生物光子相干性理论的形成、发展与争议

生物系统的超微弱光子辐射(UPE)是自然界一个普遍的生命现象,是生物体固有的一种功能属性。关于UPE的产生机制却存在两种理论假说即相干性理论和代谢发光之破缺理论。然而,随着研究的不断深入,生物光子相干性理论被越来越多的研究者所认可。我们综述了自1923年以来UPE的研究进展,详细介绍了生物光子相干性理论的形成背景及其提出过程,总结了生物光子相干性理论的主要实验以及存在的争议,概括说明UPE作为生命系统普遍存在的一种现象,其研究不仅对生命科学领域具有重大的科学意义,在医学、中医学、农业、食品和环境科学等领域也具有广泛的应用价值。     

经络本质探究

目的 探究如何利用红外热像仪显现经络和气（能量）.方法 经络是生命信息能量的谐振通道,信息能量的传播不需要有形管道,可以用探测能量的仪器探测显现,热像仪通过温度监视,可检测出物体传热、温升的情况.结果 利用热像仪显现了针刺足三里穴时胃经的经络线、针刺合谷穴时大肠经的经络线以及针刺后溪穴时小肠经的经络线,探测显现结果和中医学理论完全相符.结论 用热像仪把不具解剖意义的经络显现让人可见,证明经络是生命信息能量的谐振通道,实验探测结果和中医学完全相符,证明中医经络学说是科学的理论.     

Monte Carlo方法在生物组织中光子迁移的原理、发展及应用

Monte Carlo(MC)方法被广泛应用于光在人体组织迁移问题的研究中.MC方法与有限元或有限微分方法相比,由于不需要边界条件的假设,具有很好的灵活性和高精度而一直被重视.它能够求解生物组织中光分布,为其他研究提供理论基础.在给出MC方法在生物组织中光子迁移原理的基础上,详述了新提出的优化MC方法.该优化MC方法通过对伪随机数产生、余弦函数和对数函数的近似而大幅度减少了MC仿真的时间.接着介绍了MC方法在脑部光子迁移的应用.最后讨论了将该MC方法在生物组织中光子迁移的进一步发展方向.     

基于可见光波段的L3光子晶体谐振腔集成微流槽折射率生物传感器

L3二维光子晶体谐振腔集成微流槽折射率生物传感器在氮化镓(GaN)衬底材料上制备而成,其表面集成微流槽用于盛装生物样本。谐振腔的共振峰的中心频率对微流槽内生物样本折射率的变化十分敏感。该文分别对微流槽内生物样本折射率是1.33,1.48,1.518的情况进行了理论仿真。结果表明,GaN衬底的L3二维光子晶体谐振腔共振峰的中心频率可以设计在650 nm附近,共振峰的半高宽度为9.8 nm,共振峰中心频率随折射率变化产生的频移(即灵敏度)是35 nm/RIU(Refractive Index Unit)。测量共振峰的频移可实现对生物样本折射率变化的检测。     

经络是生命信息能量的谐振通道———经络本质初探

经络是生命信息能量谐振通道,只要介质的谐振频率相同,都可让此频率的信息能量通过,而不需要有形通道,这就是解剖学上找不到经络的原因.用检测能量的仪器如热像仪等可测量经络中的能量及其变化情况并显示经络.生命信息能量的载体是远红外电磁波,显示远红外电磁波的通行传导情况,就会找到生命信息能量的通道(经络).为显示经络的存在及功能,用正电子断层扫描(positionemissiontomography,PET)从分子水平显示针灸前后经络及脏腑中生物分子的代谢、受体及神经介质活动的情况,用单光子扫描仪(single-photonemissioncomputedtomography,SPECT)观察针灸前后脏腑、经络中血流的相互影响及变化.活着的人有生命信息,有经络现象;死亡的人没有生命信息,因此没有经络.     

中药生地黄对栅藻生物光子辐射的影响

通过测量生地黄、BG11培养基、栅藻的生物光子辐射,以及生地黄对栅藻生物光子辐射的影响,并将实验数据进行分析处理,我们发现生地黄会使栅藻的生物光子辐射发生明显的变化,随着生地黄汤剂体积的增大,栅藻的自发发光平均强度及延迟发光初始强度均呈先增大后减小的变化趋势,最高值位于350 ul处。在一定范围内,生地黄汤剂的体积与栅藻的自发发光平均强度呈较好的线性关系。这说明栅藻的生物光子辐射对其所处液体环境的变化具有高度的灵敏性,为栅藻作为生物指示剂奠定了基础。     

