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1.
Objectives
To compare the sensitivity of enhancing multiple sclerosis (MS) lesions in gadolinium-enhanced 2D T1-weighted gradient-echo (GRE) and spin-echo (SE) sequences, and to assess the influence of visual conspicuity and laterality on detection of these lesions.Methods
One hundred MS patients underwent 3.0T brain MRI including gadolinium-enhanced 2D T1-weighted GRE and SE sequences. The two sets of contrast-enhanced scans were evaluated in random fashion by three experienced readers. Lesion conspicuity was assessed by the image contrast ratio (CR) and contrast-to-noise ratio (CNR). The intracranial region was divided into four quadrants and the impact of lesion location on detection was assessed in each slice.Results
Six hundred and seven gadolinium-enhancing MS lesions were identified. GRE images were more sensitive for lesion detection (0.828) than SE images (0.767). Lesions showed a higher CR in SE than in GRE images, whereas the CNR was higher in GRE than SE. Most misclassifications occurred in the right posterior quadrant.Conclusions
The gadolinium-enhanced 2D T1-weighted GRE sequence at 3.0T MRI enables detection of enhancing MS lesions with higher sensitivity and better lesion conspicuity than 2D T1-weighted SE. Hence, we propose the use of gadolinium-enhanced GRE sequences rather than SE sequences for routine scanning of MS patients at 3.0T.Key Points
? 2D SE and GRE sequences are useful for detecting active MS lesions. ? Which of these sequences is more sensitive at high field remains uncertain. ? GRE sequence showed better sensitivity for detecting active MS lesions than SE. ? We propose GRE sequence for detecting active MS lesions at 3.0T.2.
ObjectivesThe purpose of this study is to compare the various magnetic resonance imaging (MRI) sequences when they are used to visualize and evaluate cerebral venous thrombosis.MethodsEleven patients with cerebral venous thrombosis were retrospectively analyzed using computed tomography, MRI, magnetic resonance angiography (MRA), and conventional angiography. The MR sequence included T1-weighted spin echo (SE) imaging, obtained before and after administration of contrast medium, T2-weighted turbo spin echo (TSE), fluid-attenuated inversion recovery (FLAIR), T2*-weighted conventional gradient-echo (GRE), as well as three-dimensional (3D) venous time-of-flight MRA and conventional angiography.ResultsIn all of our patients, the venous sinus thromboses were most successfully detected during the T2*-weighted GRE sequence. The thrombosis was well visualized with the T1-weighted SE sequence in three of four patients in whom it was in the subacute stage. The T2*-weighted GRE sequence was superior to the T2-weighted TSE, T1-weighted SE, and FLAIR sequences in all patients. Enhanced 3D MR venography showed the thrombosed segment of the venous sinus and well correlated with the conventional angiographic findings.ConclusionsThe T2*-weighted conventional GRE sequences may be the best method for detecting of cerebral venous thrombosis. Therefore, it would seem to be beneficial to integrate a T2*-weighted conventional GRE sequence into the MR protocol to diagnose cerebral venous thrombosis. 相似文献
3.
