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1.
分析感音神经神经性聋512耳的0.5k、1k、2k和4kHz纯音听阈级与短声诱发ABRⅠ、Ⅴ波潜伏期的关系,结果表明,各频率的有效刺激级(ECL)与Ⅰ、Ⅴ波潜伏期均有很好的相关性。与正常耳比较。显示感音神经性聋耳在能引出ABR时,就有重振现象。4kHz纯音主观听阈大于50dBHTL的感音性听力减退耳,ABR波Ⅴ潜伏期比同一有效刺激级的正常组短,Ⅰ-Ⅴ波间期与正常组一致。  相似文献   

2.
短音诱发的听性脑干反应与纯音听阀的关系   总被引:1,自引:0,他引:1  
本文对健康青年人20耳分别采用短声及0.5k,1k,2k,4kHz短音测试ABR反应阈及潜伏期,并与其主观听阈及纯音阈作比较。发现短声,短音2k,4kHz反应阈与主观听阈非常接近,亦与纯音2k,4kHz的听阈均值接近,表明短声主要反映听阈2k-4kHz频率范围。刺激声包络上升时间与Ⅲ,Ⅴ波的潜伏期间呈正相关关系,尤以V波显著。结果表明,短音刺激记录ABR具有频率特性,与纯音听阈测试及短音主观听阈有相应关系。  相似文献   

3.
短音诱发听性脑干反应的特性观察   总被引:5,自引:2,他引:5  
目的 了解短音(tone pip)诱发的听性脑干反应(TP-ABR)的特征及其各频率反应阈与纯音听阈的关系。方法 对正常听力青年人30耳分别采用短声(click)、短音(0.5、1、2、4、6、8kHz)测试,记录各自不同强度下ABR的波形,观察V波潜伏期的改变。结果 tone pip与常规click声诱发的ABR极为相似,均有很高的可重复性和可靠性;ABR反应阈均较其主观听阈高,尤其是频率越低,反应阈越高,低频个体差异较大;随频率(0.5-8kHz)和强度(40-120dB peSPL)增加Ⅰ波Ⅴ潜伏期递减;各频率的反应阈与音听阈均有较好的相关性。结论 短音刺激记录的TP-ABR具有频率特性,其反应阈在相应频率的客观听力评估中有应用价值。  相似文献   

4.
3种不同条件短纯音诱发听性脑干反应频率特异性观察   总被引:1,自引:0,他引:1  
目的 :观察比较线性窗短纯音、加宽频带噪声掩蔽的线性窗短纯音及Blackman窗门控短纯音对听性脑干反应 (ABR)频率特异性的影响。方法 :16例听力正常成年人分别接受 3种不同条件短纯音诱发的ABR测试 ,记录各自在 1、2、4kHz不同声强下的ABR波V潜伏期。结果与结论 :① 4、2kHz各刺激声强及 1kHz 70dBnHL以下声强时 ,3种不同条件短纯音有着相同的频率特异性 ;在低频 (1kHz)高声强 (≥ 70dBnHL)时 ,线性窗短纯音因有频谱播散现象而需加用掩蔽噪声来改善频率特异性或需直接采用Blackman窗门控短纯音。②宽频带噪声掩蔽短纯音及Blackman窗门控短纯音在 1、2、4kHz各刺激强度下可获得相同的频率特异性反应 ,但宽频带噪声掩蔽短纯音诱发的反应振幅相对较小 ,因此Blackman窗短纯音更为可取  相似文献   

5.
目的研究高刺激声强(90dB SPL)下豚鼠听性脑干反应(ABR)波Ⅰ、波Ⅲ、波Ⅴ的波幅测量方法。方法11只(22耳)2-3月龄白毛雌豚鼠,初测听力正常,测量短声(Click)、短纯音(4k、8k、12k、16k、24k、32kHz)下的听性脑干反应,记录反应阈及90dB SPL刺激声强下的基线高度、波Ⅰ、波Ⅲ、波Ⅴ的潜伏期、波间期、波峰高度、波谷高度,比较波幅的两种测量方法,即波峰-基线和波峰-波谷在90dB SPL刺激声强下,波Ⅰ、Ⅲ、Ⅴ两种测量方法的稳定性,并比较两种测量方法下波Ⅰ波幅与Ⅰ/Ⅴ波幅比的稳定性。结果 90dB SPL声强下ABR波Ⅰ、波Ⅲ、波Ⅴ的波幅两种测量方法,波峰至基线比波峰至波谷所得的数据更集中,离散程度更小;两种方法的波Ⅰ波幅的变异系数均小于Ⅰ/Ⅴ波幅比。结论在豚鼠中,使用波峰-基线的幅度测量方法得到的最高刺激声强下的ABR波Ⅰ、波Ⅲ、波Ⅴ波幅更稳定;在正常豚鼠中判断波Ⅰ波幅有无下降,直接通过比较波Ⅰ波幅,比通过Ⅰ/Ⅴ波幅比的变异度更小。  相似文献   

