原发性皮肤间变性大细胞淋巴瘤

报告1例原发性皮肤间变性大细胞淋巴瘤.患者女,24岁.左手中指红斑33 d,根据皮损组织病理及免疫组化标记结果诊断为原发性皮肤间变性大细胞淋巴瘤.     

原发性皮肤间变性大细胞淋巴瘤1例

患者男,56岁。反复皮肤结节13年,皮损组织病理及免疫组化检查结果提示间变性大细胞淋巴瘤,免疫组化检查:CD30(2+),EMA(2+),Ki-67抗原(+75%),ALK,CD20,CD3,CD45RO,CD79α,MPO均阴性,诊断:间变性大细胞淋巴瘤。     

ALK-1蛋白阳性的原发性皮肤CD30+间变性大细胞淋巴瘤1例

报告1例ALK-1蛋白阳性的原发性皮肤CD30+间变性大细胞淋巴瘤.患儿女,6岁.因左下眼睑包块5个月就诊.入院检查见左下眼睑一2.5 cm×3.0 cm×0.5 cm红色包块,组织病理学检查示真皮内大片大细胞浸润,细胞核呈间变性;免疫组化染色示UCHL-1(+)、CD30(+)、ALK-1(+),EBER原位杂交为阴性.ALK蛋白表达模式为细胞质与细胞核.回顾相关文献,该例原发性皮肤CD30+间变性大细胞淋巴瘤检测到ALK蛋白阳性表达系国内首例报告.     

原发性皮肤CD30+间变性大细胞淋巴瘤1例

报告1例原发性皮肤CD30+间变性大细胞淋巴瘤.患者男,72岁.右足拇趾红肿,外侧有一2.0 cm×2.5 cm红色溃疡面,伴血性液体渗出,近端有一1.5 cm×2.0 cm暗红色结节,表面结痂.皮损组织病理及免疫组化标记确诊为原发性皮肤CD30+间变性大细胞淋巴瘤.     

原发性皮肤间变性大细胞淋巴瘤1例

原发性皮肤间变性大细胞淋巴瘤(primary cutaneous anaplastic large cell lymphoma,PC-ALCL)临床少见,泛发者罕见.现将笔者诊治的1例报告如下.     

原发性皮肤间变性大细胞淋巴瘤1例

报告1例原发性皮肤间变性大细胞淋巴瘤。患者女,49岁。右小腿结节1年,溃烂5个月。皮损组织病理检查:真皮内有密集的淋巴样细胞浸润,瘤细胞大、核呈肾形或不规则形、核分裂像多见,免疫组化示瘤细胞约70?30阳性、约20?45Ro阳性,而CD3、CD20、MPO、TIA-1、ALK-1均为阴性。诊断为原发性皮肤间变性大细胞淋巴瘤。     

原发性皮肤CD30+间变性大细胞淋巴瘤1例

间变性大细胞淋巴瘤(anaplastic large cell lymphoma,ALCL)1985年首先由Stein等报告,临床上分系统性和皮肤原发性.皮肤原发性临床少见,现报告1例.     

原发性皮肤间变性大细胞淋巴瘤1例

临床资料：患者，男 69岁，发现下腹部皮肤肿块1年，表面出现破溃6个月，于2001年10月8日来我科就诊。患者2000年11月时发现左下腹部皮肤有一个蚕豆大暗红色结节，渐扩大至鸽蛋大，约半年后表面开始溃破，有黄色分泌物，皮损组织病理示：慢性炎症。多次给予抗菌素治疗，皮损无好转。2001年6月在原皮损左下方又起一蚕豆大肿块，     

原发性皮肤间变性大细胞淋巴瘤1例

原发性皮肤间变性大细胞淋巴瘤（primaiy cutaneous anaplastic large cell lymphoma.C-ALCL）是间变性大细胞淋巴瘤（naplastic large cell lymphoma,ALCL）中的一个类型，     

泛发性原发皮肤CD30+间变性大细胞淋巴瘤

报告1例泛发性原发皮肤CD30+问变性大细胞淋巴瘤.患者男,44岁.因全身皮肤多发红斑、结节、溃疡50余天就诊,皮损组织病理及免疫组化检查结果提示间变性大细胞淋巴瘤,免疫组化检查:瘤细胞CD3(++),CD30(++),Ki-67约50%(+),CD20、Ckpan、S-100蛋白、HMB45、间变性淋巴瘤激酶(ALK)-1均阴性,诊断为间变性大细胞淋巴瘤.     

