生物医学工程学科发展的思考

本文分析了国内外生物医学工程学科发展历程和学科特征。基于生物医学大数据时代的特点,提出了基于理论驱动型和应用驱动型生物医学工程学科发展的新思路,阐明了在大数据时代生物医学工程学科的发展特色,以期对生物医学工程学科建设与发展提供有益参考。     

生物医学工程专业研究生跨学科培养模式研究

生物医学工程是理工医相结合的综合性交叉学科。该学科要求培养在知识结构上既懂医学又掌握工程技术的复合型人才,这对该学科研究生知识、能力和素质的培养提出了更高的要求。由于各高校生物医学工程专业学科背景与培养侧重点不同。生物医学工程研究生培养模式各异。本文从生物医学工程学科特征与现状分析人手。介绍了中南大学生物医学工程学科发展历程与现状。并结合中南大学生物医学工程学科强大的工程背景、夯实的医学研究与实践发展平台,对生物医学工程研究生跨学科的培养计划、课程设置和培养过程管理等方面进行了系统分析与探讨。同时从科研选题、中期考核和论文答辩等环节对培养过程管理进行了展开讨论。为生物医学工程研究生跨学科复合型人才的培养提供借鉴。     

上海市生物医学工程学会放射医学工程专业委员会换届改选

正在上海市生物医学工程学会常务副理事长冯晓源教授与专委会李克秘书长的领导下,于2018年6月28日顺利地完成了上海市生物医学工程学会放射医学工程专业委员会第9届委员会换届改选工作。上海市生物医学工程学会放射医学工程专业委员会(前身为上海市生物医学工程学会放射医学工程研究会)成立于1990年2月28日,是生物医学工程学会中成立较早的专科分会之一。在放射医学与相关工程的跨界合作中起到了重要的作用。     

2007中国生物医学工程联合学术年会（CBME’07）第一轮通知

为了反映生命科学、信息科学、电子科学在生物医学工程领域交叉与融合所取得的最新成果,促进相关学者的交流与合作,提升我国生物医学工程的整体水平,由中国电子学会生物医学电于学分会、中国生物医学工程学会生物医学测量分会、中国生物医学工程学会生物信息与控制分会、中国生     

《生物医学工程与临床》稿约

《生物医学工程与临床》是天津市生物医学工程学会、天津市第三中心医院、中国医学科学院生物医学工程研究所联合主办的生物医学工程及其相关临床医学的综合性学术刊物,贯彻“百花齐放、百家争鸣”和理论与实践相结合的方针,报道国内外有关生物医学工程及其在临床中的研究、应用,是我国生物医学工程学和其相关的临床医学工作者进行学术交流的园地。     

征稿简则

《生物医学工程学进展》是由上海市科学技术协会主管,上海市生物医学工程学会主办的生物医学工程学领域的综合性学术刊物,国内外公开发行。办刊宗旨是引导生物医学工程工作者研究用于防病、治病、人体功能辅助及卫生保健的各种材料的前沿科学和先进技术。内容包括生物医学工程、生物材料、人造器管、生物力学、生物信息与控制、生物医学仪器、生物医学测量、心脏起搏与电生理、医学超声工程、康复工程、生物芯片与传感器、医学图像与成像、核医学装     

论中国高等院校生物医学工程本科专业的核心竞争力

生物医学工程是一门交叉学科,我国对生物医学工程专业学生的培养有着多样化的特点,各高校多根据学校学科特色及研究优势,制定针对不同类型人才的培养方案,体现了各学校的专业特色,但这种多样性弱化了生物医学工程专业区别于其他工程专业的核心竞争力.因此本文从《生物医学工程类教学质量国家标准》出发,基于生物医学工程产业的要求,明确了生物医学工程专业本科生应具备的知识体系结构,提出了生物医学工程专业本科生区别于其他工程专业学生的显著特征,即核心竞争力,包括多学科交叉知识体系,以及与医生顺畅交流的沟通能力、生理信息测量与分析的实践能力和大数据综合与分析处理的决策能力.     

