融合成像超声造影术中即时评估肝癌射频消融疗效

目的 探讨融合成像超声造影(CEUS)在肝癌射频消融(RFA)术中即时评估消融疗效的临床价值.方法 行肝癌RFA治疗的患者90例,在RFA后分别行融合成像CEUS和常规CEUS评价消融效果,同时定义每组中二维超声显示欠佳、直径＞5 cm及穿刺入径困难的病灶为困难病灶,以消融术后1个月的CT/MRI结果为金标准,比较两组病例及其中困难病例的完全消融率.结果 融合成像CEUS组及常规CEUS组分别有48及68个病灶,困难病例分别有19及18个,两组病例的病灶大小、困难病灶比例、联合行经动脉化疗栓塞或经皮无水酒精注射治疗的比例差异无统计学意义(P =0.052,P=0.136,P=0.185,P=1.000).术后随访提示融合成像CEUS组及常规CEUS组完全消融率分别为100％(48/48)和92.6％ (63/68),两者比较差异无统计学意义(P=0.145).两组中困难病例的完全消融率分别为100％(19/19)及72.2％(13/18),两组比较差异有统计学意义(P=0.020).结论 融合成像CEUS能在术中即时评价消融疗效,尤其能提高困难病例的完全消融率,可作为常规CEUS的补充方法.     

CT/MR超声造影融合成像在肝癌消融术中的应用探讨

通过选取笔者所在医院治疗的53例肝癌病例,分别是普通超声成像和利用CT/MR超声造影融合成像技术进行引导消融,对不同的成像方法进行分析和总结。结果本研究数据显示,因普通超声清晰度欠佳而不能进行的消融术,在CT/MR超声融合成像的引导下可以进行,并且治疗效果与普通超声相比无明显差异。肝癌消融术中,普通成像与CT/MR超声融合成像均能达到引导肝癌消融术的治疗目的,但是在普通超声成像清晰度欠佳而不能进行的情况下,在CT/MR超声融合成像的引导下得以成功进行肝癌消融术,CT/MR超声融合成像在临床肝癌消融术中具有不可或缺的价值。     

超声造影对肝癌射频微创治疗的应用价值

目的：评价超声造影对肝癌射频微创治疗的价值。方法：98例肝癌患者126个病灶在超声引导下射频消融治疗,其中原发性肝癌51例60个病灶,转移性肝癌47例66个病灶。治疗前及治疗后行超声造影检查,并与同期增强CT比较,治疗中51例69个病灶使用了超声造影引导消融。结果：126个病灶治疗1个月后超声造影判定89.7%（113/126）的病灶达到完全消融,10.3%（13/126）的病灶消融不全;增强CT判定88.9%（112/126）的病灶达到完全消融,11.1%（14/126）的病灶消融不全,两者比较差异无显著性,P＞0.01。结论：超声造影在肝癌射频微创治疗中不但起着定位肿瘤、引导穿刺、监测治疗过程的作用,而且是评价肝癌射频消融疗效的有效方法。     

高强度聚焦超声治疗原发性肝癌即时超声造影评价并指导补充治疗的疗效观察

目的 探讨高强度聚焦超声(HIFU)治疗原发性肝癌即时超声造影评价并指导补充治疗的临床应用价值.方法 55例原发性肝细胞癌患者(68个病灶)随机分为A、B两组,其中A组30例(38个病灶)治疗前及治疗后10 min进行超声造影检查,并对未完全灭活的病灶针对性地行HIFU补充治疗;B组25例(30个病灶)为对照组.观察治疗的安全性及治疗后两组患者临床症状、甲胎蛋白、影像学等各项指标的变化,并比较两组患者的远期疗效.结果 HIFU治疗后即时超声造影发现A组19个病灶未完全灭活并补充治疗.全部患者均无严重并发症出现.治疗后A、B两组患者甲胎蛋白值下降率分别为86.7%(26/30)、64.0%(16/25);肿瘤完全坏死率分别为97.3%(37/38)、60.0%(18/30);半年、1年生存率分别为100%、90.0%和76.0%、68.0%;两组差异均具有统计学意义(P＜0.05).结论 HIFU治疗原发性肝癌即时超声造影评价并指导补充治疗有利于病灶的完全灭活,可以缓解症状,改善生活质量,延长生存期,具有较好的临床应用价值.     

