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目的了解天津市部分老年高知人群轻度认知功能障碍(MCI)现况及其影响因素。方法采用蒙特利尔认知评估问卷(MoCA),对天津市某三甲医院体检中心来院体检的2105名老年高知人群进行问卷调查,并应用单因素及多元logistic回归分析轻度认知功能障碍的影响因素。结果 2105名天津老年高知人群平均MoCA得分为26.81±1.85,MCI检出402人,检出率为19.10%;单因素分析结果显示,性别(χ~2=21.23,P0.01)和甘油三酯异常(χ~2=5.84,P0.05)对老年人MCI的检出均有影响;多因素logistic回归分析显示,女性(OR=0.29,95%CI:0.42~0.70)、未饮用葡萄酒(OR=0.63,95%CI:0.40~0.99)、甘油三酯异常(OR=1.34,95%CI:1.09~1.71)进入回归模型(P0.05)。结论影响天津市老年高知人群MCI检出的因素中女性、未饮用葡萄酒是保护因素,甘油三酯异常是危险因素,可针对影响因素进行有针对性的预防。 相似文献
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目的 了解年龄≥65岁的高干人员轻度认知功能障碍的患病情况及其相关危险因素,为进行有效防治提供参考依据.方法 选取在广州市第一人民医院体检的老年高干454例为研究对象,分别给予简易精神状态量表(mini mental state examination,MMSE)的认知量表和蒙特利尔认知量表(Montreal cognitive assessment,MoCA)评估,进行两种量表得分相关性分析和MCI检出率比较.同时根据临床诊断标准将研究对象分为正常组(96名)和MCI组(337例),分析轻度认知功能障碍的相关危险因素.结果 MoCA和MMSE得分显著相关(r = 0.563,P < 0.01),MoCA检出率(78.98%)大于MMSE检出率(45.96%).年龄、抑郁得分、收缩压、高血压在两组之间的差异有显著统计学意义(P < 0.01).MCI组中,年龄、高血压和抑郁得分均是MCI的独立危险因素(P < 0.01).结论 老年高干人群中,年龄、高血压和抑郁均是MCI的独立危险因素,有针对性的对其干预可减少痴呆的发生. 相似文献
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目的 调查上海市虹口区社区居家模式老年人群轻度认知功能障碍(MCI)患者的危险因素。方法分为两步,第一步采用整群分层抽样的方法随机选取上海市虹口区4个街道社区,采用AD8简体中文版对社区卫生服务中心年度体检的≥65岁健康体检老年人进行评测,AD8≥2分为有认知功能障碍;第二步为完成第一步的认知功能障碍受试者,完成一般资料调查表、MMSE、MoCA等量表评测,进行临床诊断,以临床诊断的MCI患者作为研究对象,共163例,并随机选取健康照料者及体检健康人群127例作为健康对照组;采用Logistic回归分析筛查MCI患者的危险因素;组间比较采用秩和检验或t检验,计数资料采用卡方检验。结果第一步共8549名社区老年人完成评估;第二步有163例诊断为MCI,单因素logistic回归分析可见性别、年龄、教育年限、年收入、社会活动、锻炼、睡眠障碍与MCI的发生有关(P<0.05);多因素logistic回归分析表明女性、高龄、教育程度低、低年收入、缺少社会活动、缺少锻炼、睡眠障碍为虹口区社区居家模式MCI患者的高危因素。结论上海市虹口区社区老年人认知功能障碍的发病率较高,女性、高龄、教育程度低、低年收入、缺少社会活动、缺少锻炼、睡眠障碍是轻度认知功能障碍的主要危险因素。 相似文献
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《中风与神经疾病杂志》2019,(6):536-540
目的研究轻度认知功能障碍(MCI)和血管性轻度认知功能障碍(VaMCI)患者各认知功能脑区域脑血流量(CBF)的特点,为早期诊断提供科学依据。方法选择2016年1月-2018年1月昆明市延安医院神经内科门诊及住院部确诊的24例MCI患者(MCI组)和24例VaMCI(VaMCI组)患者及24名老年健康志愿者(正常对照组)作为研究对象,运用动脉自旋标记(ASL)技术采集3组受试者认知功能脑区域的CBF数据。结果与正常对照组相比,MCI组双侧额叶、双侧海马脑血流灌注增加,双侧颞叶、楔前叶等部位脑血流灌注降低(P 0. 05);与正常对照组相比,VaMCI组双侧额叶、双侧海马脑血流灌注增加,双侧楔前叶、角回等部位脑血流灌注降低(P 0. 05);与MCI组相比,VaMCI组左侧颞叶、双侧扣带回、左侧杏仁核脑血流灌注增加,右侧颞叶、右侧扣带回等部位脑血流灌注降低(P 0. 05)。结论 MCI患者和VaMCI患者认知功能脑区域脑血流灌注具有不同的特点,磁共振ASL技术能够为两者的鉴别提供影像学帮助。 相似文献
