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原发性小肠肿瘤:附30例分析 总被引:4,自引:1,他引:3
本文报告原发性小肠肿瘤30例,由于本病无特异临床表现,术前误诊率高达70%。本组30例均经手术和病理证实,其中恶性肿瘤26例(87%),良性肿瘤4例(13%)。男19例,女11例。因此病少见,故不易做到早期诊断和治疗,作者强调诊断本病需注意临床和病理的特征,方可提高原发性小肠肿瘤的诊断率。 相似文献
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目的探讨原发性腹膜后肿瘤术后复发的相关问题。方法回顾性分析10余年间资料较全的36例原发性腹膜后肿瘤术后复发的病例,探讨分析其预防术后复发的措施和再次手术问题。结果原发性腹膜后肿瘤术后复发是可预防的,36例都进行了再次或多次手术,相应延长了生存时间或减轻了症状。结论术后定时随诊,早期发现复发,提高病人对疾病的认识和进一步完善医疗保险制度,充分的术前准备和器官受累的正确估计以及充足的血源是预防再次复发的关键。再次或多次手术是完全必要的。 相似文献
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30例原发于眼眶恶性淋巴瘤的放疗疗效 总被引:1,自引:0,他引:1
目的:分析原发于眼眶恶性淋巴瘤的放射治疗方法.方法:30例原发于眼眶恶性淋巴瘤均为非霍奇金淋巴瘤.Ann-Arbor分期:Ⅰ a期21例,Ⅱa期9例.放射治疗剂量30~58Gy,3~6周.结果:1、3、5年局部控制率分别为96.7%、93.3%和90.0%.随诊3、5、10年生存率分别为100%、93.30%和76.7%,5例疾病进展.结论:局部放射治疗是原发于眼眶恶性淋巴瘤有效的治疗方法,放射治疗剂量为34~45Gy,3.5~4.5周;低度恶性放射剂量为30~35Gy,不需行淋巴引流区预防照射.对恶性程度高及有外侵犯者应辅加化疗. 相似文献
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目的:探讨原发性前列腺癌及高级别前列腺上皮内肿瘤(PIN)22条常染色体等位基因杂合性缺失及其意义采用显微切割技术提取前列腺癌及高级别前列腺上皮内肿瘤各10例的DNA,然后采用PCR及微卫星多态性技术,对22条常染体上的382个微卫星标志位点进行高密度allelotype分析。结果:10例原发性前列腺癌在染色体1p,1q,2p,2q,6q,8p,8q,10q,11q,13q,16p,17p等部位存在高频杂合性缺失(LOH),前列腺上皮内肿瘤则在染色体2p,2q,6q,8p,10q,1q等区易检测到LOH.结论:前列腺癌患者2q14,8p12-21,10q23-24,13q14等区域存在高频的LOH,位于这些区域的抑癌基因在前列腺癌发生,发展过程中起着重要作用。 相似文献
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Maja Cesen Mazic Raoul C. Reulen Janez Jazbec Lorna Zadravec Zaletel 《Radiology and oncology》2022,56(3):380
BackgroundThe aim of the study was to investigate long-term risk and spectrum of subsequent neoplasm (SN) in childhood cancer survivors and to identify how trends in therapy influenced cumulative incidence of SN.Patients and methodsThe population-based cohort comprises 3271 childhood cancer patients diagnosed in Slovenia aged ≤ 18 years between 1st January 1961 and 31st December 2013 with a follow-up through 31st December 2018. Main outcome measures are standardised incidence ratios (SIRs), absolute excess risks (AERs), and cumulative incidence of SN.ResultsAfter median follow-up time of 21.5 years for 5-year survivors, 230 patients experienced 273 SN, including 183 subsequent malignant neoplasm (SMN), 34 meningiomas and 56 nonmelanoma skin cancers. 10.5% patients received radiotherapy only, 31% chemotherapy only, 26.9% a combination of chemotherapy and radiotherapy and 16.1% surgery only. The overall SIR was almost 3 times more than expected (SIR 2.9), with survivors still at 2-fold increased risk after attained age 50 years. The observed cumulative incidence of SMN at 30-year after diagnosis was significantly lower for those diagnosed in 1960s, compared with the 1970s and the 1980s (P heterogeneity < 0.001). Despite reduced use of radiotherapy over time, the difference in cumulative incidence