粒细胞肉瘤18例临床分析

目的探讨粒细胞肉瘤患者的临床特点、治疗方法和预后。方法回顾性分析18例粒细胞肉瘤患者临床特点、治疗方法,并进行随访,应用Kaplan-Meier法行生存分析和Log-Rank检验行差异显著性检验。结果 18例粒细胞肉瘤患者中男10例,女8例,中位年龄40岁。好发部位为椎管、淋巴结、乳腺、骨、鼻腔、眼眶等。18例粒细胞肉瘤3年总生存率12.1%,化疗与不化疗患者的3年生存率比较差异有统计学意义(P=0.001),单独化疗与放化疗结合的3年生存期比较差别无统计学意义(P=0.263),合并CML和MDS-RAEB的患者3年生存期与其他患者无明显差异(P0.05)。结论粒细胞肉瘤应早期诊断,及时化疗,局部放疗不能提高生存率。     

宫颈粒细胞肉瘤临床病理分析

目的探讨宫颈粒细胞肉瘤的临床病理学特征、诊断及鉴别诊断。方法对1例宫颈粒细胞肉瘤进行光镜观察及免疫组化检测,结合文献进行分析。结果患者42岁,因月经淋漓不净10天就诊,体检见宫颈膨大,直径约6.0cm,质地硬脆易出血,活检显示肿瘤细胞弥漫分布,在宫颈腺体间浸润性生长,瘤细胞小至中等大小,胞质少,核圆形、椭圆形,核分裂易见,肿瘤细胞间偶见未成熟嗜酸性粒细胞。免疫组化瘤细胞表达MPO、CD43、CD68、CD45。骨髓及外周血无急性髓细胞白血病（AML）表现。结论宫颈粒细胞肉瘤十分罕见,形态上易与其他小细胞肿瘤混淆,免疫组化有助于诊断与鉴别诊断。粒细胞肉瘤恶性度高,预后差。     

乳腺孤立性粒细胞肉瘤1例并文献复习

粒细胞肉瘤（granulocytic sarcoma，GS）是急性粒细胞白血病肿瘤样增生的一种特殊类型，是一种由未成熟粒细胞形成的髓外肿瘤，临床上非常少见。而外周血和骨髓均无白血病表现的所谓孤立性粒细胞瘤（isolated granulocytic sarcoma）极为罕见，原发于乳腺者更为罕见，临床医生对此认识不足，常造成误诊、误治。本文报道1例，并就孤立性GS的临床特点、诊断和治疗策略进行文献复习。     

宫颈原发性粒细胞肉瘤:病例报告并文献复习

目的:提高对原发性宫颈粒细胞肉瘤(PGSC)诊断的认识,提出治疗的新思路。方法:报道我院确诊的1例PGSC,搜集近10年国内外报道的PGSC病例进行临床和病理分析。结果:13例PGSC以阴道不规则流血为主要临床表现,需免疫组化确诊,治疗上多采用联合化疗。结论:免疫组化对PGSC早期诊断极为重要,全身强烈化疗可延长生存期,及早鞘内注射可预防中枢神经系统白血病。     

急性粒细胞性白血病并发网状细胞肉瘤1例报告

1病例 患，女，24岁。左领下发现一桂元大肿物半年余，明显增大并持续性发热、头痛、咳嗽1月。上述症状加重并全身散在性出血点1周入院。查体：T39.7℃，全身皮肤有散在性出血点，两颌下淋巴结肿大，右侧为3×3cm大小，左侧为1．5×1.5cm大小，颈部、腋下、腹股沟处广布肿大的淋巴结，无活动及明显压痛，心肺(一)，肝肋下1.5cm，睥肋下4.5cm大，质中等，胸骨柄压痛明显。     

慢性粒细胞性白血病伴粒细胞肉瘤1例

粒细胞肉瘤(granulocyticsarcoma,GS)是一种罕见的发生于髓外由未成熟髓系细胞构成的实体瘤,又称为绿色瘤.为提高对本病的认识,现将瑞金医院血液科2009年4月10日收治的1例慢性粒细胞性白血病(chronic myelogenous leukemia,CML)伴GS患者的临床资料分析总结如下.     