2019中国生物医学工程大会征文通知

正中国生物医学工程学会定于2019年11月14-16日在山东济南山东会堂举办"2019中国生物医学工程大会暨创新医疗峰会",作为主要议题,会议将展现我国生物医学工程领域学科发展和科学研究的新成果和新进展。诚邀国内专家与同行踊跃投稿,积极参加会议交流。大会将设青年优秀论文竞赛,鼓励生物医学工程领域的在校学生或年轻学者(1983年12月31日之后出生者)参加。1.征文范围:生物医学成像与图像处理,生物力学,生物医学传感、测量与可穿戴系统,神经工程,健康工程、生物医学和健康信息学,康复工程,生物材料与组织工程,纳米医学与工程,生物医学光子学,医学物理与     

征稿简则

正《生物医学工程学进展》创刊于1979年,是中国最早创办的生物医学工程领域的学术刊物。由上海市科学技术协会主管,上海市生物医学工程学会主办,国内外公开发行。主编由上海市生物医学工程学会理事长冯晓源教授亲自担任,编辑委员会由国内外生物医学领域中各学科的领军人物:著名院士、专家、教授等组成。《生物医学工程学进展》是中国科技论文统计源期刊,已被中国知网、万方、维普等多家数据库全文收录。《生物医学工程学进展》办刊宗旨是引导生物医学工程工作者研究用于防病、治病、人体功能辅助及卫生保健的材料、设备与仪器的前沿科学和创新科技与先进技术。内容包括生物医学工程、临床医学工程、生物材料、人造器管、生物力学、生物信息与控制、生物医学仪器、生物医学测量、心脏起搏与电生理、医学超声工程、康复工程、生物芯片与传感器、医学图像与成像、核医学装置、介入医疗工程技术、计算机在生物医学工程中应用等方面的最新科研成果和科技动态。     

中国电子学会生物医学电子学分会和中国生物医学工程学会生物医学测量分会、生物医学信息与控制分会、生物医学传感技术分会联合年会召开

中国电子学会生物医学电子学分会和中国生物医学工程学会生物医学测量分会、生物医学信息与控制分会、生物医学传感技术分会联合年会召开１９９４年１１月２～４日在南京召开了上述四个分科学会的联合年会，组织了学术交流和工作会议，有各分会委员近８０人出席了会议。会...     

An update on the molecular pathology of urinary bladder tumors

Urothelial carcinoma is the fourth most common tumors after prostate cancer, lung, and colorectal carcinoma but the second most common urologic malignancy. Urothelial carcinoma composed more than 90% of bladder tumors while squamous cell carcinoma and adenocarcinomas composed 5% and 2% respectively. The intense research involving the different molecular aspects of bladder cancer has provided a great insight into identifying more about molecular profiling and pathways of bladder cancer.In this review, we will highlight the general concepts of the molecular features; profiling and classification as well as the molecular pathways for bladder carcinomas, especially urothelial carcinoma. Also, we will discuss the advances of molecular biomarkers for screening, early diagnosis, surveillance and potential prognosis of urothelial carcinoma of the bladder. Studies showed that accumulation of genetic alterations involving the clonal expansion of altered cells with growth advantages through sequential multi-step pathways results in progression of bladder tumors.The accumulated research data from literature has revealed that the genomic signatures of urothelial carcinoma are required to subclassify bladder cancer into genetically distinct subgroups. These findings could improve the understating of pathogenesis as well as will provide new therapeutic modules e.g. targeted therapy.     

分子标记在生物材料分子生物相容性中的应用现状

对生物材料进行生物相容性的评价是进入临床实验前的关键环节.随着分子生物学的迅速发展,研究者已经深入到分子水平对生物材料进行生物相容性的评价,并提出了分子生物相容性的概念.当前,主要任务是借助分子生物学技术,确定更多的分子标记物,以便建立分子生物相容性评价标准,并藉此指导设计出相容性更好的生物材料.     

