复方倍他米松注射液治疗面部增生性瘢痕疗效观察

2008年2月～2009年11月,我们使用复方倍他米松注射液皮损内注射治疗面部增生性瘢痕患者,取得了满意疗效,现报道如下。     

A型肉毒毒素联合复方倍他米松治疗大面积增生性瘢痕的临床疗效观察

目的探讨A型肉毒毒素联合复方倍他米松治疗大面积增生性瘢痕的临床效果。方法回顾性分析2017年3月至2019年3月于北部战区总医院烧伤整形科收治的39例大面积增生性瘢痕患者的临床资料,根据采用的治疗方法分为A组:A型肉毒毒素联合复方倍他米松瘢痕内注射组(13例);B组:A型肉毒毒素瘢痕内注射组(12例);C组:复方倍他米松瘢痕内注射组(14例)。记录治疗的总有效率,参照温哥华瘢痕评分量表(vancouver scar score sheet,VSS)对3组患者的瘢痕色泽、血管分布、柔软度进行综合评分;采用彩色多普勒超声诊断仪测量瘢痕厚度,并参照视觉模拟评分量表(visual analogue scale,VAS)评价患者的痛痒觉改善情况;记录不良反应发生情况;随访6个月。结果A组的总有效率(92.31%)、VSS值、瘢痕厚度、VAS值评价均明显优于B组(75.00%)和C组(50.00%),其差异有统计学意义(P<0.05)。A、B组经3次治疗后,痛痒症状明显缓解,病情趋于稳定。治疗6个月随访时A组患者未再复发,B组复发2例。3组中有极个别患者在治疗后偶发针孔周围皮肤红肿,于1~2 d自行缓解,未发生严重的不良反应。结论A型肉毒毒素联合复方倍他米松治疗大面积增生性瘢痕安全有效,能提高单次治疗的有效面积及效果并减少激素用量及其并发症,值得临床推广应用。     

超脉冲CO_2激光联合点阵铒激光治疗面部凹陷性瘢痕与增生性瘢痕的疗效比较

目的：比较超脉冲CO2激光联合点阵铒激光治疗面部凹陷性瘢痕与增生性瘢痕的临床效果。方法：2007年3月～2010年1月,我们应用超脉冲CO2激光联合点阵铒激光治疗面部瘢痕患者71例,其中凹陷性瘢痕33例和增生性瘢痕38例,分析两组病例疗效差别及可能的原因。结果：所有患者总有效率为77.5%,凹陷性瘢痕组有效率为87.9%,而增生性瘢痕组为68.4%,两组间有效率差别有统计学意义（P〈0.05）。结论：超脉冲CO2激光联合点阵铒激光是治疗面部瘢痕的方法之一,面部凹陷性瘢痕的疗效优于增生性瘢痕。     

脉冲染料激光联合点阵铒激光治疗增生性瘢痕的临床体会

增生性瘢痕厚而硬,早期瘢痕表面呈红色、潮红或紫色,又痛又痒,影响患者工作和休息,故患者求治心切。目前主要的治疗方法包括糖皮质激素注射、外科手术切除、放射治疗、硅凝胶外用、激光照射、压迫疗法、干扰素注射等。由于单一疗法的复发率较高,故多采用两种或两种以上方法联合治疗。2009年8月～2011年1月,笔者科室对60例病程在1～10周的瘢痕患者采用脉冲染料激光联合点阵铒激光治疗,随访3～6个月,效果良好,现报道如下。     

倍他米松病损内注射治疗瘢痕疙瘩疗效观察

目的：寻求简单有效的治疗瘢痕疙瘩的方法。方法：采用二丙酸倍他米松／倍他米松磷酸二钠病损内注射治疗瘢痕疙瘩６０例。结果：经１年随访,总有效率达８８．３３％。结论：通过讨论二丙酸倍他米松／倍他米松磷酸二钠作用机理、优点、不良反应等,作者认为该方法安全可靠、疗效显著。并发症少,尤其适合于中小面积瘢痕疙瘩的治疗。     

冷冻联合瘢痕内注射治疗儿童增生性瘢痕疗效观察

增生性瘢痕（hypertrophic scar，Hs）是创伤愈合的异常结局，瘢痕明显高于周围正常皮肤，局部增厚变硬，表面呈红色、潮红或紫红并伴有不同程度的瘙痒，严重者可影响人体表美观并导致功能障碍。临床上儿童创伤、烧烫伤及一些外科手术后形成增生性瘢痕的病例很多。近两年来，我们采用二联法，     

