Blood pressure regulation: role for neutrophils?

Traditionally, neutrophils and neutrophil-derived enzymes have been viewed to play a role exclusively in host defense. However, there is growing evidence that neutrophils also contribute to the regulation of vascular tone.     

Blood pressure and atherosclerosis

2005188 No association between 3 polymorphisms of transforming growth factor β3 gene and essential hypertension in Chinese. HU Bang-chuan (呼邦传), et al. Shanghai Instit Hyperten Ruijin Hosp, Shanghai 2nd Med Univ Shanghai 200025. Chin J Cardiol, 2005;33(2):127-130. Objective: To investigate possible association between the single nucleotide polymorphisms (SNPs) of transforming growth factor β3 (TGF-β3) gene and     

Should we treat high-normal blood pressure?

OBJECTIVES: To examine the risk of cardiovascular disease associated with high-normal blood pressure in English adults and estimate the proportion of these individuals who are at high cardiovascular risk. DESIGN AND SETTING: Cross-sectional survey of England in 1998. PARTICIPANTS: Nationally representative sample of 12,341 individuals aged 18-80 years living in private households in England. MAIN OUTCOME MEASURE: Percentage of individuals with high-normal blood pressure who have cardiovascular disease, diabetes mellitus or a 10-year cardiovascular event risk of at least 20%. RESULTS: Of the 12,341 participants, 2413 (19.6%) had high-normal blood pressure. About 5.3% of those aged 18-80 years with high-normal blood pressure had cardiovascular disease or diabetes, and a further 7.6% were at a predicted cardiovascular event risk of at least 20% over 10 years. The mean predicted risk was 8.7% for men and 6.3% for women in the high-normal blood pressure category. The majority of men aged 61-80 years were at high cardiovascular risk. On average, men and women with high-normal blood pressure had a greater incidence of cardiovascular disease and diabetes mellitus, and a greater predicted mean cardiovascular risk than those with normal blood pressure. Extending antihypertensive treatment to individuals with high-normal blood pressure who are at high cardiovascular risk would involve treating an additional 2.5% of the English population aged 18-80 years. CONCLUSION: These findings support the view that individuals with high-normal blood pressure at high risk for cardiovascular disease should be targeted for blood pressure-lowering treatment.