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1.
Transvenous defibrillation lead systems have been demonstrated to reduce operative morbidity and mortality associated with
implantation of cardioverter-defibrillators. To determine the best position for the proximal electrode in transvenous systems,
defibrillation thresholds were compared for three positions in a single-pathway, two-lead system. Two defibrillation lead
electrodes were transvenously inserted into seven dogs. The distal electrode was positioned in the right ventricular apex.
The proximal electrode was randomized to one of three positions: (1) the superior (cranial) vena cava (SVC) at he junction
of the right atrium, (2) the left innominate vein at the junction of the SVC, or (3) the external jugular vein. Biphasic defibrillation
thresholds for converting electrically induced ventricular fibrillation were determined for the three positions of the proximal
electrode in each dog. The innominate vein position resulted in the lowest defibrillation threshold (555±123 V) as compared
to the SVC (640±126 V;p=0.0612) and the jugular vein (709±117 V;p=0.0013). Lead impedance gradually increased with increasing dostamce between the two shocking electrodes: 58.4±11.4 Ω for
SVC, 76.2±13.8 Ω for innominate vein, and 94.9±10.2 Ω for jugular vein proximal lead electrode position (p<0.05 for all pairwise comparisons). In two-electrode transvenous defibrillation lead systems, positioning the proximal electrode
in the left innominate vein produced the lowest defibrillation threshold. 相似文献
2.
E. J. Woo P. Hua Dr J. G. Webster W. J. Tompkins R. Pallás-Areny 《Medical & biological engineering & computing》1992,30(1):97-102
We have studied the effect of the electrode configuration on the measurement of body impedance and found that the electrode
configuration greatly affects the impedance measurement using the four-electrode method. We studied the characteristics of
the compound electrode and found that the compound electrode provides the four-electrode method in a compact form. A new method
of measuring the skin impedance using simple electrodes at low frequencies was developed. At high frequencies where the effect
of internal tissue impedance is not negligible, we used the compensation method using compound electrodes, because they measure
the voltage right under the skin. At 50 kHz, we measured the real part of the skin impedance of less than 80 Ω on the thorax.
We propose a simple instrument which can measure accurate skin impedance at various frequencies. 相似文献
3.
A computer simulation is used to investigate the relationship between skin impedance and image artefacts in electrical impedance
tomography. Sets of electrode impedance are generated with a pseudo-random distribution and used to introduce errors in boundary
voltage measurements. To simplify the analysis, the non-idealities in the current injection circuit are replaced by a fixed
common-mode error term. The boundary voltages are reconstructed into images and inspected. Where the simulated skin impedance
remains constant between measurements, large impedances (>2kΩ) do not cause significant degradation of the image. Where the
skin impedances ‘drift’ between measurements, a drift of 5% from a starting impedance of 100Ω is sufficient to cause significant
image distortion. If the skin impedances vary randomly between measurements, they have to be less than 10 Ω to allow satisfactory
images. Skin impedances are typically 100–200 Ω at 50 kHz on unprepared skin. These values are sufficient to cause image distortion
if they drift over time. It is concluded that the patient's skin should be abraded to reduce impedance, and measurements should
be avoided in the first 10 min after electrode placement. 相似文献
4.
Surface electrodes are commonly used electrodes clinically, in applications such as functional electrical stimulation for
the restoration of motor functions, pain relief, transcutaneous electrical nerve stimulation, electrocardiographic monitoring,
defibrillation, surface cardiac pacing, and advanced drug delivery systems. Common to these applications are occasional reports
of pain, tissue damage, rash, or burns on the skin at the point where electrodes are placed. In this study, we quantitatively
analyzed the effects of acute noninvasive electrical stimulation from concentric ring electrodes (CRE) to determine the maximum
safe current limit. We developed a three-dimensional multi-layer model and calculated the temperature profile under the CRE
and the corresponding energy density with electrical-thermal coupled field analysis. Infrared thermography was used to measure
skin temperature during electrical stimulation to verify the computer simulations. We also performed histological analysis
to study cell morphology and characterize any resulting tissue damage. The simulation results are accurate for low energy
density distributions. It can also be concluded that as long as the specified energy density applied is kept below 0.92 (A2/cm4·s−1), the maximum temperature will remain within the safe limits. Future work should focus on the effects of the electrode paste. 相似文献
5.