声脉冲辐射力弹性成像声触诊组织定量技术评价肝癌射频消融疗效的初步研究

目的探讨声脉冲辐射力弹性成像声触诊组织定量(VTQ)技术在肝癌射频消融(RFA)疗效评价中的价值。方法在我院行RFA的62例肝癌患者共72个病灶为研究对象,术后20~40 d以常规超声、超声造影、VTQ及增强CT进行疗效评价。应用VTQ技术定量检测肝癌病灶RFA术前和术后的组织硬度,比较治疗前后的剪切波速度(SWV)。以增强CT结果为标准,评估VTQ技术在肝癌RFA术后疗效诊断中的应用价值。结果 VTQ检测64个消融完全的肝癌消融前后的SWV值分别为(2.65±0.58)m/s和9.00 m/s,差异有统计学意义(P0.05);8个术后局部残留病变消融前后的SWV值分别为(2.43±0.29)m/s和(2.50±0.25)m/s,差异无统计学意义。以增强CT为标准:72个肝癌病灶RFA后9个残留,63个完全消融。VTQ诊断消融后残留病灶的敏感性、特异性和准确性分别为77.8%、98.4%和95.8%,超声造影分别为100%、96.9%和97.2%;VTQ与增强CT检查结果一致性好(Kappa=0.800,P0.05)。结论 VTQ技术能反映消融灶的组织硬度,辅助识别残存肿瘤,对评价肝癌RFA疗效有重要价值。     

超声造影在特殊部位肝癌治疗中的价值

目的探讨超声造影在治疗特殊部位肝癌中的价值。方法回顾特殊部位肝癌瘤体158个,术前行超声造影明确肿瘤浸润范围,根据治疗方法分为联合治疗组和微波消融组,在术后1个月评价术后消融效果并观察有无重大并发症。结果超声造影显示的肿瘤范围大于常规超声显示的范围,联合治疗组完全消融率为91.0%,微波消融组完全消融率为73.9%,术后均无重大并发症出现。结论超声造影可清晰显示肿瘤浸润范围,对肿瘤的疗效评价有一定的帮助。     

超声造影评估肝癌消融局部疗效价值的研究

目的评价超声造影判定肝癌消融局部疗效的价值。 方法对183例肝细胞性肝癌共248个结节行超声引导下经皮化学或热消融治疗，用超声造影判定局部疗效，造影剂为声诺维，使用低机械指数连续成像技术。以同期的增强CT或MRI作为金标准，作诊断性试验评估超声造影的判定效能。 结果增强CT或MRI判定78．2％（194／248）的病灶达到完全消融，21．8％（54／248）的肿瘤消融不全；超声造影判定79．O％（196／248）的病灶达到完全消融，21.0％（52／248）的病灶消融不全。同增强CT或MRI比较，超声造影诊断的敏感性、特异性、阳性预测值、阴性预测值、准确性分别为90．7％（49／54）、98．5％（191／194）、94．2％（49／52）、97．4％（191／196）、96．8％（240／248）。 结论超声造影判定肝癌消融局部疗效具有与增强CT或MRI同等的价值。     

超声造影评价射频消融治疗肝癌的疗效

目的探讨超声造影评价射频消融治疗肝癌疗效的临床应用价值。方法 25例原发性肝癌患者(28个病灶)和4例转移性癌患者(8个病灶)经射频消融治疗后行常规超声和超声造影检查,评价治疗后肿瘤灭活、残存或复发情况。结果 36个病灶中,27个病灶在造影各时相均未见增强,提示肿瘤完全灭活;9个病灶在动脉相呈局部形态不一增强,门脉相及延迟相消退,提示有残存肿瘤。超声造影的诊断准确性为91.7%,敏感性为87.5%,特异性为92.9%。结论超声造影判断射频消融治疗肝癌疗效准确性较高,可作为肝癌局部治疗疗效评价的重要方法,可临床推广应用。     

超声造影对肝癌介入治疗局部疗效评估的临床价值

目的 探讨超声造影评价肝癌介入治疗局部疗效的价值.方法 对经病理证实的103例肝癌患者136个病灶治疗前后分别行常规超声、增强CT、超声造影,数字减影血管造影(DSA)检查,并对比分析.结果 超声造影和常规超声对术后病灶检测的敏感性、特异性和准确性分别为95.8%、95.6%、98.5%和92.3%、77.4%、83.1%.超声造影与增强CT/DSA具有很好的一致性(Kappa值=0.93),明显高于常规超声(Kappa值=0.66).结论 超声造影是一种判定肝癌介入治疗疗效并及时指导治疗的有效途径.     