Molecular methods for serovar determination of Salmonella

Abstract

Salmonella is a diverse foodborne pathogen, which has more than 2600 recognized serovars. Classification of Salmonella isolates into serovars is essential for surveillance and epidemiological investigations; however, determination of Salmonella serovars, by traditional serotyping, has some important limitations (e.g. labor intensive, time consuming). To overcome these limitations, multiple methods have been investigated to develop molecular serotyping schemes. Currently, molecular methods to predict Salmonella serovars include (i) molecular subtyping methods (e.g. PFGE, MLST), (ii) classification using serovar-specific genomic markers and (iii) direct methods, which identify genes encoding antigens or biosynthesis of antigens used for serotyping. Here, we reviewed reported methodologies for Salmonella molecular serotyping and determined the “serovar-prediction accuracy”, as the percentage of isolates for which the serovar was correctly classified by a given method. Serovar-prediction accuracy ranged from 0 to 100%, 51 to 100% and 33 to 100% for molecular subtyping, serovar-specific genomic markers and direct methods, respectively. Major limitations of available schemes are errors in predicting closely related serovars (e.g. Typhimurium and 4,5,12:i:-), and polyphyletic serovars (e.g. Newport, Saintpaul). The high diversity of Salmonella serovars represents a considerable challenge for molecular serotyping approaches. With the recent improvement in sequencing technologies, full genome sequencing could be developed into a promising molecular approach to serotype Salmonella.     

Molecular tools for identification of Zygomycetes and the diagnosis of zygomycosis

The identification of Zygomycetes and diagnosis of zygomycosis are notoriously difficult. However, there have been recent advances, particularly in the availability and evaluation of new molecular approaches. Two main issues are of importance: the identification to species level of a strain isolated in culture, and the identification of a zygomycete in tissues. By using several molecular targets and by increasing the number of available DNA sequences in international databases, several studies have shown that accurate molecular identification of Zygomycetes to species level is feasible. The internal transcribed spacer (ITS) region may be used as a first-line molecular target for the identification of Zygomycetes in pure culture. However, cultures from infected tissues are often negative and the different Zygomycetes share similar morphology according to histopathology. Furthermore, differentiation of a zygomycete from another hyalohyphomycete can sometimes be difficult in histopathology. Thus, alternative methods for the diagnosis of zygomycosis and for species identification directly from tissues are needed. For this purpose, molecular methods have been recently evaluated, both on unfixed fresh/frozen material and on formalin-fixed, paraffin-embedded biopsies. This review discusses the molecular approaches currently available for the identification of Zygomycetes and the diagnosis of zygomycosis.     

Photoelectrochemical Bisphenol S Sensor Based on ZnO‐Nanoroads Modified by Molecularly Imprinted Polypyrrole

Molecularly imprinted polymers are important tools for the design of sensors and other molecular recognition based analytical systems. In this paper the development of a photoelectrochemical sensor for selective bisphenol determination is reported. The sensor is based on a glass/ZnO/MIP‐Ppy structure consisting of glass modified by a ZnO layer (glass/ZnO), which is functionalized by molecularly imprinted conducting polymer polypyrrole (MIP‐Ppy). The sensitivity of the sensor to bisphenol is in the range of 0.7–12.5 µm . Selectivity tests to other bisphenolic compounds are performed. Some aspects of a photoinduced response mechanism in glass/ZnO/MIP‐Ppy nanostructures are predicted and discussed.     

A new molecular paradigm in mycosis fungoides and Sézary syndrome

Mycosis Fungoides (MF) and Sézary Syndrome (SS) are clonal proliferations of mature T-cells manifesting as lymphoproliferative disorders in which the neoplastic cells show a strong propensity for skin-homing. While the predominant site of presentation in MF is the skin, the peripheral blood carries a significant tumor burden in Sézary Syndrome such that it resembles a “leukemic” disease. While the genetic basis of these diseases has been studied using different approaches in the previous years, recent genome-wide studies employing massively parallel sequencing techniques now offer new insights into the molecular pathogenesis of these diseases. In this chapter, we discuss the recent findings elucidating the genomic landscape of MF and SS. The pathways targeted by mutational alterations are discussed and a model for understanding the pathogenesis of these diseases is proposed. It is anticipated that prognostic stratification and therapeutic targeting based on mutational signatures will be achieved in the near future based on the improved understanding of the molecular pathogenesis of these diseases.     