Petrofsky J Prowse M Bain M Ebilane E Suh HJ Batt J Lawson D Hernandez V Abdo A Yang TN Mendoza E Collins K Laymon M 《European journal of applied physiology》2008,103(3):265-273
Electrical stimulation is commonly used for strengthening muscle but little evidence exists as to the optimal electrode size,
waveform, or frequency to apply. Three male and three female subjects (22–40 years old) were examined during electrical stimulation
of the quadriceps muscle. Two self adhesive electrode sizes were examined, 2 cm × 2 cm and 2 cm × 4 cm. Electrical stimulation
was applied with square and sine waveforms, currents of 5, 10 and 15 mA, and pulse widths of 100–500 μs above the quadriceps
muscle. Frequencies of stimulation were 20, 30, and 50 Hz. Current on the skin above the quadriceps muscle was measured with
surface electrodes at five positions and at three positions with needle electrodes in the same muscle. Altering pulse width
in the range of 100–500 μs, the frequency over a range of 20–50 Hz, or current from 5 to 15 mA had no effect on current dispersion
either in the skin or within muscle. In contrast, the distance separating the electrodes caused large changes in current dispersion
on the skin or into muscle. The most significant finding in the present investigation was that, while on the surface of the
skin current dispersion was not different between sine and square wave stimulation, significantly more current was transferred
deep in the muscle with sine versus square wave stimulation. The use of sine wave stimulation with electrode separation distances
of less then 15 cm is recommended for electrical stimulation with a sine wave to achieve deep muscle stimulation. 相似文献
6.
Movement-induced potentials of streaming potential type were studied in various electrode configurations. The geometric design
of the electrode was important for the reduction of noise generated by the movements of gel. Potential and impedance variations
were measured for electrode movements in electrolytes. The impedance variations were small and the streaming potentials were
electrolyte-concentration dependent and in the order of 10μV. The same type of study was carried out for electrodes applied
to the skin. The conclusion from this experiment is that skin deformation potentials dominate the disturbance pattern in this
type of recordings. 相似文献
7.
Noise and motion artefacts interfere with ambulatory ECG recording. In the paper the hypothesis that proper skin preparation
and electrode design and placement could reduce the artefact levels is tested. The comparison of four commercial electrodes
shows differences in adhesive strength and levels of skin irritation but does not indicate significant differences in the
artefact levels produced by the electrodes. Four treatments are compared—no skin preparation, rubbing with alcohol, abrasion
and puncturing—for their effectiveness in reducing motion artefact. Skin preparations do not reduce the motion artefact significantly
but cause much discomfort. Therefore, skin preparation is not recommended. We recorded the signal (QRS complex) to-noise (artefact
at the electrode site) ratio at 15 thoracic locations and recommend two pairs for ambulatory ECG recording. The statistical
experimental design procedures used can also be adopted for comparison and testing for improvement of other electrode properties
and designs. 相似文献
8.
The properties of skin adminttance were investigated with the intention of applying them to skin moisturisation measurement.
Skin admittance is determined by measuring relative permittivity and the resistivity of the stratum corneum, and by contact
ratio between dry electrode and stratum corneum. It was found, however, that the contact ratio is the predominant factor producing
the change of skin admittance induced by changes in the water content of skin. To measure skin admittance, the following conditions
were found to be approriate: (a) frequency of about 100 kHz; (b) concentric electrodes, the diameter of the measuring (inner)
electrode being about 5 mm, and (c) an electrode pressure of about 100 g cm−2. Based on these optimal conditions, a system for measuring skin admittance was constructed. All measuring procedures were
automated. Experimental observations made with this system have indicated its usefulness for the measurement of skin moisturisation. 相似文献
9.
Comparison of neural damage induced by electrical stimulation with faradaic and capacitor electrodes
McCreery D. B. Agnew W. F. Yuen T. G. H. Bullara L. A. 《Annals of biomedical engineering》1988,16(5):463-481
Arrays of platinum (faradaic) and anodized, sintered tantalum pentoxide (capacitor) electrodes were implanted bilaterally
in the subdural space of the parietal cortex of the cat. Two weeks after implantation both types of electrodes were pulsed
for seven hours with identical waveforms consisting of controlled-current, chargebalanced, symmetric, anodic-first pulse pairs,
400 μsec/phase and a charge density of 80–100 μC/cm2 (microcoulombs per square cm) at 50 pps (pulses per second). One group of animals was sacrificed immediately following stimulation
and a second smaller group one week after stimulation. Tissues beneath both types of pulsed electrodes were damaged, but the
difference in damage for the two electrode types was not statistically significant. Tissue beneath unpulsed electrodes was
normal. At the ultrastructural level, in animals killed immediately after stimulation, shrunken and hyperchromic neurons were
intermixed with neurons showing early intracellular edema. Glial cells appeared essentially normal. In animals killed one
week after stimulation most of the damaged neurons had recovered, but the presence of shrunken, vacuolated and degenerating
neurons showed that some of the cells were damaged irreversibly. It is concluded that most of the neural damage from stimulations
of the brain surface at the level used in this study derives from processes associated with passage of the stimulus current
through tissue, such as neuronal hyperactivity rather than electrochemical reactions associated with current injection across
the electrode-tissue interface, since such reactions occur only with the faradaic electrodes. 相似文献
10.
