Analysis of point-selection pattern in acupuncture-moxibustion treatment of amblyopia

Objective

To analyze and summarize the characteristics and pattern in the selection of points and meridians by searching the clinical research literature about acupuncture-moxibustion treatment of amblyopia in the recent 17 years.

Methods

By searching Chinese and English databases, such as China National Knowledge Infrastructure (CNKI), PubMed, etc., the points in 52 articles in conformity with the requirements were analyzed by frequency statistics by the order of meridians, major points, and adjunct points to summarize the rules and characteristics of the point selection.

Results

In 52 articles, there were 21 articles on ear acupuncture and 31 articles on acupuncture-moxibustion treatment. Ten meridians were involved in acupuncture-moxibustion treatment of amblyopia, and the leading 3 meridians were the Bladder, Stomach and Gallbladder Meridians. There were 34 points, 10 extraordinary points and 37 ear points were used in acupuncture-moxibustion treatment of amblyopia. The top 10 major points were Jingming (BL 1), Taiyang (EX-HN 5), Cuanzhu (BL 2), Fengchi (GB 20), Baihui (GV 20), Hegu (LI 4), Guangming (GB 37), Sibai (ST 2), Chengqi (ST 1) and Sizhukong (TE 23). The top 5 adjunct points were Zusanli (ST 36), Shenshu (BL 23), Ganshu (BL 18), Sanyinjiao (SP 6) and Taixi (KI 3).

Conclusion

Acupuncture-moxibustion treatment of amblyopia is characterized by the selection of the points mainly from yang meridians, based upon syndromes differentiation plus personal experience, and the points mainly around the eyes and by stressed use of ear points.

     

Points selection pattern in acupuncture-moxibustion treatment of gouty arthritis: an analysis based on bibliometrics

Objective

To discuss the selection pattern of points and meridians in acupuncture-moxibustion treatment of gouty arthritis (GA) by analyzing clinical literatures related to GA, and to provide reference for acupuncture-moxibustion treatment of GA.

Methods

Clinical literatures related to GA treated with acupuncture-moxibustion published between January 1981 and July 2017 were collected from Chinese databases. The points, meridians, frequency and treatment methods were analyzed.

Results

A total of 78 studies were included. For meridians, the top 5 meridians used were the Spleen Meridian (67 times), Liver Meridian (59 times), Stomach Meridian (53 times), Kidney Meridian (49 times) and Large Intestine Meridian (44 times). For points selection, the leading 5 points were Taichong (LR 3) (79 times), Taibai (SP 3) (68 times), Sanyinjiao (SP 6) (61 times), Taixi (KI 3) (57 times) and Yinlingquan (SP 9) (55 times). For major and adjunct points, the 5 most significant major points were Taichong (LR 3) (79 times), Taibai (SP 3) (68 times), Sanyinjiao (SP 6) (61 times), Yinlingquan (SP 9) (37 times) and Taixi (KI 3) (32 times). The 5 most significant adjunct points were Yanglingquan (GB 34) (31 times), Fenglong (ST 40) (30 times), Xuehai (SP 10) (29 times), Taixi (KI 3) (25 times) and Quchi (LI 11) (21 times). For treatment methods, the top 5 methods used were acupuncture-moxibustion alone for 15 studies, acupuncture combined with medicinal herbs for 11 studies, acupuncture-moxibustion combined with medicinal herbs for 10 studies, acupuncture alone for 7 studies, and electroacupuncture combined with bloodletting for 5 studies.

Conclusion

The main meridians chosen in acupuncture-moxibustion treatment of GA were the Spleen, Liver, Stomach, Kidney and Large Intestine Meridians, conforming to the syndrome differentiation principle of tonifying spleen and kidney, clearing heat and draining dampness. Points mainly locate at lower limbs and feet around the affected area, which was a reflection of peripheral treatment function of points. The data mining results of meridian and point selection in acupuncture-moxibustion treatment of GA conform to the disease and syndrome differentiation theory and provide references for acupuncture-moxibustion treatment of GA.

