听觉事件相关电位P300检测对两种脑梗死早期认知功能损害的临床应用分析

目的探讨听觉事件相关诱发电位(event related potential,ERP)-P300对非痴呆型脑梗死患者血管性认知功能障碍(vascular cognitive impairment,VCI)的应用价值。方法选取60例脑梗死后认知功能损害但未达到痴呆诊断标准的患者,包括皮质梗死患者30例,皮质下梗死患者30例,同时选取30例作为正常对照组患者。对所有患者进行P300检测,观察3组间P300潜伏期及波幅。结果与正常对照组[潜伏期(282.41±23.87)ms和波幅(14.06±1.39)μv]相比,皮质梗死组([潜伏期(339.82±21.27)ms和波幅(10.04±1.18)μv]和皮质下梗死组[潜伏期(362.66±24.34)ms和波幅(10.89±0.76)μv]P300的潜伏期差异均有统计学意义(F=52.94,P<0.05),且波幅差异也均有统计学意义(F=86.83,P<0.05);皮质下梗死组P300潜伏期与皮质梗死组相比差异也有统计学意义,但二者的波幅相比差异无统计学意义。结论脑梗死早期患者存在认知功能的受损,ERP-P300测试有利于脑梗死早期认知功能障碍的诊断,为干预治疗前移评估提供重要意义。     

脑梗死与血管性认知功能障碍临床分析

目的解析脑梗死、血管性认知障碍（VCI）临床表现及影像学检查特点对VCI早进行识别、干预,从而极大改善患者预后。方法回顾性分析55例脑梗死患者均做影像学检查（头CT或MRI）且对患者做日常生活能力指数（ADL）评分,认知功能评分（CDR）评分,并分为正常认知组（CDR=0）、非痴呆性血管性认知功能障碍（VCIND）组（CDR=0．5,ADL=20分）及血管性痴呆（VaD）组（CDR≥1,ADL〉20分）。结果VCI31例占脑梗死（5613％）,其中VCIND23例（41．8％）,VaD8例（14．5％）。结论梗死的面积、部位、数目和VCI发生率密切相关。脑白质疏松和脑萎缩,尤其是脑萎缩与VCI的发病关系更为密切。     

短期甲基苯丙胺类物质滥用者的脑诱发电位变化

目的:探讨短期滥用甲基苯丙胺类物质者的脑诱发电位变化。方法:对73例滥用时间≤12个月的甲基苯丙胺类物质者行听觉诱发电位AEP、视觉诱发电位VEP、体感诱发电位SEP及事件相关电位P300检测,并以30例正常人作对照。结果:短期滥用甲基苯丙胺类物质者AEP的P1、N1、P2、N2潜伏期;VEP的P1潜伏期;SEP的N2潜伏期均长于正常对照组(P<0.01或P<0.05);SEP的N1潜伏期短于正常对照组(P<0.05)。AEP的P2、N1-P2、P2-N2波幅;VEP的P2、N1-P2、P2-N2波幅;SEP的P2、P2-N2波幅均低于正常对照组(P<0.01或P<0.05)。P300靶刺激各项指标:N1、P2、N2、P3潜伏期,P2、P3波幅及非靶刺激各指标:N1、P2潜伏期,P2波幅,与正常对照组比较,差异均无显著性(P>0.05)。结论:甲基苯丙胺类物质短期滥用者出现了AEP、VEP、SEP的多项改变;但未出现事件相关电位P300异常;滥用时间长短对认知功能的损害程度有影响。     

老年血管性认知功能障碍患者血脂及血红蛋白改变的临床意义

<正>脂质代谢紊乱、血红蛋白异常改变被认为是血管性认知功能障碍(Vascular cognitive impairment,VCI)的重要因素,且与心脑血管病的发生密切相关。目前对VCI尚无统一的分类标准,一般将VCI分为3种临床亚型:无痴呆的VCI(Vascular cognitive impairment,nodementia,VCIND)、血管性     

