经阴道超声诊断深部浸润型子宫内膜异位症的临床价值分析

目的:探讨深部浸润型子宫内膜异位症(DIE)应用经阴道超声(TVS)诊断的临床价值。方法:选取2017年10月—2020年11月本院收治的80例DIE患者为研究对象,所有患者术前均接受TVS检查,并将检查结果与病理诊断结果相比,分析TVS诊断DIE的检出率及对累及组织检查的敏感度、特异度、阳性预测值、阴性预测值。结果:术后病理诊断结果为80例均为DIE,其中23例累及宫骶韧带,21例累及阴道直肠隔,26例累及子宫直肠陷窝,6例累及直肠,4例累及阴道。TVS诊断结果为73例为DIE,检出率为91.25%,其中22例累及宫骶韧带,18例累及阴道直肠隔,24例累及子宫直肠陷窝,5例累及直肠,4例累及阴道。TVS诊断DIE与术后病理诊断结果具有较高一致性(P<0.05)。TVS诊断DIE阴道直肠隔、宫骶韧带、子宫直肠陷窝、直肠、阴道等不同受累位置的敏感度、特异度、阳性预测值、阴性预测值分别为85.71%、88.14%、81.82%、89.66%;95.65%、91.23%、91.67%、92.86%;92.31%、92.59%、85.71%、96.15%;83.33%、93.24%、71.43%、94.52%;100.00%、85.53%、100.00%、85.53%,诊断效能较为理想。结论:TVS诊断DIE有较高检出率,且能够对病灶位置进行准确定位,有效反映患者病变累及状况,具有较高应用价值。     

子宫骶韧带深部内膜异位症的超声诊断

目的:探讨经阴道超声对子宫骶韧带深部内膜异位症的诊断价值并分析总结其超声图像特征。方法:选取我院2018年10月—2020年6月收治的110例经病理证实为深部浸润型子宫内膜异位症(Deep infiltrated endometriosis,DIE)患者作为研究对象。收集所有患者的手术病理结果、超声图像、临床资料等,分析经阴道超声对骶韧带深部内膜异位的诊断价值,并总结超声图像特征。结果:110例患者中,经手术及病理证实骶韧带受累的54例,双侧累及25例,单侧累及29例(左侧19例,右侧10例),合并卵巢囊肿占56%(30/54);超声图像发现骶韧带受累42例,合并卵巢囊肿占64%(27/54);经阴道超声诊断子宫骶韧带D I E的灵敏度、特异度、阳性预测值和阴性预测值分别是78%、84%、82%、80%。子宫骶韧带DIE患者的超声图像主要表现为骶韧带部位回声减低、增厚,19例患者超声图像可见宫颈两侧骶韧带部位结节状或条索状的低回声,内可有小囊性暗区,边缘规则或不规则;彩色多普勒血流成像(color Doppler flow imaging,CDFI)显示未及明显血流信号。结论:DIE中骶韧带受累的超声图像具有一些特征的表现;阴道超声在骶韧带子宫内膜深部浸润中具有很好的诊断价值。     

三维能量多普勒超声检测宫颈高级别鳞状上皮病变

目的 前瞻性研究三维能量多普勒超声（3D PDUS）检测宫颈高级别鳞状上皮内病变（HSIL）的临床价值。方法 收集120例疑似宫颈病变患者,排除宫颈有明显肿块者。对所有患者均行二维常规经阴道超声和3D PDUS检查,对照病理学结果进行分析。采用4D view VOCAL软件获得宫颈三维血管参数,包括血管化指数（VI）、血流指数（FI）及血管化血流指数（VFI）。以病理结果为金标准,采用ROC曲线分析3D PDUS诊断HSIL的敏感度和特异度,并计算曲线下面积。结果 120例中,病理证实HSIL患者59例,二维超声诊断12例,3D PDUS诊断36例。HSIL患者的三维血管参数均高于宫颈良性病变患者,差异均有统计学意义（P均<0.05）。二维超声诊断HSIL的敏感度和特异度分别为20.33%（12/59）、75.40%（46/61）,3D PDUS诊断HSIL的敏感度和特异度分别为61.01%（36/59）、81.96%（50/61）。ROC曲线分析显示当VI为3.38时,曲线下面积为0.883,特异度和敏感度分别为68.0%和72.9%,当FI为32.18时,曲线下面积为0.723,特异度和敏感度分别为68.2%和76.3%,当VFI为1.18时,曲线下面积为0.888,特异度和敏感度分别95.5%和72.9%。结论 VFI可用于临床早期鉴别宫颈HSIL。     

