磁共振特征追踪技术定量左心室应变评估急性STEMI患者微血管阻塞

目的 采用心脏磁共振特征追踪技术（CMR-FT）量化急性ST段抬高型心肌梗死（STEMI）患者急性期左心室心肌应变及心功能改变，探讨其检测心肌梗死伴微血管阻塞（MVO）的可行性。方法 收集78例急性STEMI患者（梗死组）和10名健康志愿者（对照组）的CMR动态电影序列图像及钆对比剂延迟强化成像（LGE）资料。采用CMR-FT分析电影序列图像左心室整体心肌应变[整体峰值径向应变（GPRS）、周向应变（GPCS）及纵向应变（GPLS）]、节段心肌应变[节段峰值径向应变（PRS）、周向应变（PCS）及纵向应变（PLS）]和左心室心功能[左心室射血分数（LVEF）、左心室舒张末期容积指数（LVEDVi）、左心室收缩末期容积指数（LVESVi）及心脏指数（CI）]。根据LGE评估是否存在MVO，将患者分为MVO组（n=50）和无MVO组（n=28），将其左心室心肌节段分为MVO节段组（n=173）和无MVO节段组（n=1 075）。根据左心室节段应变绘制ROC曲线，并计算AUC值。结果 梗死组左心室GPRS、GPCS、GPLS、PRS、PCS及PLS与对照组差异均有统计学意义（P均<0.001）；梗死组左心室LVEF、LVEDVi、LVESVi与对照组差异有统计学意义（P均<0.05）；MVO节段组左心室PRS、PCS、PLS与无MVO节段组差异均有统计学意义（P均<0.001）；PRS和PCS取24.65%和－14.05%时检测MVO的敏感性、特异性、AUC分别为89.0%、60.6%、0.816和75.7%、75.9%、0.818。结论 采用CMR-FT测量左心室心肌节段峰值应变可检测急性STEMI患者是否发生MVO，为临床对急性STEMI患者进行早期风险分层管理提供了无创、便捷的新方法。     

基于可变形配准算法的心肌形变分析对肥厚型心肌病的诊断及预后预测的价值探讨

目的 :探讨基于可变形图像配准(deformableregistration algorithms,DRA)算法的心肌形变分析在肥厚型心肌病(hypertrophic cardiomyopathy,HCM)中的诊断及预后预测价值。方法:回顾性收集本院确诊的HCM患者23例,另招募23名年龄性别匹配的健康志愿者(对照组),均行心脏MRI扫描。HCM组按有无心肌延迟强化(late gadolinium enhancement,LGE)分为LGE(+)组和LGE(-)组。采用基于DRA算法的TrufiStrain软件进行心肌形变分析,测量整体径向应变峰值(global peak radial strain, GPRS)、整体环向应变峰值(global peak circumferential strain, GPCS)和整体纵向应变峰值(global peak longitudinal strain, GPLS)以及心尖部、中部和基底部的径向应变峰值(peak radial strain, PRS)、环向应变峰值(peak circumferential strain, PCS)和纵向应变峰值(peak longitudinal strain,PLS),探讨心肌形变参数在HCM中的诊断效能及其与心室壁厚度、LGE间的关系。结果:除心尖部PCS外,HCM组的GPRS、GPCS、GPLS及基底部和中部PRS、PCS、PLS,以及心尖部的PRS、PLS均明显低于对照组(P0.05),而HCM组的整体及各部分3个方向(环向、纵向、径向)的应变率比值均明显小于对照组(P0.05),且LGE(-)组及对照组各部分的PRS、PCS、PLS及3个方向的舒张早期和晚期应变率比值[径向应变率比值(ratio of radial strain rate during early and late diastole,REL),环向应变率比值(ratio of circumferential strain rate during early and late diastole,CEL)和纵向应变率比值(ratio of longitudinal strain rate during early and late diastole,LEL)]均大于LGE(+)组(P0.05)。GPRS、GPCS、GPLS、REL、CEL、LEL均与左心室心肌最大厚度明显相关(P0.05)。GPRS、GPCS、GPLS、REL、CEL及LEL诊断HCM的曲线下面积分别为0.686、0.905、0.921、0.972、0.974及0.917,GPRS、GPCS、GPLS、REL、CEL及LEL预测HCM患者是否有LGE的曲线下面积均大于0.871。结论:基于DRA的心肌形变分析在诊断HCM、预测HCM患者发生LGE中具有重要价值,且与心肌厚度密切相关。     

