血清非高密度脂蛋白脂固醇在冠心病合并高脂蛋白血症中的诊断意义

为探讨非高密度脂蛋白胆固醇在冠心病合并高脂蛋白血症发病学中的作用及临床意义 ,从太原市 5 471名居民血脂分析中 ,选取 183名冠心病稳定期合并高脂蛋白血症患者 ,及 194名身体健康的正常体检者 ,分别测定血清甘油三酯、总胆固醇和高密度脂蛋白胆固醇 ,低密度脂蛋白胆固醇和极低密度脂蛋白胆固醇根据Friedewald公式计算 ,并按Frost法计算出非高密度脂蛋白胆固醇的含量。结果发现 ,冠心病合并Ⅱa和Ⅱb型高脂蛋白血症患者 ,其血清低密度脂蛋白胆固醇及非高密度脂蛋白胆固醇含量与正常组比较有显著性差异 (P <0 .0 0 1) ;而合并Ⅳ型高脂蛋白血症患者血清低密度脂蛋白胆固醇含量与正常组比较无差异 (P >0 .0 5 ) ,但非高密度脂蛋白胆固醇的含量显著高于正常组 ,差异有显著性统计学意义 (P <0 .0 0 1)。提示血清非高密度脂蛋白胆固醇含量变化在冠心病合并ⅡaⅡb及Ⅳ型高脂蛋白血症患者中具有诊断意义。     

高胆固醇血症患者血小板B族Ⅰ型清道夫受体表达的变化

目的 通过观察高胆固醇血症患者B族Ⅰ型清道夫受体表达的变化,探讨B族Ⅰ型清道夫受体在动脉粥样硬化发生中的作用及其表达变化的机制.方法 随机选取健康对照60例和高胆固醇血症患者80例,肘静脉取血,分离血清、血浆并提取血小板,放射免疫法检测血浆血管紧张素Ⅱ水平,硝酸还原酶法检测血清一氧化氮含量,实时定量聚合酶链反应和免疫印迹法分别检测血小板B族Ⅰ型清道夫受体的mRNA和蛋白表达水平.结果 高脂组的血浆血管紧张素Ⅱ水平和血清一氧化氮水平均较对照组明显升高(P<0.01).高脂组血小板B族Ⅰ型清道夫受体的mRNA和蛋白表达均较对照组明显降低(P<0.05和0.01).高脂组的血管紧张素Ⅱ水平与B族Ⅰ型清道夫受体的表达呈显著负相关(r=-0.488,P<0.05).结论 高胆固醇血症患者血小扳B族Ⅰ型清道夫受体表达的降低与血管紧张素Ⅱ的刺激有关.     

牛磺酸抑制高脂合并高同型半胱氨酸血症致兔动脉粥样硬化

目的 研究牛磺酸拮抗高血脂合并高同型半胱氨酸血症所致动脉粥样硬化的作用及原理.方法 雄性新西兰大耳白兔33只,随机分成3组:正常组、模型组、干预组.0、2、12周自兔心脏采血化验相关指标,处死兔取腹主动脉行病理学染色.结果 干预组同型半胱氨酸、高密度脂蛋白胆固醇与模型组比较差异没有显著性(P＞0.05),然而甘油三酯、总胆固醇、低密度脂蛋白胆固醇、氧化型低密度脂蛋白降低,差异有显著性(P＜0.05).干预组的粥样斑块面积、内皮厚度和血管细胞间黏附分子1阳性细胞百分比均较模型组明显减少(P＜0.05).结论 牛磺酸作为一种内源性的细胞防护物质,虽然不能降低血清同型半胱氨酸水平,但是可以通过抑制内皮增生和血管平滑肌细胞增殖迁移、降血脂以及抗氧化应激从而桔抗动脉粥样硬化.     