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目的评估帕金森病(Parkinson’s disease,PD)患者的认知功能状态,分析帕金森病合并轻度认知功能障碍(Parkinson’s Disease with Mild Cognitive Impairment,PD-MCI)的特点。方法纳入PD患者64例,采用神经心理测试组评估其注意、视空间、执行和记忆等认知域的功能。结果本组PD患者中,认知功能正常24例(37.5%),PD-MCI 30例(46.9%),帕金森病痴呆10例(15.6%)。在PD-MCI患者中,单个认知领域轻度损害(60.0%)较多个认知域型轻度认知损害(40.0%)更常见,累及较多的认知域依次为记忆(20例,66.7%),执行(13例,43.3%),视空间(12例,36.7%)。早期PD患者PD-MCI发生率为36.4%,痴呆发生率为3.0%;中晚期PD患者PD-MCI发生率为58.1%,痴呆发生率达29.0%,两组差异有显著性(χ2=18.222,P<0.001)。PD患者的病情程度与认知功能状态呈负相关(Spearman相关系数=-0.553,P<0.001)。结论轻度认知功能障碍(mild cogni-tive impairment,MCI)在PD患者中常见,即使在疾病早期,其发生率也较高,其中单个认知领域轻度损害较多个认知域型轻度认知损害更常见。PD患者的病情越严重,认知功能状态越差。 相似文献
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刘佳 《国际神经病学神经外科学杂志》2010,37(3)
轻度认知功能障碍(MCI)在老年人群非常普遍。遗传学研究作为研究MCI诊断和预测的方法能提供很有价值的线索。虽然我们对MCI进展为AD现有的相关遗传学知识了解有限,但仍有足够的机会去研究和发现。本文就目前MCI的相关热点致病基因进行综述,并探讨了基因研究中存在的一些问题以及今后发展的方向。 相似文献
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由于老龄化问题严重,伴随而来的是老年认知功能障碍呈递增趋势.帕金森病(PD)是常见的导致认知障碍疾病之一,临床对导致帕金森病认知障碍和痴呆的临床特征和神经机制的认识显著增加.在确诊帕金森病的同时,部分患者已存在一定程度的认知障碍,但程度尚轻微,未达到影响功能独立性的严重程度,故易被患者、照料人员,甚至医务工作者忽视.然... 相似文献
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目的 探讨帕金森病患者轻度认知功能障碍(PD-MCI)的临床特点。方法 纳入85例非痴呆的帕金森病(PD)患者,并进行临床资料的采集及相关量表评估。结果 PD-MCI组55例(64.7%),PD-认知正常组30例(35.3%)。PD-MCI组的年龄及发病时年龄显著高于PD-认知正常组(P<0.05),PD-MCI组MoCA评分中的视空间与执行功能、注意、语言、抽象、延迟回忆得分显著低于PD-认知正常组(P<0.01)。PD-MCI组的MoCA评分与UPDRS Ⅲ评分及发病年龄呈负相关,与受教育水平呈正相关。结论 与认知功能正常的PD患者比较,PD-MCI患者在视空间与执行功能、注意、语言、抽象、延迟回忆等方面均有损害,且认知损害程度与发病年龄、运动症状严重程度及受教育水平有关。 相似文献
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胰岛素抵抗与轻度认知功能障碍关系的临床研究 总被引:5,自引:1,他引:4
目的探讨胰岛素抵抗(IR)与轻度认知功能障碍(MCI)的关系;明确IR是否为MCI的独立危险因素。方法102例IR患者进行MMSE、GDS、CMS、ADL等评测;按Petersen标准诊断MCI。结果IR患者MCI发病率高,且重型IR患者高于轻型IR患者、患有糖尿病(DM)的IR患者高于非DM的IR患者、以血糖控制不良者为甚;MCI患者表现IR且空腹胰岛素水平高(P〈0.01)。Logistic回归分析显示受教育程度、空腹胰岛素水平、高血压病、糖化血红蛋白最终进入方程。结论IR患者MCI发生率较高,氓的MCI患者空腹胰岛素水平高;IR影响认知功能的各个环节;IR、高胰岛素水平、高血压病和高血糖是MCI的独立危险因素。 相似文献
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Psychiatric symptoms/syndromes in elderly persons with mild cognitive impairment. Data from a cross-sectional study 总被引:1,自引:0,他引:1
Objective – This study examined the prevalence of psychiatric syndromes and symptoms in elderly persons with mild cognitive impairment (MCI).