超声二维斑点追踪成像技术评价大鼠急性心肌梗死后局部心肌存活性

目的 探讨超声二维斑点追踪成像技术评价大鼠急性心肌梗死后局部心肌存活性的应用价值.方法 20只Wistar大鼠随机分为急性心肌梗死组和假手术组,每组10只.于基础状态和恢复灌注24 h后对各组大鼠行超声心动图检查,记录左心室乳头肌短轴高帧频二维图像,测量节段心肌的收缩期峰值径向应变(PRS)、环向应变(PCS),并采用解剖M型超声测量左心室舒张末期内径(LVID_d)、左心室收缩末期内径(LVID_s)、短轴缩短率(FS)、射血分数(EF)和室壁增厚率(TR).实验结束后取大鼠心脏行左心室乳头肌短轴TTC染色并计算节段心肌的梗死面积(AN).以TTC染色作为金标准,ROC曲线分析上述二维应变及TR参数评价梗死节段的准确性.结果 ①与心肌梗死组基础状态及假手术组术后相比,心肌梗死组术后的LVID_d和LVID_s值均明显增加,FS、EF和前间隔TR值均明显降低(P<0.05);②与心肌梗死组基础状态及假手术组术后相比,心肌梗死组术后的前间隔、前壁、前侧壁、后侧壁和后间隔的PRS及PCS值均明显减低,心肌梗死组术后前间隔、前壁和前侧壁的PRS及PCS值明显低于其他节段(P<0.05);③以TTC染色所得节段心肌AN>50%为梗死节段,ROC曲线分析显示PCS为判断梗死心肌的最佳指标,PCS值为临界值(-6.14%)时诊断梗死心肌的敏感度为93.75%,特异度为90.91%.结论 超声二维斑点追踪成像技术能准确量化局部心肌功能.     

超声二维斑点追踪成像技术定量评价正常大鼠左心室整体和局部心肌功能

目的 探讨二维超声斑点追踪成像技术(2D-STI)评价正常大鼠左心室整体和局部心肌功能的应用价值.方法 20只健康成年雄性Wistar大鼠分别于基础状态和低剂量多巴酚丁胺负荷时接受超声心动图检查,记录左心室乳头肌短轴高帧频图像.测量节段心肌的收缩期峰值径向应变(PRS)、环向应变(PCS)及左心室整体峰值径向应变(G_(PRS))和环向应变(G_(PCS)),并采用解剖M型测量左心室舒张末期内径和收缩末期内径(LVIDd、LVIDs)、短轴缩短率(FS)、射血分数(EF).观察负荷实验时各项指标的动态变化,分别分析EF和左心室整体二维应变值(G_(PRS)、G_(PCS))的相关性.结果 基础状态时大鼠左心室乳头肌短轴各节段PRS值差异无统计学意义(P>0.05),各节段PCS值存在不均一性,前间隔和前壁的PCS测值最大,下壁的PCS测值最小(P<0.05).多巴酚丁胺负荷时,左心室乳头肌短轴G_(PRS)、G_(PCS)、节段心肌的PRS、PCS值和常规超声心动图的FS和EF随多巴酚丁胺剂量增加而增大(P<0.05);多巴酚丁胺剂量为10.0 μg/(kg·min)时上述指标与剂量为5.0 μg/(kg·min)时差异均无统计学意义(P>0.05).基础和负荷状态时EF和左心室整体二维应变值(G_(PRS)、G_(PCS))均有良好的相关性.结论 2D-STI技术可无创、简便地评价正常大鼠基础状态和低剂量多巴酚丁胺负荷时左心室整体和局部心肌形变,具有良好的重复性.     

三维斑点追踪成像评价肥厚型心肌病患者左心室整体和局部收缩功能

目的 应用三维斑点追踪成像(3D-STI)检测肥厚型心肌病(HCM)患者左心室心肌整体及各节段峰值应变, 评估HCM左心室收缩功能。方法 收集43例HCM患者(病例组)和23名健康志愿者(对照组), 病例组分为室间隔肥厚型HCM(sHCM)亚组(22例)、心尖肥厚型HCM(aHCM)亚组(8例)和混合型HCM(mHCM)亚组(13例), 对所有受检者进行3D-STI检测, 获得左心室射血分数(LVEF), 左心室心肌整体纵向峰值应变(GPLS)、圆周峰值应变(GPCS)、面积峰值应变(GPAS)、径向峰值应变(GPRS)及各节段峰值应变, 比较组间上述参数差异。结果 病例组LVEF与对照组比较无明显变化(P >0.05)。3D-STI中病例组与对照组比较左心室心肌GPLS、GPAS和GPRS均明显减低(P均 <0.01), GPCS无明显变化;心肌应变减低sHCM亚组主要集中于间隔基底段及中间段, aHCM亚组主要集中于心尖段, mHCM亚组主要集中于中间段及心尖段。结论 HCM患者左心室常规收缩功能参数可正常, 左心室心肌三维纵向应变、面积应变、径向应变减低, 可通过3D-STI进行检测, 不同类型HCM患者应变减低节段分布与肥厚部位有关。     

