共查询到20条相似文献,搜索用时 15 毫秒
1.
Müller R Göpfert E Breuer D Greenlee MW 《Documenta ophthalmologica. Advances in ophthalmology》1998,97(2):121-134
The dependency of the N200 amplitude of the motion-onset VEP evoked by a parafoveal grating of variable speed (0.25 – 13.5
deg/s, corresponding to 0.5 – 27 Hz) and constant contrast (4%) was studied. Additional measurements were made with parafoveally
presented gratings of constant speed (2 deg/s, corresponding to 4 Hz) and a variable contrast (0.5 – 64%) before and after
adaptation to a stationary or drifting grating. In this latter experiment, simultaneous psychophysical measurements were made
of the perceived speed. The amplitude of the N200 wave increased with increasing stimulus speed within the slow speed range
up to 1.5 deg/s (corresponding to 3 Hz). Adaptation to a stationary grating had no significant effect on the relationship
between the N200 amplitude and stimulus contrast. Contrary to this, adaptation to a slowly drifting grating (1 deg/s, corresponding
to 2 Hz) or to a rapidly drifting grating (4 deg/s, corresponding to 8 Hz) reduced the N200 amplitude significantly. Adaptation
to a stationary grating slightly reduced the perceived speed of subsequently viewed gratings. Adaptation to a slowly drifting
grating increased the perceived speed of the subsequently viewed gratings, whereas adaptation to a rapidly drifting grating
decreased the perceived speed. The findings can be best explained by a two-channel model of speed perception. While the motion
VEP reflects the sum of both channel activities, the psychophysical measures point to the antagonistic encoding of low and
high velocities.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
2.
Müller R Bochmann G Greenlee MW Göpfert E 《Documenta ophthalmologica. Advances in ophthalmology》2003,107(2):115-126
The N200 amplitude of the motion-onset VEP evoked by a parafoveal grating of variable speed (0.25–13.5°/s), constant spatial frequency (2 cpd), contrast (4%), and direction (horizontally rightward) was studied before and after adaptation to a stationary or drifting grating (1 or 4°/s). Psychophysical measurements were made simultaneously of the perceived speed. In the unadapted condition the slope of the N200 amplitude versus speed function is positive, but lower for high compared to low speeds. The N200 amplitude increases slightly after stationary adaptation. An increase in perceived speed is also evident after stationary adaptation. This increase is more pronounced for low compared to high speeds. Motion adaptation reduces N200 amplitudes over the entire speed range, whereas perceived speeds change from under-estimation to over-estimation when the speed exceeds 1.8°/s after 1°/s adaptation and 4.5°/s after 4°/s adaptation. The simultaneous evaluation of motion VEP and psychophysical results supports the view that the neurons generating the N200 component are also involved in speed perception. The data suggest the existence of a limited number (three or more) speed channels. 相似文献
3.
The N200 amplitude of the motion-onset VEP evoked by a parafoveal grating of variable contrast (0.5-64%), constant speed (2 degrees/s), direction (horizontally rightward), and spatial frequency (2 cpd) was studied before and after adaptation to a stationary or drifting grating (1, 2, or 4 degrees/s rightward or leftward). These results are compared to those for the pattern-appearance VEP. Psychophysical measurements were made simultaneously of the perceived speed. While iso-directional (rightward) adaptation leads to a mean amplitude reduction of 39%, the decrease after counter-directional adaptation has a size of 20%. The post-adaptation matches of perceived speed differ in dependence on the iso-directional adapting speed and decrease on average to 98%, 85%, and 69% of the pre-adapt perceived speed after 1, 2, and 4 degrees/s adapting speeds, respectively. The perceived speed is moderately reduced (83% of the pre-adapt value) after counter-directional adaptation nearly independently of the adapting speed. A model of velocity processing is presented, which enables us to predict the trends of the experimental motion VEP and perceived speed data. 相似文献
4.
The relation between the amplitude of visual responses to a checkerboard stimulus and the degree of lateral displacement of the checks was examined across different check sizes with simultaneously recorded electroretinograms (ERGs) and visual-evoked potentials (VEPs). The amplitudes of both the b-wave and the after-potential of the ERG increase linearly with pattern displacement. However, the major components of the VEP (N70 and P100) were smaller than expected from linearity for both small checks with small displacements (thresholding) and for large checks with large displacements (saturation). These results suggest that the ERG is proportional to the number of receptors stimulated, but the VEP reflects neural processes influenced by the spatial structure of the stimulus. 相似文献
5.