容积超声造影对肝肿瘤射频消融效果的评估

目的探讨容积超声造影评估肝肿瘤射频消融效果的价值。方法对22只新西兰白兔肝脏VX2肿瘤和22例肝癌患者进行射频消融治疗,治疗前后分别进行二维及容积超声造影,所有患者治疗前后行增强CT检查,动物肝脏均做病理学检查。结果消融前所有病灶二维及容积超声造影均表现为早期动脉相病灶内均匀或不均匀高增强;消融后,动物实验中19个病灶的疗效判断二维超声造影与病理结果相同;22个病灶容积超声造影与病理结果相同;临床研究中20个病灶的疗效判断二维超声造影与增强CT相同,24个病灶容积超声造影结果与增强CT相同。结论容积超声造影有可能更好地评估肝脏肿瘤消融治疗效果。     

经直肠超声造影诊断直肠癌的价值

目的 探讨经直肠超声造影对直肠癌的诊断价值.方法 21例直肠癌患者,常规超声观察病变二维声像图和彩色血流特点,超声造影观察病变组织内造影剂强化特点、增强时间、增强水平、增强形态及变化;对声像图进行定量分析,绘制肿瘤与正常肠壁的感兴趣区血流灌注的时间-强度曲线,并进行拟合,分析其峰值强度及达峰时间.结果 常规超声表现:直肠肠壁增厚,回声减低,边界不清,肿瘤内部回声不均,内部和周边可探及丰富的彩色血流信号,呈高速高阻血流频谱.超声造影表现:病灶呈快速高增强模式,与周围正常肠壁回声差异显著;可清楚显示病灶的大小、边界与侵袭范围;其肿瘤血管走行扭曲,形态不规则,并能够显示彩色多普勒超声不能显示的微血管.应用超声造影伪彩编码与叠加技术,有助于增强对肿瘤与周边正常组织关系的认识.与正常肠壁相比,肿瘤的达峰时间减小,达峰强度增加.结论 直肠癌超声造影具有典型的声像图表现,可以为直肠癌的术前诊断与术后评估监控提供更加丰富的信息.     

肝血管平滑肌脂肪瘤的超声造影表现

Objective To investigate the features of hepatic angiomyolipoma(AML) on contrast enhanced ultrasound (CEUS). Methods Ten pathologically proved AML lesions in 9 patients were evaluated by using baseline ultrasound and CEUS. CEUS was performed with contrast pulse sequencing technique and the contrast agent of SonoVue. Results On baseline ultrasound, 7 lesions exhibited mixed echoic,which was obvious hyperechoic combined with partly of hypoechoie; 3 lesions exhitited obvious hypereehoic. On color Doppler flow imaging artery signals were detected in all lesions. And the lesions had plenty or slightly plenty of artery supply,with resistive index about 0.53 4±0.10 (0.48~0.62). On CEUS, in the arterial phase, 9 lesions exhibited hyper-enhanced. In the portal phase, 5 lesions exhibited iso-enhancement,1 lesion was slightly hyper-enhancement and 3 lesions was hypo-enhancement. In the late phase 6 lesions were iso-enhancement and 3 lesions were hypo-enhancement. One lesion was all hypo-enhancement in all three phases. Conclusions There are some characteristic manifestations of hepatic AML in CEUS, which are helpful for the diagnosis of hepatic AML in a way,but we still need more experiences.     

肝血管平滑肌脂肪瘤的超声造影表现

Objective To investigate the features of hepatic angiomyolipoma(AML) on contrast enhanced ultrasound (CEUS). Methods Ten pathologically proved AML lesions in 9 patients were evaluated by using baseline ultrasound and CEUS. CEUS was performed with contrast pulse sequencing technique and the contrast agent of SonoVue. Results On baseline ultrasound, 7 lesions exhibited mixed echoic,which was obvious hyperechoic combined with partly of hypoechoie; 3 lesions exhitited obvious hypereehoic. On color Doppler flow imaging artery signals were detected in all lesions. And the lesions had plenty or slightly plenty of artery supply,with resistive index about 0.53 4±0.10 (0.48~0.62). On CEUS, in the arterial phase, 9 lesions exhibited hyper-enhanced. In the portal phase, 5 lesions exhibited iso-enhancement,1 lesion was slightly hyper-enhancement and 3 lesions was hypo-enhancement. In the late phase 6 lesions were iso-enhancement and 3 lesions were hypo-enhancement. One lesion was all hypo-enhancement in all three phases. Conclusions There are some characteristic manifestations of hepatic AML in CEUS, which are helpful for the diagnosis of hepatic AML in a way,but we still need more experiences.     