     

Effects of acupuncture-moxibustion on monocyte Th1/Th2 cytokine in peripheral blood of patients with perennial allergic rhinitis

目的：观察针灸对常年性变应性鼻炎患者临床症状、体征、Th1／Th2细胞因子的影响,以及对Th1／Th2的调控作用,以期为针灸治疗本病提供客观依据,进而探讨其作用机制。方法：选择30例常年性变应性鼻炎患者为治疗组,30例健康人为对照组。治疗前、第1疗程后、第2疗程后观察临床症状和体征的评分,观察鼻黏膜,采用酶联免疫吸附试验（ELISA）测定外周血单个核细胞（PBMC）经PHA诱导培养后上清液中的白细胞介素-4（m-4）、干扰素-γ（IFN-γ）以及粒细胞-巨噬细胞集落刺激因子（GM—CSF）的含量。结果：治疗组治疗前的IL-4、GM—CSF水平均显著高于对照组（P〈0．01）,而IFN—γ水平显著低于对照组（P〈0．01）。治疗组的GM—CSF水平与IL-4呈正相关（P〈0．01）,与IFN—γ呈负相关（P〈0．01）。治疗组经治疗后IL-4和GM—CSF水平较治疗前均有显著性下降（P〈0．01）,IFN—γ水平升高（P〈0．05）,且治疗后IL-4、GM—CSF、IFN—γ水平均与对照组无显著性差异。结论：针灸对常年性变应性鼻炎患者症状及体征有明显的改善作用,并且能够加强机体免疫力。调节患者体内Th1和Th2细胞因子的表达,纠正失衡的Th1／Th2细胞因子网络可能是产生疗效的机制。     

Effect of acupuncture plus thunder-fire moxibustion on MMP-3, TIMP-1 and TGF-β1 in rats with knee osteoarthritis

Objective

To observe the effect of acupuncture plus thunder-fire moxibustion on the expressions of matrix metalloproteinase-3 (MMP-3), tissue inhibitor of metalloproteinase-1 (TIMP-1) and transforming growth factor-β1 (TGF-β1) in cartilage of knee osteoarthritis (KOA) rats, and to explore the mechanism of acupuncture plus thunder-fire moxibustion in the treatment of KOA.

Methods

Thirty Sprague-Dawley (SD) rats were randomly divided into a blank control group, a model group and an acupuncture-moxibustion group by random digits table, 10 rats in each group. Rats in the model group and the acupuncture-moxibustion group were injected with papain in the right posterior knee joint to prepare the models. The levels of MMP-3 and TIMP-1 in rat synovium of each group were measured by enzyme-linked immunosorbent assay (ELISA) after 2 weeks of treatment. The level of TGF-β1 was determined by Motic B5 Micro-camera system.

Results

The levels of MMP-3 and TIMP-1 in the cartilage of the model group were significantly higher than those in the blank control group (all P<0.01); the levels of MMP-3 and TIMP-1 in the acupuncture-moxibustion group were lower than those in the model group, and the between-group differences were statistically significant (all P<0.05). The levels of MMP-3 and TIMP-1 in the acupuncture-moxibustion group were higher than those in the blank control group, and the differences were statistically significant (all P<0.05). The level of TGF-β1 in cartilage tissues of the model group was significantly lower than that in the blank control group (P<0.01); the level of TGF-β1 in the acupuncture-moxibustion group was higher than that in the model group (P<0.05), but it was lower than that in the blank control group, and the between-group difference was statistically significant (P<0.05).

Conclusion

Acupuncture plus thunder-fire moxibustion can effectively recover the abnormal expressions of MMP-3 and TIMP-1 in KOA model rats and somewhat up-regulate TGF-β1, which may be one of its mechanisms of acupuncture plus thunder-fire for KOA.

     

Analysis of acupoint-selection patterns in acupuncture-moxibustion treatment of polycystic ovarian syndrome based on data mining

Objective

To analyze the meridian and acupoint-selection patterns in acupuncture-moxibustion treatment of polycystic ovarian syndrome (PCOS) by data mining technique, for exploring acupoints that could be effective for PCOS and providing suggestion and reference in selecting acupoints for the acupuncture-moxibustion treatment of PCOS.

Methods

Literatures related to the acupuncture-moxibustion treatment of PCOS published before April 2018 were collected. By a self-made data mining program developed using Microsoft Excel 2007, a database of acupuncturemoxibustion treatment of PCOS was then established. The correlation analysis was performed for the frequency of use of acupoints and acupoint groups. Cluster analysis was also conducted.