磁共振特征性追踪技术对肥厚型心肌病心肌应变的初步研究

目的采用心脏磁共振特征性追踪(cardiovascular magnetic resonance feature tracking,CMR-FT)技术对肥厚型心肌病患者的心功能及心肌节段应变进行分析,探讨CMR-FT对肥厚性心肌病患者早期运动异常检测的可行性。材料与方法对17例肥厚型心肌病患者及14名健康志愿者进行3.0 T SSFP电影序列扫描,使用CVI软件检测心功能,并对48个肥厚的心肌节段及健康志愿者中42个正常心肌节段进行特征性追踪(feature tracking,FT)后处理。结果肥厚型心肌病患者与健康志愿者左心功能参数(左心室舒张末期容积、左心室收缩末期容积及左心室射血分数)的差异无统计学意义(P均0.05),肥厚的心肌节段的圆周应变、长轴应变及峰值收缩期圆周应变、峰值收缩期长轴应变均低于正常的心肌节段[(-5.26±2.70)%vs(-11.68±2.06)%,(-7.92±5.07)%vs(-13.93±3.89)%,(-10.44±5.46)%vs(-18.43±2.99)%,(-12.29±8.17)%vs(-20.26±2.93)%,P均0.05]。结论对于心功能正常的肥厚性心肌病患者,CMR-FT技术能够早期检测出肥厚患者肥厚心肌节段应变的变化,提示心肌应变量的改变能够比左心室功能参数更早地发现心肌收缩功能异常。     

二维应变超声心动图评价大鼠急性心肌梗死模型局部心肌功能改变的应用价值

目的 探讨二维应变超声心动图定量评价大鼠急性心肌梗死模型左室局部心肌功能改变的应用价值.方法 60只Wistar大鼠随机分为两组:实验组50只,制备急性冠状动脉心肌梗死模型;假手术组10只.两组分别于术前及术后1周、4周、8周行超声心动图检查.解剖M型超声心动图测量左室舒张末期及收缩末期内径(LVIDd、LVIDs)、短轴缩短率(FS)、射血分数(EF)和左室质量(LVM).记录左室乳头肌短轴高帧频图像,应用二维应变分析软件测量各节段的收缩期峰值径向应变(PRS)、环向应变(PCS).实验组大鼠检查结束后处死,取出心脏行TTC染色并计算梗死面积;VG染色观察心肌组织中的胶原纤维.结果 根据TTC染色结果将实验组大鼠左窀分为梗死心肌、梗死周围和远处心肌.术后1周VG染色显示实验组大鼠左室各节段均出现不同程度的胶原纤维沉着.与术前及同时期假手术组相比,实验组大鼠于术后1周时梗死心肌、梗死周围及远处心肌的PRS、PCS均明显降低(P<0.01),并持续至第8周.与术后1周时相比,术后4周、8周实验组大鼠梗死心肌、梗死周围及远处心肌的PRS、PCS差异无统计学意义.实验组大鼠于术后4周和8周LVIDd、LVIDs及LVM明显增加,FS明显减低(P<0.05).二维应变测量组间及组内比较均具有高度一致性.结论 二维应变超声心动图可定量评价大鼠心肌梗死模型不同血供区域局部心肌的功能改变,为无创性跟踪心肌梗死后左室重构进程提供了一种敏感可行的方法.     