Molecular magnetic resonance imaging

Molecular MRI (mMRI) is a special implementation of Molecular Imaging for the non-invasive visualisation of biological processes at the cellular and molecular level. More specifically, mMRI comprises the contrast agent-mediated alteration of tissue relaxation times for the detection and localisation of molecular disease markers (such as cell surface receptors, enzymes or signaling molecules), cells (e.g. lymphocytes, stem cells) or therapeutic drugs (e.g. liposomes, viral particles). MRI yields topographical, anatomical maps; functional MRI (fMRI) provides rendering of physiologic functions and magnetic resonance spectroscopy (MRS) reveals the distribution patterns of some specific metabolites. mMRI provides an additional level of information at the molecular or cellular level, thus extending MRI further beyond the anatomical and physiological level. These advances brought by mMRI are mandatory for MRI to be competitive in the age of molecular medicine. mMRI is already today increasingly used for research purposes, e.g. to facilitate the examination of cell migration, angiogenesis, apoptosis or gene expression in living organisms. In medical diagnostics, mMRI will pave the way toward a significant improvement in early detection of disease, therapy planning or monitoring of outcome and will therefore bring significant improvement in the medical treatment for patients.In general, Molecular Imaging demands high sensitivity equipment, capable of quantitative measurements to detect probes that interact with targets at the pico- or nanomolar level. The challenge to detect such sparse targets can be exemplified with cell surface receptors, a common target for molecular imaging. At high expression levels (bigger than 106 per cell) the receptor concentration is approx. 10(15) per ml, i.e. the concentration is in the micromole range. Many targets, however, are expressed in even considerably lower concentrations. Therefore the most sensitive modalities, namely nuclear imaging (PET and SPECT) have always been at the forefront of Molecular Imaging, and many nuclear probes in clinical use today are already designed to detect molecular mechanisms (such as FDG, detecting high glucose metabolism). In recent years however, Molecular Imaging has commanded attention from beyond the field of nuclear medicine. Further imaging modalities to be considered for molecular imaging primarily include optical imaging, MRI and ultrasound.     

Breast carcinoma: Is molecular evaluation a necessary part of current pathological analysis?

Breast cancer is the most common women cancer and is the second leading cause of cancer-related mortality in women. While the last two decades revolutionized breast cancer treatment with the development and use of therapies targeting steroid receptors and HER2/neu, there are limits to the risk estimation provided by traditional clinicopathologic parameters and IHC. Therefore, there is continued potential for inaccurate risk stratification of breast cancer patients which may lead to over- or under-treatment. In this review, we discuss the latest developments in the area of breast cancer research which have lead to better understanding of the breast cancer mechanisms, provided more accurate risk stratification, and identified potential new treatment targets. Specifically, we review the new dualistic model of breast carcinogenesis, which can inform pathologic diagnosis and tumor grading; we also discuss the intrinsic molecular classification of breast cancer and its impact on diagnosis and treatment; lastly, we compare the most common commercial molecular prognostic and predictive assays, with their respective strengths and weaknesses, and their clinical utility.     

The portal protein plays essential roles at different steps of the SPP1 DNA packaging process

A large number of viruses use a specialized portal for entry of DNA to the viral capsid and for its polarized exit at the beginning of infection. These families of viruses assemble an icosahedral procapsid containing a portal protein oligomer in one of its 12 vertices. The viral ATPase (terminase) interacts with the portal vertex to form a powerful molecular motor that translocates DNA to the procapsid interior against a steep concentration gradient. The portal protein is an essential component of this DNA packaging machine. Characterization of single amino acid substitutions in the portal protein gp6 of bacteriophage SPP1 that block DNA packaging identified sequential steps in the packaging mechanism that require its action. Gp6 is essential at early steps of DNA packaging and for DNA translocation to the capsid interior, it affects the efficiency of DNA packaging, it is a central component of the headful sensor that determines the size of the packaged DNA molecule, and is essential for closure of the portal pore by the head completion proteins to prevent exit of the DNA encapsidated. Functional regions of gp6 necessary at each step are identified within its primary structure. The similarity between the architecture of portal oligomers and between the DNA packaging strategies of viruses using portals strongly suggests that the portal protein plays the same roles in a large number of viruses.     

家畜寄生虫分子疫苗的研究进展

家畜寄生虫分子疫苗的研究进展李国清林辉环翁亚彪孔繁瑶１（华南农业大学动物医学系，广州５１０６４２）家畜寄生虫病长期以来一直是动物卫生和公共卫生的重要问题，目前的控制方法主要依靠药物防治。但这种方法有明显的缺点和局限，最严重的问题是抗药性的大量出现，例...