甲状腺机能障碍患者的体感诱发电位

应用电子计算机迭加平均技术,记录了24名甲状腺机能亢进症(甲亢)、4名甲状腺机能减退症(甲减)患者和32名正常受试者的正中神经体感诱发电位(SEPs)。在24名甲亢患者中F_(?)峰值潜伏期延长者12例,N_(13)-N_(20)传导时间缩短者2例;4例甲减患者中,Ep峰值潜伏期延长者3例,N_(20)峰值潜伏期延长者1例,N_(13)-N_(20)传导时间延长者1例。结果表明,甲状腺机能异常者不仅可出现外周神经传导功能障碍,而且也可能出现中枢传导功能的异常。     

三碘甲状腺原氨酸对大鼠体感诱发电位的影响

连续腹腔注射三碘甲状腺原氨酸(T_3)过程中,观察成年雄鼠(Sprague-Dawley)体感诱发电位(SEPs)的变化,以探讨T_3对大鼠本体感觉传导功能活动的影响。实验结果显示,在正常大鼠颅顶(C_3)可记录到N_1,P_1,N_2及P_2成份,注射T_3后大鼠SEPs的P_1,N_2和P_2成份的峰值潜伏期随着给药时间的延长而缩短,而N_1成份的峰值潜伏期无变化。由此町见,T_3对大鼠本体感觉传导成份具有选择性和特异性影响。     

体感诱发电位与体感诱发电位地形图及其临床应用

体感诱发电位（Somatosensory Evoked Potential,SEP）一﹑概念：即躯体感觉诱发电位,它是给皮肤或末梢神经以刺激,神经冲动沿传入神经通路至脊髓感觉通路﹑丘脑至大脑皮层中央后回感觉区,在刺激的对侧头皮相应部位记录到的电活动。二﹑体感诱发电位的分类：（一）按记录和刺激电极放置部位分类1﹑上肢和下肢体感诱发电位2﹑感觉神经动作电位3﹑节段性诱发电位4﹑三叉神经体感诱发电位5﹑其他脑干诱发电位或反射6﹑膈神经和肋间神经诱发电位7﹑食管﹑直肠脑诱发电位8﹑二氧化碳激光痛觉诱发电位9﹑外阴部诱发电位10﹑     

兔水中毒时体感诱发电位

应用水负荷附加抗利尿激素,复制水中毒模型。当水负荷增加兔体重10%后,体感诱发电位(SEP)成份P7、N9、P12和N15峰值潜伏期随体重增加而逐渐延长。体重增加10%及15%时,P12和N15成份振幅均增大,但当增加体重15%以上时,两成份振幅减小或消失。水负荷后SEP峰间潜伏期的延长以P12—N15最显著。各种程度水负荷时,P7和N9的振幅均无显著变化。结果说明,水负荷增加体重10%后,可使神经元的传导发生延缓及皮层神经元兴奋性改变;不同程度的水负荷对神经元兴奋性的影响并不相同,此外水负荷对大脑皮层功能的影响较低位脑干严重。     

颈椎病患者短潜时体感诱发电位的初步研究

为探讨短潜时体感诱发电位对颈椎病诊断的意义，检测了15例颈椎病患的短潜时体感诱发电位(SSEP)，并与对照组比较。结果表明：颈椎病患SSEP的N20、P25波潜伏期及N13-N20峰间潜伏期(即中枢神经传导时间，CCT)和N13-P25峰间潜伏期均比对照组明显延长，其SSEP异常率为73，3％。提示短潜时体感诱发电位检查能客观评价颈椎病患的神经功能，有助于评价疗效和判断预后。     

糖尿病性神经病变的体感诱发电位观察

对已确诊Ⅱ型(非胰岛素依赖型)糖尿病的105例患者进行了体感诱发电位(SEP)观察。结果显示SEP正常25例(23.8％),异常80例(76.2％)。其异常发生率与年龄、病程、血糖控制情况有显著相关性,即年龄大、病程长及长期血糖控制差的患者SEP异常率高。结果还显示,有神经系统症状的患者SEP多为异常,而临床尚未出现神经系统症状者SEP也可出现异改变,提示该检查对糖尿病性神经病变的早期诊断有一定价值。     

老年糖尿病患者肋间神经刺激体感诱发电位研究

目的 :探讨肋间神经刺激体感诱发电位 (ISEP)对评价老年糖尿病 (DM)患者躯干神经功能障碍的价值 ,并分析引起ISEP异常的相关因素。方法 :对 5 2例正常人 ,35例老年DM病人在双侧第3、5、7、9肋间隙刺激 ,皮层C1、C2 记录ISEP ,同时进行运动诱发电位、体感诱发电位、脑干听觉诱发电位位、耳蜗电图、视觉诱发电位等电生理检查 ,并分析与血液生化检查异常的相关关系。结果 :老年DM病人ISEP异常 2 6例 ,异常率 74%。与正常对照组相比有显著性差异 ,ISEP与餐后血糖、空腹血糖、糖化血红蛋白、病程、血清胰岛素及C肽水平呈正相关 (r=0 2 43～ 0 90 5 ,P =0 0 1～ 0 0 5 )。结论 :ISEP可客观评价胸部神经根病 ,可作为糖尿病病人胸段神经根病、肋间神经痛等疾病早期诊断及预后判断的依据。     