辛伐他汀降脂治疗对老年人血管内皮功能及颈动脉内膜—中膜厚度的影响

了解辛伐他汀降脂治疗对老年人血管内皮依赖性舒张功能,颈动脉内膜－内膜厚度的影响,采用高分辨率超声技术检测20例对照者,20例原发性高胆固醇血症及20例冠心病伴高胆固醇血症患者降脂治疗前后血管内皮依赖性舒张功能及颈动脉内膜－中膜厚度的变化。结果发现,与对照组比较,原发性高胆固醇血症患者及冠心病伴高胆固醇血症患者肱动脉血流介导性舒张明显减弱,颈动脉内膜－中膜厚度明显增加,服用辛伐他汀20mg/d,治疗3－4月后,原发性高胆固醇血症患者及冠心病伴高胆固醇血症患者血浆总胆固醇明显下降,肱动脉内皮依赖性舒张较治疗前明显改善,但仍低于对照组,治疗前后颈动脉内膜－中膜厚度无显著性改变,提示老年单纯高胆固醇血症及合并冠心病患者存在内皮功能障碍,经辛伐他汀降脂治疗后,血管内皮依赖性舒张功能明显改善,但颈动脉内膜一中膜厚度无明显改善。     

糖尿病高血钒与高血脂相关分析

通过对54例Ⅱ型糖尿病人检测血钒,发现其增高与正常人比较有显著性差异,P＜0.001.高钒血症与高胆固醇血症和高甘油三酯血症均无相关,P＞0.05.     

血管紧张素转化酶基因多态性对血清血管紧张素转化酶水平及血脂的影响

为探讨血管紧张素转化酶基因多态性对本地人群高血压患者和正常人血清血管紧张素转化酶及血脂水平的影响,采用聚合酶链反应技术,对118例高血压患者和98例正常人的血管紧张素转化酶基因插入/缺失多态性进行分型,并检测血清血管祭张素转化酶活性及血脂含量。结果发现,高血压组血管紧张素转化酶三种基因型(缺失纯合子型、插入纯合子型和杂合子型)及插入/缺失等位基因的频率与正常对照组比较差异无统计学意义(X2=0.468,P=0.791;X2=0.379,P=0.538)。血清血管紧张素转化酶活性在三种基因型之间差异有显著性意义(F=17.107,P=0.000)。高血压组总胆固醇、低密度脂蛋白胆固醇、脂蛋白(a)高于正常对照组(P<0.05);高血压组三种基因型之间血脂各指标含量及正常对照组三种基因型之间总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和载脂蛋白B含量差异有显著性意义(P<0.05)。此结果提示,血管紧张素转化酶基因多态性与血清血管肾张素转化酶活性及血脂含量有关,缺失纯合子型高血压患者血清血管紧张素转化酶活性最高且易患高脂血症。     

高脂血症患者LDL氧化易感性及调脂药物干预的影响

目的观察高脂血症对LDL氧化易感性的影响以及调脂药物干预后的改变.方法应用短程密度梯度超速离心分离血浆LDL,对11例高甘油三酯血症患者口服微粒化非诺贝特200 mg/d、10例高胆固醇血症患者口服普伐他汀10 mg/d治疗4周前后和6例正常人的LDL在体外以CuCl2诱导氧化,测定LDL开始氧化的迟滞期和氧化速率.结果 (1)LDL氧化的迟滞期,在高甘油三酯血症患者和高胆固醇血症患者均较正常组明显缩短(43.8±11.6,40.8±10.7 vs 70.5±14.6 min, P均<0.01).(2)LDL的氧化速率,在高甘油三酯血症患者和高胆固醇血症患者均较正常组明显增快(0.036±0.004,0.031±0.011 vs 0.020±0.011 O.D./min,P均<0.05).(3)高甘油三酯血症患者给微粒化非诺贝特治疗后LDL氧化的迟滞期显著延长(62.4±5.0 min,P<0.01),氧化速率明显减慢(0.031±0.003 O.D./min,P<0.05).(4)高胆固醇血症患者于普伐他汀治疗后LDL氧化的迟滞期明显延长(58.8±6.1 min,P<0.05),氧化速率无显著性变化(0.025±0.009 O.D./min,P>0.05).结论高甘油三酯血症患者和高胆固醇血症患者LDL氧化易感性增高,微粒化非诺贝特和普伐他汀能够降低高甘油三酯血症患者及高胆固醇血症患者LDL的氧化易感性.     

