Subject Index to Volume 21

ABSTRACT

A novel amperometric immunosensor, based on graphite paste (graphite powder and paraffin oil), has been constructed for the assay of l-T₄. The graphite paste is impregnated with mouse monoclonal anti-(+)-3,3′,5,5′-tetraiodo-l-thyronine (anti-l-T₄). The immunosensor can be reliably used for the assay of l-T₄ in thyroid and in drugs, using chronoamperometry technique, at ppt up to ppb concentration levels. The potential used for l-T₄ assay was +450 mV vs. Ag/AgCl electrode. The surface of the immunosensor can be regenerated by simply polishing, obtaining fresh immunocomposite ready to be used in a new assay.