for the first 15 years after diagnosis was not significant for patients treated before or after 1995 (p = 0.11).ConclusionsRisks of developing a SMN in this study are similar to other European population-based cohorts. The intensity of treatment peaked later and use of radiotherapy declined slower compared to high income countries, making continuous surveillance even more important in the future.Key words: population-based study, childhood cancer survivors, subsequent neoplasm 相似文献
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多原发恶性肿瘤的病理诊断和免疫组织化学研究 总被引:3,自引:0,他引:3
本文报道62例多原发恶性肿瘤(MPMN)的免疫组织化学在病理诊断中的意义,尤其是51例发生在同一系统、同一器官或对称性器官,且组织结构相似的MPMN,颇难定原发或继发。通过免疫组织化学(CEA、HCG和K_(12))研究发现:MPMN的不同癌灶中,3种免疫组化染色常不相同。而对照组中,原发灶和继发灶两者反应基本一致。研究结果提示,MPMN灶可能具有各自的代谢和功能特性。应用免疫组化方法可能有助于与继发性癌瘤相鉴别。 相似文献
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Marleen J. ter Avest Romane M. Schook Lyan G. Koudstaal Katrien Grünberg Marinus A. Paul Egbert F. Smit Pieter E. Postmus 《Case reports in oncology》2014,7(1):122-125
Background
The finding of a renal mass on imaging is suggestive of metastatic non-small cell lung cancer in the presence of a lung tumor but can also have another origin.Case Report
We describe the case of a patient diagnosed with stage IV lung cancer based on a renal metastasis. A second opinion including review of histopathological data and additional imaging followed by lung surgery and cryoablation of the kidney lesion revealed two tumors of different origins, non-small cell lung cancer and a renal cell carcinoma.Discussion
The presence of a renal mass diagnosed on a CT scan in a patient with lung cancer is not always synonymous with metastatic disease. Confirmation of diagnosis by tissue sampling is mandatory, especially if a synchronous primary tumor is possible.Key words: Non-small cell lung cancer, Second opinion, Renal cell carcinoma, Diagnosis/treatment, Metastatic disease, Synchronous primary tumor 相似文献10.
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Piña-Oviedo S Del Valle L Padilla-Longoria R Mendoza-Ramón H Ortiz-Hidalgo C 《Pathology oncology research : POR》2008,14(4):497-502
Adamantinomas are rare, low-grade malignant intra-osseous tumors composed of epithelial and mesenchymal elements, which show
a marked predilection for the tibia and fibula of young adult male patients. Although cases of adamantinoma located to the
axial skeleton have been reported either as recurrent or metastatic disease, only two cases of primary adamantinoma located
to the thoracic wall have been previously described. In this study we present the clinical, radiological and histopathological
features of a 24-year-old male with a slow growing, solid-cystic, painful mass, located to the right 11th rib, which was morphological