C. E. Wright D. E. Williams N. Drasdo G. F. A. Harding 《Documenta ophthalmologica. Advances in ophthalmology》1985,59(4):365-384
Changes in the ERG and VEP across the life span were investigated. The dark adapted and scotopic ERGs both showed a progressive increase in the implicit times of the A and B waves and a reduction in the amplitude of the AB configuration. There was also an increase in the implicit times of the oscillatory potentials of the photopic ERG.The flash and pattern onset-offset VEP both showed changes in waveform with age whilst the waveform of the pattern reversal VEP was constant. The amplitudes of the components of the flash and pattern reversal VEP were very high in the teenage group, but once reduced, were constant from the twenties onwards, showing no further consistent age changes.The latencies of the components of the pattern VEPs showed an increase with age which could be accounted for by the reduction in retinal illuminance due to the decrease in pupil diameter with age. However, the increase in the latency of the flash major positive (P2) component was greater than that expected from the decrease in retinal illuminance alone, suggesting that this is due to neural factors. 相似文献
6.
Klistorner A Fraser C Garrick R Graham S Arvind H 《Documenta ophthalmologica. Advances in ophthalmology》2008,116(1):19-27
Aim To compare performance of multi-focal and full-field Visual Evoked Potentials (VEP) in patients with optic neuritis (ON).
Method 26 patients with unilateral ON were enrolled. Multi-focal VEP (MF VEP) was recorded using AccuMap™ system. Four bipolar channels
were analysed. Full-field VEP (FF VEP) was performed according to ISCEV standard using ESPION™ with frontal-occipital electrode
placement. Pattern-reversal protocol was implemented with check size of 60′ and field of view of 30°. Result For both tests amplitude and latency of affected eye were statistically different from non-affected eye. The asymmetry of
amplitude and latency between two eyes was also very similar for both tests. Averaged Relative Asymmetry Coefficient of amplitude
(RAC) for the FF VEP was 0.10 ± 0.15 and for the MF VEP was 0.12 ± 0.12 (P = 0.21, paired t-test). Averaged latency difference between affected and non-affected eyes was 13.0 ± 12 ms for FF and 14.1 ± 11.1 ms for
MF VEPs (P = 0.14, paired t-test). Coefficient of correlation (r) of p100 component of the FF VEP and averaged MF VEP was 0.60 (P < 0.0001) for amplitude and 0.79 (P < 0.0001) for latency. Correlation improved when amplitude and latency asymmetry between two eyes was analysed (r = 0.81 and r = 0.92 respectively). Overall 73% of affected eyes were identified as abnormal by amplitude and/or latency of the FF VEP
and 89% was considered abnormal when MF VEP was used. Analysis of individual cases revealed superior performance of MF VEP
in detecting small or peripheral defects. 相似文献
7.
Doz. Dr. E. Göpfert R. Müller E. M. Simon 《Documenta ophthalmologica. Advances in ophthalmology》1990,75(2):165-173
We studied amplitude of the wave N200 of the motion-onset VEP by varying the side length of a square stimulation field between 0.5 and 7 degrees. A significant increase in amplitude was obtained between 0.5 and 1 degree of side length in central stimulation and between 0.5 and 5 degrees in 10-degree peripheral stimulation. Variations of spatial frequency between 0.34 and 6.8 c/deg did not modify the amplitude size, ie, no tuning effect could be found. The results of simultaneous and separate stimulation of foveal and parafoveal regions support the observation that the stimulation field size is a minor influence. Features of motion-sensitive cortical neurons, such as those found in monkeys, could account for this behavior. 相似文献
8.
《Vision research》1996,36(1):181-190
Visual evoked potentials (VEPs) produced by pattern reversal were compared with those elicited by onset of motion in 37 amblyopic children (20 with anisometropic amblyopia, seven with strabismic amblyopia and 10 with both anisometropia and strabismus). The amplitudes and peak latencies of the main P1 peak in the pattern-reversal VEP and of the motion-specific N2 peak in the motion-onset VEP through the amblyopic eye were compared with those through the normal fellow eye. Regardless of the type of amblyopia, the amplitude of the pattern-reversal VEP for full-field stimulation was significantly smaller and its latency significantly longer through the amblyopic eye (P < 0.001). In contrast, neither the amplitudes nor the latencies of the N2 motion-onset VEPs differed significantly between amblyopic and non-amblyopic eyes. For pattern-reversal VEPs through the amblyopic eyes, the extent to which amplitude was reduced and latency prolonged correlated well with the reduction of visual acuity, whereas the amplitudes and latencies of motion-onset VEPs did not vary with visual acuity. Even for stimuli restricted to the central visual field (5 or 2 deg diameter) or to the peripheral field (excluding the central 5 deg), motion-onset responses were indistinguishable through the two eyes, while pattern-reversal responses always differed significantly in amplitude. These results suggest that the source of motion-onset VEPs (probably an extrastriate motion-sensitive area) is less affected in amblyopia than that of pattern-reversal VEPs (probably the striate cortex). The motion pathway, presumably deriving mainly from the magnocellular layers of the lateral geniculate nucleus, may be relatively spared in amblyopia. 相似文献
9.