6.
耳科正常成人短纯音及切迹噪声掩蔽短纯音诱发的ABR比较   总被引:1,自引:1,他引:0  
目的在耳科正常成人中比较短纯音(tone burst)及同侧切迹噪声(notched noise)掩蔽短纯音诱发的听性脑干反应(ABR)反应阈对纯音听阔的预估;研究短纯音及两种不同强度切迹噪声掩蔽短纯音诱发的ABR(分别命名为tb—ABR、amtb—ABR和bmtb—ABR)的波形特点及差异。方法对20例(40耳)耳科正常人行纯音测听,并记录短纯音ABR和两种不同强度切迹噪声掩蔽短纯音诱发的ABR,对结果进行分析比较。结果①相同频率tb—ABR、amtb—ABR、bmtb—ABR的反应阈接近,无统计学差异。②各频率tb—ABR、amtb—ABR、bmtb—ABR反应阚与相应频率纯音听阈之差的平均值均在15dB以内。在相同频率,三种测试方法所得的反应阈与纯音听阈之差的平均值接近,无统计学差异。③在相同刺激强度,无论采用哪种测试方法,波V潜伏期均随频率升高而缩短。当刺激强度和频率相同时,波V潜伏期均表现为tb-ABR最短,amtb—ABR次之,bmtb—ABR最长,差异具有统计学意义。结论短纯音及同侧切迹噪声掩蔽短纯音诱发的ABR的反应阈均可用于预估纯音听阚。  相似文献   

7.
为了解Logon诱发听性脑干反应的频率特异性,在文中以2~8kHz Logon及短声作为刺激声信号,来观察0.25~8kHz纯音听力正常青年人及听力曲线表现为4kHz“V”型下降,而2kHz及8kHz听阈正常青年人的听性脑干反应.结果示听力正常青年人高强度各频率Logon刺激均可引出分化很好的包括5个反应波的波形,其中I、Ⅲ波检出率最高为100%,Ⅳ、Ⅴ波常融合为一个波;听性脑干反应阈4kHz及8kHz较2kHz略低,Ⅰ波潜伏期随频率升高而缩短,Ⅲ波潜伏期缩短轻微,Ⅴ波潜伏期各频率差异无显著性意义,各波波间期随频率升高而延长.听力曲线表现为4kHz“Ⅴ”型下降,而2kHz及8kHz听阈正常的青年人,短声听性脑干反应阈、各波潜伏期、波间期均无明显异常,而4kHz Logon刺激听性脑干反应阈显著升高,2、8kHz Logon刺激听性脑干反应阈基本正常,Logon刺激听性脑干反应阈与纯音听阈线性相关.因此可以认为2~8kHz Logon刺激诱发听性脑干反应具有频率特异性,可做为相应频率听觉敏度测试的客观指标.  相似文献   