Radio frequency (RF) current delivered through a thin catheter can be used to perforate the pulmonary valve or the atrial
septum to treat pulmonary atresia in newborns. To understand better the mechanisms of RF perforation, a numerical model is
developed, and experiments are performed in isolated canine cardiac tissue. The model consists of a cylindrical domain with
a tissue layer between two blood layers. The finite-difference method is used to compute both the potential and temperature
distributions. When the tissue temperature exceeds 100°C in all points that are directly in front of the catheter, these points
are considered to be instantly vaporised, and the catheter advances over these points. The computed temperature time course
coincides with measured temperature at small voltages (<16 V). Simulated perforation occurs when the voltage exceeds a threshold
of 70–80V for a catheter diameter of 0.30–0.44 mm, which coincides with experimental observations in the myocardium. A voltage
exceeding this perforation threshold tends to decrease tissue damage. Shorter electrodes (0.7 mm as against 2.4 mm) with smaller
diameters produce a more rapid perforation. In conclusion, numerical simulations provide insights into aspects of RF perforation,
such as electrode size, current, speed of perforation and collateral damage. 相似文献
11.
C. Gondran E. Siebert S. Yacoub E. Novakov 《Medical & biological engineering & computing》1996,34(6):460-466
The electrochemical noise from dry NASICON-based surface electrodes and pregelled Ag−AgCl electrodes is evaluated in saline
solutions and on the skin. The electrochemical noise from the electrode/electrolyte interface is found to be negligible (less
than 1 μV peak to peak). On the skin, the noise level is highly dependent on the patient. At high frequencies, the skin/electrode
interface noise is equal to ‘thermal noise’ and can be related to the real part of the skin/electrode impedance. At low frequencies
(f<100 Hz), excess noise is observed that varies as f−2. It is tentatively ascribed to a non-stationary process or noise of electrochemical origin due to the ionic nature of the
skin. The contribution of residual EMG signal of low amplitude (5 μV peak to peak) is suggested for electrodes with large
surface area.
Reprint requests and correspondence should be addressed to Frist 相似文献
12.
An intrafascicular electrode for recording of action potentials in peripheral nerves 总被引:12,自引:0,他引:12
Mark S. Malagodi Dr. Kenneth W. Horch Andrew A. Schoenberg 《Annals of biomedical engineering》1989,17(4):397-410
We are developing a new type of bipolar recording electrode intended for implantation within individual fascicles of mammalian
peripheral nerves. In the experiments reported here we used electrodes fabricated from 25 μm diameter Pt wire, 50 μm 90% Pt-10%
Ir wire and 7 μm carbon fibers. The electrodes were implanted in the sciatic nerves of rats and in the ulnar nerves of cats.
The signal-to-noise ratio of recorded activity induced by nonnoxious mechanical stimulation of the skin and joints was studied
as a function of the type of electrode material used, the amount of insulation removed from the recording zone, and the longitudinal
separation of the recording zones of bipolar electrode pairs. Both acute and short term (two day) chronic experiments were
performed.
The results indicate that a bipolar electrode made from Teflon™-insulated, 25 μm diameter, 90% Pt-10% Ir wire, having a 1–2 mm long recording zone, can be used for recording of peripheral
nerve activity when implanted with one wire inside the fascicle and the other lead level with the first lead, but outside
the fascicle. No insulating cuff needs to be placed around the nerve trunk. 相似文献
13.