Elisabetta Panfili Laura Pierdicca Luca Salvolini Luigi Imperiale Jeffrey Dubbini Andrea Giovagnoni 《La Radiologia medica》2014,119(2):113-120
Purpose
The purpose of the study was to compare the artefacts produced by different hip prostheses on magnetic resonance imaging (MRI).Materials and methods
An identical MRI protocol was used to perform a quali-quantitative in vitro evaluation of artefacts caused by different hip prosthetic materials at different field strengths: prosthesis number 1, composed of cobalt–chrome–molybdenum (head and stem); prosthesis number 2, composed of ceramic (head) and titanium (stem); prosthesis number 3, composed of cobalt–chrome (head) and titanium (stem). All prostheses were imaged with both a clinical 1 Tesla (T) (Signa Horizon, General Electrics) and 1.5 T (Achieva, Philips) MRI system, using spin echo (SE) and gradient echo (GRE) sequences: sagittal T1 SE, coronal T2 fast SE (FSE), axial T1 SE, axial T2 FSE, sagittal T2 GRE, axial T2* GRE, coronal T1 GRE, axial T1 GRE. The artefacts produced by each prosthesis were assessed in each sequence at the different field strengths, by measuring the two longest diameters of the artefact in each section and sequence and comparing them to the actual diameters so as to obtain a ratio expressing the effective degree of artefact.Results
Cobalt–chrome produced the largest artefacts both in SE (1.73 at 1 T and 2.37 at 1.5 T) and GRE sequences (2.8 at 1 T and 3.06 at 1.5 T) followed by titanium (SE, 1.6 at 1 T, 2.13 at 1.5 T; GRE, 2 at 1 T, 2.94 at 1.5 T) and cobalt–chrome–molybdenum (SE, 1.51 at 1 T, 1.67 at 1.5 T; GRE, 2.13 at 1 T and 2.48 at 1.5 T); ceramic produced the smallest artefacts in all sequences (SE, 1.0 at 1 T and 1.18 at 1.5 T; GRE, 1.3 at 1 T and 1.22 at 1.5T). Increasing the magnetic field strength, titanium showed the greatest variations in artefact size, and ceramic the smallest ones.Conclusions
The composition of prosthetic implants is decisive in determining the quality of MR imaging. 相似文献4.
A R G Cortes R Abdala-Junior M Weber E S Arita J L Ackerman 《Dento maxillo facial radiology》2015,44(8)
Objectives:
Susceptibility artefacts from dental materials may compromise MRI diagnosis. However, little is known regarding MRI artefacts of dental material samples with the clinical shapes used in dentistry. The present phantom study aims to clarify how pulse sequences and sequence parameters affect MRI artefacts caused by metal–ceramic restorations.Methods:
A phantom consisting of nickel–chromium metal–ceramic restorations (i.e. dental crowns and fixed bridges) and cylindrical reference specimens immersed in agar gel was imaged in 1.5 and 3.0 T MRI scanners. Gradient echo (GRE), spin echo (SE) and ultrashort echo time (UTE) pulse sequences were used. The artefact area in each image was automatically calculated from the pixel values within a region of interest. Mean values for similar pulse sequences differing in one parameter at a time were compared. A comparison between mean artefact area at 1.5 and 3.0 T, and from GRE and SE was also carried out. In addition, a parametric correlation between echo time (TE) and artefact area was performed.Results:
A significant correlation was found between TE and artefact area in GRE images. Higher receiver bandwidth significantly reduced artefact area in SE images. UTE images yielded the smallest artefact area at 1.5 T. In addition, a significant difference in mean artefact area was found between images at 1.5 and 3.0 T field strengths (p = 0.028) and between images from GRE and SE pulse sequences (p = 0.005).Conclusions:
It is possible to compensate the effect of higher field strength on MRI artefacts by setting optimized pulse sequences for scanning patients with metal–ceramic restorations. 相似文献5.
PURPOSE: To evaluate the diagnostic accuracy of common magnetic resonance (MR) imaging sequences for detection of small pulmonary nodules by using a chest phantom and porcine lungs containing simulated lesions. MATERIALS AND METHODS: Fourteen porcine lungs containing 366 porcine myocardial tissue implants were inflated inside a phantom. Two-dimensional (2D) and three-dimensional (3D) gradient-echo (GRE), T2-weighted turbo spin-echo (SE), and T2-weighted single-shot SE train MR sequences were performed. Spiral computed tomography (CT) was performed for comparison. Blinded observers read the images and recorded the sizes and locations of visible nodules by consensus. The sensitivity of each imaging method for depicting single nodules of given sizes was calculated. Specificities, positive predictive values (PPVs), and negative predictive values (NPVs) for detection of one or more nodules of various sizes were calculated. RESULTS: Sensitivities of 3D GRE, 2D GRE, T2-weighted turbo SE, and T2-weighted single-shot SE train MR imaging and of CT were 0.50, 0.40, 0.12, 0.00, and 0.55, respectively, for detection of 1.4-mm nodules and 0.88, 0.84, 0.69, 0.06, and 0.96, respectively, for detection of 4.2-mm nodules. The 95% CIs for CT and GRE MR imaging overlapped, but those for turbo SE and single-shot SE train MR imaging differed significantly (P <.05). For detection of nodules larger than 5 mm, all examinations except single-shot SE train MR imaging yielded a specificity, PPV, and NPV of 1.00 each. For detection of nodules smaller than 5 mm, diagnostic accuracy of 3D GRE MR imaging was high: Specificity, PPV, and NPV all were approximately 0.90. Two-dimensional GRE MR imaging results were influenced by false-positive findings: Specificity was 0.64; PPV, 0.74; and NPV, 1.00. CONCLUSION: Common MR imaging sequences such as 3D GRE have high diagnostic accuracy in depicting small pulmonary nodules when artifacts from cardiac and respiratory motion are absent. 相似文献
6.