高频超声诊断小儿原发性小肠淋巴管扩张症

目的 探讨高频超声诊断小儿原发性小肠淋巴管扩张症（PIL）的价值。方法 回顾性分析20例临床诊断PIL患儿，均接受腹部高频超声检查，13例并接受组织病理学检查，计算超声诊断PIL的准确率、敏感度、特异度、阳性预测值和阴性预测值。结果 高频超声诊断PIL的准确率、敏感度、特异度、阳性预测值和阴性预测值分别为80.00%（16/20）、92.31%（12/13）、57.14%（4/7）、80.00%（12/15）和80.00%（4/5）。结论 高频超声可较准确地在肠壁增厚患儿中筛查出PIL。     

经直肠腔内超声弹性成像术前评价T4期直肠癌

目的 评价弹性成像技术术前评价T4期直肠癌的能力。方法 应用经直肠腔内超声对经病理证实的直肠癌患者进行检查,对超声诊断为UT3期及UT4期的45例患者应用弹性成像技术再次分期,并分别与术后病理T分期进行对照。结果 常规经直肠腔内超声与应用弹性成像技术对T4分期的诊断准确率分别为75.56%（34/45）、86.67%（39/45）,敏感度分别为64.29%（9/14）、78.57%（11/14）,特异度分别为80.65%（25/31）,90.32%（28/31）,二者的敏感度和特异度差异无统计学意义。UT分期、弹性成像分期与病理一致性检验的Kappa值分别0.441和0.689。结论 术前评价T4期直肠癌时,弹性成像与病理结果的一致性好,有助于T4期患者术前分期。     

经会阴实时三维超声评估不同术式治疗中盆腔脱垂疗效

目的 探讨经会阴实时三维超声定量分析评价经阴道单侧骶棘韧带悬吊术、双侧骶棘韧带悬吊术及采用网片的双侧骶棘韧带吊带固定术治疗重度中盆腔器官脱垂效果的价值。方法 回顾性分析96例接受手术治疗的中盆腔脱垂Ⅲ度及以上患者,根据术式分为经阴道单侧骶棘韧带悬吊术组（A组,n=23）、双侧骶棘韧带悬吊术组（B组,n=34）和采用网片的双侧骶棘韧带吊带固定术组（C组,n=39）。于术后1、3、6个月以经会阴实时三维超声测量宫颈外口最低点距耻骨联合后下缘距离（CVD）和肛提肌裂孔面积（ALH）,计算并比较术后6个月复发率。结果 A组术后3、6个月CVD较术后1个月减低（P=0.005、0.012）;术后6个月ALH较术后3个月增加（P=0.002）。B组术后6个月CVD、ALH与术后3个月差异有统计学意义（P=0.014、0.007）。C组术后6个月ALH与术后1个月差异有统计学意义（P=0.009）。术后6个月,A、B、C组的复发率分别为13.04%（3/23）、8.82%（3/34）和2.56%（1/39）,C组低于A和B组（P均<0.017）。结论 采用网片的双侧骶棘韧带吊带固定术治疗中盆腔脱垂术后稳定性好、复发率低;经会阴实时三维超声可直观、准确评估手术疗效。     

实时三维经食管超声心动图诊断二尖瓣乳头肌断裂

目的 探讨实时三维经食管超声心动图（RT-3D-TEE）诊断二尖瓣乳头肌断裂（PMR）的临床价值。方法 回顾性分析35例疑诊二尖瓣PMR患者,术前以经胸超声心动图（TTE）及RT-3D-TEE观察二尖瓣病变情况及是否合并PMR。以手术结果为金标准,计算术前RT-3D-TEE和TTE诊断二尖瓣PMR的效能。结果 35例中,25例术中证实为二尖瓣PMR,包括前外侧PMR 2例,后内侧PMR 23例;完全型PMR 1例,部分型PMR 24例。10例为非二尖瓣PMR。对23例行二尖瓣位人工瓣膜置换术,2例行二尖瓣成形术。术前RT-3D-TEE诊断二尖瓣PMR 23例,TTE诊断PMR 20例,RT-3D-TEE诊断二尖瓣PMR符合率[92.00%（23/25）]高于TTE[80.00%（20/25）,P=0.033]。RT-3D-TEE诊断PMR的敏感度、特异度、准确率、阳性预测值、阴性预测值和约登指数分别为92.00%（23/25）、100%（10/10）、94.29%（33/35）、100%（23/23）、83.33%（10/12）和0.92;术前TTE诊断二尖瓣PMR的敏感度、特异度、准确率、阳性预测值、阴性预测值及约登指数分别为80.00%（20/25）、90.00%（9/10）、82.86%（29/35）、95.24%（20/21）、64.29%（9/14）及0.70。结论 RT-3D-TEE可从不同角度和层面准确提供二尖瓣解剖及病理改变的超声特征,是确诊二尖瓣PMR的有效方法,可为术前诊断、术中监测及术后评估提供可靠信息。     