The impedance of rabbit skin has been measured in the frequency range 1–60 kHz using a simple a.c. bridge method and stainless
steel electrodes. The effect of four important drugs, namely, adrenaline, noradrenaline, atropine and histamine, has been
examined. It was found that all these drugs produced a decrease in the skin impedance in varying degrees, suggesting a penetration
of the ions through the underlying layers of the skin. For the purpose of analysis, all these data are compared with their
own controls. The order of applying the two drugs adrenaline and noradrenaline at the same site on the skin of an animal does
not produce a change in the nature of the relative impedance variation. It was observed that the effect produced by noradrenaline
is more pronounced than that by adrenaline. The effect produced by these drugs was compared with that produced by pure hydration
of the skin. It was found that the change produced in the latter case is much less than that produced by drugs, thus showing
a clear difference between the two effects. 相似文献
14.
Kuniharu Takei Takeshi Kawano Takahiro Kawashima Kazuaki Sawada Hidekazu Kaneko Makoto Ishida 《Biomedical microdevices》2010,12(1):41-48
We report on the development of a microtube electrode array as a neural interface device. To combine the desired properties
for the neural interface device, such as low invasiveness with a small needle and a good signal-to-noise ratio in neural recordings,
we applied the structure of a glass pipette electrode to each microtube electrode. The device was fabricated as sub-5-μm-diameter
out-of-plane silicon dioxide microtube arrays using silicon microneedle templates, which are grown by the selective vapor–liquid–solid
method. The microtubes had inner diameters of 1.9–6.4 μm and a length of 25 μm. Impedances ranged from 220 kΩ to 1.55 MΩ,
which are less than those for conventional microneedles. In addition, the microtube electrodes had less signal attenuation
than conventional microneedle electrodes. We confirmed that the effects of parasitic capacitances between neighboring microtubes
and channels were sufficiently small using a test signal. Finally, neural responses evoked from a rat peripheral nerve were
recorded in vivo using a microtube electrode to confirm that this type of electrode can be used for both electrophysiological measurements
and as a neural interface device. 相似文献
15.
Hernández-Labrado GR Polo JL López-Dolado E Collazos-Castro JE 《Medical & biological engineering & computing》2011,49(4):417-429
Applied low-intensity direct current (DC) stimulates and directs axonal growth in models of spinal cord injury (SCI) and may
have therapeutic value in humans. Using higher electric strengths will probably increase the beneficial effects, but this
faces the risk of tissue damage by electricity or toxic reactions at the electrode–tissue interface. To inform the optimisation
of DC-based therapeutics, we developed a finite element model (FEM) of the human cervical spine and calculated the electric
fields (EFs) and current densities produced by electrodes of different size, geometry and location. The presence of SCI was
also considered. Three disc electrodes placed outside the spine produced low-intensity, uneven EFs, whereas the EFs generated
by the same electrodes located epidurally were about three times more intense. Changes in electrical conductivity after SCI
had little effect on the EF magnitudes. Uniformly distributed EFs were obtained with five disc electrodes placed around the
dura mater, but not with a paddle-type electrode placed in the dorsal epidural space. Replacing the five disc electrodes by
a single, large band electrode yielded EFs > 5 mV/mm with relatively low current density (2.5 μA/mm2) applied. With further optimisation, epidural, single-band electrodes might enhance the effectiveness of spinal cord DC stimulation. 相似文献
16.
During ablative neurosurgery of movement disorders, for instance therapy of Parkinson's disease, temperature monitoring is
crucial. This study aims at a quantitative comparison of measurement deviations between the maximum temperature located outside
the lesioning electrode and two possible thermocouple locations inside the electrode. In order to obtain the detailed temperature
field necessary for the analysis, four finite element models associated with different surroundings and with different power
supplies are studied. The results from the simulations show that both the power level and the power density as well as the
surrounding medium affect the temperature measurement and the temperature field in general. Since the maximum temperature
is located outside the electrode there will always be a deviation in time and level between the measured and the maximum temperature.
The deviation is usually 2–7 s and 3–12°C, depending on, for example, the thermocouple location and surrounding medium. Therefore,
not only the measured temperature but also the relation between measured and maximum temperature must be accounted for during
therapy and device design. 相似文献
17.