频域光子迁移技术及其在生物组织光学特性检测中的应用

确定生物组织光学特性参数在无损光诊断和光动力治疗等领域有重要的意义。本文重点分析了频域光子迁移技术用于组织光特性检测的原理，介绍了不同的实现方法     

频域光子迁移技术及其在生物组织光学特性检测中？…

确定生物组织光学特性参数在无损光诊断和光动力治疗等领域有重要的意义。本文重点分析了频域光子迁移技术用于组织光特性检测的原理，介绍了不同的实现方法。     

心经、心包经原络配穴法为主治疗无症状性心肌缺血疗效观察

目的 观察心经、心包经原络配穴法为主治疗无症状心肌缺血临床疗效。方法 选取2015年1月~2018年1月我院老年病科、心内科收治的无症状心肌缺血患者68例,随机分为治疗组和对照组,每组34例。对照组采用口服单硝酸异山梨酯和复方丹参滴丸治疗,治疗组在对照组基础上加以心经、心包经原络配穴法针刺治疗,观察两组患者治疗前后的临床疗效、ST段压低次数及ST段压低持续总时间的变化。结果 治疗组总有效率为91.18%,高于对照组的79.41%,差异具有统计学意义（P＜0.05）。两组患者治疗后ST段压低次数及ST段压低持续总时间均优于治疗前,统计学意义显著（P＜0.01）;治疗后,治疗组心电图ST段压低次数及ST段压低持续总时间改善均优于对照组,差异具有统计学意义（P＜0.05）。结论 心经、心包经原络配穴法为主治疗无症状性心肌缺血,疗效确切,可改善心电图缺血ST段。     

类风湿关节炎的骨病变从络病论治

背景:历代医家虽对类风湿关节炎骨病变有着丰富的论述,但鲜有从络病体系探讨者。目的:从药物治疗分类、病因分析以及"络息成积"以及等几个方面进行总结报道。方法:检索中国知网、EI、SCI、ISTP数据库1900年至今的相关文献;英文检索词为"The bone erosion of Rheumatoid arthritis,TCM collaterals theory"。选取其中内外共十余篇资料从药物治疗分类、病因分析以及"络息成积"等几个方面展开分析。结果与结论:(1)类风湿关节炎骨病变诱因之一为中医之络病,内伤顽固性疾病的发展要遵从由经及络、由气入血、由功能性病变到器质性损伤的疾病发展规律;(2)类风湿关节炎骨病变之病机在于"络息成积",认为是痰聚蕴瘀,瘀存助痰,瘀积痰淫,坏血肿肉,腐骨蚀筋而使关节肿胀、畸形,甚至破坏的过程;(3)类风湿关节炎骨病变治疗之"络以通为用",目的是为了能够保证络脉的通畅,从而让脏器和气血运行正常,从而实现血管通畅,缓解类风湿关节炎病症。     

DCIS,cytokeratins, and the theory of the sick lobe

We postulate that ductal carcinoma in situ (DCIS), and consequently breast carcinoma in general, is a lobar disease, as the simultaneously or asynchronously appearing, often multiple, in situ tumor foci are localized within a single lobe. Although the whole lobe is sick, carrying some form of genetic instability, the malignant transformation of the epithelial cells may appear localized to a part or different parts of the sick lobe at the same time or with varying time difference. It may be confined to terminal ductal lobular units (TDLUs), to ducts or both. The malignant transformation is often associated with aberrant branching and/or aberrant lobularization within the sick lobe. Involvement of a single individual TDLU or of a group of adjacent TDLUs generates a unifocal lesion. Multifocal lesions appear if distant TDLUs are involved. Diffuse growth pattern in DCIS indicates involvement of the larger ducts. The extent of the involved area in multifocal or diffuse cases varies considerably. Diffuse growth pattern with or without evidence of aberrant arborisation within the sick lobe seems to characterize a subgroup of DCIS with unfavourable prognosis. In this paper, we discuss the anatomical, embryological and pathological background of the theory of the sick lobe and present supporting evidence from modern radiological breast imaging, long-term follow-up studies and from our own series of 108 DCIS cases.     

Effects of Mixed Herbal Extracts from Parched Puerariae Radix, Gingered Magnoliae Cortex, Glycyrrhizae Radix and Euphorbiae Radix (KIOM-79) on Cardiac Ion Channels and Action Potentials

KIOM-79, a mixture of ethanol extracts from four herbs (parched Puerariae radix, gingered Magnoliae cortex, Glycyrrhizae radix and Euphorbiae radix), has been developed for the potential therapeutic application to diabetic symptoms. Because screening of unexpected cardiac arrhythmia is compulsory for the new drug development, we investigated the effects of KIOM-79 on the action potential (AP) and various ion channel currents in cardiac myocytes. KIOM-79 decreased the upstroke velocity (V_max) and plateau potential while slightly increased the duration of action potential (APD). Consistent with the decreased V_max and plateau potential, the peak amplitude of Na⁺ current (I_Na) and Ca²⁺ current (I_Ca,L) were decreased by KIOM-79. KIOM-79 showed dual effects on hERG K⁺ current; increase of depolarization phase current (I_depol) and decreased tail current at repolarization phase (I_tail). The increase of APD was suspected due to the decreased I_tail. In computer simulation, the change of cardiac action potential could be well simulated based on the effects of KIOM-79 on various membrane currents. As a whole, the influence of KIOM-79 on cardiac ion channels are minor at concentrations effective for the diabetic models (0.1-10 µg/mL). The results suggest safety in terms of the risk of cardiac arrhythmia. Also, our study demonstrates the usefulness of the cardiac computer simulation in screening drug-induced long-QT syndrome.     

