Luteoma of the ovary during pregnancy (author's transl)]

The tumor of lutein cells of the ovary during pregnancy was first described by Sternberg (1963) as "luteoma of pregnancy". Up to 1973/74 66 cases were published. This benign tumor occurring only during pregnancy probably arises under stimulation of chorionic gonadotropin and may cause a virilization of the mother and female infant. After birth the ovarian tumors regress spontaneouly. Lutein cell tumors are usally discovered incidentally at laparotomy (cesarean section) in late pregnancy and require no radical surgical treatment. The feature of these tumors and some related questions are discussed on the basis of on own observation being, to our knowledge, the first case of this type in Central Europe.     

Hypophosphatemia (author's transl)]

Too often neglected, dosage of phosphatemia should yet be kept on mind. The role of phosphorus in bone mineralisation and regulation of acid-base balance is well known. Phosphorus is also an energy purveyor during numerous biologic reactions, and depp deprivation may lead to a lot of pathologic situations, sometimes severe. Mild hypophosphatemia is not rare and occurs in various clinical or therapeutic circumstances; deep hypophosphatemia is rather uncommon, occuring chiefly during hyperalimentation or realimentation of starving patients, especially alcoolics. Deep hypophosphatemia (by depletion or transfert) mainly induces clinical and pathological manifestations; they are subsequent to alterations of glucose metabolism, leading to a failure in ATP and 2,3 DPG synthesis. these metabolic events particularly explain muscular and hematological manifestations of hypophosphatemia. Phosphorus loading per os, or in severe cases intravenously corrects the biological abnormalities and improves clinical manifestations.     

Cystinosis (author's transl)]

Cystinosis (syn. crystine storage disease) is inherited as an autosomal recessive trait. The severety of clinical symptoms may vary considerably. The most severe form of nephropathic cystinosis causes death of the affected patients at the age of 2 to 4 years (subacute course) or before puberty (primary chronical course). Three autopsy cases are demonstrated. Each of these children died from complications of chronic renal failure, caused by kidney contraction as a sequela of chronic interstitial nephritis. Cristalline cystine deposits were found in the renal interstium as well as in the RES cells of spleen and liver. Because of water solubility of L-cystine aqueous fixation and staining solutions must be avoided. Diagnostic doubly refractive brick- or needle-shaped cystine cristals can be demonstrated in frozen sections or tissue smears from spleen, liver, lymphnode and bone marrow.     

Application of adsorption chromatography to the colorimetric determination of urinary estrogens in late pregnancy (author's transl)]

A new extraction procedure of urinary estrogens, based upon adsorption chromatography on Amberlite XAD-2, was deviced for a selective and complete extraction of these components. Estrogens were then quantified, without preliminar hydrolysis, by the colorimetric Kober reaction, modified by Ittrich. The reliability of this method has been established by comparison with four other methods.