肝血管平滑肌脂肪瘤的超声造影表现

目的 探讨肝血管平滑肌脂肪瘤(angiomyolipoma,AML)的超声造影表现.方法 回顾性分析9例经病理确诊的肝AML患者共10个病灶的常规超声和超声造影表现.超声造影采用SonoVue和对比脉冲序列成像技术.结果 常规超声7个病灶呈现混合回声,即明显高回声伴片状低回声;3个病灶呈明显高回声.彩色多普勒超声检查所有病灶均测得动脉血供,且血供丰富或较丰富或稀少,阻力指数平均0.53±0.10(0.48～0.62).超声造影显示9个病灶动脉期均呈高增强;门脉期5个为等增强,1个为高增强,3个为低增强;延迟期6个为等增强,3个为低增强.1个病灶三期均为低增强.结论 超声造影上肝AML的增强表现具有一定特征性,可用于提示诊断,但仍需积累更多经验.     

胆囊功能不良的超声微泡造影研究

目的：观察胆囊功能不良患者超声微泡造影情况,为胆囊切除手术术前的评估作一定的参考。方法采用超声微泡造影对77例胆囊功能不良患者（研究组）和22例胆囊功能正常者（正常对照组）进行检查,获取造影剂到达时间（AT）、灌注时间（IT）、峰值强度（PI）、基础增强强度（BI）、胆囊壁的增强强度（EI）等参数。然后将研究组经保守治疗后按照排胆分数（GBEF）分为GBEF≥50%和GBEF＜50%两组,观察比较AT、IT、EI的结果。结果研究组的AT、 IT 、EI均明显大于正常对照组,差异均有统计学意义（t分别=3.07、2.88、3.21,P均＜0.05）。研究组内GBEF≥50%亚组的AT、 IT 、EI均明显大于GBEF＜50%亚组,差异均有统计学意义（t分别=2.77、3.53、4.20,P均＜0.05）。结论超声微泡造影对评价胆囊功能不良患者保守治疗的预后及选择治疗方式上具有较大的参考价值。     

肝血管平滑肌脂肪瘤的超声造影表现

Objective To investigate the features of hepatic angiomyolipoma(AML) on contrast enhanced ultrasound (CEUS). Methods Ten pathologically proved AML lesions in 9 patients were evaluated by using baseline ultrasound and CEUS. CEUS was performed with contrast pulse sequencing technique and the contrast agent of SonoVue. Results On baseline ultrasound, 7 lesions exhibited mixed echoic,which was obvious hyperechoic combined with partly of hypoechoie; 3 lesions exhitited obvious hypereehoic. On color Doppler flow imaging artery signals were detected in all lesions. And the lesions had plenty or slightly plenty of artery supply,with resistive index about 0.53 4±0.10 (0.48~0.62). On CEUS, in the arterial phase, 9 lesions exhibited hyper-enhanced. In the portal phase, 5 lesions exhibited iso-enhancement,1 lesion was slightly hyper-enhancement and 3 lesions was hypo-enhancement. In the late phase 6 lesions were iso-enhancement and 3 lesions were hypo-enhancement. One lesion was all hypo-enhancement in all three phases. Conclusions There are some characteristic manifestations of hepatic AML in CEUS, which are helpful for the diagnosis of hepatic AML in a way,but we still need more experiences.     

肝血管平滑肌脂肪瘤的超声造影表现

Objective To investigate the features of hepatic angiomyolipoma(AML) on contrast enhanced ultrasound (CEUS). Methods Ten pathologically proved AML lesions in 9 patients were evaluated by using baseline ultrasound and CEUS. CEUS was performed with contrast pulse sequencing technique and the contrast agent of SonoVue. Results On baseline ultrasound, 7 lesions exhibited mixed echoic,which was obvious hyperechoic combined with partly of hypoechoie; 3 lesions exhitited obvious hypereehoic. On color Doppler flow imaging artery signals were detected in all lesions. And the lesions had plenty or slightly plenty of artery supply,with resistive index about 0.53 4±0.10 (0.48~0.62). On CEUS, in the arterial phase, 9 lesions exhibited hyper-enhanced. In the portal phase, 5 lesions exhibited iso-enhancement,1 lesion was slightly hyper-enhancement and 3 lesions was hypo-enhancement. In the late phase 6 lesions were iso-enhancement and 3 lesions were hypo-enhancement. One lesion was all hypo-enhancement in all three phases. Conclusions There are some characteristic manifestations of hepatic AML in CEUS, which are helpful for the diagnosis of hepatic AML in a way,but we still need more experiences.     