Histologic and physiologic evaluation of electrically stimulated peripheral nerve: Considerations for the selection of parameters 总被引:4,自引:0,他引:4
William F. Agnew Ph.D. Douglas B. McCreery Ted G. H. Yuen Leo A. Bullara 《Annals of biomedical engineering》1989,17(1):39-60
Helical electrodes were implanted around the left and right common peroneal nerves of cats. Three weeks after implantation
one nerve was stimulated for 4–16 hours using charge-balanced, biphasic, constant current pulses. Compound action potentials
(CAP) evoked by the stimulus were recorded from over the cauda equina before, during and after the stimulation. Light and
electron microscopy evaluations were conducted at various times following the stimulation. The mere presence of the electrode
invariably resulted in thickened epineurium and in some cases increased peripheral endoneurial connective tissue beneath the
electrodes. Physiologic changes during stimulation included elevation of the electrical threshold of the large axons in the
nerve. This was reversed within one week after stimulation at a frequency of 20 Hz, but often was not reversed following stimulation
at 50–100 Hz. Continuous stimulation at 50 Hz for 8–16 hours at 400 μA or more resulted in neural damage characterized by
endoneurial edema beginning within 48 hours after stimulation, and early axonal degeneration (EAD) of the large myelinated
fibers, beginning by 1 week after stimulation. Neural damage due to electrical stimulation was decreased or abolished by reduction
of the duration of stimulation, by stimulating at 20 Hz (vs. 50 Hz) or by use of an intermittent duty cycle. These results
demonstrate that axons in peripheral nerves can be irreversely damaged by 8–16 hours of continuous stimulation at 50 Hz. However,
the extent to which these axons may subsequently regenerate is uncertain. Therefore, protocols for functional electrical stimulation
in human patients probably should be evaluated individually in animal studies. 相似文献
18.
D. T. Godin P. A. Parker R. N. Scott 《Medical & biological engineering & computing》1991,29(6):585-590
Bioelectric events measured with surface electrodes are subject to noise components which may be significant in comparison
with low-level biological signals such as evoked neuroelectric potentials, and myoelectric potentials. In an effort to better
understand noise arising from these electrodes, electrode and measurement system noise is modelled. The effect of electrode
surface area on electrode impedance and noise is studied using circular stainless-steel electrodes of varying diameters. The
main contributions of the work are the development of a model for stainless-steel electrode noise as a function of electrode
area, and demonstrating that, for the band-width of interest to evoked neuroelectric and myoelectric signals (8–10 000 Hz),
the primary noise components are thermal and amplifier current generated. The magnitudes of both of these depend on the electrode
impedance magnitude. Electrode impedance is shown to be a power function of both electrode diameter and frequency, consistent
with a capacitive electrode model. 相似文献
19.
Theisen D Vanlandewijk Y Sturbois X Francaux M 《European journal of applied physiology》2000,83(6):539-544
Skin blood flow (SKBF) was evaluated during arm-cranking exercise in able-bodied control subjects (AB; n=6) and in individuals with low- (LP; T10–T12 lesions; n=6) and high-level paraplegia (HP; T5–T9 lesions; n=6), using laser Doppler flowmetry (LDF). During moderate exercise SKBF decreased to [mean (SD)] 82 (15)% of the pre-exercise
resting level in AB, whereas it increased to 158 (52)% in LP and to 112 (51)% in HP (the LP:AB difference, P < 0.05). During intense exercise SKBF increased to 366 (180)% of the resting level in AB, whereas it increased only moderately
[147 (68)%] in both paraplegic groups (the paraplegic:AB difference, P < 0.05). The paraplegics developed a higher esophageal and leg skin temperature, which was attributed to the lack of active
vasodilation and evaporative cooling over the legs. The results indicate that individuals with paraplegia suffer from impaired
cutaneous vasoconstriction at the onset of arm exercise, and possess only a limited vasodilatory capability in the paralyzed
regions. During intense exercise, thermoregulation depends critically on active cutaneous vasodilation and skin cooling.
Accepted: 25 August 2000 相似文献
20.
Conclusion Thus, maximum density of electrical current is observed in the cylindrical part of the AES electrodes closer to the counter
electrode. The inhomogeneity of the electrical current density distribution over the electrode surface is due to the specific
shape and mutual orientation of the electrodes. Within the working range of electric stimulation currents, the inhomogeneity
is substantially levelled because of nonlinearity of polarization characteristics of electrode material (12Kh18N9 stainless
steel) in 1% solution of hydrochloric acid.
The developed distributed model adequately describes the experimental data and it can be used for assessing functional performance
and optimizing AES electrodes coated with various materials. Further development of the model could provide dynamic monitoring
of the electrode-electrolyte system.
Tomsk State Academy of Management Systems and Radioelectronics. Tomsk Polytechnical University. Translated from Meditsinskaya
Tekhnika, No. 5, pp. 28–31, September–October, 1996. 相似文献