复方倍他米松联合5%咪喹莫特治疗瘢痕疙瘩的临床观察

目的：观察复方倍他米松注射液皮损内注射联合5%咪喹莫特外涂治疗瘢痕疙瘩的临床疗效和安全性。方法：将80名瘢痕疙瘩患者分为两组,治疗组给予复方倍他米松注射液皮损内注射,每2周1次,同时外涂5%咪喹莫特隔日1次,总疗程为8周;对照组单纯给予复方倍他米松注射液皮损内注射。结果：1个月随访时,治疗组及对照组改善率分别为67.57%及60.47%,无显著差异;3个月随访时,治疗组改善率为80.56%,显著高于对照组的65.85%。治疗期间无失访患者,不良反应为注射部位轻中度疼痛感、不适感,偶见轻度萎缩、轻度毛细血管扩张及多毛。结论：复方倍他米松注射液皮损内注射联合5%咪喹莫特外涂治疗瘢痕疙瘩安全有效、复发率低,患者依从性好。     

铒像素激光在瘢痕治疗中的临床应用

目的 探讨铒像素激光在浅表性瘢痕治疗中的临床疗效.方法 对156例浅表性瘢痕患者采用铒像素激光进行治疗,每次治疗间隔1个月,每疗程5次.每次治疗时先划区域,选择治疗参数.治疗区域内定点连续发射5～10个脉冲激光照射.结果 本组患者治疗2～8次.随访3～6个月,瘢痕平复,色素变浅,质地改善.治疗有效率为95.5%.结论 采用像素激光治疗浅表性瘢痕,创伤小,无瘢痕、感染及色素沉着等并发症发生,瘢痕得到有效的修复.随着治疗次数的增加,瘢痕表面上皮修复更完善,效果也更显著.     

复方利多卡因乳膏在Er:YAG激光面部治疗中的应用

目的:评价复方利多卡因乳膏在面部Er:YAG激光治疗中的止痛效果。方法:选取Er:YAG激光面部治疗的患者270例,治疗前采用复方利多卡因乳膏外涂封包面部治疗部位60～90min,然后采用Er:YAG激光治疗,观察治疗过程中患者对疼痛的反应及不良反应的发生。结果:270例患者,外涂复方利多卡因软膏封包后,采用Er:YAG激光治疗,按痛觉评价标准统计疼痛反应:I级164例,占60.74%;Ⅱ级90例,占33.33%;Ⅲ级16例,占5.93%。结论:复方利多卡因乳膏在面部Er:YAG激光治疗中镇痛效果好、不良反应少。     

铒激光微剥脱治疗脂溢性角化病63例疗效观察

目的:观察铒激光微剥脱治疗脂溢性角化病的临床疗效。方法:采用铒激光微剥脱治疗脂溢性角化病63例,210个皮损,根据皮损的部位、性质及对激光的反应,选择能量10～12.5J/cm2治疗。结果:63例患者,共计210个皮损,治疗8周后随访,176个皮损痊愈,治愈率83.80%,34个皮损显效,有效率100%,未出现创面感染和瘢痕形成。结论:铒激光微剥脱治疗脂溢性角化病有效且安全。     

铒激光治疗脂溢性角化病117例的疗效观察

目的 观察铒激光治疗脂溢性角化病的临床疗效.方法 自2005年3月至2008年6月,采用铒激光治疗脂溢性角化病患者117例,共470个皮损.根据患者的年龄、皮损的性质和部位以及皮肤组织对铒激光的反应,选择能量密度为0.3～0.5j/cm2.治疗1次者102例,治疗2次者15例,每次治疗间隔3～6个月.结果 治疗后随访了所有的患者6个月,痊愈者89例(76.1%),显效者28例(23.9%),总有效率为100%,未出现感染和瘢痕等并发症.结论 铒激光是治疗脂溢性角化病较安全、有效的方法.     

Er:YAG laser therapy for peri-implant infection: a histological study

The purpose of this study was to evaluate the effects of Er:YAG laser on degranulation and implant surface debridement in peri-implant infection. The peri-implant infection was experimentally induced in dogs, and the treatment was performed using an Er:YAG laser or a plastic curet. Animals were sacrificed after 24 weeks, and undecalcified histological sections were prepared and analyzed. Degranulation and implant surface debridement were obtained effectively and safely by Er:YAG laser. Histologically, a favorable formation of new bone was observed on the laser-treated implant surface, and the laser group showed a tendency to produce greater bone-to-implant contact than the curet group. These results indicate that the Er:YAG laser therapy has promise in the treatment of peri-implantitis. Contract grant sponsor: 21^st Century Center of Excellence Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone in Tokyo Medical and Dental University and a Grant-in-Aid for Scientific Research(c)(2) (No. 16592064) (A.A.), Ministry of Education, Culture, Sports, Science and Technology of Japan.     