8.
气骨导短音ABR在听力正常成年人中的特性   总被引:6,自引:0,他引:6  
目的 研究耳科正常成年人气导和骨导短音诱发的听性脑干反应(auditory brain stem response,ABR)的特点,探讨短音ABR反应阈与纯音听阈的关系及骨导短音ABR对于鉴别听力损失类型的作用.方法 对耳科正常成年人(20例,男/女=10/10)应用SmartEP听觉诱发电位仪记录受试者短音气导和骨导ABR.结果 气导0.5 kHz、1 kHz、2 kHz、4 kHz短音诱发的ABR反应阈分别为(24.8±7.3)dB nHL、(16.1±6.5)dB nHL、(13.5±5.5)dB nHL、(11.9±5.8)dB nHL,分别较对应频率气导纯音听阈高(19.5±9.3)dB、(13.4±6.6)dB、(12.2±6.0)dB、(12.2±7.2)dB,骨导0.5 kHz、1 kHz、2 kHz、4 kHz短音诱发的ABR反应阈为(28.4±9.2)dB nHL、(19.0±7.4)dB nHL、(15.1±7.7)dB nHL、(13.6±6.4)dB nHL,分别较对应频率骨导纯音听阈高(32.0 10.3)dB、(19.4±10.0)dB、(14.2±8.2)dB、(16.1±6.9)dB.各频率气导与骨导短音ABR反应阈无显著性差异.短音ABR的波形与短声ABR相似,随刺激声频率降低,Ⅰ、Ⅲ波引出率降低.短音ABR各波潜伏期均较短声长,且随频率降低,各波潜伏期延长.反应阈强度骨导短音ABR的Ⅴ波潜伏期比气导短音Ⅴ波潜伏期长,其中0.5 kHz和1 kHz该差异具显著性.结论 短音ABR的反应阈可以用于预测纯音听阈,骨导短音ABR的反应阈及短音ABR反应阈的气骨导差有助于鉴别听力损失的类型.  相似文献   

9.
正常新生儿和婴儿的短音听性脑干反应和听觉稳态反应   总被引:1,自引:0,他引:1  
目的 建立听力正常婴儿短音听性脑干反应(tone-pip ABR)和听觉稳态反应(auditorysteady state response,ASSR)反应阈的正常参考值,研究其听觉发育的生物学规律,并比较两种听力检测技术的频率特性.方法 选取0~6月龄听力正常婴儿80例(160耳),按月龄分为四组:新生儿组、42 d组、3月龄组和6月龄组,每组20例(40耳),男女例数均等,分别记录其短声ABR的潜伏期及在0.25、0.5、1、2、4、8 kHz频率范围内tone-pip ABR和ASSR的反应阈.结果 在70 dB正常听力级短声刺激下,短声ABRⅠ、Ⅲ、Ⅴ波潜伏期、Ⅰ~Ⅲ、Ⅲ~Ⅴ、Ⅰ~Ⅴ波间期随月龄增加逐渐缩短,波Ⅰ于42 d前、波Ⅲ于3个月前发育变化显著.tone-pip ABR波形与短声ABR相似,Ⅰ、Ⅲ、Ⅴ波潜伏期随频率增加逐渐缩短,波形分化逐渐清晰.不同频率、不同月龄tone-pip ABR和ASSR反应阈差异具有统计学意义(P值均<0.05).除0.25 kHz外,其余频率tone-pip ABR反应阈均低于ASSR.不同月龄tone-pip ABR和ASSR听力曲线形状相似.结论 0~6月正常婴儿tone-pip ABR的潜伏期和波间期随月龄增加逐渐缩短,而反应阈无明显变化.tone-pip ABR和ASSR均有稳定的频率特异性,tone-pip ABR反应阈低于ASSR,可能更接近主观纯音听阈.  相似文献   