Studies of visual acuity in human infants between 1 and 6 months of age using the visual-evoked potential (VEP) and forced-choice preferential looking (FPL) have shown that acuity is one to two octaves higher by VEP estimates than by FPL estimates. In an attempt to study these differences, the authors obtained both VEP and FPL data from 26 3-month-old infants. VEP data were obtained with gratings of 0.31, 0.62, 1.25 and 2.50 cycles/deg, which were counterphase alternated at 2 Hz. FPL data were obtained for stationary gratings using either the method of constant stimuli or a staircase procedure. Our study revealed three major findings: (1) recordable VEPs can be obtained for spatial patterns that are below threshold by behavioral measures; (2) the use of different scoring criteria that yields comparable VEP and FPL group mean acuities does not yield a significant correlation between VEP amplitude acuity and FPL acuity for individual infants, probably because of the inherent "noise" in each technique; and (3) when VEP latency rather than amplitude is used to estimate acuity, there is a significant correlation between electrophysiology and behavior. 相似文献
10.
Visual motion processing is strongly susceptible to adaptation. A variety of patterns have been used as stimuli in previous studies. Three of these, namely random dots, barcode-like gratings, and sinusoidal gratings, were compared in the present study using motion-onset visual evoked potentials (VEPs). We assessed the effects of the adaptation pattern and the test pattern to which the VEP is recorded. Furthermore, we evaluated the interaction between both, i.e. whether differences between adaptation and test pattern affect the response. Isodirectional and antidirectional adaptation were used to differentiate between the actual motion adaptation and associated flicker adaptation. Motion adaptation was almost 2.5-fold stronger (p < 0.01) if the same rather than different pattern types were used for both adaptation and test. This implies that separate neural populations are involved, suggesting the presence of pattern-tuned motion mechanisms. 相似文献
11.
Studies of infant visual development have shown that acuity estimated with pattern visually evoked potential (VEP) techniques is higher than acuity estimated with preferential looking (PL) techniques. A major difference is that VEP stimuli are temporally modulated while PL stimuli are typically stationary. We measured PL acuity in 2-10-month-old infants for stationary gratings and for gratings phase alternating at 2.5, 7.5, 14 and 23 reversals/sec using a computer generated staircase method. The acuity functions were temporally tuned at 7.5 or 14 rev/sec for infants 3 months and older. Acuity for 7.5 and 14 rev/sec gratings was 0.5 to 1.0 octave higher than for stationary, 2.5 and 23 rev/sec gratings. When adults' grating acuity was measured foveally and 5 deg eccentrically, tuning occurred only for the eccentric targets, suggesting that the retinal area used by the infants to detect gratings acts like the adult perifovea. In a second experiment, VEP and PL acuity were both measured from the same infants using 14 reversals/sec gratings. The VEP/PL acuity difference was less for phase alternating gratings than for stationary gratings. The magnitude of the difference was age dependent, decreasing from 2 octaves at 2 months to 0.5 octave at 12 months. Even though the use of phase alternating gratings results in improved PL acuity, temporal modulation does not completely account for the difference between VEP and PL acuity. 相似文献
12.
Kremlácek J Kuba M Kubová Z Chlubnová J 《Documenta ophthalmologica. Advances in ophthalmology》2004,109(2):169-175
Motion-onset related visual evoked potentials (M-VEPs) were recorded as a result of the three basic (translating, radial and rotating) and one complex (spiral) motion stimulations in five subjects. Low contrast, retinotopically scaled patterns evoked potentials with major motion-onset specific negativity N160 with maximum in the parieto-temporal region. All multidirectional motion stimuli elicited the motion-onset response of significantly higher amplitude and shorter latency compared to the translating (unidirectional) motion. The rotation-onset evoked potentials had significantly shorter latencies than the rest of explored stimuli. The most stable responses with the largest N160 amplitude were recorded to the radial motion. After masking of the central 20° of the visual field these motion-onset VEPs were acquired without statistically significant amplitude drop. The efficiency and usefulness of the radial stimulus is presented in two clinical cases. 相似文献
13.