绍兴地区某老年体检人群高尿酸血症危险因素的Logistic回归分析

目的探讨绍兴地区老年人群的高尿酸血症(HUA)患病率及其主要危险因素。方法入组2015年度绍兴市立医院体检中心年龄60周岁退休工人4 160例,根据HUA临床诊断标准分为HUA组(691例)及对照组(3 469例)。通过多元Logistic回归分析探讨影响HUA的高危因素。结果在入组老年体检者中,HUA患病率为16.6%(691/4 160),其中男性患病率为18.01%,女性患病率为15.06%,男女性患病率无差异(P0.05)。HUA组患者高血糖、高血压、高甘油三酯、高总胆固醇、谷氨酰转肽酶异常、脂肪肝发生率明显高于正常组(P0.05)。结论高血糖、高血压、高脂血症、肝功能异常、脂肪肝等均是HUA主要高危因素,定期检测这些指标有助于HUA早期诊断与治疗。     

益多脂对高甘油三酯血症患者血管内皮依赖性舒张功能的影响

目的 :观察益多脂对高甘油三酯血症患者血管内皮依赖性舒张功能的影响。方法 :30例高甘油三酯血症患者 (治疗组 )口服益多脂治疗 8周后 ,采静脉血用酶法测定甘油三酯 (TG)和总胆固醇 (TC)的浓度 ;采用高分辨率血管外超声法检测治疗前后肱动脉内皮依赖性血管舒张功能 ,并与 2 8例正常对照者 (对照组 )比较。结果 :治疗组血流介导的内皮依赖性血管舒张功能明显减弱 ,与对照组相比差异有显著性意义 [(4 .1± 0 .5 ) %∶(10 .1± 0 .8) % ],单因素相关分析发现 :血浆TG浓度与血流介导的肱动脉内皮依赖性舒张功能下降值之间呈负相关 (r =- 0 .6 3,P <0 .0 1)。治疗 8周后血流介导的内皮依赖性血管舒张功能增加 (4 .6± 1.2 ) % (P <0 .0 1) ,单因素相关分析显示 :肱动脉内皮依赖性血管舒张功能改善的程度与TG的基础值无相关性 (r =0 .2 84,P >0 .0 5 ) ,与TG的降低程度呈正相关 (r =0 .5 39,P <0 .0 1)。结论 :益多脂对高甘油三酯血症患者具有改善其血管内皮依赖性舒张功能的作用     

血管生成素样蛋白3抑制剂研究进展

家族性高胆固醇血症是一种常染色体显性遗传病,传统调脂药物对于这类患者的效果非常不理想。血管生成素样蛋白3单克隆抗体的出现为这些患者带来了希望。现综述血管生成素样蛋白3相关研究进展。     

慢性肾脏疾病患者高甘油三酯血症和高同型半胱氨酸血症的关系

目的 探讨慢性肾脏疾病患者高甘油三酯血症与高同型半胱氨酸血症的关系.方法 收集173例慢性肾脏疾病患者血液标本,检测肌酐、血脂和同型半胱氨酸水平,并按肌酐值和甘油三酯水平分为四组:肾功能代偿期正常甘油三酯水平组、肾功能代偿期高甘油三酯血症组、肾功能失代偿期正常甘油三酯水平组和肾功能失代偿期高甘油三酯血症组.结果 高甘油三酯血症组同型半胱氨酸水平明显高于正常甘油三酯水平组(P<0.05),但相关性分析显示两者无显著相关性(P>0.05).结论 慢性肾脏疾病患者高甘油三酯血症与高同型半胱氨酸血症没有相关关系.     

长春瑞滨联合贝伐单抗治疗非小细胞肺癌的临床分析

目的分析长春瑞滨联合贝伐单抗治疗非小细胞肺癌(NSCLC)的临床疗效及生存情况。 方法选择我院2017年4月至2020年3月接诊的42例NSCLC患者作为观察对象,依据临床治疗方案将患者分为观察组22例和对照组20例,给予对照组患者顺铂+长春瑞滨治疗,观察组患者在对照组基础上联合贝伐单抗治疗。评估两组患者治疗2周后的临床疗效、血清肿瘤因子[血清血管生成素样蛋白2(ANGPTL2)、抗菌肽人类阳离子抗菌蛋白18(hCAP18)及血清癌胚抗原(CEA)]水平、药物不良反应及12个月随访后的生存情况。 结果观察组疾病控制率(81.82%)高于对照组(60.00%),差异有统计学意义(P<0.05);治疗后,两组患者的血清hCAP18、CEA及ANGPTL2水平均低于治疗前,且观察组较对照组更低,差异有统计学意义(P<0.05);观察组1年生存率(77.27%)高于对照组(45.00%),差异具有统计学意义(P<0.05);两组患者的不良反应发生率比较差异无统计学意义(P>0.05)。 结论给予NSCLC患者长春瑞滨联合贝伐单抗治疗,有助于改善患者的临床疗效,提高患者的疾病控制率,降低患者的血清hCAP18、CEA及ANGPTL2水平,提高患者的1年生存率,且安全性较好。     