10.
目的:分析正常 Wistar 大鼠短声(click)及短纯音(tone burst,TB)诱发听性脑干反应(cABR、tb-ABR)结果,标准化 Wistar大鼠ABR测试方法,为大鼠听觉研究提供参考。方法正常成年雄性 Wistar 大鼠15只,分别进行cABR和tbABR(4、8、12、16、24、32 kHz)测试,观察80、50、20 dB SPL 强度下各波的引出率,以引出率最高的波来判断阈值,同时量取该波的潜伏期和幅值,检测ABR波Ⅱ、Ⅳ振幅I/O曲线。结果①20 dB SPL强度下cABR和tbABR波Ⅱ和波Ⅳ最晚消失的比例几乎相同;②cABR 阈值为21.83±4.45 dB SPL,4~32 kHz 频率tbABR阈值分别为24.33±5.37、14.17±4.37、14.33±4.68、16.67±4.22、23.00±5.81、31.00±7.36 dB SPL;③80 dB SPL cABR波Ⅰa、Ⅰb、Ⅱ、Ⅲ、Ⅳ、Ⅴ潜伏期分别为1.76±0.12、2.13±0.11、2.67±0.16、3.49±0.28、4.39±0.29、5.45±0.41 ms,tbABR 4 kHz波Ⅰa、Ⅰb、Ⅱ、Ⅲ、Ⅳ、Ⅴ潜伏期分别为2.02±0.09、2.88±0.16、3.77±0.25、4.69±0.29、5.78±0.41 ms,8 kHz分别为1.76±0.07、2.28±0.10、2.63±0.16、3.49±0.21、4.44±0.28、5.48±0.43 ms,12 kHz分别为1.76±0.08、2.24±0.12、2.61±0.25、3.53±0.25、4.46±0.32、5.52±0.45 ms,16 kHz分别为1.79±0.10、2.25±0.12、2.70±0.18、3.62±0.27、4.52±0.37、5.61±0.49 ms,24 kHz分别为1.75±0.09、2.27±0.11、2.67±0.16、3.60±0.27、4.52±0.38、5.60±0.51 ms,32 kHz分别为1.77±0.10、2.24±0.12、2.64±0.20、3.59±0.34、4.52±0.40、5.61±0.52 ms;④I/O曲线示在高强度时波Ⅱ振幅明显高于波Ⅳ,但在低强度时,波Ⅱ振幅与波Ⅳ基本相同,甚至波Ⅳ振幅高于波Ⅱ。结论正常成年大鼠短声及短纯音诱发ABR波Ⅳ出现率最高,低强度声刺激时,波Ⅱ、Ⅳ振幅基本相同,甚至波Ⅳ振幅高于波Ⅱ,可以波Ⅳ最后消失的强度为阈值。  相似文献   

11.
Young adult male Sprague-Dawley (SD) and Long-Evans (LE) rats were evaluated using the auditory brainstem response (ABR). ABRs were evoked by stimuli with intensities ranging from 15 to 100 dB peSPL. Stimuli were tone bursts of 2000, 4000 and 8000 Hz. As stimulus intensity decreased from 100 to 15 dB, the ABR peak latencies prolonged, interpeak latencies (IPLs) shortened and amplitudes decreased. As stimulus frequency decreased from 8000 to 2000 Hz, ABR latencies prolonged, amplitudes decreased and ABR thresholds increased. The longest IPLs were in response to the 4000 Hz tone bursts. SD rats had ABRs with shorter peak latencies, larger amplitudes and lower thresholds than LE rats. The IPLs usually did not show significant strain-dependent differences. Our observations on stimulus intensity and frequency are consistent with previous reports. Our observations also suggest that the SD (albino) rat has better auditory acuity than the LE (pigmented) rat over the frequency range of 2000 to 8000 Hz. This implies that previous concerns about the use of albino animals in audiological research are somewhat overstated.  相似文献   

12.
To characterize the patterns of ABR waves in tree shrews, we must understand the hearing sensitivity and auditory function of healthy adult tree shrews. Fifteen tree shrews (30 ears) were stimulated with clicks and tone-pips at 11 different frequencies from 1 to 60?kHz. The ABR waves were recorded and analyzed. The ABR consisted of five to seven positive waves in the first 10?ms after a click stimulus, and the average hearing threshold of component III was 27.86?±?3.78?dB SPL. Wave III was the largest and most clear. The ABR threshold was related to the tone-pip sitmulus by a “U” shaped curve. The sensitive frequency was approximately 8?kHz in tree shrews. The latencies systematically decreased with increasing stimulus frequencies. The ABR amplitudes of wave III increased as the sound pressure level increased. All of these results provide an empirical basis for future studies of hearing diseases in tree shrews.  相似文献   

13.
Objective: High doses of sodium salicylate (SS) are known to induce tinnitus, general hyperexcitability in the central auditory system, and to cause mild hearing loss. We used the auditory brainstem response (ABR) to assess the effects of SS on auditory sensitivity and temporal processing in the auditory nerve and brainstem. ABRs were evoked using tone burst stimuli varying in frequency and intensity with presentation rates from 11/s to 81/s.

Design: ABRs were recorded and analysed prior to and after SS treatment in each animal, and peak 1 and peak 4 amplitudes and latencies were determined along with minimal response threshold.

Study Sample: Nine young adult CBA/CaJ mice were used in a longitudinal within-subject design.