肝血管平滑肌脂肪瘤的超声造影表现

Objective To investigate the features of hepatic angiomyolipoma(AML) on contrast enhanced ultrasound (CEUS). Methods Ten pathologically proved AML lesions in 9 patients were evaluated by using baseline ultrasound and CEUS. CEUS was performed with contrast pulse sequencing technique and the contrast agent of SonoVue. Results On baseline ultrasound, 7 lesions exhibited mixed echoic,which was obvious hyperechoic combined with partly of hypoechoie; 3 lesions exhitited obvious hypereehoic. On color Doppler flow imaging artery signals were detected in all lesions. And the lesions had plenty or slightly plenty of artery supply,with resistive index about 0.53 4±0.10 (0.48~0.62). On CEUS, in the arterial phase, 9 lesions exhibited hyper-enhanced. In the portal phase, 5 lesions exhibited iso-enhancement,1 lesion was slightly hyper-enhancement and 3 lesions was hypo-enhancement. In the late phase 6 lesions were iso-enhancement and 3 lesions were hypo-enhancement. One lesion was all hypo-enhancement in all three phases. Conclusions There are some characteristic manifestations of hepatic AML in CEUS, which are helpful for the diagnosis of hepatic AML in a way,but we still need more experiences.     

肝血管平滑肌脂肪瘤的超声造影表现

Objective To investigate the features of hepatic angiomyolipoma(AML) on contrast enhanced ultrasound (CEUS). Methods Ten pathologically proved AML lesions in 9 patients were evaluated by using baseline ultrasound and CEUS. CEUS was performed with contrast pulse sequencing technique and the contrast agent of SonoVue. Results On baseline ultrasound, 7 lesions exhibited mixed echoic,which was obvious hyperechoic combined with partly of hypoechoie; 3 lesions exhitited obvious hypereehoic. On color Doppler flow imaging artery signals were detected in all lesions. And the lesions had plenty or slightly plenty of artery supply,with resistive index about 0.53 4±0.10 (0.48~0.62). On CEUS, in the arterial phase, 9 lesions exhibited hyper-enhanced. In the portal phase, 5 lesions exhibited iso-enhancement,1 lesion was slightly hyper-enhancement and 3 lesions was hypo-enhancement. In the late phase 6 lesions were iso-enhancement and 3 lesions were hypo-enhancement. One lesion was all hypo-enhancement in all three phases. Conclusions There are some characteristic manifestations of hepatic AML in CEUS, which are helpful for the diagnosis of hepatic AML in a way,but we still need more experiences.     

肝血管平滑肌脂肪瘤的超声造影表现

Objective To investigate the features of hepatic angiomyolipoma(AML) on contrast enhanced ultrasound (CEUS). Methods Ten pathologically proved AML lesions in 9 patients were evaluated by using baseline ultrasound and CEUS. CEUS was performed with contrast pulse sequencing technique and the contrast agent of SonoVue. Results On baseline ultrasound, 7 lesions exhibited mixed echoic,which was obvious hyperechoic combined with partly of hypoechoie; 3 lesions exhitited obvious hypereehoic. On color Doppler flow imaging artery signals were detected in all lesions. And the lesions had plenty or slightly plenty of artery supply,with resistive index about 0.53 4±0.10 (0.48~0.62). On CEUS, in the arterial phase, 9 lesions exhibited hyper-enhanced. In the portal phase, 5 lesions exhibited iso-enhancement,1 lesion was slightly hyper-enhancement and 3 lesions was hypo-enhancement. In the late phase 6 lesions were iso-enhancement and 3 lesions were hypo-enhancement. One lesion was all hypo-enhancement in all three phases. Conclusions There are some characteristic manifestations of hepatic AML in CEUS, which are helpful for the diagnosis of hepatic AML in a way,but we still need more experiences.