and immunohistochemically diagnosed as a primary classic adamantinoma. Radiological studies showed a multiloculated lesion
with a solid component. The patient underwent a whole surgical resection of the lesion. Histologically, multiple foci of epithelial
cells with basaloid and squamous components were found intermixed within a fibrous stromal tissue. Immunohistochemical analysis
demonstrated expression of cytokeratins, EMA, vimentin and other epithelial markers. Primary affection of the rib is an unusual
feature of classic adamantinomas. 相似文献
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目的 通过分析广西医科大学 1970~ 1989年 2 0年间口腔颌面部肿瘤的病理检查资料 (来自广西各地区 ) ,进一步了解口腔颌面部肿瘤的发病状况。方法 分析经病理检查首次确诊原发于口腔颌面部肿瘤 52 0 1例 ,按其性质、组织类型、性别、就诊年龄与部位进行统计分析 ,并与首次确诊的全身原发肿瘤进行比较。结果 口腔颌面部肿瘤占全身肿瘤的 7 6 7% ,占头颈肿瘤19 39% ,恶性肿瘤略高于良性 ,恶性肿瘤男女之比 1 6 8∶1,良性肿瘤高发年龄组为 2 1~ 30岁 ,恶性肿瘤高发年龄组为 51~ 6 0岁 ,恶性肿瘤中以癌为最多 (82 0 7% ) ,而癌中以鳞状细胞癌最多 ,好发于舌部。结论 我校病理检查的口腔颌面部肿瘤各构成比 ,除恶性肿瘤高于良性外 ,基本上与国内外各地区的报告相似。 相似文献
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目的:探讨幼少女卵巢肿瘤的临床特点.方法:回顾性分析我院1987年1月~2003年12月间收治的年龄未满18岁的卵巢肿瘤患者124例.其中,良性肿瘤88例,交界性肿瘤3例,恶性肿瘤33例.结果:患者年龄3岁~18岁,平均14.3岁;10岁以下、11岁~14岁、15岁~18岁三个年龄段,各组卵巢肿瘤所占的比例分别为11.29%、29.03%、59.68%;而在各组中生殖细胞肿瘤所占的比例分别为100%、63.89%、66.22%,上皮性肿瘤所占的比例分别为0%、33.33%、32.64%;恶性肿瘤所占比例分别为35.71%、41.67%、17.57%.临床表现以腹痛、腹胀、腹部包块为主要表现的占了82.26%;冰冻切片对肿瘤的良恶性诊断符合率高(98.2%).结论:幼少女卵巢肿瘤发生率随年龄的增长而升高.组织类型以生殖细胞肿瘤为主,但随着年龄增长,上皮性肿瘤所占的比例升高.临床表现方面由患儿或家长发现腹部包块的占了很大比例,提示我们要重视对幼少女进行生殖系统检查.冰冻切片检查对决定手术范围有着重要的意义. 相似文献
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幼少女卵巢肿瘤的临床特点分析 总被引:7,自引:0,他引:7
目的:探讨幼少女卵巢肿瘤的临床特点。方法:回顾性分析我院1987年1月-2003年12月问收治的年龄未满18岁的卵巢肿瘤患者124例。其中,良性肿瘤88例,交界性肿瘤3例,恶性肿瘤33例。结果:患者年龄3岁-18岁,平均14.3岁;10岁以下、11岁-14岁、15岁-18岁三个年龄段,各组卵巢肿瘤所占的比例分别为11.29%、29.03%、59.68%;而在各组中生殖细胞肿瘤所占的比例分别为100%、63.89%、66.22%,上皮性肿瘤所占的比例分别为0%、33.33%、32.64%;恶性肿瘤所占比例分别为35.71%、41.67%、17.57%。临床表现以腹痛、腹胀、腹部包块为主要表现的占了82.26%;冰冻切片对肿瘤的良恶性诊断符合率高(98.2%)。结论:幼少女卵巢肿瘤发生率随年龄的增长而升高。组织类型以生殖细胞肿瘤为主,但随着年龄增长,上皮性肿瘤所占的比例升高。临床表现方面由患儿或家长发现腹部包块的占了很大比例,提示我们要重视对幼少女进行生殖系统检查。冰冻切片检查对决定手术范围有着重要的意义。 相似文献
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目的 通过分析广西医科大学1970~1989年20年间口腔颌面部肿瘤的病理检查资料(来自广西各地区),进一步了解口腔颌面部肿瘤的发病状况。方法 分析经病理检查首次确诊原发于口腔颌面部肿瘤5201例,按其性质、组织类型、性别、就诊年龄与部位进行统计分析,并与首次确诊的全身原发肿瘤进行比较。结果 口腔颌面部肿瘤占全身肿瘤的7.67%,占头颈肿瘤19.39%,恶性肿瘤略高于良性,恶性肿瘤男女之比1.68∶1,良性肿瘤高发年龄组为21~30岁,恶性肿瘤高发年龄组为51~60岁,恶性肿瘤中以癌为最多(82.07%),而癌中以鳞状细胞癌最多,好发于舌部。结论 我校病理检查的口腔颌面部肿瘤各构成比,除恶性肿瘤高于良性外,基本上与国内外各地区的报告相似。 相似文献
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对42例临床病理资料齐全的肝脏肿块针吸切片、涂片和涂片AgNOR颗粒进行分析。切片为正常肝细胞4例、肝细胞异型7例、恶性肿瘤31例。HE涂片与切片诊断符合率,在良性为100%(11/11)例,恶性为87%(27/31例)。3组涂片AgNOR颗粒计数各为1.64±0.74、4.52±1.20和8.53±1.87,3组间差异非常显著P<0.01。以7个颗粒做良恶性分界,AgNOR校正涂片诊断后,恶性符合率可达97%(30/31例)。提议使用HE涂片定位脱色复染AgNOR,严格选定被计数的细胞,对涂片误诊原因作了分析。 相似文献