Results: No measurable effects of presentation rate were found on ABR threshold prior to SS; however, following SS administration increasing stimulus rates lowered ABR thresholds by as much as 10?dB and compressed the peak amplitude by intensity level functions.

Conclusions: These results suggest that SS alters temporal integration and compressive nonlinearity, and that varying the stimulus rate of the ABR may prove to be a useful diagnostic tool in the study of hearing disorders that involve hyperexcitability.  相似文献   

14.
目的 总结在有听力损失儿童中行短纯音诱发的听性脑干反应(tbABR)测试时记录到的声诱发短潜伏期负反应(acoustically short latency negative response,ASNR)的特点.方法 在有听力损失的0~6岁儿童中应用SmartEP听觉诱发电位仪记录短声和短纯音ABR的反应阈,在记录到ASNR的受试者中分析其反应阈和潜伏期.结果 在所有80受试耳中共7耳(8.75%)在cABR测试中引出ASNR,40耳(50%)在tbABR测试中引出ASNR,其中1 kHz引出率最高(37耳,46.25%),2 kHz次之(25耳,31.25%).引出ASNR者ABR波V反应阈最低65 dB nHL,ASNR反应阈最低80 dB nHL.0.5、1、2和4 kHz短纯音诱发的ASNR潜伏期分别为6~8、5~7、3~5、3~4 ms.随刺激强度的增加,其潜伏期缩短.结论 有听力损失的儿童tbABR测试中可以记录到AS-NR,但不影响以波V反应阈评估听力.  相似文献   

15.
Ipsilateral masking levels and normal thresholds for tone pip auditory brainstem responses (ABRs) were investigated in normal subjects for the purpose of establishing recording parameters and norms for frequency-specific tone pip ABR testing. White noise was found to effectively mask ABRs to tone pips at mean signal-to-noise ratios of between -1 and -5.5 dB [dB peak-equivalent (pe) SPL/dB SPL] depending on the tone pip frequency. ABR thresholds were established for tone pips in the presence of ipsilateral masking with high-pass filtered noise for 50-Hz tone pips and notched noise for tone pips from 1,000 to 4,000 Hz, at a nominal signal-to-noise ratio of -5 dB (i.e. with the noise SPL measured prior to filtering). Thresholds occurred between 28.6 and 36.6 dB pe SPL, equivalent to 4.4-8.8 dB nHL. ABR thresholds for masked and unmasked tone pips did not differ significantly.  相似文献   

16.
Henry KS  Kale S  Scheidt RE  Heinz MG 《Hearing research》2011,280(1-2):236-244
Noninvasive auditory brainstem responses (ABRs) are commonly used to assess cochlear pathology in both clinical and research environments. In the current study, we evaluated the relationship between ABR characteristics and more direct measures of cochlear function. We recorded ABRs and auditory nerve (AN) single-unit responses in seven chinchillas with noise-induced hearing loss. ABRs were recorded for 1-8 kHz tone burst stimuli both before and several weeks after 4 h of exposure to a 115 dB SPL, 50 Hz band of noise with a center frequency of 2 kHz. Shifts in ABR characteristics (threshold, wave I amplitude, and wave I latency) following hearing loss were compared to AN-fiber tuning curve properties (threshold and frequency selectivity) in the same animals. As expected, noise exposure generally resulted in an increase in ABR threshold and decrease in wave I amplitude at equal SPL. Wave I amplitude at equal sensation level (SL), however, was similar before and after noise exposure. In addition, noise exposure resulted in decreases in ABR wave I latency at equal SL and, to a lesser extent, at equal SPL. The shifts in ABR characteristics were significantly related to AN-fiber tuning curve properties in the same animal at the same frequency. Larger shifts in ABR thresholds and ABR wave I amplitude at equal SPL were associated with greater AN threshold elevation. Larger reductions in ABR wave I latency at equal SL, on the other hand, were associated with greater loss of AN frequency selectivity. This result is consistent with linear systems theory, which predicts shorter time delays for broader peripheral frequency tuning. Taken together with other studies, our results affirm that ABR thresholds and wave I amplitude provide useful estimates of cochlear sensitivity. Furthermore, comparisons of ABR wave I latency to normative data at the same SL may prove useful for detecting and characterizing loss of cochlear frequency selectivity.  相似文献   