Incidence and risk factors of severe hypertriglyceridaemia in the era of highly active antiretroviral therapy: the Aquitaine Cohort, France, 1996–99

¹ Unité INSERM 330, Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Université Victor Segalen Bordeaux 2, Bordeaux and ² Centre d'Information et de Soins de l'Immunodéficience Humaine, Centre Hospitalier Universitaire de Bordeaux, France Objective To estimate the incidence of serum hypertriglyceridaemia > 6 mm/L (HTG) and identify associated factors in the era of highly active antiretroviral therapy (HAART). Methods A prospective cohort, multirisk, both genders, of HIV‐infected patients was treated with several patterns of antiretrovirals. Cox's model was used to estimate the effect of explanatory variables documented at the first normal triglyceride measurement (< 2 mm/L) on the subsequent occurrence of HTG. Results Among 925 patients (27% treated with a protease inhibitor (PI) containing regimen and 48% treated with other HAART combinations) followed 25 months in median with a median triglyceridaemia of 1.1 mm/L at baseline, 70 experienced an HTG, 4.2 cases per 100 person years[95% confidence interval (CI)=2,2,3,3–5]. Univariate analysis retained the following as risk factors of HTG: male gender, homosexual transmission group, greater age, higher body weight, AIDS stage, ≥ 2 antiretrovirals including PI, higher triglyceride level and lower CD4+ cell count at baseline. In multivariate analysis, the risk of HTG remained associated with being male homosexual [hazard ratio (HR) = 1.68, P = 0.04], at the AIDS stage (HR = 1.84, P = 0.03), with increased triglyceride level (HR = 2.82 for 1 mm/L higher at baseline, P < 10^?3), impaired CD4+ cell count (HR = 1.2 for 100 cells/μL lower, P = 0.02) and increased body weight (HR = 1.3 for 10 kg higher, P = 0.02). Conclusions Baseline triglyceride level and being overweight are risk factors of HTG, together with advanced HIV disease, but the contribution of HAART is not demonstrated.     

脑梗死并高脂血症患者血浆P-选择素水平的变化及降脂干预

为研究动脉粥样硬化性脑梗死患者动脉粥样硬化病变的炎症反应以及降脂干预对其产生的影响 ,以酶标多克隆抗体夹心法及硝酸还原酶比色法测定 36例健康对照组、30例急性脑梗死并高胆固醇血症组及 2 8例急性脑梗死并高甘油三酯血症组患者应用辛伐他汀治疗前后血浆P 选择素、氧化型低密度脂蛋白和血清一氧化氮的水平。结果发现 ,两组脑梗死患者血浆P 选择素和氧化型低密度脂蛋白水平较对照组明显增高 ,血清一氧化氮水平明显减低。急性脑梗死并高胆固醇血症组患者的血浆P 选择素水平与血浆氧化型低密度脂蛋白和低密度脂蛋白水平呈显著正相关 ,与血清一氧化氮水平呈显著负相关 ;急性脑梗死并高甘油三酯血症组患者的血浆P 选择素水平与氧化型低密度脂蛋白和甘油三酯水平呈显著正相关。辛伐他汀治疗 6周后 ,两组脑梗死患者的血浆P 选择素和氧化型低密度脂蛋白水平明显减低 ,血清一氧化氮水平明显回升。以上提示 ,急性脑梗死并高胆固醇血症和高甘油三酯血症患者均存在着动脉粥样硬化病变的炎症反应 ,其炎症反应的发展与血浆P 选择素水平的变化及血浆氧化型低密度脂蛋白、低密度脂蛋白、甘油三酯和血清一氧化氮水平的变化相一致 ,降脂干预可阻止动脉粥样硬化病变炎症反应的发展     

