乳头糜烂性腺瘤病1例

患者女,50岁。左乳头反复糜烂、结痂1年。皮肤科情况:左乳头皮肤略隆起,中央有角化痂,去除角化痂皮后,露出红色糜烂面。皮损组织病理示:肿瘤位于真皮内,与表皮相连,无包膜,可见乳腺导管上皮细胞明显增生,形成大小不等的管样结构和实体细胞巢,周围可见肌上皮细胞包绕,间质内透明样变性及少量淋巴细胞及浆细胞浸润。免疫组化:肿瘤团块E-cadherin强阳性。行局部乳头及乳晕楔形切除术,现随访中。     

乳头糜烂性腺瘤病1例

患者女,42岁。因右乳头溢血1年,于2005年8月25日来我科门诊就诊。患者近1年来,无明显诱因右乳头经常溢血,皮损呈暗红色,略隆起,中央覆暗红色痂,不痛不痒。乳罩上经常有血迹,经期前溢血增多。皮肤科检查:右乳头皮肤略隆起,中央有暗红色的痂(图1)。右乳房未触及结节及肿块。实验室检查:血、尿常规和肝、肾功能均正常。胸部B超显示:双侧乳房小叶增生。皮损组织病理检查示:肿瘤由基底样细胞组成,呈巢状及索状,细胞核圆,嗜碱性,胞质少,细胞形状大小不一,无异形(图2A);在基底样细胞聚集的外周系一层肌上皮细胞,其外是一层红染的基膜;瘤组织中可见…     

乳头糜烂性腺瘤病1例

<正>临床资料患者,女,48岁。主因右乳头结节1年,于2009年7月2日就诊。患者1年前无明显诱因右乳头出现粉红色丘疹,逐渐长大,无自觉症状。半年前皮损出现渗液、结痂,外用盐水及酒精擦洗,无明     

乳头糜烂性腺瘤病

报告1例乳头糜烂性腺瘤病。患者女,31岁。右侧乳头红斑、糜烂,间断性血性溢液半年,不伴疼痛。皮损组织病理检查:肿瘤位于真皮内,与表皮相连,无包膜,可见乳腺导管上皮细胞明显增生,形成大小不等的管样结构和实体细胞巢,周围可见肌上皮细胞包绕。免疫组化:细胞角蛋白(CK)5/6阳性,抑癌基因(p63)、钙调蛋白(Caplonin)及平滑肌肌动蛋白(SMA)阳性,提示肌上皮细胞的完整性。诊断:乳头糜烂性腺瘤病。患者病灶完整切除后,随访18个月,未见复发。     

乳头肿胀糜烂结痂——乳头糜烂性腺瘤病

诊断:乳头糜烂性腺瘤病.皮损组织病理特点:表皮不规则向下延伸,呈扩张的管状结构.有些部位细胞增生很明显,几乎充满管腔.导管主要由两层细胞组成,腔面细胞呈高柱状,可见顶浆分泌样表现,外层为致密的立方形细胞.     

乳头糜烂性腺瘤病一例

患者女,４２岁,因左侧乳头反复糜烂、渗液、结痂２年于１９９９年６月来本院就诊。患者于２年前在无明显诱因下出现左乳头浸润性红斑,伴反复糜烂、破溃、渗血、结痂,时有瘙痒感。按湿疹处理无效。症状经久不愈且乳头明显结节状增厚、增粗。临床初步诊断为乳房Paget病。体检：一般情况好,各系统检查无异常。皮肤科情况：左乳头明显增粗,直径为１．２cm,表面结节状增生,伴结痂、少量渗液,痂下为鲜红肉芽组织,病变未累及乳晕（图１）。未触及乳头和乳腺实质性肿块,腋下淋巴结无肿大。左乳头病理学检查示：真皮层结缔组织较丰富,可…     

乳头侵蚀性腺瘤病1例

报告 1例 15岁女性乳头侵蚀性腺瘤病典型病例。初诊考虑为湿疹或Paget病。依靠组织病理学的特异性表现确诊为乳头侵蚀性腺瘤病。     

乳头糜烂性腺瘤病一例

患者女，23岁，因左侧乳头溢液2年，于我科就诊。近2年无明显诱因左乳头出现糜烂、溢液，初发病时面积为粟粒大小，以后逐渐扩大至整个乳头，无自觉症状，曾外用治疗湿疹的药物，药名不祥，无明显疗效。体检：各系统检查无异常。皮肤科检查：左乳头表面粗糙，浸润，轻度增生，高于右侧乳头，表面少量浆痂，病变侵及整个乳头，未达乳晕（图1）。临床初步诊断：乳房Paget病。环钻法进行活组织病理检查：表皮不规则向下延伸，呈扩张的管状结构，导管由两层细胞组成，近腔面的内层为柱状细胞，外层为立方细胞，有些区域在其腔面见顶浆分泌样表现，有些则呈乳头状增生，突入腔内（图2）。病理诊断：乳头糜烂性腺瘤病。患者因担心治疗后影响哺乳，故未进行治疗。     