Methods – Data from a population-based study (the Kungsholmen Project) were used. All subjects with a Mini-Mental State Examination (MMSE) score ≤23 and a comparable random of those ≥24 were selected for further examination. Physicians carefully examined the included persons and those affected with dementia were excluded. The rest were stratified into 14 groups according to age and level of education. The mean MMSE score was calculated for each group and those subjects with scores 1SD below the age- and education-specific mean were classified as MCI. A structured psychiatric interview was performed and diagnoses of depression, anxiety and psychosis were made according to DSM-III-R.
Results – Being suspicious was the only symptom and being affected by an anxiety syndrome was the only diagnosis found to be associated with MCI. The association with suspiciousness might reflect the feeling of losing control that probably accompanies the loss of cognitive function experienced by the person. The association with anxiety syndromes might be a result of the fact that physical disorders have been reported to be more common in persons with cognitive impairment, as well as in persons with anxiety syndromes.
Conclusion – The results of this study suggest that the psychiatric syndromes present in MCI might be related to MCI per se . Additionally, it might reflect a developing dementia or a concomitant physical disorder. 相似文献
Methods – Data from a population-based study (the Kungsholmen Project) were used. All subjects with a Mini-Mental State Examination (MMSE) score ≤23 and a comparable random of those ≥24 were selected for further examination. Physicians carefully examined the included persons and those affected with dementia were excluded. The rest were stratified into 14 groups according to age and level of education. The mean MMSE score was calculated for each group and those subjects with scores 1SD below the age- and education-specific mean were classified as MCI. A structured psychiatric interview was performed and diagnoses of depression, anxiety and psychosis were made according to DSM-III-R.
Results – Being suspicious was the only symptom and being affected by an anxiety syndrome was the only diagnosis found to be associated with MCI. The association with suspiciousness might reflect the feeling of losing control that probably accompanies the loss of cognitive function experienced by the person. The association with anxiety syndromes might be a result of the fact that physical disorders have been reported to be more common in persons with cognitive impairment, as well as in persons with anxiety syndromes.