彩色多普勒超声诊断中弓韧带压迫综合征

目的 探讨彩色多普勒超声诊断中弓韧带压迫综合征（MALS）的价值。方法 采用彩色多普勒超声对41例腹痛患者的腹腔动脉进行筛查,观察腹腔干起始段走行、管腔内径,再分别测量起始段狭窄处平静状态、深吸气末、深呼气末收缩期峰值速度（PSV_calm、PSV_insp、PSV_exp）,并计算深呼气末与深吸气末血流速度变化率（流速变化率）。对照组为100例接受腹部超声检查的无腹痛患者,分别测量上述各参数,比较MALS患者（MALS组）和对照组各参数的差异。以CTA结果为金标准,构建ROC曲线分析PSV_exp、流速变化率以及两者联合诊断MALS的价值。结果 彩色多普勒超声共检出20例MALS,CTA检出19例。超声诊断MALS的敏感度为89.47%（17/19）、特异度为86.36%（19/22）、准确率为87.80%（36/41）、阳性预测值为85.00%（17/20）。MALS组腹腔干起始段血流峰值速度及流速变化率明显高于对照组（P均<0.01）。PSV_exp、流速变化率的ROC曲线下面积分别为0.936、0.920（P<0.01）。以PSV_exp=330 cm/s为阈值,诊断MALS的敏感度和特异度分别为85.7%和90.9%。当流速变化率=120%时,诊断MALS的敏感度和特异度分别为87.7%和89.4%。结论 彩色多普勒超声可清晰显示腹腔干狭窄的部位、狭窄程度;将PSV_Exp≥330 cm/s或流速变化率≥120%或两者联合作为超声参考指标评估MALS,均有较高的诊断价值,且两者联合诊断的特异度最高。     

乳腺可视化触诊成像系统鉴别诊断乳腺良恶性病变：与临床触诊、X线及超声对照

目的 探讨乳腺可视化触诊成像系统对乳腺病灶良恶性病变的鉴别诊断价值。方法 对169例乳腺病变患者（共195个病灶）行触诊成像、临床触诊和X线,对其中151例行超声检查。比较以上4种方法鉴别乳腺良恶性病变的敏感度、特异度,评估各方法对不同腺体类型乳腺病灶的诊断价值。结果 触诊成像对良恶性病灶的诊断敏感度为82.40%,特异度为80.00%,敏感度高于临床触诊（60/125,48.00%,P<0.001）但低于X线（117/125,93.60%,P=0.003）及超声（105/110,95.45%,P<0.001）,特异度高于X线（39/70,55.71%,P=0.002）及超声（38/61,62.29%,P=0.023）。对于不同腺体类型的乳腺,触诊成像鉴别良恶性病灶的敏感度和特异度变化不大。结论 触诊成像对于鉴别乳腺良恶性病灶具有较高的应用价值,有望成为现有乳腺检查技术的补充。     

CT浆膜高强化征鉴别诊断T3期与T4a期胃癌

目的 探讨CT所示浆膜高强化征鉴别诊断T3期与T4a期胃癌的价值。方法 回顾性分析104例经手术病理证实的胃癌T3期或T4a期患者术前腹部三期增强扫描CT图像,观察并比较各期图像浆膜高强化征的出现率。以出现浆膜高强化征为诊断T4a期的标准,计算浆膜高强化征诊断T4a期胃癌的准确率、敏感度、特异度、阳性预测值和阴性预测值。结果 104例胃癌患者中,T3期34例,T4a期70例。浆膜高强化征判断T4a期胃癌的准确率、敏感度、特异度、阳性预测值及阴性预测值分别为77.88%（81/104）、81.43%（57/70）、70.59%（24/34）、85.07%（57/67）及64.86%（24/37）。T4a期胃癌动脉期、静脉期及实质期浆膜高强化征出现率分别为32.86%（23/70）、75.71%（53/70）、62.86%（44/70）,动脉期与静脉期（P<0.001）、动脉期与实质期（P=0.001）间差异有统计学意义,静脉期与实质期之间差异无统计学意义（P=0.143）。结论 浆膜高强化征诊断胃癌T4a期具有较高准确率、敏感度及特异度,可用于判断胃癌浆膜受侵,推荐在静脉期或实质期观察该征象。     

Accuracy of rectal endoscopic ultrasonography and magnetic resonance imaging in the diagnosis of rectal involvement for patients presenting with deeply infiltrating endometriosis.