A comparison of pulse sequences in the detection of post-traumatic bone marrow abnormalities at low field strength MRI 总被引:1,自引:0,他引:1
Objective and patients. One hundred and forty-one patients with recent joint trauma, aged 12–71 years, were imaged on a 0.2-T dedicated MRI system
and evaluated for bone bruises. The most beneficial sequences were compared. Design. The diagnosis of post-traumatic bone marrow abnormalities was established in 20 of 141 patients on the basis of decreased
signal intensity on T1-weighted SE and GRE sequences and increased signal intensity on T2-weighted TSE and fat-suppressed
IRGE sequences. Signal changes within the bone marrow were evaluated and statistically correlated with normal bone. Results. The highest signal alteration was found on T1-weighted SE and GRE sequences, followed by IRGE, which detected smaller differences
in signal intensity. T2-weighted TSE imaging showed the least contrast. The areas with bone marrow changes were approximately
equal in size on T1-weighted SE and T2-weighted TSE sequences. The same areas depicted on IRGE and GRE sequences proved to
be significantly larger (P<0.01). Conclusion. Using a 0.2-T dedicated system T1-weighted SE, T1-weighted GRE and IRGE sequences were most effective in detecting conspicuous
bone marrow alteration, while the T2-weighted TSE sequence was inferior. GRE and IRGE imaging showed areas about 4 times larger
depicting bone marrow changes. On suspicion of bone bruise, a protocol including GRE and IRGE pulse sequences could be most
beneficial. 相似文献
7.
Bartolozzi C Donati F Cioni D Procacci C Morana G Chiesa A Grazioli L Cittadini G Cittadini G Giovagnoni A Gandini G Maass J Lencioni R 《European radiology》2004,14(1):14-20
The aim of this study was to compare unenhanced MRI, MnDPDP-enhanced MRI, and spiral CT in the detection of hepatic colorectal metastases. Forty-four patients with hepatic colorectal metastases were examined with unenhanced and MnDPDP-enhanced MRI and with unenhanced and contrast-enhanced spiral CT. The MR examination protocol included baseline T1-weighted spin-echo (SE), T1-weighted gradient-recalled-echo (GRE), and T2-weighted fast-SE sequences; and T1-weighted SE and T1-weighted GRE sequences obtained 30–60 min after administration of 0.5 µmol/kg (0.5 ml/kg) mangafodipir trisodium (MnDPDP). Images were interpreted by three blinded readers. Findings at CT and MRI were compared with those at intraoperative US, which were used as term of reference. Intraoperative US detected 128 metastases. In a lesion-by-lesion analysis, the overall detection rate was 71% (91 of 128) for spiral CT, 72% (92 of 128) for unenhanced MRI, and 90% (115 of 128) for MnDPDP-enhanced MRI. MnDPDP-enhanced MRI was more sensitive than either unenhanced MRI (p<0.0001) or spiral CT (p=0.0007). In a patient-by-patient analysis, agreement with gold standard was higher for MnDPDP-enhanced MRI (33 of 44 cases) than for spiral CT (22 of 44 cases, p=0.0023) and unenhanced MRI (21 of 44 cases, p=0.0013). MnDPDP-enhanced MRI is superior to unenhanced MRI and spiral CT in the detection of hepatic colorectal metastases. 相似文献
8.
