共查询到18条相似文献,搜索用时 78 毫秒
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鼻型NK/T细胞淋巴瘤是近年来提出的一种淋巴瘤亚型[1],为发生于鼻腔及面中部进行性毁损性病变,过去曾诊断为致死性中线肉芽肿、中线恶性网状细胞增多症、多形性网状细胞增多症等。现报告我科所见1例并结合文献复习如下。 相似文献
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患者男,60岁,藏族。全身斑块、结节及肿块6月,肿块破溃伴疼痛2月。皮损病理组织示:表皮变薄,基底层液化变性,瘤细胞在真皮及皮下脂肪层呈弥漫性浸润,瘤细胞形态不一,核深染,可见血管中心性浸润及凝固性坏死。免疫组化标记瘤细胞CD3,CD3ε,CD56,TIA-1,粒酶B均为(+),CD30约10%(+),CD8(-),CD79a(-),EBER1/2原位杂交(+)。TCR-γ重排未见明确克隆性重排条带。诊断:皮肤结外鼻型NK/T细胞淋巴瘤。 相似文献
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报告1例累及皮肤的结外鼻型NK/T细胞淋巴瘤。患者女,74岁。鼻根部出现红肿、破溃。根据皮损、组织病理检查和免疫组化染色结果确诊。 相似文献
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报告1例结外鼻型NK/T细胞淋巴瘤患者。患者男,36岁。因"全身散在浸润性红斑、紫红色斑块4个月"就诊。皮肤科检查:躯干、四肢散在分布硬币至核桃大小的红色、紫红色斑块,浸润感明显,双侧腹股沟及腋下淋巴结肿大,左侧睾丸肿胀。经皮肤组织病理及免疫组化检查确诊为"结外鼻型NK/T细胞淋巴瘤"。 相似文献
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Nasal natural killer (NK)/T cell lymphoma is an Epstein-Barr virus (EBV) associated lymphoma that arises in the nasal area and aggressively invades surrounding tissues. Our patient was a 48-year-old male who had had nasal obstruction and nasal discharge for 2 years and infiltrating plaques and necrosis on his nasal dorsum for three months. He developed fever and fatigue two weeks before admission. Biopsy from both skin and nasal mucosa revealed atypical medium-sized tumor cells infiltrating into the dermis. Immunohistochemical studies revealed that the tumor cells were UCHL-1, cytoplasmic CD3, CD56, TIA-1, and granzyme B positive, and CD8 and CD20 negative. In situ hybridization for EBV-DNA was positive. Clonal TCRb and TCRg gene rearrangement were negative. The patient was treated with cyclophosphamide, vincristine, and prednisone (COP) and with local radiotherapy, but he died 20 days later. We reviewed the cases of nasal NK/T cell lymphoma reported in mainland China in the Chinese literature during the last 5 years. 相似文献
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鼻部NK/T细胞淋巴瘤累及皮肤 总被引:2,自引:1,他引:2
为了探讨鼻部NK/T细胞淋巴瘤累及皮肤的临床表现、病理、免疫表型及EB病毒相关性。通过临床表现及病程,分析原发及累及部位。通过UCHL-1,CD56,多克隆CD3,CD8,CD20,TIA-1,粒酶B(GrB)等对肿瘤细胞免疫表型进行研究,EBV-EBER探针原位杂交检测肿瘤细胞阳性率分析其病因及发病。结果本例皮肤及鼻部取材组织病理表现为坏死及中等大小的异型性肿瘤细胞增生浸润,UCHL-1+,CD56+,CD3+,CD8-,CD20-,TIA-1+,granzyme B ,为NK/T细胞淋巴瘤表型。EBV瘤细胞阳性率达60%,进一步证实为鼻部NK/T细胞淋巴瘤,EBV相关性。支持鼻部NK/T细胞淋巴瘤是具有特殊免疫表型,与EB病毒有高度相关性的独立疾病,临床进展迅速,病程短,提示为高度侵袭性。 相似文献
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In the CD56+ cutaneous nasal-type NK/T-cell lymphoma strongly associated with latent EBV infection, subcutaneous or dermal nodules are the most common skin findings, but great morphologic heterogeneity has been noted including papules, infiltrated plaques, and ulcerated tumors, and TCR genes are mostly germline. We describe a case of nasal and nasal-type NK/T-cell lymphoma featuring multiple erythematous polycyclic patches on the trunk, which is similar to patch stage mycosis fungoides or other cutaneous T cell lymphoma. Immunohistochemical study of a skin biopsy specimen revealed CD2+, CD3epsilon+, CD56+, and CD45RO+ expression in the neoplastic cells. In situ hybridization using an anti-sense Epstein Barr virus early regions probe showed a positive reaction. However, clonal TCR beta gene rearrangement was found. 相似文献
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患者女,46岁。双下肢相继出现红色结节及溃疡4月余,鼻部溃疡1个月。右大腿皮损组织病理示:大淋巴样细胞弥漫浸润;免疫组化染色:CD2,CD3,CD56,TIA-1,Grb和EBER均(+),CD20(-)。诊断:鼻型节外NK/T细胞淋巴瘤。 相似文献
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Sitthinamsuwan P Pongpruttipan T Bunyaratavej S Karoopongse E Kummalue T Sukpanichnant S 《Journal of cutaneous pathology》2011,38(12):1004-1008
We report a 51-year-old woman with cutaneous involvement by extranodal NK/T-cell lymphoma (TCL) of the colon that microscopically mimicked mycosis fungoides (MF). She had a history of fever of unknown origin for 2 months and then developed multiple erythematous papules on her trunk and extremities. A skin biopsy revealed superficial infiltration by atypical small to medium-sized lymphocytes with epidermotropism and Pautrier collections. Immunohistochemical studies showed expression of CD3 and TIA-1 with lack of expression (double negative) of CD4 and CD8. Initially, we reported the diagnosis as MF, cytotoxic variant. Thereafter, computerized tomography scan incidentally identified a colonic mass. A colonic biopsy revealed infiltration of atypical lymphoid cells with the same morphology and immunophenotype as those found in the skin. Additionally, CD56 and Epstein-Barr virus-encoded RNA in situ hybridization in both skin and colonic biopsies were diffusely positive. Thus, extranodal NK/TCL was diagnosed. Delta T-cell receptor (TCR) gene rearrangement was documented in the skin biopsy by polyacrylamide gel electrophoresis and fluorescence capillary gel electrophoresis methods. There was no TCR gene rearrangement detected in the colonic biopsy. Unfortunately, the patient died within 2 months of diagnosis. 相似文献