冠心病患者外周血白细胞脂蛋白脂酶mRNA的表达

为探讨冠心病患者外周血白细胞脂蛋白脂酶mRNA表达与冠状动脉变程度的关系及意义。用冠状动脉造影后半定量分析获得冠状动脉病变程度,外周血白细胞脂蛋白脂酶mRNA表达用逆转录聚合酶链反应测定,结果发现,冠心病患者各组及正常对照组外周血白细胞中均能检测到特异的脂蛋白脂酶mRNA逆转录聚合酶链反应产物,各组间脂蛋白脂酶mRNA逆转录聚合酶链反应产物测定值差异无显著性（P＞0．05）,冠心病患者中,血甘油三酯水平高者,与甘油三酯水平正常者比较,脂蛋白脂酶mRNA逆转录聚合酶反应产物测定值差异无显著性（P＞0．05）,冠心病患者用肝素前后各组脂蛋白脂酶mRNA逆转录聚合酶链反应产物测定值差异无显著性（P＜0．05）;用肝素后只有血甘油三酯水平低于用肝素前（P＜0．05）,结果提示外周血白细胞脂蛋白脂酶mRNA表达与冠状动脉病变程度无关,肝素无刺激外周血白细胞脂蛋白脂酶mRNA表达的作用。     

Higher levels of circulating ANGPTL2 are associated with macular edema in patients with type 2 diabetes

Macular edema (ME) is an inflammatory disease characterized by increased microvascular permeability. Here, we proposed that plasma angiopoietin-like protein 2 (ANGPTL2) level may be related to the severity of ME patients with type 2 diabetes mellitus (T2DM). In this cross-sectional study, 172 T2DM patients were recruited and divided into clinically significant macular edema (CSME), non-CSME (nCSME), and control groups. Serum ANGPTL2 level was quantified by ELISA and best corrected vision acuity (BCVA) was detected. After adjust age, sex, body mass index (BMI), and duration of diabetes variables, ANGPTL2 performed statistics difference among CSME-, nCSME-groups, and control group (4.46 [3.97, 4.96, 95%CI] ng/mL in CSME group, 3.80 [3.42, 4.18, 95%CI] ng/mL in nCSME-group, 3.33 [3.03, 3.63, 95%CI] ng/mL in control, P < .01). After adjustment of confounding factors, high levels of circulating ANGPTL2 were related with the diagnosis of ME, BCVA, and C reactive protein (CRP) through univariate regression analysis (P < .05). Meanwhile, in the multiple regression model, ANGPTL2 took the mainly effect proportion for the diagnosis of diabetic macular edema (DME), with a LogWorth value 3.559 (P < .001). Our study suggested that elevated circulating ANGPTL2 may be associated with the development of DME and the severity of visual impairment in patients with type 2 diabetes.     

Increased serum levels of interleukin-8 in polyarteritis nodosa and Behçet’s disease

The pathogenesis of Behçets disease (BD) and polyarteritis nodosa (PAN) is not yet well established. Endothelial cells have been shown to express chemokines that are involved in inflammatory processes. Interleukin-8 (IL-8) is a potent chemoattractant and activator of neutrophils. We evaluated serum IL-8 levels in patients with PAN and BD. We measured serum IL-8 levels in 21 patients with BD and 16 with PAN. Sera from 30 age-matched healthy blood donors were used as normal controls. Serum IL-8 levels were measured by an enzyme-linked immunosorbent assay (ELISA). The mean serum IL-8 level of the active BD (1522.31 pg/ml) and that of the active PAN (654.8 pg/ml) was significantly higher than that of the normal controls (40.39 pg/ml, P <0.05). There was no difference in mean serum IL-8 levels between patients with inactive disease and normal controls. We found higher serum levels of IL-8 in those patients with more severe disease. These results suggest that IL-8 may play a role in the pathogenesis of PAN and/or BD. Our study also suggests a possible relation between serum IL-8 levels and the severity of these diseases.Abbreviations BD Behçets disease - PAN Polyarteritis nodosa     

Association of High Mobility Group Box Chromosomal Protein 1 and Receptor for Advanced Glycation End Products Serum Concentrations With Extraglandular Involvement and Disease Activity in Sjögren's Syndrome

Objective

To assess serum levels of high mobility group box chromosomal protein 1 (HMGB‐1) and the soluble receptor for advanced glycation end products (sRAGE) in patients with Sjögren's syndrome (SS) and explore correlations with disease activity.

Methods

Thirty‐nine patients with SS and 21 healthy controls were included in this cross‐sectional study. Clinical and laboratory values were obtained from all patients. Disease activity was assessed using the European League Against Rheumatism SS Disease Activity Index (ESSDAI). Serum samples were collected and HMGB‐1 and sRAGE levels were measured using enzyme‐linked immunosorbent assay (ELISA), and HMGB‐1 concentrations were semiquantified by Western blotting.

