrectomy produced a greater immunohumoral response than a laparoscopic approach. The influence of these observations on ischemia-reperfusion injury or on immediate graft function after kidney transplantation has not been clearly established.     

腹腔镜微创手术与开放手术治疗成人Ⅰ型胆总管囊肿的临床比较

目的比较腹腔镜微创手术与开放手术治疗成人Ⅰ型胆总管囊肿的临床效果。方法回顾性分析2013年3月~2016年2月于我院接受手术治疗的60例成人Ⅰ型胆总管囊肿患者的临床资料,按手术方式分为腹腔镜组(腹腔镜胆总管囊肿切除术+改良胆肠袢式吻合术,n=28)与开放组(传统开放性手术,n=30),记录两组手术前后谷丙转氨酶(ALT)、谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)、总胆红素(TBIL)、C反应蛋白(CRP)水平的变化,统计两组手术时间、术中出血量、术后首次进食时间、肛门排气时间、排便时间、拔管时间、住院时间,比较两组术后不同时间点视觉模拟评分(VAS)的变化,统计两组术后并发症发生情况。结果①术前,两组各实验室指标对比差异无统计学意义(P0.05),术后两组TBil上升,与术前比较差异有统计学意义(PO.05),但组间比较差异无统计学意义(P0.05);术后腹腔镜组CRP水平低于开放组,对比差异有统计学意义(PO.05)。②腹腔镜组术中出血量少于开放组,术后首次进食时间、肛门排气时间、排便时间、拔管时间、住院时间均短于开放组,对比差异有统计学意义(PO.05)。③与术后3 h比较,两组术后12 h、24 h、48 h、72 h VAS评分均降低(P0.05),腹腔镜组术后不同时间点VAS评分均低于开放组(P0.05)。④腹腔镜组术后并发症发生率低于开放组(P0.05)。结论在成人Ⅰ型胆总管囊肿患者的临床治疗中,采用腹腔镜微创手术治疗,对患者肝功能及胆汁排泄影响小,同时患者术中出血少,术后恢复速度快,住院时间短,疼痛程度低,并发症发生率低。     

Comparison of cortisol and inflammatory response between aged and middle-aged patients undergoing total hip arthroplasty: a prospective observational study

Background

To investigate the differences in the perioperative serum cortisol, C-reactive protein (CRP) and interleukin-6 (IL-6) levels between aged and middle-aged patients undergoing total hip arthroplasty (THA).

Methods

Sixty patients (30 aged and 30 middle-aged) undergoing THA for osteoarthritis between August 2016 and January 2017 participated in this study. Blood samples were collected preoperatively and at 6 hours, 24 hours and 3 days after surgery to measure the cortisol, CRP and IL-6 concentrations. The clinical outcomes were assessed using the visual analogue scale (VAS) pain score and Harris hip score (HHS).

Results

No significant differences were found between the two groups before the operation in the cortisol, IL-6 and CRP levels; the VAS score; or the HHS. Cortisol was significantly lower at 6 hours after surgery in the aged group than in the middle-aged group (P < 0.05). IL-6 at 6 and 24 hours after surgery, CRP at 3 days after surgery and the VAS score at 6 and 24 hours after surgery in the aged group were significantly higher than those in the middle-aged group (P < 0.05). In the aged group, weak correlations were found between the cortisol concentration 6 hours after THA and the IL-6 level 24 hours after THA (r = ?0.37, P = 0.04) and between the IL-6 level 6 hours after THA and the VAS score 24 hours after THA (r = 0.42, P = 0.02).

Conclusion

Aged patients showed lower cortisol levels at 6 hours after surgery and higher IL-6 levels at 6 and 24 hours after surgery than middle-aged patients undergoing THA.

     

腹腔镜辅助手术治疗高龄梗阻性结肠癌病人的临床分析

目的探讨腹腔镜辅助下手术治疗高龄梗阻性结肠癌病人的临床效果以及相关机制。方法采用前瞻性研究方法,选择2012年2月至2015年8月诊治的高龄梗阻性结肠癌病人120例,根据随机抽签原则分为观察组与对照组各60例,观察组采用腹腔镜辅助下手术治疗,对照组采用开腹手术治疗,记录两组预后情况。结果所有病人均顺利完成手术,观察组无中转开腹情况,不过观察组的术中出血量、肠蠕动恢复时间及术后住院时间均明显少于对照组,差异有统计学意义(P0.05),两组手术时间对比差异无统计学意义(P0.05)。观察组术后1个月的肺部感染、吻合口瘘、切口感染、肠梗阻等并发症发生率为6.7%,对照组为23.3%,观察组明显少于对照组,差异有统计学意义(P0.05)。观察组与对照组术前CD133阳性表达率分别为85.0%和81.7%,术后1个月的阳性表达率分别为6.7%和20.0%,观察组术后1个月的CD133阳性表达率明显低于对照组,差异有统计学意义(P0.05)。两组术后1个月的血清白细胞介素(IL)-6和IL-10含量均明显少于术前,差异有统计学意义(P0.05),同时术后1个月观察组的血清IL-6和IL-10含量也均明显少于对照组,差异有统计学意义(P0.05)。结论腹腔镜辅助下手术治疗高龄梗阻性结肠癌能减轻炎症反应,抑制CD133分子的表达,具有更好的微创性,能减少术后并发症的发生,从而促进病人康复。