Results

A total of 92 articles were recruited finally. Sanyinjiao (SP 6), Conception Vessel and chest-abdomen region ranked the top on the list of the most frequently used acupoints, meridians and regions, respectively. Correlation analysis showed that the acupoint group with the highest confidence was Sanyinjiao (SP 6) and Zusanli (ST 36), and the group with the highest support was Sanyinjiao (SP 6) and Guanyuan (CV 4). Cluster analysis revealed five effective clusters: Guanyuan (CV 4) and Sanyinjiao (SP 6); Zhongwan (CV 12) and Tianshu (ST 25); Zhongji (CV 3), Zusanli (ST 36) and Qihai (CV 6); Xuehai (SP 10), Shenshu (BL 23), Taichong (LR 3) and Guilai (ST 29); Ganshu (BL 18), Taixi (KI 3), Yinlingquan (SP 9) and Pishu (BL 20).

Conclusion

According to the confidence and support report, Sanyinjiao (SP 6) and Zusanli (ST 36) or Sanyinjiao (SP 6) and Guanyuan (CV 4) are recommended in acupuncture-moxibustion treatment of PCOS, with adjunct points selected for different patterns, e.g. Zhongwan (CV 12) and Tianshu (ST 25) for tonifying spleen and expelling dampness; Zhongji (CV 3) and Qihai (CV 6) for supplementing qi and cultivating blood; Xuehai (SP 10), Shenshu (BL 23), Taichong (LR 3) and Guilai (ST 29) for tonifying kidney and dissolving stasis; Ganshu (BL 18), Taixi (KI 3), Yinlingquan (SP 9) and Pishu (BL 20) for tonifying kidney and spleen and regulating liver.

     

Reflection and prospect on acupuncture-moxibustion in treating Hashimoto’s thyroiditis

Objective

To categorize and summarize the clinical and mechanism studies of the past 30 years on the treatment of Hashimoto’s thyroiditis (HT) with moxibustion, moxibustion plus medication, and acupuncture plus medication, etc., and to analyze the current problems.

Methods

The clinical and laboratory studies related to the treatment of HT with acupuncture-moxibustion therapies published before June 2015 were retrieved from MEDLINE, Excerpta Medica Database (EMBASE), China National Knowledge Infrastructure (CNKI), Wanfang Academic Journal Full-text Database (Wanfang) and Chongqing VIP Database (CQVIP).

Results

Moxibustion, moxibustion plus medication, and acupuncture plus medication can produce certain therapeutic effects in treating HT.

Conclusion

The research on the treatment of HT with acupuncture-moxibustion therapies is rather limited in the amount and content. In the future, standardization should be fortified, specific moxibustion research needs deepening, and the action mechanism of moxibustion should be emphasized.

     

艾灸对溃疡性结肠炎大鼠结肠KGF-1、KGF-2和IL-6蛋白表达的影响

目的:观察艾灸对溃疡性结肠炎大鼠结肠角质细胞生长因子-1 (Keratinocyte Growth Factor-1,KGF-1)、角质细胞生长因子-2(Keratinocyte Growth Factor-2,KGF-2) KGF-2和白介素-6(Interleukin-6,IL-6)蛋白表达的影响,进一步探讨艾灸治疗溃疡性结肠炎的作用机制.方法:将SD大鼠随机分为正常组、模型组、隔药灸组和柳氮磺胺吡啶(Sulfasalazine,SASP)组.隔药灸组采用隔药灸天枢和气海穴治疗;SASP组采用柳氮磺胺吡啶灌胃干预.干预结束后,应用HE染色光镜下观察各组大鼠结肠病理学变化,采用免疫组织化学法检测大鼠结肠KGF-1、KGF-2和IL-6蛋白表达变化.结果:与模型组比较,隔药灸组和SASP组大鼠结肠病理学均有一定的改善;与正常组比较,模型组大鼠结肠KGF-1、KGF-2和IL-6蛋白表达均显著增加(P＜0.05);经隔药灸和SASP干预后,大鼠结肠KGF-1、KGF-2和IL-6蛋白表达均显著降低(P＜0.05).结论:隔药灸和SASP均能下调溃疡性结肠炎大鼠结肠KGF-1、KGF-2和IL-6的蛋白表达,该作用可能是隔药灸和SASP治疗溃疡性结肠炎的重要机制之一.     