17.
Auditory middle latency responses (MLR) and auditory brainstem responses (ABR) were measured with epidural electrodes in unanesthetized gerbils. Response thresholds of simultaneously recorded MLRs and ABRs, and latencies and amplitudes of MLR peaks were analyzed with respect to stimulus intensity (10-80 dB SPL) and frequency (0.5, 1, 2, 4, 8 and 16 kHz). Only minor changes in the latencies of the MLR were associated with increases in stimulus intensity. Changes in latencies were more apparent for waves A and B as compared to wave C, and were significant only at low intensities. Latencies did not change significantly as a function of stimulus frequency. Amplitudes of the MLR were highly variable between animals, particularly waves B and C, and showed complex changes with intensity. In general, wave amplitudes were inversely related to stimulus frequency. The gerbil MLR resembles MLRs recorded under similar conditions in guinea pig, cat, and rat. Some qualitative similarities between gerbil and human MLRs are apparent. Results indicate that the MLR is a less sensitive measure of hearing threshold relative to the fast waves of the ABR at frequencies above 1 kHz. However, clearly defined MLRs are elicited with a wide range of stimulus frequencies. Because the surface recorded MLR reflects activation of central auditory pathways, including the cortex, it may provide an electrophysiological measure which can be utilized to study central components of normal and pathological auditory function.  相似文献   

18.
OBJECTIVE: To determine the clinical usefulness of the dichotic multiple-frequency (MF) auditory steady-state response (ASSR) technique for estimating normal hearing compared to a 0.5-kHz tone burst and broadband click auditory brainstem response (ABR) protocol in a sample of adults. MATERIAL AND METHODS: A comparative experimental research design was selected in order to compare estimations of normal hearing obtained with the dichotic ASSR technique at 0.5, 1, 2 and 4 kHz with a 0.5-kHz tone burst and broadband click ABR protocol. The recording times required for each procedure were also compared. Normal-hearing subjects (n = 28) were selected according to immittance values within normal limits and pure-tone behavioural thresholds of < 25 dB HL across frequencies. RESULTS: The dichotic MF ASSR estimated normal hearing to be, on average, 30-34 dB HL across the range 0.5-4 kHz. The mean estimate of normal hearing for 0.5 kHz using tone burst ABRs was 30 dB nHL and the mean click ABR threshold was 16 dB nHL, i.e. 14-18 dB better than the ASSR thresholds. The dichotic MFASSR technique recorded 8 thresholds (4 in each ear) in a mean time of 23 min. The ABR protocol recorded 4 thresholds (2 in each ear) in a mean time of 25 min. CONCLUSION: Both the dichotic MF ASSR and ABR protocols provided a time-efficient estimation of normal hearing. There was no significant difference between the tone burst ABR and MF ASSR techniques in terms of estimation of normal hearing at 0.5 kHz. The dichotic MF ASSR technique proved more time-efficient by determining more thresholds in a shorter time compared to the ABR protocol.  相似文献   

19.
目的研究儿童短纯音(tone burst)及同侧切迹噪声(notched noise)掩蔽短纯音诱发的ABR反应阈,与短声诱发的听性脑干反应(click-evoked auditory brainstem response,c-ABR)以及40Hz听觉事件相关电位(40Hz Auditory Event Related Potentials,40Hz AERP)反应阈的关系,以评价这些测试方法在儿童听力评估中的应用价值。方法应用SmartEP听觉诱发电位仪在29例(53耳)儿童(男18例,女11例,年龄2月-8岁)中测试短声ABR、短纯音ABR、两种不同强度切迹噪声掩蔽短纯音诱发的ABR(分别定义为c-ABR、tb-ABR、amtb-ABR和bmtb-ABR)及40Hz AERP。结果(1)fb-ABR、amtb-ABR、bmtb-ABR在2kHz、4kHz两个频率的反应阈与c-ABR的反应阈接近,反应阈之间有较好的相关性;(2)tb-ABR、amtb-ABR、bmtb-ABR的反应阈与40Hz AERP的反应阈在0.5、1、2、4kHz各个频率均接近并有较好的相关性。结论使用短纯音及同侧切迹噪声掩蔽短纯音诱发的ABR的反应阈预测儿童的纯音行为听阈是可行的。  相似文献   

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