OBJECTIVE: To compare the accuracy of rectal endoscopic ultrasonography (REU) and magnetic resonance imaging (MRI) for predicting rectal wall involvement in patients presenting histologically proven deeply infiltrating endometriosis (DIE). METHODS: This was a retrospective study of a continuous series of 81 patients presenting histologically proven DIE who underwent preoperative investigations using both REU and MRI. The sonographer and the radiologist, who were unaware of the clinical findings and patient history, but knew that DIE was suspected, were asked whether there was involvement of the digestive wall. RESULTS: Rectal DIE was confirmed histologically in 34 of the 81 (42%) patients. For the diagnosis of rectal involvement, sensitivity, specificity and positive and negative predictive value for REU were 97.1%, 89.4%, 86.8% and 97.7% and for MRI they were 76.5%, 97.9%, 96.3% and 85.2%. CONCLUSION: The sensitivity and negative predictive value of REU were higher than those of MRI suggesting that REU performs better than MRI in the diagnosis of rectal involvement for patients presenting with DIE. Prospective studies with a large number of patients are needed in order to validate these preliminary results.     

Value of endorectal ultrasonography for diagnosing rectovaginal septal endometriosis infiltrating the rectum

BACKGROUND AND STUDY AIMS: Rectovaginal septal endometriosis (RVSE) can pose serious therapeutic problems when there is infiltration of the rectal septum (which occurs in approximately half of the cases). The aim of this study was to assess the value of endoscopic ultrasonography in diagnosing rectal wall involvement by pelvic endometriosis. PATIENTS AND METHODS: A prospective study was carried out from May 1998 to March 2003 at a single hospital center. The 30 patients included in the study presented with suspected RVSE and underwent systematic anorectal endoscopic ultrasonographic exploration prior to the surgical intervention. The endoscopic ultrasonography was carried out under general anesthesia with a 7.5-MHz miniprobe equipped with a distal balloon. RESULTS: The anorectal endoscopic ultrasonographic examination (EUS) showed the presence of endometriosis in the rectovaginal septum in 26 patients (88 %), in the uterosacral ligaments in 10 patients (33 %), and in the ovaries in two patients (6 %). At EUS, the nodules were infiltrating the rectal wall in 17 patients (56 %). The surgical exploration demonstrated endometriosis in the rectovaginal septum in 26 cases, the uterosacral ligaments in 22 cases, and the ovaries in 16 cases. The rectal wall was completely infiltrated in 12 cases and only partly in four cases, and intestinal tract resection was required in 10 cases. The sensitivity, specificity, and positive and negative predictive value of anorectal endoscopic ultrasonography as a means of diagnosing endometriosis of the rectovaginal septum and infiltration of the rectal wall were found to be 96 %, 100 %, 100 % and 83 %, and 92 %, 66 %, 64 % and 92 %, respectively; and the diagnostic accuracy was at 96 % and 80 %, respectively. The sensitivity for detecting nodules in the uterosacral ligaments or in the ovaries was 42 % and 14 %, respectively, leading to diagnostic accuracy rates of 56 % and 53 %. CONCLUSIONS: In terms of its sensitivity and its negative predictive value, anorectal endoscopic ultrasonography is a very effective means of detecting endometriosis of the rectovaginal septum and assessing possible infiltration of the rectal wall. However, this method is not as accurate for nodules located far from the EUS probe, as is the case with the uterosacral ligaments and ovaries.     

Accuracy of transvaginal sonography and rectal endoscopic sonography in the diagnosis of deep infiltrating endometriosis.