Intestinal anti-inflammatory activity of ellagic acid in the acute and chronic dextrane sulfate sodium models of mice colitis

Ethnopharmacological relevance

Pomegranate (Punica granatum L.; Lythraceae) has traditionally been used for the treatment of various inflammatory diseases, including ulcerative colitis (UC). Because its fruits and extracts are rich in ellagitannins, which release ellagic acid when hydrolyzed, consumption of pomegranate products is currently being widely promoted for their potential health effects, including the prevention of inflammatory diseases and cancer. To evaluate the anti-inflammatory effects of ellagic acid on dextran sulfate sodium (DSS)-induced acute and chronic experimental colitis in two different strains of mice and to elucidate its possible mechanisms of action.

Materials and methods

In the acute UC model, female Balb/C mice were treated with DSS (5%) for seven days while concomitantly receiving a dietary supplement of ellagic acid (2%). In the chronic UC model, female C57BL/6 mice received four week-long cycles of DSS (1% and 2%) interspersed with week-long recovery periods along with a diet supplemented with ellagic acid (0.5%).

Results

In acute model of UC, ellagic acid ameliorated disease severity slightly as observed both macroscopically and through the profile of inflammatory mediators (IL-6, TNF-α, and IFN-γ). In the chronic UC model, ellagic acid significantly inhibited the progression of the disease, reducing intestinal inflammation and decreasing histological scores. Moreover, mediators such as COX-2 and iNOS were downregulated and the signaling pathways p38 MAPK, NF-κB, and STAT3 were blocked.

Conclusions

Our study reinforces the hypothetical use of ellagic acid as an anti-inflammatory complement to conventional UC treatment in chronic UC patients and could be considered in the dietary prevention of intestinal inflammation and related cancer development.     

Exploration of the clinical regularity of acupuncture and moxibustion treatment for cerebral palsy syndrome

目的：回顾1954～2007年针灸文献,探索针灸治疗脑性瘫痪用穴和治疗方法的规律。方法：根据《中国现代针灸信息数据库》数据,采用计量分析方法进行综合分析。结果：足三里、曲池、合谷应用频次为最,百会、四神聪等头部穴位的应用也较频繁,治疗方法以针刺、头针、水针为主。结论：针刺疗法的介入可以提高脑性瘫痪的疗效。建议取百会、四神聪、足三里、曲池、合谷为针灸治疗脑性瘫痪的基础方。     

Exploration of the clinical regularity of acupuncture and moxibustion treatment for insomnia

目的：回顾1956-2007年针灸丈献,探索针灸治疗失眠症的用穴及治疗方法规律。方法：根据“中国现代针灸信息数据库”数据,采用计量分析方法进行综合分析。结果：提示三阴交、神门应用频次为最,治疗方法以针刺为主。结论：建议百会、四神聪、三阴交、神门作为针灸治疗失眠症的基础用穴,并结合辨证选穴。     

Clinical observation on the post-stroke shoulder pain and blood viscosity treated by acupuncture-moxibustion therapy

目的：探讨针灸治疗中风后偏瘫肩痛的临床疗效。方法：将90例中风后偏瘫肩痛患者按1：1：1随机分为3组。分别采用针灸、针灸加中药、中药进行治疗。结果：3组间疗效、全血黏度经统计学处理,针灸组、针灸加中药组与中药组相比具有显著性差异（P〈0．01）;而针灸组与针灸加中药组之间无显著性差异（P〉0．05）。结论：针灸治疗对中风后偏瘫肩痛具有良好疗效,对异常全血黏度有近期调节降低作用。     

Exploration of clinical regularities in acupuncture and moxibustion treatment for allergic rhinitis

目的：回顾1956～2007年针灸文献,探索针灸治疗变应性鼻炎用穴和治疗方法的规律。方法：根据《中国现代针灸信息数据库》数据,采用计量分析方法进行综合分析。结果：迎香、肺俞应用频次为最,治疗方法以针剁和水针为主。结论：建议迎香、印堂、肺俞、大椎作为针灸治疗变应性鼻炎基础方,并辨证选穴。     

Effects of Jianpi herbal suppository on hemorheology and CD62p in patients with ulcerative colitis

Objective

To compare the effects of a Chinese herbal suppository (Jianpi suppository) and Western Medicine (mesalazine) on hemorheology and CD62p in patients with ulcerative colitis (UC).

Methods

In a randomized trial, 120 mild to moderate UC patients were randomly divided into two equal groups. The Jianpi suppository group used Chinese herbal suppository rectally, while the mesalazine group was treated with mesalazine tablets orally. Two 15-day courses of treatment were carried out in both groups. Changes in the hemorheology and CD62p indices in patients were observed.