从免疫遗传学看基因——Ⅳ、DNA复制与转录中的跳越现象

我们在第三篇文章中提出了空间离散基因的空间转录模型。该模型的关键是DNA聚合酶、RNA聚合酶在转录时可能借助DNA的交叉(细胞分裂间期的染色质网络)从一条DNA单链跳越到另一条DNA单链上去,或借助R环由一条DNA的某一区段跳越到另一区段上去。染色体畸变、DNA损伤的修复、一个B-细胞SIg的多种类及其互相转化、一个B-细胞SIg的多特异性及其互相转化以及免疫球蛋白肽链的顺反式结构,都表明跳越转录的可能性。     

一种基于多色彩通道动态阈值的舌苔舌质分离算法

舌苔舌质分离是实现舌诊图像自动分析重要的预处理工作,舌苔舌质分离后便于计算,消除相互的干扰,才能得到比较好的定量化结果.本文在结合中医依靠经验辨识舌苔舌质的基础上,借鉴以往的单通道定阈值舌苔舌质分离算法,提出使用多个色彩通道动态选取阈值,再根据先验的空间信息辅助判断,最终分离舌苔舌质的算法.通过与手工分离结果以及现有自动分离算法的比较,分析表明该算法在分离舌苔舌质的准确度以及处理速度上都有较好的效果.     

Pattern of pyramidal tract collateralization to medial thalamus,lateral hypothalamus and red nucleus in the cat

Summary Stimulating electrodes were placed in the red nucleus, lateral hypothalamus and medial thalamus in order to determine whether pyramidal tract (PT) neurons send collaterals to those sites. The red nucleus projections are well-known, but it was discovered that PT neurons also project into the other two sites. All of the fibers that sent collaterals to all three sites originated from fast PT neurons. Those that responded to stimulation of the skin and that sent collaterals to two or three sites were predominantly fast PT neurons. Those neurons that responded only to cerebral peduncle stimulation were predominantly slowly-conducting, when compared with the set of PT neurons in response to cerebral peduncle stimulation. The patterns of collateral branching to red nucleus and to lateral hypothalamus were similar, suggestimg a similar synaptic effect of the pyramidal system in the two sites. Measurement of the speed of conduction from three sites along the length of corticospinal fibers revealed large changes on some, but not all, fibers; there was no evident pattern to these changes that might be associated with collateral branching. A new hypothesis concerning the functional role of fast PT neurons in regulating movement is presented.Dr. Canedo was supported by a Fogarty International Research Fellowship     

急性胆囊炎患者相关经穴电学特性研究

本文利用作者已建立的一种客观反映经络功能活动的电导和电位检测的方法技术,研究了胆囊炎患者手术前后胆经上与病症有关穴的电学动力学特征并与健康正常人进行了对照分析。所得结果显示:炎症期间,阳陵泉和胆囊穴的电导和电位动力学各指标发生了显著增加的变化,随着炎症的解除,各指标向正常值转化。说明,经穴电导和电位动力学指标可以从一个方面客观表现经络反映病症的功能。利用检测经穴电学动力的特征可望发展为急腹症炎症诊断的一种技术。     

The Effects of Stress, Anxiety, and Outdoor Temperature on the Frequency and Severity of Raynaud's Attacks: The Raynaud's Treatment Study

It was expected that stress and anxiety would be related to Raynaud's phenomenon (RP) attack characteristics when mild outdoor temperatures produced partial or no digital vasoconstriction. Hypotheses were that in warmer temperature categories, compared to those below 40°F, higher stress or anxiety would be associated with more frequent, severe, and painful attacks. The Raynaud's Treatment Study recruited 313 participants with primary RP. Outcomes were attack rate, severity, and pain. Predictors were average daily outdoor temperature, stress, anxiety, age, gender, and a stress-by-temperature or an anxiety-by-temperature interaction. Outcomes were tested separately in multiple linear regression models. Stress and anxiety were tested in separate models. Stress was not a significant predictor of RP attack characteristics. Higher anxiety was related to more frequent attacks above 60°F. It was also related to greater attack severity at all temperatures, and to greater pain above 60°F and between 40° and 49.9°F.