丹参药液经皮透入综合治疗对血管性痴呆患者P300的影响

目的 研究丹参药液经皮透入综合治疗对血管性痴呆（vascular dementia,VD）患者事件相关电位（P300）的影响.方法 对60例血管性痴呆患者随机分为经皮药物透入治疗组及对照组,治疗前后由专业治疗师对两组患者分别进行修改长谷川痴呆量表（HDS）评定以及事件相关电位（P300）检查等.结果 经丹参药液经皮透入综合治疗后,总有效率对照组为36.66%,治疗组为66.66%,HDS（x）对照组为11.78,治疗组为18.35,两组之间差异有极显著性（P＜0.01）,治疗组优于对照组;治疗后治疗组与对照组患者P300波幅（x）分别为7.77 uv和5.76 uv,潜伏期（x）分别为301.18 ms和385.03 ms,治疗组患者P300波幅升高,潜伏期缩短,与对照组比较差异有极显著性（P＜0.01）.同时,治疗组组内HDS和P300波幅与潜伏期的治疗前后差异也有极显著性（P＜0.01）.结论 丹参药液经皮透入综合治疗能较好地改善血管性痴呆患者的认知能力,可作为血管性痴呆患者的辅佐治疗手段及早期预防措施之一.     

脑白质变性与诱发电位P300、脑电图、血浆载脂蛋白B的相关性研究

目的：探讨头颅CT未显示脑白质变性的轻度认知损害（MCI）患者的事件相关电位（ERP）P300、脑电图（EEG）和血浆载脂蛋白B的特点,为早期血管性痴呆的诊断提供帮助。方法：对60例MCI患者行头颅CT检查,根据有无脑室周围、半卵圆区、皮质下白质斑片状影,将上述患者分为脑白质变性组及非脑白质变性组,均进行P300、EEG及血浆载脂蛋白B检查．进行相关性分析,并与健康老年组32例做比较。结果：脑白质变性组与非脑白质变性组P300检查比较,P300峰潜伏期有显著延长,部分非脑白质变性患者P300峰潜伏期有轻度延长,与健康组相比有显著差异;脑电图检查,脑白质变性组以δ、θ波为主,轻-中度异常比例显著高于非脑白质变性组,非脑白质变性组以δ、θ波为主;健康老年组以α波为主;血浆载脂蛋白B化验,各组之间无显著差异。结论：P300潜伏期延长提示MCI患者可能有早期血管性痴呆：EEG颞部θ波增多提示MCI患者可能有早期血管性痴呆。载脂蛋白B化验未见明显差异．在本次研究中对于早期血管性痴呆诊断无确切临床意义。     

海洛因依赖者脑诱发电位研究

目的探讨海洛因依赖者听觉诱发电位和视觉诱发电位的变化特点及其应用。方法使用意大利百胜有限公司Galileo Sirius全数字化32导脑诱发电位仪对32例海洛因依赖者和30例正常人听觉诱发电位和视觉诱发电位的变化进行对照分析。结果海洛因依赖者具有以下特点(1)与正常人比较,海洛因依赖者AEP,VEP波形稳定性差、清晰度降低、粗糙,偶有切迹或双峰波,尤以主波群(N1-P2-N2)最明显;(2)与正常人比较,海洛因依赖者AEP,VEP中波N1,P3潜伏期延长(P<0.05),波P2,N2潜伏期缩短(P<0.05),同时N1-P2,P2-N2、P2波幅降低(P<0.05或P<0.01)。结论海洛因依赖者的AEP,VEP有一定特点,结合吸毒史、戒断症状和尿检吗啡阳性等指标对其诊断具有很大意义。     

血管性痴呆的事件相关电位研究

目的探讨血管性痴呆(VaD)患者的事件相关电位(P300)的改变特征。方法对65例VaD患者进行P300及智能测定,并以65例正常人作对照。结果VaD患者P300潜伏期为(396.6±35.4)m s,波幅为(7.14±3.21)μV,与正常对照组相比差异有统计学意义(P<0.05)。潜伏期的改变与患者的智能改变呈负相关(P<0.05〉)。结论P300可以作为评价VaD患者高级神经活动功能损害的客观量化指标之一。     

P300电位对癫痫性精神障碍患者认知功能的评估价值

目的探讨P300电位对癫痫性精神障碍患者认知功能的评估价值。方法选取2016年2月～2018年5月我院收治的癫痫性精神障碍患者75例,纳入观察组,另取同时期健康体检者75例,纳入对照组。对两组患者分别进行P300电位测定,并用认知能力筛查试验(CASI)对其认知功能进行评价,进行对比分析。结果在P300电位潜伏期与波幅比较方面,观察组患者N2、P3潜伏期长于对照组患者,P3波幅更大(P <0.05)。而在N1、P2潜伏期和P2波幅方面,两组患者差异无统计学意义(P> 0.05)。两组患者在CASI试验各项及总分方面差异均有统计学意义(P <0.05)。对P300电位P3波幅与CASI总分进行Pearson相关性分析,结果显示两项指标具有正相关关系(r=0.385,P=0.001)。结论癫痫性精神障碍患者P300电位和认知功能与正常人相比均有差异,其中,认知功能水平降低与P300电位P3波幅下降有关,但具体机制仍有待于进一步研究。     