OBJECTIVES: To compare the accuracy of transvaginal sonography (TVS) and rectal endoscopic sonography (RES) for the diagnosis of deep infiltrating endometriosis (DIE), with respect to surgical and histological findings. METHODS: This was a longitudinal study of 81 consecutive patients referred for surgical management of DIE, who underwent both TVS and RES preoperatively. The diagnostic criteria were identical for TVS and RES, and were based on visualization of hypoechoic areas in specific locations (uterosacral ligaments, vagina, rectovaginal septum and intestine). We calculated the sensitivity, specificity, predictive values and accuracy of TVS and RES for the diagnosis of DIE. RESULTS: Endometriosis was confirmed histologically in 80/81 (98.7%) patients. Endometriomas and DIE were present in 43.2% and 97.5% of the women, respectively. For the diagnosis of DIE overall, TVS and RES, respectively, had a sensitivity of 87.3% and 74.7%, a positive predictive value of 98.6% and 98.3%, and an accuracy of 86.4% and 74%. For the diagnosis of uterosacral endometriosis, they had a sensitivity of 80.8% and 46.6%, a specificity of 75% and 50.0%, a positive predictive value of 96.7% and 89.5% and a negative predictive value of 30% and 9.3%. For the diagnosis of intestinal endometriosis, they had a sensitivity of 92.6% and 88.9%, a specificity of 100% and 92.6%, a positive predictive value of 100% and 96% and a negative predictive value of 87% and 80.6%. CONCLUSION: TVS is apparently more accurate than is RES for predicting DIE in specific locations, and should thus be the first-line imaging technique in this setting.     

耦合剂充盈法腔内超声对直肠癌术前T分期的诊断价值

目的 评价耦合剂充盈法腔内超声在直肠癌术前T分期诊断中的价值.方法 对115例直肠癌患者行耦合剂充盈法腔内超声检查,进行术前T分期,并与手术及术后病理分期对照.结果 115例直肠癌术前T分期诊断总符合率89.57%,T1、T2、T3、T4期诊断灵敏度和特异度分别为93.10%、61.11%、96.61%、88.89%和97.67%、96.91%、89.29%、99.06%;过度判断6.96%(8/115),判断不足3.48%(4/115).结论 耦合剂充盈法腔内超声在直肠癌术前T分期诊断中有重要价值.     

Diagnostic accuracy of transvaginal sonography for deep pelvic endometriosis.

OBJECTIVE: To determine the accuracy of transvaginal sonography (TVS) for the diagnosis of deep pelvic endometriosis. METHODS: In a prospective study, 142 women with clinical signs of endometriosis underwent TVS followed by surgical and histopathological investigations. The presence and extent of endometriosis involving the uterosacral ligaments, vagina, rectovaginal septum, intestines, bladder and ovaries shown by TVS were compared with surgical and histological findings. The sensitivity, specificity, predictive values and accuracy of TVS for predicting deep pelvic endometriosis were assessed. RESULTS: Ovarian and deep pelvic endometriosis were found by surgery and histology in respectively 83 (58.5%) and 79 (55.6%) of the 142 patients. The sensitivity, specificity, and positive and negative predictive values of TVS for the diagnosis of deep pelvic endometriosis were 78.5%, 95.2%, 95.4% and 77.9%, respectively. The sensitivity and specificity of TVS for endometriotic involvement of the uterosacral ligaments, vagina, rectovaginal septum and intestines were 70.6% and 95.9%, 29.4% and 100%, 28.6% and 99.3%, and 87.2% and 96.8%, respectively. The sensitivity and specificity of TVS for bladder involvement were 71.4% and 100%, respectively. CONCLUSION: TVS accurately diagnoses intestinal and bladder endometriosis, but is less accurate for uterosacral, vaginal and rectovaginal septum involvement.     

不同超声检查对直肠乙状结肠深部浸润型子宫内膜异位症诊断价值的Meta分析

目的 采用Meta分析评价经阴道增强超声（E-TVS）、经阴道超声（TVS）、经直肠超声（TRS）对直肠乙状结肠深部浸润型子宫内膜异位症的诊断价值。方法 检索1990年1月-2016年6月关于E-TVS、TVS、TRS诊断直肠乙状结肠深部浸润型子宫内膜异位症（DIE）的中英文文献,提取纳入研究的信息,采用Meta-disc 1.4软件对研究数据进行统计学分析。结果 共纳入25篇英文文献。E-TVS的敏感度、特异度、阳性似然比、阴性似然比、诊断性比值比分别为0.92、0.96、16.64、0.09、227.95;TVS为0.83、0.97、16.95、0.17、112.97;TRS为0.94、0.96、14.43、0.08、208.72。3组SROC曲线下面积分别为0.9804、0.9663、0.9790。结论 3种超声检查方法对直肠乙状结肠DIE的诊断价值由高至低依次为E-TVS、TRS、TVS。E-TVS可作为超声诊断直肠乙状结肠DIE的首选方法。     