O.M. Abdulaal L. Rainford P.J. MacMahon P. Kenny F. Carty M. Galligan A. Cradock F.H. Alhazmi A. McGee 《Radiography》2021,27(2):389-397
IntroductionTo investigate the impact of parameter optimisation for novel three-dimensional 3D sequences at 1.5T and 3T on resultant image quality.MethodsFollowing institutional review board approval and acquisition of informed consent, MR phantom and knee joint imaging on healthy volunteers (n = 16) was performed with 1.5 and 3T MRI scanners, respectively incorporating 8- and 15-channel phased array knee radiofrequency coils. The MR phantom and healthy volunteers were prospectively scanned over a six-week period. Acquired sequences included standard two-dimensional (2D) turbo spin echo (TSE) and novel three-dimensional (3D) TSE PDW (SPACE) both with and without fat-suppression, and T21W gradient echo (TrueFISP) sequences. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were measured for knee anatomical structures. Two musculoskeletal radiologists evaluated anatomical structure visualisation and image quality. Quantitative and qualitative findings were investigated for differences using Friedman tests. Inter- and intra-observer agreements were determined with κ statistics.ResultsPhantom and healthy volunteer images revealed higher SNR for sequences acquired at 3T (p-value <0.05). Generally, the qualitative findings ranked images acquired at 3T higher than corresponding images acquired at 1.5T (p < 0.05). 3D image data sets demonstrated less sensitivity to partial volume averaging artefact (PVA) compared to 2D sequences. Inter- and intra-observer agreements for evaluation across all sequences ranged from 0.61 to 0.79 and 0.71 to 0.92, respectively.ConclusionBoth 2D and 3D images demonstrated higher image quality at 3T than at 1.5T. Optimised 3D sequences performed better than the standard 2D PDW TSE sequence for contrast resolution between cartilage and joint fluid, with reduced PVA artefact.Implications for practiceWith rapid advances in MRI scanner technology, including hardware and software, the optimisation of 3D MR pulse sequences to reduce scan time while maintaining image quality, will improve diagnostic accuracy and patient management in musculoskeletal MRI. 相似文献
9.
Kakeda S Korogi Y Hiai Y Ohnari N Moriya J Kamada K Hanamiya M Sato T Kitajima M 《European radiology》2007,17(9):2345-2351
The objective of this study is to compare the detectability of brain metastases at 3T among three contrast-enhanced sequences,
spin-echo (SE) sequence, inversion recovery fast SE (IR-FSE) sequence (both with section thickness of 6 mm), and three-dimensional
fast spoiled gradient-echo (3D fast SPGR) sequence with 1.4 mm isotropic voxel. First, phantom studies were performed to quantify
the contrast-enhancement ratio (CER) with three sequences. In 21 consecutive patients with brain metastases, axial images
of three sequences at 3T were obtained after administration of gadoteridol. Two neuroradiologists assessed the detectability
of brain metastases for the three sequences. In the phantom study, no evident difference in the CER was demonstrated among
three sequences. Significantly more brain metastases were detected with 3D fast SPGR than with SE and IR-FSE (a total of 97
lesions with 3D fast SPGR vs. 64 with SE and 63 with IR-FSE). In particular, 3D fast SPGR was superior to the other two sequences
in detection of the small lesions (<3 mm). At 3T, the contrast-enhanced 3D fast SPGR with 1.4 mm isotropic voxel is clinically
more valuable for detecting small brain metastases than the SE and IR-FSE with section thickness of 6 mm. 相似文献
10.