Results

In ELISA, HMGB‐1 serum levels did not differ between healthy controls and patients with SS (P = 0.783). When measured by semiquantitative Western blotting, HMGB‐1 levels were increased in patients with SS compared to healthy controls (P = 0.012). HMGB‐1 serum levels detected by Western blotting were higher in patients with extraglandular manifestations (P = 0.003) and were correlated with ESSDAI disease activity (r = 0.544, P < 0.0001). Furthermore, sRAGE was elevated in the sera of patients with SS (P = 0.003) compared to healthy controls and was also correlated with the ESSDAI (r = 0.545, P = 0.002).

Conclusion

Serum levels of total HMGB‐1 and sRAGE were elevated in patients with SS compared to healthy controls and correlated with disease activity as measured by the ESSDAI. Patients with extraglandular involvement had high serum levels of HMGB‐1.

     

2型糖尿病患者血浆血管生成素样蛋白3的变化及其与颈动脉内膜-中层厚度相关性的研究

目的 观察T2DM患者血浆血管生成素样蛋白3（ANGPTL3）水平和颈动脉内膜-中层厚度（IMT）变化,探讨两者的相关性. 方法 选取T2DM患者（T2DM组）99例和正常对照者（NC组）40名,均测定体重、血压等一般指标,同时测量颈动脉IMT,以ELISA法检测血浆ANGPTL3含量. 结果 （1）与NC组比较,T2DM组ANGPTL3增高,与FPG呈线性相关（P＜0.05）.（2）两组中,颈动脉IMT与ANGPTL3均有相关性（r=0.172,0.320）.（3）多元逐步回归分析显示,ANGPTL3、年龄、HDL-C降低及SBP均是颈动脉IMT增厚的危险因素. 结论 T2DM患者体内ANGPTL3增加,且颈动脉IMT增厚,ANGPTL3可能与动脉粥样硬化（AS）相关.     

高甘油三酯血症对大鼠急性胰腺炎模型中胰腺导管上皮细胞间紧密连接的影响研究

目的研究高甘油三酯血症(hypertriglyceridemia,HTG)对大鼠急性胰腺炎(acute pancreatitis,AP)模型胰腺组织细胞间紧密连接(tight junctions,TJs)的影响。方法48只4周龄雄性SD大鼠随机分成普通饲养组(24只)和高脂饲养组(24只),4周后普通饲养组随机分为C组和AP组,高脂饲养组随机分为HTG组和高甘油三酯血症急性胰腺炎(HTGP)组。AP组和HTGP组经腹腔注射雨蛙肽建立AP模型,C组和HTG组经腹腔注射同等剂量的生理盐水,分别于造模24 h、48 h处置大鼠,采用HE染色法观察胰腺病理改变,免疫组织化学法检测胰腺组织中TJs蛋白脂解刺激脂蛋白受体(LSR)、Tricellulin蛋白(TRIC)、ZO-1、occludin、claudin-7定位及表达,透射电镜观察胰腺导管上皮细胞间TJs变化情况。结果高脂饲养组的大鼠血清甘油三酯(triglyceride,TG)较普通饲养组明显升高(P<0.05);HTG组胰腺组织病理评分高于C组(P<0.05),相同时点HTGP组胰腺组织病理评分高于AP组,但差异无统计学意义(P>0.05);HTG组LSR、TRIC表达显著低于C组(P<0.05),AP组和HTGP组的24 h时点LSR、TRIC、occludin、claudin-7表达均低于相应对照组(P<0.05),HTGP组24 h时点LSR和TRIC的表达显著低于AP组的对应时点(P<0.05);透射电镜观察AP组和HTGP组的24 h时点,发现主胰管上皮细胞TJs较C组和HTG组减少、细胞间隙增宽,且HTGP组比AP组的细胞间隙增宽更明显。结论TJs蛋白LSR、TRIC、ZO-1、occludin、claudin-7在HTG及HTGP大鼠胰腺组织中表达较非高脂模型下降,其中以三细胞间紧密连接(tricellular tight junctions,tTJs)蛋白LSR及TRIC下降明显,提示HTG可能减弱胰腺组织的tTJs,进而加重胰腺组织损伤。