原发性皮肤CD30~+间变性大细胞淋巴瘤一例

患者,男,50岁。背部、前胸多发结节伴轻压痛半年余。皮损组织病理检查示:表皮角化过度、棘层肥厚;真皮全层及皮下组织间变性弥漫肿瘤细胞浸润、瘤细胞体积大,可见核分裂相。免疫组化结果:85%CD30强阳性,Ki-67约40%(+),CD3(++),LCA(+)。诊断:原发性皮肤CD30~+间变性大细胞淋巴瘤,T细胞型。     

Primary cutaneous anaplastic large cell lymphoma

Primary cutaneous anaplastic large cell lymphoma (PC‐ALCL) is a CD30+ lymphoproliferative disorder (LPD) of the skin with a relatively good prognosis in the absence of high‐stage disease. CD30+ LPDs comprise approximately 25%‐30% of primary cutaneous lymphomas and as a group represent the second most common clonal T‐cell neoplasm of the skin behind mycosis fungoides. Diagnosis of PC‐ALCL relies strongly on clinicopathologic correlation given the potential morphologic, clinical and molecular overlap with the other cutaneous CD30+ LPD, lymphomatoid papulosis, and more aggressive hematolymphoid neoplasms.     

皮肤原发间变大细胞淋巴瘤一例

患者,男,75岁。因躯干及四肢泛发红斑水疱伴瘙痒半年,加重伴双下肢多处溃疡2^＋月入院。患者发病半年前因外伤双下肢出现红斑丘疹水疱,破溃后流黄水,形成糜烂面,逐渐发展至躯干及双上肢,部分红斑丘疹上覆蛎壳状鳞屑,溃疡面上覆黑色坏死样痂皮,就诊于成都多家医院。诊断为＂银屑病＂,治疗效果不佳。患者双下肢水肿明显,溃疡处分泌物增多,故来我院就诊。患者自觉瘙痒疼痛。既往史：有高血压、糖尿病、冠心病。对＂磺胺类药物＂过敏。     

Primary cutaneous anaplastic large cell lymphoma with subsequent leg involvement

Primary cutaneous anaplastic large cell lymphoma (C-ALCL) is regarded as an indolent type of cutaneous T-cell lymphoma. However, a few recent publications revealed that C-ALCL patients with initial leg involvement had significantly worse survival than those without initial leg involvement. Herein, we report a case of C-ALCL with subsequent leg involvement, which led to death after chemoradiation therapy. A 75 years old Japanese man presented with multiple erythematous nodules in his left arm and the side of his left chest. Histopathological and immunohistochemical studies led to the diagnosis of primary C-ALCL. At the initial diagnosis, no leg lesion was found. One year after the initial diagnosis, C-ALCL appeared in his right lower thigh and left hip. Radiation therapy, low-dose etoposide and CHOP therapy were performed; however, the patient died of malignant lymphoma 4 years after the initial diagnosis. We speculated that the occurrence of subsequent leg involvement may also be indicative of a worse prognosis, as in the case with initial leg involvement in C-ALCL. Therefore, we propose that C-ALCL patients with initial or subsequent leg involvement should be classified as a distinct clinicopathological variant of C-ALCL (“leg-type” involvement) and that they may require intense therapy.     

CD56 expression in a case of primary cutaneous CD30+ anaplastic large cell lymphoma

We describe clinicopathological features of an unusual case of CD30+/CD56+ T-cell lymphoma in a 58-year-old Korean man who presented with disseminated nodules, papules and hyperpigmented patches. Coexpression of CD30 and CD56 in T-cell lymphoma is very rare. Our patient did not respond to an intensive chemotherapy regimen, in contrast to the previously reported cases of primary cutaneous CD30+ anaplastic large cell lymphoma. Coexpression of CD56 might therefore identify a subset of CD30+ lymphomas with more aggressive features.     

富含中性粒细胞的原发皮肤CD30阳性大细胞间变淋巴瘤二例

富含中性粒细胞的原发皮肤CD30阳性大细胞间变淋巴瘤是原发皮肤CD30阳性大细胞间变淋巴瘤的一种组织学亚型,具有较为独特和复杂的临床和组织学特点,容易误诊.我们报道2例富含中性粒细胞的原发皮肤CD30阳性大细胞间变淋巴瘤,患者均表现为具有脓性分泌物的红斑、结节,组织学除了大量表达CD30的多形性细胞外,尚可见大量的中性粒细胞.     

富含中性粒细胞的原发皮肤CD30阳性大细胞间变淋巴瘤二例

富含中性粒细胞的原发皮肤CD30阳性大细胞间变淋巴瘤是原发皮肤CD30阳性大细胞间变淋巴瘤的一种组织学亚型,具有较为独特和复杂的临床和组织学特点,容易误诊.我们报道2例富含中性粒细胞的原发皮肤CD30阳性大细胞间变淋巴瘤,患者均表现为具有脓性分泌物的红斑、结节,组织学除了大量表达CD30的多形性细胞外,尚可见大量的中性粒细胞.