Arzu Ozturk Nafi Aygun Seth A. Smith Brian Caffo Peter A. Calabresi Daniel S. Reich 《Neuroradiology》2013,55(4):431-439
Introduction
In multiple sclerosis (MS), spinal cord imaging can help in diagnosis and follow-up evaluation. However, spinal cord magnetic resonance imaging (MRI) is technically challenging, and image quality, particularly in the axial plane, is typically poor compared to brain MRI. Because gradient-recalled echo (GRE) images might offer improved contrast resolution within the spinal cord at high magnetic field strength, both without and with a magnetization transfer prepulse, we compared them to T2-weighted fast-spin-echo (T2-FSE) images for the detection of MS lesions in the cervical cord at 3T.Methods
On a clinical 3T MRI scanner, we studied 62 MS cases and 19 healthy volunteers. Axial 3D GRE sequences were performed without and with off-resonance radiofrequency irradiation. To mimic clinical practice, all images were evaluated in conjunction with linked images from a sagittal short tau inversion recovery scan, which is considered the gold standard for lesion detection in MS. Two experienced observers recorded image quality, location and size of focal lesions, atrophy, swelling, and diffuse signal abnormality independently at first and then in consensus.Results
The number and volume of lesions detected with high confidence was more than three times as high on both GRE sequences compared to T2-FSE (p?<?0.0001). Approximately 5 % of GRE scans were affected by artifacts that interfered with image interpretation, not significantly different from T2W-FSE.Conclusions
Axial 3D GRE sequences are useful for MS lesion detection when compared to 2D T2-FSE sequences in the cervical spinal cord at 3T and should be considered when examining intramedullary spinal cord lesions. 相似文献11.
Hersh Chandarana Kai T. Block Matthew J. Winfeld Shailee V. Lala Daniel Mazori Emalyn Giuffrida James S. Babb Sarah S. Milla 《European radiology》2014,24(2):320-326
Objective
To compare the image quality of contrast-enhanced abdominopelvic 3D fat-suppressed T1-weighted gradient-echo imaging with radial and conventional Cartesian k-space acquisition schemes in paediatric patients.Methods
Seventy-three consecutive paediatric patients were imaged at 1.5 T with sequential contrast-enhanced T1-weighted Cartesian (VIBE) and radial gradient echo (GRE) acquisition schemes with matching parameters when possible. Cartesian VIBE was acquired as a breath-hold or as free breathing in patients who could not suspend respiration, followed by free-breathing radial GRE in all patients. Two paediatric radiologists blinded to the acquisition schemes evaluated multiple parameters of image quality on a five-point scale, with higher score indicating a more optimal examination. Lesion presence or absence, conspicuity and edge sharpness were also evaluated. Mixed-model analysis of variance was performed to compare radial GRE and Cartesian VIBE.Results
Radial GRE had significantly (all P?<?0.001) higher scores for overall image quality, hepatic edge sharpness, hepatic vessel clarity and respiratory motion robustness than Cartesian VIBE. More lesions were detected on radial GRE by both readers than on Cartesian VIBE, with significantly higher scores for lesion conspicuity and edge sharpness (all P?<?0.001).Conclusion
Radial GRE has better image quality and lesion conspicuity than conventional Cartesian VIBE in paediatric patients undergoing contrast-enhanced abdominopelvic MRI.Key Points
? Numerous techniques are required to provide optimal MR images in paediatric patients. ? Radial free-breathing contrast-enhanced acquisition demonstrated excellent image quality. ? Image quality and lesion conspicuity were better with radial than Cartesian acquisition. ? More lesions were detected on contrast-enhanced radial than on Cartesian acquisition. ? Radial GRE can be used for performing abdominopelvic MRI in paediatric patients. 相似文献12.
MR temperature measurement in liver tissue at 0.23 T with a steady-state free precession sequence. 总被引:2,自引:0,他引:2
D Germain E Vahala G J Ehnholm T Vaara M Ylihautala M Savart A Laurent J Tanttu H Saint-Jalmes 《Magnetic resonance in medicine》2002,47(5):940-947
MRI can be used for monitoring temperature during a thermocoagulation treatment of tumors. The aim of this study was to demonstrate the suitability of a 3D steady-state free precession sequence (3D Fast Imaging with Steady-State Precession, 3D TrueFISP) for MR temperature measurement at 0.23 T, and to compare it to the spin-echo (SE) and spoiled 3D gradient-echo (3D GRE) sequences. The optimal flip angle for the TrueFISP sequence was calculated for the best temperature sensitivity in the image signal from liver tissue, and verified from the images acquired during the thermocoagulation of excised pig liver. Factors influencing the accuracy of the measured temperatures are discussed. The TrueFISP results are compared to the calculated values of optimized SE and 3D GRE sequences. The accuracy of TrueFISP in the liver at 0.23 T, in imaging conditions used during thermocoagulation procedures, is estimated to be +/-3.3 degrees C for a voxel of 2.5 x 2.5 x 6 mm(3) and acquisition time of 18 s. For the SE and GRE sequences, with similar resolution and somewhat longer imaging time, the uncertainty in the temperature is estimated to be larger by a factor of 2 and 1.2, respectively. 相似文献
13.
