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Andrew Korda Rodney P. Shearman Ian D. Smith 《The Australian & New Zealand journal of obstetrics & gynaecology》1972,12(3):166-169
Summary: Fourteen pregnancies between the 12th and 19th weeks of gestation were terminated by intra-uterine administration of prostaglandin F2α . In 7 patients the method of administration was transcervically into the extra-ovular space; in the other 7, administration was directly into the amniotic sac. The methods of administration, the doses used, the side effects and results are discussed. The findings indicate that intra-amniotic administration is the procedure of choice: firstly, because of the incidence of genital tract infection after transcervical administration; secondly, because 3 patients in the transcervical group had incomplete abortions and required anaesthesia for curettage; and finally, the induction-abortion interval was significantly less when the drug was administered into the uterine cavity. 相似文献
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M. A. Quinn M. Jalland R. Wein M. Kloss 《The Australian & New Zealand journal of obstetrics & gynaecology》1981,21(2):93-95
Summary: Tylose gel containing either 10 mg prostaglandin F2α or sterile water was inserted into the posterior vaginal fornix of 130 patients either 12 hours or 4 hours before suction curettage. No benefit in terms of cervical softening or blood loss was noted in patients who received the prostaglandin gel. 相似文献
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Alastair H. MaeLennan Roslyn C. Green 《The Australian & New Zealand journal of obstetrics & gynaecology》1980,20(2):80-83
Summary: A randomised double-blind trial involving 90 patients was set up to compare the efficacy of 25 mg PG F2α , 50 mg PG F2α and a placebo on cervical ripening when given in a vaginal tylose gel on the evening before surgical induction of labour. Preliminary stretching of the cervix and sweeping of the fetal membranes was not undertaken. In the 30 control patients, labour was not initiated and the mean improvement in the cervical score before surgical induction the next morning was 0.86. In the group of 30 patients receiving 25 mg PG F2α , labour commenced during the night in 9 patients and the mean improvement in the cervical score was 3.76 (P < 0.0005); the corresponding figures for the 30 patients receiving 50 mg of PG F2α were 10 patients coming into labour and cervical score improvement of 4.63 (P < 0.0005). he difference in the mean improvement of the cervical score between the 2 prostaglandin groups was not significant. Significantly fewer prostaglandin-treated patients needed augmentation during labour with intravenous oxytocin (P < 0.025) and there was a significant increase in the spontaneous delivery rate in the combined prostaglandin-treated group (P < 0.025). There was no statistical difference in the outcome of labour between the 2 prostaglandin groups. It was not possible to predict the patients whose cervices would not respond to PG F2α pretreatment (15%) or those in whom labour would be initiated (30%). No side effects were experienced. 相似文献
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Alastair H. MacLennan Roslyn C. Green 《The Australian & New Zealand journal of obstetrics & gynaecology》1980,20(2):87-90
Summary: The effect on labour of 50 mg intravaginal PG F2α or a standard intravenous oxytocin regimen was compared in 2 randomised trials involving a total of 83 patients, 23 of whom had experienced spontaneous rupture of the membranes (S.R.O.M.) and 60 of whom had artificial rupture of the membranes (A.R.M.) to induce labour. In each trial, labour had not been initiated by membrane rupture alone. In both trials only 20% of the patients receiving PG F2α required further augmentation of labour with intravenous oxytocin. The mean length of labour in patients receiving PG F2α was 2.5 hours shorter in the A.R.M. trial and 3.0 hours shorter in the S.R.O.M. trial than the mean length of labour in patients receiving intravenous oxytocin (P < 0.01). In the A.R.M. trial, the PG F2α -treated group had significantly less analgesic requirements (P < 0.001). Although more normal deliveries occurred in the patients treated with PG F2α than oxytocin in both trials, die numbers did not reach statistical significance.