血管性认知功能损害的病理机制与预防

血管性认知损害（VCI）是一种异质性疾病,由脑血管病变或脑灌流受损引起,涵盖了从轻微认知损害到血管性痴呆（VaD）。本文综述VCI的病理机制及其预防研究进展。     

Sex and strain differences in the visual evoked potentials of albino and hooded rats

Visually evoked potentials were recorded n male and female rats from albino and hooded strains. Recording were made at 4 different flash intensities in unanesthetized animals. Clear sex and strain differences were observed. Females had larger amplitude P1-N1 and N1-P2 components and shorter latency N1 peaks than males. Albino rats had larger amplitude P1-N1, N2-Pe and P3-N3 components and longer latency P2 and P3 peaks than hooded rats. Variations in flash intensity produced greater alterations in latencies and N1-P2 amplitudes in hooded rats than in albino rats, but greater alterations in N1, N2 and P3 latencies in albino rats than in hooded rats. Hooded rats are recommended as more valuable for studies of chemically induced change in the visual evoked potential.     

海洛因依赖者人格特征与事件相关电位P_(300)的相关性分析

目的:探讨海洛因依赖者的人格特征与事件相关电位P300的相关性。方法:采用艾森克人格问卷(EPQ)对31例海洛因依赖者和33例正常对照进行人格测定,并用意大利GalileoSirius32导脑诱发电位仪检测事件相关电位P300。结果:与对照组比较,海洛因依赖者E量表分低(t=-2·227,P=0·030);N量表分高(t=2·644,P=0·010);潜伏期N1短(t=-2·113,P=0·039);潜伏期P3长(t=2·453,P=0·017)。海洛因依赖者的P量表与潜伏期P3呈正相关(r=0·302,P=0·049);E量表与潜伏期P2、波幅P2呈负相关(r=-0·358,P=0·024;r=-0·367,P=0·021);N量表与潜伏期N1、N2、波幅P3呈负相关(r=-0·528,P=0·001;r=-0·302,P=0·049;r=-0·328,P=0·036)以及与潜伏期P3呈正相关(r=0·332,P=0·034)。结论:本研究表明海洛因依赖者具有内倾、情绪不稳定、神经质的人格特征,并且与其事件相关电位P300存在一定关联。     

军人创伤后应激障碍与适应障碍患者的P_(300)研究

目的探讨军人创伤后应激障碍(PTSD)与适应障碍(AD)患者事件相关电位P300的变异特点。方法对33例PTSD和34例AD患者以及30名健康军人(对照组),使用美国NicoletBravo脑电生理仪,以听觉靶刺激和非靶刺激序列为诱发事件运用oddball模式完成P300检测。结果三组CZ脑区P3与PZ脑区N2靶潜伏期,以及PZ脑区P3靶波幅和CZ脑区P2非靶波幅的差异有显著性(P<0.05,0.01);PTSD组CZ脑区P3与PZ脑区N2靶潜伏期延迟或前移,与对照组和AD组的差异有显著性(P<0.01);PTSD组PZ脑区P3靶波幅和CZ脑区P2非靶波幅均降低,与对照组及AD组的差异有显著性(P<0.05,0.01)。结论P300作为反映PTSD认知功能障碍的客观生理指标,可作为PTSD辅助诊断的一个脑电生理学标志。     

Differential effects of convulsants on visually evoked responses in the albino rat

Visually evoked responses (VERs) were recorded from primary visual cortex in unanesthetized albino rats during pharmacological modulation by one of the following convulsant agents: Physostigmine, picrotoxin, strychnine and Metrazol. The data were analyzed in terms of effects on VER components. The rat VER consists of six distinct waves constituted by three positive peaks(P1-P3) and three negative peaks (N1-N3). Results indicate a differential convulsant action on VER components. The administration of picrotoxin, resulted in a suppression of the peak amplitude of P1-N1 and delayed peak latencies of all components. Strychnine reliably shortened P1, N1 and P2 peak latencies, significantly increased N3 peak latency and only suppressed P3-N3 amplitude. Physostigmine essentially suppressed all component amplitudes but only increased peak latencies for P2 and P3 components. Metrazol, in general, was found to be relatively ineffective in the alteration of any VER component in a systematic manner. The data are discussed in terms of differential modes of convulsant action on the visual system. The results are likewise discussed with respect to their implications for convulsant modulation of photically evoked after-discharges.     