Conclusion – The results of this study suggest that the psychiatric syndromes present in MCI might be related to MCI per se . Additionally, it might reflect a developing dementia or a concomitant physical disorder. 相似文献
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目的:探讨上海社区老年抑郁障碍与遗忘型轻度认知功能损害(aMCI)患者之间认知功能的神经心理学差异。方法:1 068例社区老人中符合美国精神障碍诊断与统计手册第4版临床定式检查(SCID)的老年抑郁障碍患者13例及亚临床抑郁患者7例,共20例作为抑郁障碍组(DD组),并选取性别、年龄、教育程度均匹配的aMCI患者20例(aMCI组)及正常老人20名(NC组)作为对照,采用简明精神状态量表(MMSE)、蒙特利尔认知评估量表(MoCA)进行认知功能的测评。结果:3组在MMSE总分及地点定向力、计算与注意力、三步指令评分,以及MoCA总分、复制图、注意、计算、延迟回忆、时间定向评分差异有统计学意义(P0.05或P0.001)。DD组MMSE总分(P=0.034)、计算力与注意力(P=0.009)以及MoCA总分(P=0.002)、计算(P=0.006)、抽象思维(P=0.030)、时间定向(P=0.044)评分明显好于aMCI组。结论:社区老年抑郁障碍患者认知功能受损程度较老年aMCI患者轻。 相似文献
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目的:比较轻度帕金森病样体征(mild parkinsonian signs,MPS)和无MPS老人的轻度认知功能损害(mildcognitive impairment,MCI)患病情况,探讨MPS与MCI间的关系。方法:以506名大于70岁老年人为研究对象,使用国际通用帕金森病统一评分量表(The unified Parkinson's disease rating scale,UPDRS)第Ⅲ部分缩写版本评定MPS。将研究对象分为MPS组和无MPS组,分析MPS患病的危险因素及MCI患病情况。结果:MPS组较无MPS组的年龄大,患糖尿病及MCI比例高。结论:MPS与MCI的关系密切,不同类型的MPS对MCI的发病影响不同。 相似文献
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目的:探讨离退休老人轻度认知功能损害(MCI)的发生率及其影响因素。方法:采用哈金斯基缺血指数(HIS)、简易智能状态检查(中文版)(MMSE)、Reisberg总体衰退量表(GDS)、日常生活活动能力(20项版本)(ADL)等,对420名离退休老人MCI的发生情况及其影响因素进行调查,分析相互问关系。结果:离退休老人中MCI的发生率为8.6%,随年龄的增长而有升高趋势,但各年龄组之间差异无显著性。结论:离退休老人中MCI较常见,应对老年人群进行MCI的监测和干预,阻止和延缓MCI发展为痴呆,提高老年人的寿命和生活质量。 相似文献
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Prevalence of mild cognitive impairment: a population-based study in elderly subjects 总被引:18,自引:0,他引:18
Hänninen T Hallikainen M Tuomainen S Vanhanen M Soininen H 《Acta neurologica Scandinavica》2002,106(3):148-154
OBJECTIVES: Mild cognitive impairment (MCI) has been suggested as a term for a boundary area between normal aging and dementia, especially Alzheimer's disease (AD). In follow-up studies, more than 50% of MCI subjects have been converted to dementia in 3-4 years. However, the epidemiology of MCI is not well known. This study was designed to determine the prevalence of MCI in an elderly population. METHODS: A total of 806 subjects (60-76 years of age) from a population-based random sample of 1150 subjects living in the city of Kuopio in eastern Finland were evaluated. Neuropsychological tests and a structured interview including the modified Clinical Dementia Rating (CDR) were used to apply the diagnostic criteria of MCI as proposed by Mayo Clinic Alzheimer's Disease Research Centre. Thus, subjects having a test score more than 1.5 SDs below the age appropriate mean in memory tests and a CDR score of 0.5 but no dementia, were diagnosed as having MCI. RESULTS: A total of 43 subjects, 5.3%, met the MCI criteria. MCI was more prevalent in older and less-educated subjects, but no difference was found between men and women. The CDR appeared to be the most important part of the criteria. The memory tests had less impact on prevalence variables. CONCLUSIONS: The low prevalence of MCI indicate that in a population-based study design its criteria may identify a more homogeneous group of subjects at the lower end of the cognitive continuum as contrasted with various other criteria of cognitive impairment in the elderly population. This is compatible with follow-up studies showing a high probability of dementia in the MCI group. Thus, probable candidates for trials of preventive intervention for dementia can be screened from the elderly population using these diagnostic criteria. 相似文献