急性早幼粒细胞白血病并发粒细胞肉瘤1例报告及文献复习

粒细胞肉瘤（granulocytic sarcoma,GS）是一种未成熟粒细胞在髓外增生和浸润形成的肿瘤性包块,最常侵犯的部位为皮肤、淋巴结、软组织、骨及骨膜[1]。GS较多见于急性粒细胞白血病（acute myelogenous leukemia,AML）、慢性粒细胞白血病、骨髓增殖性疾病及骨髓增生异常综合征患者。在AML患者中,GS常见于存在t（8;21）、inv（16）等细胞遗传学异常者[1]。     

恶性淋巴瘤合并急性粒细胞白血病1例

我院治疗1例浆细胞肉瘤合并急性粒细胞白血病(M2)患者。现介绍如下。     

宫颈腺泡状软组织肉瘤1例

患者女性 ,2 3岁 ,主因子宫不规则出血 1月余 ,Ｂ超显示粘膜下肌瘤入院。患者 4年前开始经期出血过多 ,曾先后 9次因严重出血住院 ,均诊断子宫功能性出血。此次住院 ,患者明显贫血貌 ,Ｔ 3 7.7℃ ,Ｈｂ 80 ｇ/Ｌ ,ＷＢＣ7.4× 1 0 /Ｌ ,ＲＢＣ 3 .1× 1 0 /Ｌ ,ＲＬＴ 2 0 8× 1 0 /Ｌ ,ＢＰ 1 1 .4 /8.1ｋＰａ ,Ｂ超示子宫粘膜下肌瘤 ,术中诊断考虑恶性肿瘤 ,改行全子宫及双附件切除术 ,切除标本送病理检查。大体检查 :全切子宫及双侧附件 ,子宫 8ｃｍ× 6ｃｍ×6ｃｍ ,宫颈后唇偏左有一椭圆形肿物 ,3ｃｍ× 2 .5ｃｍ× 2ｃｍ ,突出宫颈管…     

Granulocytic sarcoma (chloroma) of the uterine cervix: a case report.

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Granulocytic sarcoma: report of three cases

Granulocytic sarcoma (GS) is a rare extramedullary solid tumour composed of malignant immature cells of the granulocytic series. It may herald, accompany or signal acute myeloid leukaemia (AML) or chronic granulocytic leukaemia (CGL). GS may also occur in patients with myelodysplastic syndromes (MDS) where it is a sign of imminent disease progression. Three cases of GS are presented; the first one involving the pancreas and preceding AML, the second case affecting uterine cervix in stable phase CGL and the third case is GS of the breast accompanying AML. Any site of the body may be involved by the GS, and morbidity depends on the local organ/tissue affected in addition to the attending primary leukaemia or MDS. Treatment of GS involves surgery, radiotherapy and chemotherapy. The objective of this communication is to enhance awareness in personnel providing health care. Further, early diagnosis and treatment affects overall outcome.     

Epithelioid sarcoma presenting as the reflex sympathetic dystrophy syndrome

A case of reflex sympathetic dystrophy caused by an epithelioid sarcoma is presented. This is the first report of a local peripheral tumour associated with the reflex sympathetic dystrophy syndrome.     

Granulocytic sarcoma preceding leukaemic transformation in myelofibrosis

A granulocytic sarcoma expanded the malar region in a patient with proven myelofibrosis over a 22 month period before undergoing rapid increase in size concomitantly with transformation to acute granulocytic leukaemia in the marrow and the widespread appearance of subcutaneous tumour deposits. Rapid response was obtained with local radiotherapy, and the systemic disease manifestations were controlled on combination courses of oral 4'-demethoxydaunorubicin and the epipodophyllotoxin VP16-213. This appears to be the first example of a granulocytic sarcoma occurring in a patient with myelofibrosis.     

Metastatic carcinoma of the cervix presenting as a psoas abscess in an HIV-negative woman

A case of advanced carcinoma of the cervix presenting as a psoas abscess is described. This unusual presentation has been reported in association with AIDS but is extremely rare in HIV-negative women. This case report emphasises the importance of awareness of unusual causes of the psoas abscess in an era when the classical tuberculous abscess is fast disappearing.     

粒细胞肉瘤2例临床分析并文献复习

<正>粒细胞肉瘤或绿色瘤(granulo cytic sarcoma,GS)是由粒系来源的幼稚前体细胞组成的髓外局灶性实体肿瘤,为白血病的一种特殊类型。根据其病理变化,可分为:①绿色瘤:瘤切面呈绿色,与肿瘤细胞内的过氧     

Granulocytic sarcoma: a diagnosis to be considered in unusual lymphoma syndromes

A series of 7 patients with granulocytic sarcoma is presented to illustrate its varied clinical picture. In particular, this condition may present with features which suggest a non-Hodgkin lymphoma. The diagnosis will only be made if a high index of suspicion is maintained and special histopathological methods are used. Granulocytic sarcoma should be treated like an acute myeloid leukaemia.