Sjöström A Kraemer M Ohlsson J Garay-Cerro G Abrahamsson M Villarreal G 《Documenta ophthalmologica. Advances in ophthalmology》2004,109(1):9-15
Extended set of visual evoked potentials (VEPs) using pattern-reversal (PREPs), linear motion-onset and radial (expansion) motion-onset stimuli (M-VEPs) (detailed specification at http:0 //www.lfhk.cuni.cz/elf) was used to verify congenital stationary night-blindness (CSNB) characteristics in 7 patients (compared to 7 age matched controls) in photopic conditions (luminance of 17 cd/m2). No differences were found in any of the M-VEPs, whilst PREPs displayed prolonged latencies in 3 of 7 CSNB patients. Additionally, the PREPs and M-VEPs were tested in 3 normal and 3 CSNB subjects (the only available ones from the original group) over large range of scotopic, mesopic and photopic luminances (from 0.0001 to 65.4 cd/m2). Both types of low luminance VEPs had distinctly increased luminance threshold needed for reliable VEPs eliciting in CSNB patients (0.06 cd/m2) when compared with controls (0.003 cd/m2); the VEP appearance threshold was almost identical with the perceptual threshold in both groups. Thus, our pilot study proved that CSNB can be objectively detected also via scotopic VEP examination. Since the prolonged PREP latencies at 17 cd/m2normalised with luminance increase, it indicates that the lower luminance stimuli (compared to the standard recommended by ISCEV) can be more sensitive for some visual disorders detection. 相似文献
14.
This review article summarises the research on the motion-onset visual evoked potentials (VEPs) and important motion stimulus parameters which have been clarified. For activation of the visual motion processing system and evocation of the motion-onset specific N2 peak (with latency of 160-200ms) from the extra-striate temporo-occipital and/or parietal cortex, the following stimulus parameters can be recently recommended: low luminance (相似文献
15.
Adaptation to a high contrast sinewave grating of 1 c/deg spatial frequency causes a large increase in the contrast threshold for a 1 c/deg test grating, but fails to raise the threshold for a squarewave grating of 0.33 c/deg, although the sensitivity of the "channel" tuned to both the third and fifth harmonic components of the squarewave test grating should be thoroughly suppressed. Following sequential adaptation to sinewave gratings of 1 and 3 c/deg spatial frequency, detection of squarewave gratings at 0.33 c/deg likewise remains unaffected. In contrast, after adaptation to a 0.33 c/deg squarewave grating with missing fundamental the contrast threshold for a squarewave test grating of the same frequency is increased by 0.25 log unit, although the higher harmonic component frequencies are less affected than by sequential sinewave adaptation. The results suggest that independent spatial frequency channels detecting harmonic components are not alone sufficient to account for the visibility of low frequency squarewaves. 相似文献
16.
Contrast response functions (CRFs) for the VEP were obtained with a Discrete Fourier Transform (DFT) technique employing swept contrast gratings. VEP CRFs in infants were found to have a form similar to those observed in adults, being linear functions of log contrast over a range of near-threshold contrasts. CRFs with low and high contrast lobes were present in infants, as they are in adults. Contrast thresholds were estimated by extrapolation of the CRF to zero microvolts. The effects of additive EEG noise and of the DFT data window on the shape of the measured CRF are considered. For large signals, the measured CRF is nearly independent of the additive noise, but at small signal values additive noise introduces a small bias towards larger amplitudes. The VEP signal-plus-noise distribution was modeled as a family of Rice distributions in order to evaluate the effects of bias on the estimates of threshold. The amount of bias depends inversely upon the slope of the CRF. The amount of bias introduced by a smoothing window also depends upon slope of the CRF as well as the sweep rate. The combined effects of additive noise and window bias were such that the total bias was nearly independent of CRF slope. Sweep VEP contrast thresholds were shown empirically to be unaffected by changes in the range of contrast swept. 相似文献
17.
Automatic gain control contrast mechanisms are modulated by attention in humans: evidence from visual evoked potentials 总被引:3,自引:0,他引:3
This study investigated the effect of attention on the contrast response curves of steady-state visual evoked potentials (VEPs) to counter-phased sinusoidal gratings. The 1 cyc/deg gratings were modulated either in luminance or chromaticity (equiluminant red-green). The luminance grating counter-phased at 9 Hz (to favour activation of the magno-cellular system), and the chromatic grating at 2.5 Hz (to favour activation of the parvo-cellular system). Attention was directed towards the gratings (displayed in the left visual field) by requiring subjects to detect and respond to randomly occurring changes in contrast. In the control condition, attention towards the grating was minimised by requiring subjects to detect a target letter amongst distracters briefly flashed in the contra-lateral visual field. Attention increased VEP amplitudes for both luminance and chromatic stimuli, more so at high than at low contrasts, increasing the slope of the contrast amplitude curves (over the non-saturating range of contrasts). The estimates of contrast threshold from extrapolation of amplitudes were unaffected by attention. Attention also changed the VEP phases, but only for luminance gratings, where it acted to reduce the magnitude of phase advance with contrast. Attention had no effect on the average phases for chromatic gratings. The results are consistent with the notion that attention acts on cortical gain control mechanisms, which are known to be different for the magno- and parvo-cellular systems. 相似文献
18.