Fractional Er:YAG laser assisting topical betamethasone solution in combination with NB-UVB for resistant non-segmental vitiligo

Resistant non-segmental vitiligo is difficult to be treated. Ablative erbium-YAG (Er:YAG) laser has been used in the treatment of vitiligo, but the ablation of entire epidermis frustrated the compliance of patients. The purpose of this study is to investigate the effects of fractional Er:YAG laser followed by topical betamethasone and narrow band ultraviolet B (NB-UVB) therapy in the treatment of resistant non-segmental vitiligo. The vitiligo lesions of each enrolled patient were divided into four treatment parts, which were all irradiated with NB-UVB. Three parts were, respectively, treated with low, medium, or high energy of Er:YAG laser, followed by topical betamethasone solution application. A control part was spared with laser treatment and topical betamethasone. The treatment period lasted 6 months. The efficacy was assessed by two blinded dermatologists. Treatment protocol with high energy of 1800 mJ/P of fractional Er:YAG laser followed by topical betamethasone solution and in combination with NB-UVB made 60% patients achieve marked to excellent improvement in white patches. The protocol with medium energy of 1200 mJ/P of laser assisted approximate 36% patients achieve such improvement. The two protocols, respectively, showed better efficacies than NB-UVB only protocol. However, fractional Er:YAG laser at low energy of 600 mJ/P did not provide such contributions to the treatment of vitiligo. The fractional Er:YAG laser in combination with topical betamethasone solution and NB-UVB was suitable for resistant non-segmental vitiligo. The energy of laser was preferred to be set at relatively high level.     

Er：YAG激光修复面部浅表瘢痕的疗效观察

目的：探讨Er：YAG激光治疗面部浅表瘢痕的疗效。方法：478例面部浅表瘢痕患者，应用Er：YAG激光首先在瘢痕表面进行表层汽化，扫描光斑重叠25％～40％，使创面的基部基本平整。结果：478例患者经治疗后瘢痕平整，有效率100％，患者满意率100％。结论：Er：YAG激光具有精确度高、损伤小、操作方便的优点，且术后并发症少、色素沉着程度轻。故我们认为Er：YAG激光是治疗面部浅表瘢痕安全、有效的方法之一。     

Modulating the Er:YAG laser

BACKGROUND AND OBJECTIVES: In the past 2 years, there has been some controversy about the optimal laser system, or combination of systems, for cutaneous resurfacing. Initially, it seemed that the Er:YAG laser would have significant advantages over the CO(2) laser. In practice, some of those who jumped early onto the Er:YAG bandwagon have been unimpressed with the degree of skin tightening that can be achieved with this system. Also, the excessive bleeding induced by the Er:YAG lasers prevented deeper vaporization. During the past 18 months, three new "modulated" Er:YAG lasers have been produced that are said to be able to achieve CO(2) laser-like effects, while maintaining the Er:YAG laser advantages. The purpose of this article is to examine these new systems and to discuss their potential benefits, if any, over the "conventional" Er:YAG lasers, and the CO(2) lasers. STUDY DESIGN/MATERIALS AND METHODS: The author has collected data from his own experience and that of his colleagues in the department of dermatology at University of California at San Francisco. The author has used all three types of modulated Er:YAG laser on patients presenting for cosmetic laser resurfacing and the treatment of many benign conditions over an 18-month period. RESULTS: All three modulated forms of Er:YAG lasers have been demonstrated to provide better coagulation than the conventional Er:YAG lasers. The Derma-K and the Contour Er:YAG lasers were able to induce tissue contraction/desiccation similar to the CO(2) laser. The author and his colleagues have induced only two cases of permanent hypopigmentation in over 50 cases during the past 18 months while using the Er:YAG laser, significantly less than might be expected with the CO(2) lasers. CONCLUSIONS: If a laser surgeon is happy with the results obtained with a high-energy, short-pulse CO(2) laser, then there seems little reason to consider changing to an Er:YAG laser. The modulated Er:YAG lasers have definite advantages over the conventional Er:YAG lasers. They exhibit better control of hemostasis and can ablate tissue to a greater depth than the conventional Er:YAG lasers. The Er:YAG lasers might induce less permanent hypopigmentation than the CO(2) lasers.     

铒激光治疗面部浅表性瘢痕的疗效观察

目的 观察铒激光治疗面部浅表性瘢痕的疗效.方法 应用铒激光先于瘢痕表面行表层汽化扫描,再于首次扫描区域行25%～40%的重叠汽化扫描,使瘢痕底部的深度变浅.对治疗后出现色素沉着的患者采用避光及相应的药物治疗.自2005年4月至2006年10月,对86例面部浅表性瘢痕患者进行了治疗.结果 治疗后随访86例患者12个月,色素沉着发生率为17.5%,经治疗后均消退;浅表性瘢痕治疗的有效率达100%,效果满意;无色素减退、瘢痕面积变大、瘢痕增生等并发症出现.结论 与传统的皮肤磨削术相比,铒激光具有疼痛轻、精确度高、损伤小、操作方便、不易感染、恢复快、治疗后并发症少等优点,是治疗面部表浅性瘢痕安全、有效的优选方法之一.治疗后的护理及药物干预可显著减少色素沉着的发生.