Evoked potential alterations following prenatal methyl mercury exposure

Pregnant hooded rats were administered either 5 mg/kg CH3, Hg or 0 mg/kg CH3 Hg by gastric intubation on day seven of gestation. Female offspring were implanted with recording electrodes 60 days after birth and had their cortically recorded visual evoked potentials studied at four different flash intensities. Mercury exposed animals had higher P1-N1 and N1-P2 amplitudes and shorter P2 and N2 latencies than controls. The data provides evidence that a single ingestion of CH3 Hg by pregnant rats is sufficient to produce long term alterations in CNS activity.     

丘脑梗死听觉事件相关电位的研究

目的：研究丘脑梗死患者听觉事件相关电位（P300）的变化特点。方法：应用听觉事件相关电位和认知能力筛查量表检测丘脑梗死患者加例（患者组）和健康查体者30例（正常对照组）。结果：患者组P300波潜伏期明显延长（P〈0．01）;P300波波幅降低（P〈0．05），认知能力筛查量表评分也明显下降（P〈0．01）。左侧与右侧丘脑梗死P300波潜伏期、波幅和认知能力检查评分比较差异无统计学意义（P〉0．05）。治疗后随访P300波潜伏期、波幅和认知能力检查评分明显好转，与治疗前比较差异有统计学意义（P〈0．05或P〈0．01）。结论：听觉事件相关电位的检查有利于丘脑梗死认知功能状态的判断及病情变化的观察。     

The effect of sodium metabisulfite on visual evoked potentials in rats with hypercholesterolemia

This study aimed to investigate the effects of hypercholesterolemia on visual evoked potentials (VEPs) and sulfite additional effects. Rats were assigned as follows: control (C), sulfite (S), hypercholesterolemia (H), vitamin E (E), sulfite + vitamin E (SE), hypercholesterolemia + sulfite (HS), hypercholesterolemia + vitamin E (HE), and hypercholesterolemia + sulfite + vitamin E (HSE). Hypercholesterolemic diet led significant increase in plasma cholesterol levels of rats. Brain thiobarbituric acid reactive substances (TBARS) levels were significantly increased in S, E, SE, HE and HSE groups compared with C. TBARS levels were increased in HE and HSE groups as compared to HS group. Nitrite levels were decreased in S, SE, H, HS and HSE groups compared with C. Nitrite level was notably increased in the HE group compared with H group. Sulfite exposure prolonged N1 and P3 latencies of VEP in group S compared with C. Prolonged VEP latencies by sulfite were significantly decreased by vitamin E in SE group. Cholesterol rich diet increased VEP latencies in comparison with control latencies. Sulfite gave rise to an additional increase in P3 latency in HS group compared with H group. Vitamin E-treated animals had notably shortened latencies of VEP components in HE and HSE groups according to the H and HS groups, respectively.     

血管性认知功能障碍病人血清微RNA-335-5p、血清应答因子水平及其临床意义

目的 探究血管性认知功能障碍（VCI）病人血清微RNA(miR)-335-5p、血清应答因子（SRF）水平及临床意义。方法以石家庄市人民医院2019年1月至2020年12月因脑卒中治疗后6个月出现VCI的110例病人为研究对象（VCI组）,其中非痴呆型血管性认知功能障碍（VCIND）者48例（VCIND组）、血管性痴呆（VD）者62例（VD组）。同时间段该院脑卒中未合并认知障碍者110例为对照组。分析各组病人发病时（入院次日）、发病后6个月、发病后1年血清miR-335-5p、SRF水平。logistic回归模型分析脑卒中病人发生VCI的影响因素。Pearson法分析血清miR-335-5p与SRF水平的相关性。受试者操作特征曲线（ROC曲线）分析血清miR-335-5p、SRF水平对VCI的预测价值。结果 VCI组发病时miR-335-5p水平0.76±0.15低于对照组1.06±0.07,而SRF水平1.52±0.24高于对照组1.01±0.09,差异有统计学意义（P<0.05）。发病时,对照组、VCIND组、VD组的miR-335-5p水平逐次降低（1.06±0.07比0....