Bashir MR Husarik DB Ziemlewicz TJ Gupta RT Boll DT Merkle EM 《Journal of magnetic resonance imaging : JMRI》2012,35(3):611-616
Purpose:
To compare conspicuity and detection rate of hypointense lesions on T1‐weighted (T1w) gradient echo (GRE) sequences with low and high flip angles (FA) in hepatocyte phase magnetic resonance imaging (MRI) using gadoxetate disodium.Materials and Methods:
This Health Insurance Portability and Accountability Act (HIPAA)‐compliant study was Institutional Review Board (IRB)‐approved. The study population consisted of patients with hypointense liver lesions undergoing MRI with gadoxetate disodium, with hepatocyte‐phase fat suppressed 3D T1w GRE sequences at both low (10–12°) and high (30–35°) FA. Contrast‐to‐noise ratios (CNRs) were calculated for liver parenchyma vs. large lesions and common bile duct (CBD) vs. liver. Three radiologists each assigned a conspicuity score (CS) for each lesion detected at low or high FA. Paired Student's t‐tests compared the lesion detection (LD) rate using only the hepatocyte phase data set compared with the entire MRI examination, and CS for low and high FA.Results:
In all, 57 large and 70 small lesions were identified in 18 patients. Average LD and CS were significantly greater at high FA versus low FA overall (LD 89.0% vs. 79.5%; CS 2.8 vs. 2.2; P < 0.05) and for small lesions (81.4% vs. 65.7%; 2.5 vs. 1.8; P < 0.05). Average liver‐to‐lesion CNR for large lesions and CBD‐to‐liver CNR was significantly greater at high FA (P < 0.05).Conclusion:
Increasing the FA in hepatocyte phase MRI with gadoxetate disodium improves hypointense lesion detection and conspicuity, particularly for small lesions. J. Magn. Reson. Imaging 2012;35:611‐616. © 2011 Wiley Periodicals, Inc. 相似文献14.
J. Beltran Emmanuelle Marty-Delfaut Jenny Bencardino Zehava Sadka Rosenberg German Steiner Francisco Aparisi Mario Padrón 《Skeletal radiology》1998,27(7):369-374
Purpose. To determine the ability of MRI to detect the presence of crystals of calcium pyrophosphate in the articular cartilage of
the knee. Design and patients. The MR studies of 12 knees (11 cases) were reviewed retrospectively and correlated with radiographs (12 cases) and the findings
at arthroscopy (2 cases) and surgery (1 case). A total of 72 articular surfaces were evaluated. Radiographic, surgical or
arthroscopic demonstration of chondrocalcinosis was used as the gold standard. Additionally, two fragments of the knee of
a patient who underwent total knee replacement and demonstrated extensive chondrocalcinosis were studied with radiography
and MRI using spin-echo T1-, T2- and proton-density-weighted images as well as two- and three-dimensional fat saturation (2D
and 3D Fat Sat) gradient recalled echo (GRE) and STIR sequences. Results. MRI revealed multiple hypointense foci within the articular cartilage in 34 articular surfaces, better shown on 2D and 3D
GRE sequences. Radiographs showed 12 articular surfaces with chondrocalcinosis. In three cases with arthroscopic or surgical
correlation, MRI demonstrated more diffuse involvement of the articular cartilage than did the radiographs. The 3D Fat Sat
GRE sequences were the best for demonstrating articular calcification in vitro. In no case was meniscal calcification identified
with MRI. Hyperintense halos around some of the calcifications were seen on the MR images. Conclusion. MRI can depict articular cartilage calcification as hypointense foci using GRE techniques. Differential diagnosis includes
loose bodies, post-surgical changes, marginal osteophytes and hemosiderin deposition. 相似文献
15.
Purpose. To estimate disease activity in patients with systemic sclerosis using contrast-enhanced MRI of the skin.