Human visual evoked potentials (VEPs) were recorded for abrupt reversals of 2 cycles/deg (c/deg) square-wave gratings combining high red-green contrast with different levels of luminance contrast. Response characteristics--2nd harmonic amplitudes and peak latencies as a function of luminance contrast--were compared for four different reversal rates ranging from 6.25 Hz to 12.5 Hz. At every reversal frequency, the VEP amplitude and latency plots were nonsymmetrical with respect to isoluminance. The amplitude dropped to a minimum within a region of rapid phase change, always at a red-green luminance contrast for which the green color had the higher luminance, at about 40% or 50% Michelson luminance contrast. The rapid phase shift around this contrast suggested a sudden change in the relative impact of VEP generators with different latencies, possibly dominated by parvocellular or magnocellular input. The most prominent VEP waveform through most of the luminance contrast range, P110, is interpreted in terms of a parvo-mediated response that is attenuated with increasing reversal frequency. Contrast-dependent changes in the P110 amplitude appear to be responsible for the VEP asymmetries reported here. 相似文献
19.
The Spectral VEP in Normal Subjects and Dichromats 总被引:1,自引:0,他引:1
Shizhou Huang De-Zheng Wu Lezheng Wu Jiongji Liang National Ophthalmological Laboratories Ministry of Public Health China Zhongshan Ophthalmic Center Sun Yat-sen University of Medical Sciences Guangzhou China 《眼科学报》1992,8(3):126-130
The spectral VEP in 13 normal subjects(25 eyes),four cases(8eyes)of protanopes and 8 cases(15 eyes)of deuteranopes were tested.Innormal subjects,the shortest latencies of N1,P1,N2 were in 560 nm and thegreatest amplitudes of N1-P1 and P1-N2 were in 560-570 nm,around which thelatencies were delayed and the amplitudes were decreased as the wave-lengthes of stimulative light increased or decreased gradually.The spectralVEP pattern of deuteranopes was similar to the normal subjects.In theprotanopes,the shorter latencies of N1,P1,N2 and greater amplitudes of N1-P1,P1-N2 appeared in 520-530 nm and 570 nm,forming the two-thoughs and two-peaks shapes,with the shortest latencies and the greatest amplitudes in 520-530 nm.There were statistically significant differences of amplitudes and/orlatencies in some wavelengthes between the protanopes and normals and be-tween the deuteranopes and normals.Eye Science 1992;8:126-130. 相似文献
20.
Fatima S. Shawkat Anthony Kriss 《Documenta ophthalmologica. Advances in ophthalmology》1997,94(4):307-320
The effect of experimental scotomata on visual evoked potentials to half-field stimulation using sequential checkerboard onset,
reversal and offset was investigated in 10 normal subjects to assess the relative sensitivity of the three stimulus modes,
and the contributions of pathways subserving macular and paramacular parts of the visual field. Four scotoma sizes (0–1.5°,
0°–2°, 0°–3° and 0°–4.5°) were used to mask the central part of the stimulus field (0°–12°). Five check sizes (6′, 12′, 20′,
50′ and 80′) were presented for each scotoma size. Peak-to-peak amplitudes and peak latencies of components on the ipsilateral
and contralateral sides of the scalp to the stimulated half-field were measured. Scotoma size was highly significant in influencing
component amplitude (p<0.0001) and latency (p<0.03) of all ipsilateral and contralateral onset components and all ipsilateral
reversal and offset components. Components that were attenuated to the greatest extent with the smallest 0°–1.5° scotoma were
the contralateral onset P105 and ipsilateral reversal P100 and N145. Onset CIII, reveral N80, and offset N85 and P110 only
showed a significant attenuation after the use of scotomata of 0°–3° and larger. Our results show that scotoma size is a significant
factor in influencing all the major visual evoked potential components, with the exception of reversal. and offset contralateral
potentials (N105 and N115), probably reflecting their paramacular origins. Reversal, ipsilateral P100 and N145, and onset,
contralateral P105, appear to be predominantly of macular origin and the most sensitive potentials for detecting effects of
small central scotomata. 相似文献