Primary carcinoid tumor arising in a retroperitoneal mature teratoma in an adult

An extremely rare case of a primary carcinoid tumor arising in a mature retroperitoneal teratoma is reported. A 53-year-old woman was admitted for further examination of an incidental retroperitoneal mass with calcification. Computed tomography scans demonstrated a tumor with fat, soft tissue and bone densities on the left renal hilum. Surgical excision of the tumor was performed with a preoperative diagnosis of retroperitoneal teratoma. The pathological diagnosis was mature teratoma, including all three germ layers. A carcinoid tumor was evident among teratoid tissues and it was thought to be a teratoma with malignant transformation. The patient did not have a carcinoid syndrome and had an uneventful recovery. She has been followed for 31 months with no recurrence. Carcinoid tumors rarely occur in teratomas of the ovary and the testis and, to our knowledge, this is the first case of carcinoid arising in a retroperitoneal mature teratoma.     

Adenocarcinomas arising from primary retroperitoneal teratoma in an adult female patient

Presented herein is a case of primary retroperitoneal teratoma with adenocarcinomatous transformation predominantly composed of signet ring cell carcinoma and intestinal-type adenocarcinoma in a 36-year-old woman. Retroperitoneum is an infrequent location for teratoma in adults and malignant transformation is exceptionally rare. Clinical manifestations, radiological studies, laboratory investigation, and pathological findings of this case are described. To the best of the authors' knowledge, 16 adult cases of primary retroperitoneal teratoma with malignant change have been reported in the literature. Herein is reported the first case of malignant teratoma with prominent component of signet ring cell carcinoma.     

Congenital intrarenal teratoma arising from a horseshoe kidney

We report a case of intrarenal teratoma arising from a horseshoe kidney. A 6-day-old girl was admitted with an abdominal mass that had been noticed at 37 weeks gestation by routine ultrasonography. At 20 days of age, a tumorectomy with a right nephrectomy was performed. The pathological diagnosis was an immature teratoma. An intrarenal teratoma is extremely rare. In addition, we believe that this case represents the first case of an immature teratoma occurring in a horseshoe kidney. The diagnosis in this type of case is difficult, but we recommend that such tumors be included in the differential diagnosis.     

Extraordinary large primary retroperitoneal cystic teratoma: An extremely rare neoplasm

Teratomas are the germ cell tumors which comprises of tissues from all the three germ cell layers. Primary retroperitoneal teratoma is a relatively rare tumor in adults. The primary retroperitoneal teratoma constitutes 6–11% of the retroperitoneal tumors. Sixty percent of the retroperitoneal teratomas occur in children less than 15 years.It occurs more commonly in females than males. The order of frequency for teratoma is ovary, testis, mediastinum and the retroperitoneum at last. Early diagnosis and surgery are the mainstay of treatment. We report a rare case of large primary retroperitoneal teratoma. This is the largest primary retroperitoneal teratoma reported in the literature to our knowledge.     

Adenocarcinoma arising from a mature cystic teratoma of the testis

A 52-year-old male diagnosed pathologically with metastatic adenocarcinoma of the skin was referred to our department. Physical examination revealed a right scrotal mass the size of child's head and several skin tumors. Right high orchiectomy and resection of skin tumors were performed. Histopathological examination revealed a well-differentiated, mucinous adenocarcinoma originating from the gastrointestinal epithelium in a mature cystic teratoma (dermoid cyst) of the testis and metastatic mucinous adenocarcinoma of the skin. We made a diagnosis of teratoma with malignant transformation (TMT) of the testis. Combination chemotherapy with low-dose cisplatin/5'-deoxy-5-fluorouridine (CDDP/5'-DFUR) was initiated, but the patient died 8 months after orchiectomy. At autopsy, similar mucinous adenocarcinoma of the testis and the skin were observed at the metastatic sites.     

Adenocarcinoma arising in anterior mediastinal mature cystic teratoma: Report of a case

Mediastinal mature teratoma with malignant components is a very rare condition. A 57-year-old man presented with a large (14 × 10 cm) encapsulated and lobulated cystic mass involving the anterior mediastinum. The most consistent diagnosis on the basis of radiological findings was mature cystic teratoma, and a surgical resection was thus indicated. The operation was performed through a median sternotomy, and the tumor was extirpated with a combined resection of the pericardium and left mediastinal pleura. Although the pathological diagnosis was mature cystic teratoma, this patient showed a recurrence of malignant effusion 7 months following the operation. The earlier resected specimen was pathologically re-reviewed according to the blocked entire mass, and small foci of adenocarcinoma were thus found within the tumor.     

Mucinous cystadenoma arising 3 years after ovarian-sparing surgery for mature teratoma in a child

We report the case of a 15-year-old girl diagnosed with mucinous cystadenoma 3 years after ovarian-sparing surgery for a mature teratoma located in the same ovary. Ovarian teratoma is the most common ovarian neoplasm in children, whereas mucinous cystadenoma is extremely rare during childhood.     

Primary retroperitoneal mature cystic teratoma in an adult: A case report

BackgroundMature cystic teratoma is one of the most common tumors of the ovaries; however, primary retroperitoneal lesions are rare entities in adults.Case summaryWe report a case of a 33 year-old woman noticing a mass in her epigastric and left upper abdominal region without any specific signs and symptoms. Radiological evaluation revealed a retroperitoneal mass with extension from the posterior aspect of the pancreas to the pelvic cavity, composed of calcifications and cystic elements.ConclusionThe tumor was resected through a midline laparotomy and the pathology report confirmed the diagnosis of a mature cystic teratoma with no evidence of malignancy or immature components.     