滋养层血流频谱作为早期宫内妊娠诊断指标的探讨

目的 探讨以滋养层血流频谱作为诊断指标,诊断早期宫内妊娠（IUP）的临床应用价值。方法 对196例疑诊早期IUP的孕妇行超声检查,分析常规二维声像图表现、血流分布及频谱特征;并将超声检查结果与临床随访及病理结果进行对照分析。结果 对76例单纯以滋养层血流频谱诊断为早期IUP（单纯频谱组）,对120例采用滋养层血流频谱联合宫内液性暗区诊断为早期IUP（频谱联合暗区组）,2组间滋养层血流收缩期峰值流速（PSV）、舒张末期峰值流速（EDV）、阻力指数（RI）、最大收缩期速度/舒张末期速度（S/D）比值及搏动指数（PI）差异均无统计学意义（P均>0.05）。孕龄与滋养层血流的PSV（r=0.697,P<0.001）、EDV（r=0.675,P<0.001）均呈正相关,与RI（r=-0.422,P=0.023）、S/D比值（r=-0.303,P=0.030）及PI（r=-0.278,P=0.037）均呈负相关。单纯以滋养层血流频谱诊断早期IUP的敏感度、特异度、阳性预测值、阴性预测值及准确率分别为84.62%（55/65）、72.73%（8/11）、94.83%（55/58）、44.44%（8/18）及82.89%（63/76）,采用滋养层血流频谱联合宫内液性暗区诊断的敏感度、特异度、阳性预测值、阴性预测值及准确率均为100%,诊断效能指标差异均有统计学意义（P均<0.05）。结论 滋养层血流频谱可用于诊断早期IUP,且与宫内液性暗区联合诊断的敏感度、特异度、阳性预测值、阴性预测值及准确率更高。     

超声造影诊断直肠癌前哨淋巴结

目的 探讨CEUS在直肠癌前哨淋巴结(SLN)诊断中的价值。方法 46例直肠癌患者中,选取接受直肠癌手术,且术中CEUS定位检测SLN的患者42例,观察SLN增强情况。术后常规病理学检测所有淋巴结,并与CEUS结果比较。结果 CEUS对SLN的检出率为91.30%(42/46),CEUS判定直肠癌SLN的敏感度87.50%(21/24)、特异度90.47%(38/42)、准确率89.39%(59/66)。结论 CEUS定位直肠癌SLN具有较好的效果,且增强方式可初步判断其是否发生转移,具有一定的临床应用价值。     

Diagnostic performance of magnetic resonance to assess treatment response after neoadjuvant therapy in patients with locally advanced rectal cancer

Purpose

Our study aimed to evaluate the diagnostic performance of rectal magnetic resonance imaging (MRI) for local restaging in patients with non-metastatic locally advanced rectal cancer (LARC) after neoadjuvant chemoradiotherapy (CRT) using surgical histopathology of total mesorectal excision as the reference standard.

Methods

Ninety-five patients with LARC who underwent rectal MRI after CRT between January 2014 and December 2016 were included. Accuracy, sensitivity, specificity, positive, and negative predictive value for local staging regarding T-stage, N-stage, circumferential resection margin, and MRI tumor regression grade (ymriTRG) were calculated, and inter-test agreements were assessed.

Results

22/95 (23.2%) patients had radiological complete response (rCR), whereas 20/95 (21.1%) had pathological complete response (pCR). Among the patients with pCR, 11/20 (55%) had rCR. Fair agreement was demonstrated between ymriTRG and pathological TRG (ypTRG) (κ = 0.255). The sensitivity and specificity for detection of pCR were 61.1% (95% CI 35.7–82.7) and 89.6% (95% CI 80.6–95.4). For the detection of ypTRG grades 1 and 2, the corresponding values were 67.2% (95% CI 54.3–78.4) and 51.6 (95% CI 33.1–69.8). The accuracy of ymriTRG was 24.2% (95% CI 15.6–32.8). Inter-test agreement in TRG between MRI and pathology was overall fair (κ = 0.255) and slight (κ = 0.179), if TRG 1 + 2.

Conclusion

Qualitative assessment on MRI for diagnosing pCR showed moderate sensitivity and high specificity, whereas the diagnosis of TRG had moderate sensitivity and low specificity with slight to fair inter-test agreement when compared with pathological specimens.