超声二维应变成像技术评价陈旧心肌梗死患者心肌存活的可行性

目的:探讨超声二维应变成像技术评价陈旧心肌梗死患者心肌存活的可行性。方法:72例准备接受血运重建术的陈旧心肌梗死患者,于术前1周行双核素心肌灌注与代谢扫描,以F-FDG代谢显像在18灌注减低节段内出现≥1分的改善视为存活心肌。同期应用二维应变成像技术检测左室短轴基底、中间及心尖各节段径向峰值应变(PRS)、圆周方向峰值应变(PCS),比较存活心肌组与非存活心肌组应变参数。结果:常规超声共检出运动异常节段258个,经同位素心肌灌注-代谢扫描诊断存活心肌节段数133个,坏死心肌节段数125个。对照组、存活心肌组的PRS和PCS均明显高于坏死心肌组(P<0.01);对照组与存活心肌组PCS无明显差异(P﹥0.05),对照组PRS明显高于显存活心肌组(P<0.01)。以峰值RS≥18.32%、峰值CS≤-10.54%为截断值,预测存活心肌敏感性分别为73.8%、75.6%,特异性分别为89.3%、85.6%,ROC曲线下面积分别为0.84和0.79。结论:超声二维应变成像技术预测存活心肌是可行的,为定量评估心肌梗死后存活心肌性提供了一种新的方法。     

心脏磁共振组织追踪技术评估冠心病心肌梗死的诊断价值

目的探讨心脏磁共振组织追踪技术(cardiovascular magnetic resonance tissue tracking technology,CMR-TT)与冠心病患者左心功能相关性及定量化评价心肌梗死的诊断价值。材料与方法对23例冠心病患者和16名健康志愿者进行3.0 T SSFP电影序列以及对比延迟增强扫描,用CVI42软件测量心功能,并使用组织追踪技术对左心室整体和节段的应变进行分析,得到心肌径向、周向、纵向三个方向CMR-TT 3D应变参数值。对上述参数值进行组间均值比较、组内相关系数(ICC)分析、Pearson相关性分析、Logistic回归模型、受试者工作特性(receiver operating characteristic,ROC)曲线分析。结果左心室整体径向应变(radial strain,RS)(ICC=0.944)、周向应变(circumferential strain,CS)(ICC=0.988)、纵向应变(longitudinal strain,LS)(ICC=0.987)均表现较好的可重复性。冠心病组左心室整体的径向应变、周向应变、纵向应变低于健康人组(30.35%±17.26%和45.46%±8.90%、-13.92%±5.7 7%和-1 9.3 4%±2.3 0%、-11.3 0%±4.7 5%和-1 6.5 4%±2.4 0%,P值均0.01)。左心室射血分数与径向应变呈强相关(r=0.774,P0.001),与周向应变呈强相关(r=0.778,P0.001),与纵向应变呈极强相关(r=0.802,P0.001)。冠心病组延迟强化(late gadolinium enhancement,LGE)阳性心肌节段径向应变、周向应变、纵向应变峰值低于LGE阴性心肌节段(9.95%和41.42%,-7.67%和-17.2%,-6.68%和-13.83%,P值均0.01)。心肌径向应变(AUC=0.914)、周向应变(AUC=0.911)在诊断心肌节段梗死中具有较高的诊断价值,纵向应变(AUC=0.819)具有一定的诊断价值;当心肌径向应变截断值为16.83%时,诊断准确度较高(Youden指数=0.7399);当周向应变截断值为-11.44%时,诊断准确度较高(Youden指数=0.7511);纵向应变在截断值为-9.41%时,诊断准确度较低(Youden指数=0.5552)。当使用径向应变和周向应变联合诊断冠心病心肌节段梗死时,AUC和特异度较各指标独立诊断时提高,在联合诊断时纵向应变无预测意义。结论心脏磁共振组织追踪技术在临床应用中具有较好的可行性及可重复性;径向应变、周向应变、纵向应变与冠心病左心室射血分数具有较强的相关性;径向应变、周向应变在诊断冠心病心肌节段梗死的诊断价值较高,纵向应变诊断价值有限。当使用径向应变和周向应变两项指标联合诊断时可提高诊断效能。这提示CMR-TT的应变分析在无需对比剂的情况下识别冠心病心肌梗死节段具有潜在的临床诊断价值。     