Results

The hemorheology and CD62p indices in the Jianpi suppository group decreased significantly more than those of the mesalazine group.

Conclusion

Jianpi suppository is effective in improving the hypercoagulability of UC patients, and therefore may be worth using in clinical practice.     

Relationships between pharmacokinetics and efficacy of Xie-xin decoction in rats with experimental ulcerative colitis

Ethnopharmacological relevance

Xie-xin decoction (XXD) has been used as a classic formula in China for the treatment of gastrointestinal dysfunction such as ulcerative colitis (UC). However, no potential action mechanisms and active compounds had been systematically investigated.

Aim of the study

To explore the effectiveness and the material basis of XXD in trinitrobenzene sulfonic acid (TNBS)-induced UC rats.

Materials and methods

XXD was administered orally for 8 days at a dosage of 2 or 4 g/kg/day. Plasma pharmacokinetic properties and colon tissue concentrations of multiple compounds from XXD were detected. Tissue damage scores, production of interleukin (IL)-10 and myeloperoxidase (MPO), expression of tumor necrosis factor-alpha (TNF-α) and nuclear factor-kappa Bp65 (NF-κBp65) in colon tissues were examined. Canonical correlation analysis was performed to evaluate the relationships between pharmacokinetics and efficacy to elucidate significantly active compounds of XXD.

Results

XXD promoted the recovery of colitis and inhibited the colonic inflammation damage in UC rats by reducing the level of MPO and the expression of TNF-α and NF-κBp65, and increasing the production of IL-10 in colon tissues. Efficacy of XXD was positively related with AUC of five plasma compounds (baicalin, berberine, wogonoside, wogonin, and rhein) and concentrations of six colon tissue compounds (coptisine, jatrorrhizine, palmatine, berberine, baicalein and emodin), respectively.

Conclusions

The multiple compounds in plasma and colon tissues from XXD might be the main material basis for therapeutic potentials in UC rats.     

The aqueous crude extract of Montanoa frutescens produces anxiolytic-like effects similarly to diazepam in Wistar rats: Involvement of GABA(A) receptor

Ethnopharmacological relevance

Fufangkushen colon-coated capsule (FCC) was a newly developed herbal drug for treating ulcerative colitis (UC) patients with traditional Chinese medicine (TCM) pattern of damp-heat accumulating in the interior.

Objective

To explore the efficacy and safety of FCC in the treatment of active UC compared with Huidi (HD, mesalazine enteric-coated tablets) were evaluated in a double-blinded and randomized clinical trial.

Materials and Methods

In the double-blind, double-dummy, multicenter, randomized and controlled study, 320 active UC patients with TCM pattern of damp-heat accumulating in the interior were assigned to two groups: 240 treated with FCC plus HD placebo treatment, 80 with HD plus FCC placebo. The drugs and their corresponding placebos were administrated at advised dosage for 8 weeks. The primary endpoint was a positive clinical response at week 8, and Mayo scoring system was employed for assessment of UC activity.

Results

At the 8th week, 72.50% of patients in FCC group (170 of 234) and 65.00% of patients in HD group (52 of 80) had achieved a clinical response. There was no statistically significance between the 2 groups (P > 0.05). The proportions of patients who had a clinical remission was similar in 2 groups (41.50% in FCC group, 41.25% in HD group, P > 0.05), mucosal healing rate at week 8 in the two groups were also without significant difference (55.13% in FCC group, 55.00% in HD group, P > 0.05). Mayo scores at week 8 showed no statistically difference in the two groups. No significant differences were observed between the safety profiles of the 2 groups (P > 0.05). No severe AEs were reported in either group. The latent class analysis indicated that FCC was superior applicable for the left hemicolon involved patients than HD.

Conclusions

Compared with HD, a mesalamine enteric-coated tablet, FCC is similarly effective and safe in the treatment of active UC with TCM pattern of damp-heat accumulation interior pattern. In addition, FCC indicates superior effect in the treatment of UC with inflamed area of the left hemicolon than HD.     