Material and Methods. In a pre-study, sequences of a low-field (0.2 T) scanner (Artoscan, Esaote, Genova, Italy) were optimized for detection of
intravenous contrast (0.1 mmol/l Gd-DTPA) in six patients with the autoimmune disease systemic scleroderma. Based on the results
of the pre-study, 17 patients with scleroderma (7 sclerotic/10 active inflammatory disease) were scanned using gradient-spoiled
3D GRE sequences (FA 90 °, TR 100 ms, TE 18 ms), which had been established as most sensitive for intravenous contrast. Contrast
enhancement of the skin was determined quantitatively by contrast-to-noise ratios (CNR), comparing post- to pre-contrast and
dynamic scans (for 6 min, 1 acquisition/min). Patients in the chronic state with sclerodactylia and active inflammation of
the hands were considered separately and compared to a control group (n = 10) matched according to age.
Results. CNR increase after intravenous contrast was significantly higher in patients with active disease (86 ± 16 % increase) than
sclerosing disease (29 ± 3 %, p < 0.05) and the control group (4 ± 2 %, p < 0.05). The dynamic examination showed a significantly slower decrease after the peak rise in the first minute in patients
with active disease (CNR 15.4 ± 0.7 to 14.2 ± 1.4) than in those with chronic disease (14.1 ± 0.5 to 11.3 ± 0.9, p < 0.05).
Discussion. Capillary leakage is the most likely explanation for the increased enhancement in patients with active scleroderma. Using
sequences optimized for contrast detection, disease activity in the course of scleroderma and response to therapy can be determined
by MRI in the future.
相似文献
16.
Objectives
To investigate the feasibility and diagnostic value of free-breathing, radial, stack-of-stars three-dimensional (3D) gradient echo (GRE) sequence (“golden angle”) on dynamic contrast-enhanced (DCE) MRI of gastric cancer.Methods
Forty-three gastric cancer patients were divided into cooperative and uncooperative groups. Respiratory fluctuation was observed using an abdominal respiratory gating sensor. Those who breath-held for more than 15 s were placed in the cooperative group and the remainder in the uncooperative group. The 3-T MRI scanning protocol included 3D GRE and conventional breath-hold VIBE (volume-interpolated breath-hold examination) sequences, comparing images quantitatively and qualitatively. DCE-MRI parameters from VIBE images of normal gastric wall and malignant lesions were compared.Results
For uncooperative patients, 3D GRE scored higher qualitatively, and had higher SNRs (signal-to-noise ratios) and CNRs (contrast-to-noise ratios) than conventional VIBE quantitatively. Though 3D GRE images scored lower in qualitative parameters compared with conventional VIBE for cooperative patients, it provided images with fewer artefacts. DCE parameters differed significantly between normal gastric wall and lesions, with higher Ve (extracellular volume) and lower Kep (reflux constant) in gastric cancer.Conclusions
The free-breathing, golden-angle, radial stack-of-stars 3D GRE technique is feasible for DCE-MRI of gastric cancer. Dynamic enhanced images can be used for quantitative analysis of this malignancy.Key Points
? Golden-angle radial stack-of-stars VIBE aids gastric cancer MRI diagnosis. ? The 3D GRE technique is suitable for patients unable to suspend respiration. ? Method scored higher in the qualitative evaluation for uncooperative patients. ? The technique produced images with fewer artefacts than conventional VIBE sequence. ? Dynamic enhanced images can be used for quantitative analysis of gastric cancer.17.