心脏磁共振T1Mapping定量分析重度主动脉瓣反流心肌纤维化程度的价值

【目的】探讨心脏磁共振(CMR)纵向弛豫时间定量(T1 mapping)技术评估重度主动脉瓣反流(AR)心肌纤维化程度的价值。【方法】选择2018年1月至2020年11月在本院进行CMR成像检查的28例重度AR患者(观察组),选择同期在本院行CMR检查,未发现器质性心脏病者为对照组。比较两组左心室心肌质量(LVMM)、左心室舒张末期容积指数(LVEDVi)、左心室收缩末期容积指数(LVESVi)、左心室每搏输出量容积指数(LVSVi)及左心室射血分数(LVEF)等结构、功能参数及心肌T1值、细胞外间质容积分数(ECV)值,并采用Pearson系数进行相关性分析。【结果】观察组LVEF低于对照组,LVEDVi、LVESVi、LVSVi、LVMM均高于对照组,差异有统计学意义(P<0.05)。延迟强化方面,观察组中有15例患者出现对比剂延迟增强(LGE),对照组中未发现LGE,组间差异有统计学意义(P<0.05)。左心室心肌纤维化方面,观察组初始T1值、ECV均高于对照组,增强后T1值低于对照组,差异有统计学意义(P<0.05)。Pearson相关系数分析显示,初始T1值、ECV值与LVEF呈负相关关系(r=-0.403、-0.400,均P<0.05);增强后T1值与LVEF无明显相关性(r=0.419,P=0.052>0.05)。【结论】CMR T1 mapping技术可反映重度AR患者心肌纤维化程度,且患者心肌纤维化程度与早期心脏重构和左心室收缩功能障碍相关。     

Predictors of left ventricular remodeling after ST-elevation myocardial infarction

Adverse left ventricular (LV) remodeling after acute ST-elevation myocardial infarction (STEMI) is associated with morbidity and mortality. We studied clinical, biochemical and angiographic determinants of LV end diastolic volume index (LVEDVi), end systolic volume index (LVESVi) and mass index (LVMi) as global LV remodeling parameters 4 months after STEMI, as well as end diastolic wall thickness (EDWT) and end systolic wall thickness (ESWT) of the non-infarcted myocardium, as compensatory remote LV remodeling parameters. Data was collected in 271 patients participating in the GIPS-III trial, presenting with a first STEMI. Laboratory measures were collected at baseline, 2 weeks, and 6–8 weeks. Cardiovascular magnetic resonance imaging (CMR) was performed 4 months after STEMI. Linear regression analyses were performed to determine predictors. At baseline, patients were 21% female, median age was 58 years. At 4 months, mean LV ejection fraction (LVEF) was 54?±?9%, mean infarct size was 9.0?±?7.9% of LVM. Strongest univariate predictors (all p?<?0.001) were peak Troponin T for LVEDVi (R²?=?0.26), peak CK-MB for LVESVi (R²?=?0.41), NT-proBNP at 2 weeks for LVMi (R²?=?0.24), body surface area for EDWT (R²?=?0.32), and weight for ESWT (R²?=?0.29). After multivariable analysis, cardiac biomarkers remained the strongest predictors of LVMi, LVEDVi and LVESVi. NT-proBNP but none of the acute cardiac injury biomarkers were associated with remote LV wall thickness. Our analyses illustrate the value of cardiac specific biochemical biomarkers in predicting global LV remodeling after STEMI. We found no evidence for a hypertrophic response of the non-infarcted myocardium.     

三维斑点追踪成像技术评价房间隔缺损患者封堵前后左心室整体应变

目的 探讨三维斑点追踪成像（3D-STI）技术定量评价房间隔缺损（ASD）患者封堵前后左心室整体应变。方法 选取介入封堵成功的继发孔型ASD患者35例,分别于术前、术后2天和1、3、6个月接受常规超声心动图检查及3D-STI检查。常规超声心动图检查获取左心室舒张末期内径（LVEDD）、左心室收缩末期内径（LVEDS）、左心室舒张末期容积（LVEDV）,左心室收缩末期容积（LVESV）、每搏量（SV）。采用3D-STI检查获取左心室整体纵向峰值应变（GPLS）、左心室整体圆周峰值应变（GPCS）、左心室整体径向峰值应变（GPRS）和左心室整体面积峰值应变（GPAS）。对术前与术后各时间点参数行统计学分析。结果 常规超声心动图检查示ASD患者术后各时间点LVEDD、LVEDS、LVEDV、LVESV、SV较术前增加（P均<0.05）,但术后2天、1、3、6个月间两两比较,差异无统计学意义（P>0.05）。3D-STI检查结果示ASD患者术后各时间点左心室GPLS、GPCS、GPRS、GPAS较术前增加（P均< 0.05）,且以术后2天增加最为明显,术后6个月GPLS、GPCS、GPAS较术后3个月增加（P均< 0.05）。结论 3D-STI技术可全面、准确地评价ASD患者封堵前后左心室心肌应变,较常规超声心动图可更客观、有效地评价术后左心室收缩功能变化。     

The role of left ventricular deformation in the assessment of microvascular obstruction and intramyocardial haemorrhage