Activation of respiratory afferents by resistive loaded breathing modifies somatosensory evoked potentials to median nerve stimulation in humans

The cortical projections of respiratory afferents (vagus and respiratory muscle nerves) are well documented in humans. It is also shown that their activation during loaded breathing modifies the perception of tactile sensation as well as the motor drive to skeletal muscles. The effects of expiratory or inspiratory loaded breathing on somatosensory evoked potentials (SEPs) elicited by median nerve stimulation were studied in eight healthy subjects. No significant changes occurred in latencies of N20, N30 and P40 throughout the expiratory loading period, except for a significant lengthening in P1 latency compared with unloaded breathing. However, inspiratory loading induced a significant increase in peak latency of N20, N30 and P40 components. We suggest that projections of inspiratory afferents from the diaphragm and the intercostal muscles, activated by inspiratory loading, could be responsible for the lengthened latency of median nerve SEP components. Thus, respiratory afferents very likely interact with pathways of the somatosensory system.     

脑电图及体感诱发电位技术在神经重症监护中的应用进展

神经电生理技术在神经重症监护中具有重要意义.其中脑电图、体感诱发电位的应用较为完善成熟,在痫样放电、脑血流量及颅内压变化等方面的应用已有多项研究证实.其检测结果的多种分级方式提供了更标准量化的病情及预后判断标准.与影像学检查相比,神经电生理技术可敏感、及时地反映生理与病理状态下的脑功能变化,可对病情复杂多变的重症神经系...     

新生儿高胆红素血症闪光视觉诱发电位的检测

应用视觉诱发电位仪对２５例高胆红素血症（简称高胆）新生儿进行了闪光视觉诱发电位（ｒｉｓｕａｌ ｅｖｏｋｅｄ ｐｏｔｅｎｔｉａｌｓ ｔｏ ｆｌａｓｈ,Ｆ－ＶＥＰ）的检测,同时测定了２０例正常新生儿作为对照。结果表明：１．高胆新生儿Ｆ－ＶＥＰ主波潜伏期延长,与正常新生儿比较有显著性差异;２．高胆新生儿胆红素浓度越高,Ｆ－ＦＶＥＰ潜伏越长。提示高胆对视觉神经通道有毒性作用,胆红素浓度越高,毒性损害越大,     

Visual evoked potentials in the forebrain of the pigeon

Summary The telencephalon of anaesthetized pigeons was systematically explored for flash evoked potentials. A short latency projection to the hyper striatum was confirmed. A second short latency projection which appears to have a major focus in the medial sector of the neostriatum caudale and a more diffuse representation in the remainder of this structure was also found. Longer latency responses were found in a band of tissue surrounding the ectostriatum although the latency of these potentials was too short to be compatible with their origin in a projection from the thalamic nucleus rotundus. The core of the ectostriatum was not responsive under the conditions of the present study. A previously reported projection to the avian archistriatum was not confirmed and evidence is presented that supposed evoked potentials in this region of the brain were confused with volume conducted electroretinograms. All forebrain evoked potentials were attenuated by repetition rates above 1 hz. The origin of these projections is discussed in conjunction with evoked potentials recorded at lower levels of the pigeon's visual system under the same conditions and in the light of available anatomical and electrophysiological evidence. It is concluded that the information about visual projections to the avian forebrain is as yet too incomplete to be useful as evidence for presumptive avian-mammalian forebrain homologies.     

Effects of essential hypertension on short latency human somatosensory‐evoked potentials

Reduced perception of somatosensory stimulation in patients with essential hypertension may be due to deficits in the ascending somatosensory pathway. Function in the ascending somatosensory pathway was assessed by measuring N9, N13, and N20 somatosensory‐evoked potentials in 14 unmedicated essential hypertensives and 22 normotensives. N9 amplitudes were smaller and N13 amplitudes marginally smaller in hypertensives than normotensives. N9 amplitudes were inversely associated with blood pressure. N20 amplitudes and N9, N13, and N20 latencies did not differ between groups. In addition, plexus‐to‐cord, cord‐to‐cortex, and plexus‐to‐cortex conduction times were not different between groups. These data suggest that hypertension affects the peripheral nervous system by reducing the number of active sensory nerve fibers without affecting myelination. However, hypertension does not seem to affect the afferent somatosensory pathway within the brain.     

糖尿病并脑梗死患者的脑干听觉诱发电位和脑电图研究

目的：研究糖尿病对脑梗塞患者脑干听觉诱发电位（BAEP）和脑电图（EEG）的影响。方法：随机选择196例高血压性脑梗死，其中86例合并糖尿病（均非胰岛素依赖型）。所有病例均发病7天内进行BAEP和EEG检查。结果：单纯高血压性脑梗死和合并糖尿病患者BAEP异常率分别约为65．4％和80．2％（x2=5．22，P＜0.05）；EEG异常率50.．9％和69．8％（x2＝7．36，P＜0.01）。合并糖尿病的脑梗死患者BAEP主波潜伏期和波间期均比高血压性脑梗死患者明显延长（P＜0．0.05～0.01）；BAEP及EEG异常程度亦以合并糖尿病患者为重。结论：糖尿病加重脑梗死患者脑功能的损害，对预后不利。