By using a theoretical model, the signal difference-to noise ratios between simulated lesions and normal white matter and gray matter were calculated as a function of lesion concentration of gadopentetate dimeglumine (GD) for two-dimensional (2D) T1-weighted spin-echo (SE), three-dimensional (3D) steady-state spoiled gradient-echo (GRE) (FLASH [fast low-angle shot]), and 3D magnetization-prepared rapid gradient echo (MP-RAGE) pulse sequences. The 3D GRE sequences provided greater contrast enhancement at relatively high [GD], and the 2D SE sequence demonstrated greater enhancement and a higher rate of enhancement at low [GD]. The results predict that at low [GD], certain lesions could probably be detected with the 2D SE sequence but possibly not with one or both of the 3D GRE sequences. At high [GD], certain lesions could probably be detected with one or both of the 3D GRE sequences but possibly not with the 2D SE sequence. This provides a potential explanation for the clinical observation that certain contrast agent enhanced lesions appear less conspicuous on 3D GRE images than on 2D SE images and vice versa. Modified parameter values were derived for the 3D FLASH and 3D MP-RAGE sequences that are predicted to produce contrast enhancement behavior equivalent or superior to that of a conventional 2D SE sequence. 相似文献
18.
目的:探讨2D、3D重建在颅骨修补术前、后颅内情况,术后并发症的观察和计算机个性化设计钛网在临床的应用。方法35例颅骨缺损患者行螺旋C T扫描,数据传至工作站行2D、3D重建,进行钛网修复体的个性化设计并应用于临床,分析颅骨修补术前、后颅内的变化,术后并发症的表现。结果35例患者修复体嵌合满意,钛网固定牢固,行修补术前脑膜弧线正常30例,脑膜凹陷5例,术后代骨板均无移位,硬膜外血肿1例,硬膜下血肿3例,头皮感染2例。结论2D、3D重建在颅骨修补术中具有重要的临床价值。 相似文献
19.
IntroductionImaging in stroke, allows its classification into ischaemic stroke (IS) or intracranial haemorrhagic stroke (ICH), ensuring time-sensitive treatment to be administered. Imaging can also allow detection of cerebral microbleeds (CMBs), which may further determine pharmacological intervention in acute stroke. True gradient echo (T21GRE) or susceptibility weighted imaging (SWI) have high sensitivity for the detection of CMBs. These two sequences are included in the national guidelines; however, the implementation of these guidelines can vary depending on local interpretation and scanner capabilities.AimTo explore the use and application of blood sensitive MRI sequences in a specialist UK stroke unit for the detection of CMBs, to improve local practice.MethodsA retrospective data analysis of the native database, spanning a 6-month period, was used. The data of 281 acute stroke patients with an MRI were reviewed and analysed. The MRI sequences applied, and the final diagnosis were noted for each case.ResultsOf the 281 acute stroke patients with MRI, 259 (92.1%) had an IS, 16 (5.68%) an ICH and 6 (2.14%) had both. Overall, 13 (4.63%) had a CMB diagnosis. All of these 13 patients had a true T21GRE sequence. CMBs were not detected in the absence of a T21GRE sequence.ConclusionT21GRE imaging is essential for detecting CMBs. When omitted, CMB incidence can be considerably lower than that suggested in the literature. Missing CMB diagnoses in stroke patients may result in suboptimal treatment pathways, compromising the patients' standard of care.Implications for practiceWhen SWI is not available, it is imperative to always include a true T21GRE sequence to detect microbleeds in suspected acute stroke cases. 相似文献
20.
Stylianos M. Chalkias Roberto S. Pozzi-Mucelli Massimo Pozzi-Mucelli Francesca Frezza Renata Longo 《European radiology》1994,4(4):353-359
In order to optimize the parameters for the best visualization of the internal architecture of the hyaline articular cartilage a study both ex vivo and in vivo was performed. Accurate T1 and T2 relaxation times of articular cartilage were obtained with a particular mixed sequence and then used for the creation of isocontrast intensity graphs. These graphs subsequently allowed in all pulse sequences (spin echo, SE and gradient time (TR), echo time (TE) and flip angle (FA) for optimization of signal differences between MR cartilage zones. For SE sequences maximum contrast between cartilage zones can be obtained by using a long TR (> 1,500 ms) with a short TE (< 30 ms), whereas for GRE sequences maximum contrast is obtained with th shortest TE (< 15 ms) combined with a relatively long TR (> 400 ms) and an FA greater than 40°. A trilaminar appearance was demonstrated with a superficial and deep hypointense ozne in all sequences and an intermediate zone that was moderately hyperintense on SET1-weighted images, slightly more hyperintense on proton density Rho and SE T2-weighted images and even more hyperintense on GRE images. 相似文献