In the setting of acute ST-elevation myocardial infarction (STEMI), it remains unclear which strain parameter most strongly correlates with microvascular obstruction (MVO) or intramyocardial haemorrhage (IMH). We aimed to investigate the association of MVO, IMH and convalescent left ventricular (LV) remodelling with strain parameters measured with cardiovascular magnetic resonance (CMR). Forty-three patients with reperfused STEMI and 10 age and gender matched healthy controls underwent CMR within 3-days and at 3-months following reperfused STEMI. Cine, T2-weighted, T2*-imaging and late gadolinium enhancement (LGE) imaging were performed. Infarct size, MVO and IMH were quantified. Peak global longitudinal strain (GLS), global radial strain (GRS), global circumferential strain (GCS) and their strain rates were derived by feature tracking analysis of LV short-axis, 4-chamber and 2-chamber cines. All 43 patients and ten controls completed the baseline scan and 34 patients completed 3-month scans. In multivariate regression, GLS demonstrated the strongest association with MVO or IMH (beta?=?0.53, p?<?0.001). The optimal cut-off value for GLS was ?13.7% for the detection of MVO or IMH (sensitivity 76% and specificity 77.8%). At follow up, 17% (n?=?6) of patients had adverse LV remodeling (defined as an absolute increase of LV end-diastolic/end-systolic volumes >20%). Baseline GLS also demonstrated the strongest diagnostic performance in predicting adverse LV remodelling (AUC?=?0.79; 95% CI 0.60–0.98; p?=?0.03). Post-reperfused STEMI, baseline GLS was most closely associated with the presence of MVO or IMH. Baseline GLS was more strongly associated with adverse LV remodelling than other CMR parameters.     

Factors associated with microvascular occlusion in patients with ST elevation myocardial infarction after primary percutaneous coronary intervention

ObjectiveThis study aimed to determine predictors of microvascular occlusion (MVO) in patients with ST elevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (pPCI).MethodsThis retrospective, observational study consecutively included 113 patients with STEMI undergoing pPCI. Cardiac magnetic resonance imaging was used to determine the presence of MVO in these patients. Biomarkers in serum were routinely tested 1 day after pPCI. Multivariable logistic regression analysis was used to evaluate significant predictors of occurrence of MVO.ResultsThere were 62 patients in the MVO group and 51 patients in the non-MVO group. C-reactive protein (CRP), thrombomodulin, lymphatic vessel endothelial hyaluronan receptor-1, syndecan-1, and troponin T (TnT) levels after the procedure were significantly higher in the MVO group than in the non-MVO group. CRP (hazard ratio [HR]=1.036), TnT (HR=1.316), and syndecan-1 (HR=1.986) levels were independently associated with MVO in patients with acute myocardial infarction after pPCI.ConclusionsLevels of CRP, TnT, and syndecan-1 can be used as serum biomarkers for MVO in patients with STEMI receiving pPCI.     

Impact of transmural necrosis on left ventricular remodeling and clinical outcomes in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction

We sought to determine which contrast-enhanced magnetic resonance imaging (CE-MRI) parameter is the best predictor for left ventricular (LV) remodeling and clinical outcomes after ST-segment elevation myocardial infarction (STEMI). In 135 patients undergoing primary percutaneous coronary intervention (PCI) for STEMI, CE-MRI was performed at a median of 7 days after PCI. Echocardiography was performed soon after PCI and at a follow-up visit. LV remodeling was defined as an increase in end-diastolic volume index ≥20 % on follow-up echocardiography. Several CE-MRI parameters such as infarct size, transmurality, microvascular obstruction (MVO), and hemorrhagic infarction were tested using a 17-myocardial segment model. Optimal cut-off values were derived from receiver-operating characteristic curve (ROC) analysis. Twenty-eight patients (21 %) demonstrated LV remodeling. Although the addition of transmural necrotic segment count, infarct size, and MVO segment count to clinical models improved the prediction of LV remodeling in multivariable regression analysis, transmural necrotic segment count had better incremental predictive value than other CE-MRI parameters. The aggregate consideration of infarct size (cut-off ≥25 %), transmural necrotic segment count (≥5), and MVO segment count (≥2) yielded better diagnostic performance than each of the individual parameters in ROC analysis (P < 0.01). In Kaplan–Meier curve analysis, patients with transmural necrotic segment counts ≥5 had a higher incidence of major adverse cardiac event than did those without. The transmural necrotic segment count is the most important predictor of LV remodeling and clinical outcomes. The combination of CE-MRI parameters including infarct size, transmural necrotic segment count, and MVO segment count appeared to increase reliability for predicting LV remodeling.