No side effects occurred in the PG F2α -treated patients or their babies and this method was much preferred by patients and nursing staff alike. 相似文献
No side effects occurred in the PG F
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M. A. LUMSDEN Research Fellow R. W. KELLY Biochemist D. T. BAIRD Professor 《BJOG : an international journal of obstetrics and gynaecology》1983,90(12):1135-1140
Summary. Menstrual fluid was collected in a contraceptive diaphragm from 16 women with primary dysmenorrhoea and 12 matched control subjects without dysmenorrhoea. Prostaglandins F2α (PGF2α ), E2 (PGE2 ) and 6-oxo-prostaglandin F1α (6-oxo-PGFlα ) were extracted and measured using gas-chromatography: mass spectrometry (GC:MS). The concentrations of both PGF2α and PGE2 were higher on days 1 and 2 in the dysmenorrhoea group than in the control group and the concentration of PGF2α was higher on day 1 than on day 2 in the dysmenorrhoea group. The concentrations of 6-oxo-PGF1α (the stable metabolite of PGI2 ) were low in both groups. These results confirm suggestions that PGF2α is important in the aetiology of dysmenorrhoea and also indicate that PGE2 may be involved. 相似文献
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Alastair Harvey MacLennan MD FRCOG FRACOG Fung Yee Chan MRCOG Kerena Eckert RN RM 《The Australian & New Zealand journal of obstetrics & gynaecology》1994,34(2):154-158
Summary: In an audit of 15,102 consecutive deliveries between 1986 and 1991, 3,168 labours were induced with intravenous oxytocin and 824 with 40 mg prostaglandin F2 a (PGF2 α) vaginal gel. Four hundred and twenty women received PGF2 α alone and 404 received PGF2 α followed by oxytocin. The main aim of the study was to audit the safety of PGF2 01 gel to stimulate labour. There were no maternal or neonatal complications attributable to this therapy. In particular, there were no cases of uterine rupture or hyperstimulation requiring surgical or pharmacological intervention. There was little difference in the evidence for fetal distress between induction methods. Although the prostaglandin and oxytocin groups were not comparable in all respects, the results of this large retrospective study confirmed the results of smaller prospective randomized trials showing a significantly shorter labour and reduced analgesia, surgical delivery and postpartum haemorrhage rates in women treated with PGF2 α alone. This is the largest reported series of PGF2 α induced labours and provides evidence of its safety and is in keeping with physiological data suggesting that PGF2 α is the main prostaglandin and oxytocic associated with normal progressive labour. Its apparent safety and potential to reduce both intervention in labour and postpartum complications merits greater attention. 相似文献
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A. J. Tyack Lecturer in Obstetrics Gynaecology Carol Lambadarios Research Assistant R. J. Parsons Lecturer in Medical Physics C. R. Stewart Lecturer in Obstetrics Gynaecology I. D. Cooke Professor of Obstetrics Gynaecology 《BJOG : an international journal of obstetrics and gynaecology》1974,81(1):52-56
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S. C. BELL Lecturer in Reproductive Biochemistry M. W. HALES Chief Technician S. R. PATEL Research Technician P. H. KIRWAN Lecturer J. O. DRIFE Senior Lecturer A. MILFORD-WARD Director 《BJOG : an international journal of obstetrics and gynaecology》1986,93(9):909-915
Summary. The levels of pregnancy-associated endometrial α1 - and α2 -globulins (α1 - and α2 -PEG), the two major proteins synthesized and secreted by the endometrium in vitro have been assayed in 210 amniotic fluid specimens obtained at termination of pregnancy or by amniocentesis, or at delivery. α1 -PEG was undetectable until week 10 and thereafter rose to peak levels between weeks 20 and 24. Levels fell 15-fold by week 35 but substantial amounts were still present at parturition. α2 -PEG was present at highest levels during early pregnancy, at weeks 6–15, but thereafter levels rapidly fell until during weeks 31–42 α2 -PEG was detectable in only 3 of 25 specimens. During weeks 15–20, when α2 -PEG levels fell and α1 -PEG levels rose, a high correlation was observed between the week of gestation and the log of the ratios of the concentration of these proteins. These observations provide the opportunity to assess the role of endometrial and decidual dysfunction in the aetiology of pregnancy disorders. 相似文献
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