Regulating effects of herb cake-partitioned moxibustion on the expression of p53 and C-myc protein in rats with ulcerative colitis

目的：从p53基因、原癌基因蛋白质C—myc表达与溃疡性结肠炎发病关系角度,探讨隔药灸对p53、C—myc表达影响,进一步探讨隔药灸治疗UC作用机制。方法：采用免疫学方法加局部刺激制备溃疡性结肠炎大鼠模型。40只SD大鼠随机数字表法分为正常组、模型组、隔药灸组、温和灸组,每组10只。温和灸组,选取天枢、气海穴悬灸,每次每穴灸10min。隔药灸组选取天枢、气海穴隔药灸,每次每穴灸2壮。免疫组织化学法检测溃疡性结肠炎大鼠结肠组织中p53、C—myc表达。结果：模型组大鼠结肠组织中p53、C-myc的表达在阳性面积、强度、免疫组织化学（immunohistochemistry,mc）指数方面均显著上调,与正常组比较具有显著差异（P〈0．01）;隔药灸组、温和灸组治疗后结肠Np53、C—myc的表达下调,与模型组比较具有显著差异（P〈0．01）结论：p53与C．myc在UC发生、发展中具有重要作用,隔药灸对UC结肠组织p53、C-myc表达水平具有调节作用。     

Regulating effects of different moxibustion therapies on bax and Bcl-2 in rats with ulcerative colitis

目的：探讨不同灸法对溃疡性结肠炎（ulcerativecolitis,UC）大鼠结肠损伤的改善作用,以及对Bcl-2mRNA、BaxmRNA表达的影响。方法：采用免疫学方法加局部刺激制备实验性UC大鼠模型。造模后采用不同灸法治疗14次,实时荧光定量PCR技术检测结肠组织Bcl-2mRNA、BaxmRNA表达。结果：（1）各治疗组结肠大体形态损伤积分和光镜下组织学损伤积分较模型组比较有明显改善（Jp〈0．05,P〈0．01）：（2）uc模型大鼠结肠组织Bcl-2mRNA的表达显著高于正常大鼠沪〈0．01）,而BaxmRNA的表达显著低于正常大鼠（P〈0．01）;（3）治疗后,隔药灸组、隔姜灸组、隔蒜灸组大鼠结肠组织Bcl．2mRNA的表达明显下调,与模型组比较有显著差异（P〈0．05或P〈0．01）;隔药灸组、隔姜灸组BaxmRNA的表达明显增高,与模型组比较有显著差异（P〈0．05）。结论：初步研究结果提示隔药灸、隔姜灸、隔蒜灸、温和灸治疗均能有效改善UC大鼠结肠病理损伤,隔药灸、隔姜灸、隔蒜灸可不同程度抑制UC大鼠结肠组织Bcl-2mRNA和BaxmRNA的表达,调节Bcl-2／BaxmRNA的比例关系。     

Efficacy observation on acupuncture-moxibustion at Ciliao (BL 32) for primary dysmenorrhea due to cold-dampness

Objective

To observe the clinical efficacy of acupuncture plus moxibustion at Ciliao (BL 32) for primary dysmenorrhea (PD) due to cold-dampness.

Methods

A total of 58 cases with PD due to cold-dampness were randomly allocated into an observation group (n=29) and a control group (n=29). Patients in the observation group were treated with acupuncture and suspended moxibustion at Ciliao (BL 32), whereas patients in the control group were treated with routine acupuncture alone. After three courses of treatment, the clinical efficacy was evaluated and compared between the two groups.

Results

After treatment, the symptom scores were significantly reduced in both groups (P<0.05), but there were no significant between-group differences in clinical efficacy and symptom scores (P>0.05).

Conclusion

With fewer points and less pain, acupuncture-moxibustion at Ciliao (BL 32) can obtain similar effect as routine acupuncture therapy for PD due to cold-dampness.

     

针灸疗法对认知功能障碍的影响(英文)

目的:观察针灸对轻度认知功能障碍的影响。方法:将60例轻度认知功能障碍患者按随机数字表随机分为治疗组和对照组,每组30例。治疗组采用针灸治疗,对照组采用药物治疗。采用简易精神状态检查法(Mini-mental State Examination,MMSE),日常生活能力量表(Activity of Daily Living,ADL)及蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)评定两组治疗前后的变化,并进行两组间比较。结果:治疗后,两组MMSE、MoCA与ADL评分高于同组治疗前水平(P<0.05)。治疗组MMSE、MoCA与ADL积分改善程度均优于对照组(P<0.05)。结论:针灸可以有效改善轻度认知功能障碍患者的认知功能。