融合性网状乳头瘤病1例

患者男,19岁.因躯干、颈部出现褐色丘疹、斑片7年余,无自觉症状,于2007年6月20日至我科就诊.患者7年前无明显诱因胸、背部出现褐色斑片、丘疹,无自觉症状,未求治.其后皮损渐增多,逐渐蔓延至上腹部、颈部、双上肢屈侧并融合成大片网状斑,表面有细小脱屑,皮损夏重冬轻.患者既往无糖尿病、高血压病和甲状腺疾病史,家族成员中也无类似疾病患者.     

Cryosurgery as a Minimally Invasive Alternative Treatment for a Patient with Erosive Adenomatosis of the Nipple

Erosive adenomatosis of the nipple (EAN), also known as nipple adenoma, florid papillomatosis, or papillary adenoma of the nipple, is a benign neoplasm originating from a lactiferous duct of the breast. Although the potential for malignant change is invariably negligible, the nature of the disease is quite intractable despite several treatment methods. Surgical excision is known as the treatment of choice, but this invasive approach is generally not acceptable to the vast majority of patients due to the cosmetic outcomes. Cryosurgery could be an alternative choice to preserve the structure of the nipple-areola complex, though its application has not been studied due to the paucity of cases. A 22-year-old female presented with a unilateral, crater-like erosion of the left nipple with serosanguineous discharge. The skin biopsy revealed proliferation of tubular structures, which corresponded to EAN. She was treated with 4 sessions of cryosurgery (open cryospray with liquid nitrogen) over 6 months, and the skin lesion resolved completely without any recurrence for 12 months. Although further study is required to determine the optimal treatment regimen for EAN, cryosurgery should be considered as an effective option to surgical excision.     

Erosive Pustular Dermatosis of the Scalp Following Herpes Zoster: Successful Treatment with Topical Tacrolimus

Erosive pustular dermatosis of the scalp (EPDS) is a rare disorder of the elderly characterized by multiple pustular lesions with erosions and crusting that result in scarring alopecia. EPDS typically develops in aged or sun-damaged skin with a history of trauma. Histopathologically, EPDS is nonspecific, showing atrophic epidermis and chronic inflammation. Bacteriological and mycological investigations of EPDS are generally negative. Although herpes zoster is a common disorder in elderly people, previously reported cases of EPDS were rarely associated with herpes zoster. We present a rare case of EPDS following herpes zoster treated successfully with topical tacrolimus.     

Erosive diseases of the vulva

Vesicobullous and inflammatory diseases produce vulvar erosions that may exhibit nonspecific morphology and represent a diagnostic challenge. An approach to arriving at the correct diagnosis is presented. Most common etiologies are reviewed.     

Blister Formation over a Soft Fibroma of the Nipple

We report a case of soft fibroma on the nipple which was accompanied by a blister. Histologically, a subepidermal blister overlying the tumor and the degeneration of the lower part of the epidermis were observed. The causes of blister formation are briefly discussed.     

Nipple leiomyoma: A rare neoplasm with a broad spectrum of histologic appearances

Cutaneous leiomyomas are rare benign smooth‐muscle tumors. These lesions are distinguished based on their cell of origin and are subclassified as pilar leiomyoma, angioleiomyoma, and genital‐type leiomyoma. Nipple leiomyoma is the least common genital‐type leiomyoma, arising from the dartoic muscle cell of the nipple. Histologic examination of the lesion is necessary for definitive diagnosis, and these uncommon tumors can pose a diagnostic challenge. We describe herein a series of six nipple leiomyomas with a spectrum of histologic appearances.     

乳头乳晕角化过度症1例

患者女,25岁。双侧乳头、乳晕呈棕色色素加深伴皮肤肥厚10余年。皮肤科检查:双侧乳头乳晕对称性皮肤色素加深呈暗褐色,乳晕范围扩大,直径5～6cm,边界清楚,皮肤明显增生肥厚,呈疣状突起,沟纹加深加宽,乳头无溢液。组织病理示表皮呈乳头瘤样增生,棘层肥厚,有角质栓塞,基底细胞色素增多。诊断:乳头乳晕角化过度症。     

Hyperkeratosis of the Nipple: Report of Two Cases

Hyperkeratosis of the nipple and areola is a rare condition; its characteristic properties are verrucous thickening and brownish discoloration of the nipples and areola. The nevoid form of the disease is extremely rare, usually seen in women in the second or third decade of life. The nipple is seldom affected alone. We report two cases of the nevoid form of hyperkeratosis of the nipple. In both female patients, lesions developed after puberty and were confined to both nipples alone. One of the patients' lesions became darker and more verrucous during pregnancy, making breast feeding impossible.