Incidental finding of renal cell carcinoma in recurrent retroperitoneal liposarcoma

This is the first reported case of concomitant renal cell carcinoma with retroperitoneal liposarcoma (also involving the kidney). It highlights the speed and aggression of liposarcoma recurrence and re-inforces the need for complete resection margins when excising liposarcomas.     

Wilms' tumor arising within a mediastinal teratoma

The majority of Wilms' tumors present in young children as an intraabdominal mass of renal origin. The use of multimodal treatment protocols according to internationally recognized treatment guidelines has resulted in extremely high cure rates even in the setting of advanced disease. By comparison, Wilms' tumors in older patients or Wilms' tumors located entirely outside the kidney are extremely rare. Because of the rarity of these tumors and the lack of established treatment guidelines specific to these lesions, older patients with atypical Wilms' tumors are at risk for under treatment and poorer outcomes. We report the case of an 18-year-old man with a Wilms' tumor arising within a mediastinal teratoma and discuss the management of this extremely rare lesion.     

Neuroendocrine carcinoma of the stomach:A case report

Neuroendocrine carcinoma(NEC)is a rare tumor,comprising1%of stomach cancers.A 55-year-old woman was referred to our hospital with biopsy-proven gastric cancer.A shallow ulcerative lesion was detected in the lesser curvature of the lower body.It was suspected to be early gastric cancerⅡA+ⅡC type.Thus,endoscopic submucosal dissection was performed.She was subsequently diagnosed with NEC,which is aggressive and carries a poor prognosis.We conducted a radical resection and a laparoscopic-assisted distal gastrectomy.The tumor had infiltrated the subserosal layer and6/42 lymph nodes were involved.The mitotic index was16/10 high power fields and the Ki-67 labeling index was 26%-50%.The final diagnosis of NEC was made according to the World health Organization 2010 criteria.She was suspected of having jumping metastasis to the proximal margin.The patient was treated with an oral anticancer drug(5-flurouracil based drug)for2 years.The patient has been followed up for 3 years without recurrence.     

The unusual imaging appearance of primary retroperitoneal teratoma: Report of a case

Primary retroperitoneal (RP) teratoma is a rare entity which has a distinctive imaging appearance. We describe herein the case of a 25-year-old man in whom a RP teratoma was found to have an extremely unusual imaging morphology by ultrasound and computed tomography (CT). The tumor was resected and histopathological examination confirmed the diagnosis of primary benign RP teratoma.     

Neuroendocrine breast carcinoma metastatic to the liver: Report of a case and review of the literature

INTRODUCTION

Primary neuroendocrine breast carcinoma (NEBC) is a rare entity of breast cancer.

PRESENTATION OF CASE

We herein report a case of right hepatectomy for a NEBC liver metastasis.

DISCUSSION

Little is known about its evolution, bilologic behavior and optimal treatment. Its malignant potential has been addressed in few reports, with cases of metachronous metastases in diverse sites, even years following treatment of the breast primarily.

CONCLUSION

Treating this kind of cancer implies both breast and hepatic surgery.Primary neuroendocrine breast carcinoma (NEBC) is a rare entity of breast cancer. Little is known about its evolution, biologic behavior and optimal treatment. Its malignant potential has been addressed in few reports, with cases of metachronous metastases in diverse sites, even years following treatment of the breast primarily. We herein report a case of right hepatectomy for a NEBC liver metastasis.     

肾脏神经内分泌癌1例报告并文献复习

目的 通过分析肾脏神经内分泌癌(neuroendocrine carcinoma,NEC)的临床病理特征、免疫表型、治疗方式及预后,提高对该类肿瘤的认识和诊疗水平. 方法 分析我科1例肾脏NEC的临床表现、病理特点及治疗方法并结合文献复习. 结果 患者表现为肉眼血尿伴腰痛.病理:肿瘤细胞中等大小,细胞核呈圆形、卵圆形,染色质为细颗粒状,肿瘤细胞排列呈小梁状、条索状,见菊形团样结构;免疫组化:CK(+)、EMA(+)、CD56(+)、Ki-67(80％)、CgA(-)、Syn(-)、CD99(-)、WT-1(-)、Vimentin(-)、NSE(-). 结论 肾脏NEC十分罕见,且临床表现与肾盂癌较为相似,其诊断主要根据病理学检查和免疫组化结果来做出判断.     

喉神经内分泌癌临床分析

目的探讨喉神经内分泌癌的临床表现、诊断及治疗。方法回顾分析我科收治的3例喉神经内分泌癌,其中非典型类癌1例,行手术切除及颈淋巴结清扫术;神经内分泌型小细胞癌2例,1例行手术切除及颈淋巴结清扫术加术后放化疗,另外1例行放化疗。结果非典型类癌1例,术后19个月发现全身多发骨转移,行化疗后珊隋况稳定。行手术及术后放化疗的神经内分泌型小细胞癌患者治疗后6个月后死于肿瘤。行放化疗的神经内分泌型小细胞癌患者在两年内死于肿瘤。结论喉神经内分泌肿瘤是一组形态预后各异的病变,正确诊断有赖于临床特点、光镜、免疫组化检查,部分患者需行超微结构检查。放射性核素标记的生长抑素类似物是神经内分泌肿瘤诊断的新方法。不同病理亚型的喉神经内分泌肿瘤的治疗方法及预后是不同的。