义齿基托和承托区粘膜菌斑及义齿性口炎

义齿基托和承托区粘膜菌斑及义齿性口炎上海第二医科大学口腔医学院（２０００１１）佘文王君综述张富强朱敏审校配戴可摘局部义齿或全口义齿后，义齿承托区口腔粘膜常出现软组织损伤和炎症。本文就配戴可摘局部义齿或全口义齿后，义齿基托组织面与义齿承托区口腔粘膜菌丛...     

制霉菌素不同制剂治疗义齿性口炎

制霉菌素不同制剂治疗义齿性口炎张燕群（北京首钢总医院门诊部口腔科）义齿性口炎（ｄｅｎｔｕｒｅｓｔｏｍａｔｉｔｉｓ），又称慢性萎缩性白色念珠菌病，是白色念珠菌感染的一种表现形式。多年来，一直以抗真菌治疗为主，制霉菌素（Ｎｙｓｔａｔｉｎ）是最常选用的药物...     

义齿性口炎的病因研究

义齿性口炎是常出现在佩戴全口义齿和可摘局部义齿患者上腭部的炎症性损害,发病机制尚不清楚。很多研究显示,白色假丝酵母菌和义齿性口炎发病有密切联系。本文就义齿性口炎的病因作一综述。     

义齿性口炎的研究

义齿性为是戴全口义齿及可摘局部义齿患者出现的问题之一,但其发现机制尚不明了,本文就其成因及预防控制的方法研究作一综述。     

义齿性口炎患者腭粘膜微生物丛及义齿菌斑的真菌学研究

目的 掌握义齿基托与口腔粘膜炎症变化及真菌间的关系。方法 对１１８例全口义齿戴用者进行了临床调查，对６０例患者的腭粘膜微生物丛与义齿菌斑进行了真菌学定量研究。结果 义齿性口炎与义齿菌斑的沉积量呈正相关关系；真菌总数及念珠菌的检出量与义齿性口炎的发生及其严重程度呈正相关关系；白色念珠菌的检出率及量、在重度炎症组与轻度炎症组之间均存在高度显著性差异（Ｐ〈０．０１）。结论 重度义齿性口炎的发生同热带念珠     

派丽奥联合咪康唑治疗义齿性口炎的疗效观察

目的：通过对派丽奥（2％盐酸米诺环素软膏）与3％硝酸咪康唑联合应用与单独使用3％硝酸咪康唑治疗义齿性口炎在药物疗效、用药周期以及对真菌和可疑致病菌的清除作用的差异比较,为义齿性口炎的临床局部用药提供参考。方法：选取32例义齿性口炎患者,随机分为实验组（派丽奥＋咪康唑组）和对照组（咪康唑组）,‘每组各16人。观察用药半月和1月后义齿性口炎患者的临床指征和口腔黏膜念珠菌及可疑致病菌等微生物学指标的变化。结果：实验组和对照组患者用药后临床症状有所改善,两组问有显著性差异（P〈0．05）;病损区的白色念珠菌和链球菌数较用药前减少,两组间比较无显著性差异（胗O．05）。治疗半月和1月后实验组患者病损区的放线菌数有明显降低（P〈0．01）,对照组无明显变化,两组问有显著性差异（P〈0．01）。结论：派丽奥与硝酸咪康唑联合应用可有效提高义齿性口炎的治愈率,缩短治疗周期,有效清除真菌和可疑致病菌。     

派丽奥联合咪康唑治疗义齿性口炎的疗效观察

目的：通过对派丽奥（2％盐酸米诺环素软膏）与3％硝酸咪康唑联合应用与单独使用3％硝酸咪康唑治疗义齿性口炎在药物疗效、用药周期以及对真菌和可疑致病菌的清除作用的差异比较,为义齿性口炎的临床局部用药提供参考。方法：选取32例义齿性口炎患者,随机分为实验组（派丽奥＋咪康唑组）和对照组（咪康唑组）,‘每组各16人。观察用药半月和1月后义齿性口炎患者的临床指征和口腔黏膜念珠菌及可疑致病菌等微生物学指标的变化。结果：实验组和对照组患者用药后临床症状有所改善,两组问有显著性差异（P〈0．05）;病损区的白色念珠菌和链球菌数较用药前减少,两组间比较无显著性差异（胗O．05）。治疗半月和1月后实验组患者病损区的放线菌数有明显降低（P〈0．01）,对照组无明显变化,两组问有显著性差异（P〈0．01）。结论：派丽奥与硝酸咪康唑联合应用可有效提高义齿性口炎的治愈率,缩短治疗周期,有效清除真菌和可疑致病菌。     

义齿性口炎的流行病学研究

本文通过对义齿性口炎的流行病学调查，其结果显示：在配戴半口义齿和全口义齿的自然人群中．义齿性口炎的罹患率分别为78％和40％；在口腔科门诊6年间就诊患者中．义齿性口炎的罹患率分别为25．3％和17．3％。以上结果均具有典型的临床意义，有必要在病因学上作进一步的研究。     

义齿性口炎患者腭粘膜微生物丛及义齿菌斑的真菌学研究

目的掌握义齿基托与口腔粘膜炎症变化及真菌间关系。方法对118例全口义齿戴用者进行了临床调查，对60例患者的腭粘膜微生物丛与义齿菌斑进行了真菌学定量研究。结果义齿性日炎与义齿菌斑的沉积量呈正相关关系；真菌总数及念珠菌的检出量与义齿性口炎的发生及其严重程度呈正相关关系；白色念珠菌的检出率及量，在重度炎症组与轻度炎症组之间均存在高度显著性差异（P＜0．01）。结论重度义齿性口炎的发生同热带念珠菌、皱褶念珠菌及白色念珠菌的混合感染密切相关。     

Antimycotic denture adhesive in treatment of denture stomatitis

The mycologic findings of Candida albicans or culturally similar yeasts in 70% of the subject sample is consistent with those of other researchers. It is, however, only one of several etiologic factors requiring concomitant study to obtain meaningful results. Use of an antimycotic denture adhesive did not prove to be effective in the treatment of denture stomatitis. Although in the trial it appeared that marginally better results were obtained with the amphotericin medicated adhesive, this could not be substantiated statistically. On retrospective testing in the laboratory, both medicated and placebo materials were found to have an inhibiting effect on the growth of C. albicans. However, it was considered that the beneficial effects noted were probably due to the adhesive and lubricant effects of the test materials in reducing denture trauma in function.     

Clinico-pathological study on denture stomatitis

The clinical and pathological study was performed in order to determine the histopathological and cytoimmunological characteristics of denture stomatitis. All specimens were biopsy materials from seventeen patients with denture stomatitis. Normal palatal mucosae from ten patients served as the control. In addition to the usual staining methods, naphtol AS-D chloroacetate esterase stain and peroxidase-antiperoxidase method were used to detect mast cells and plasma cells. Denture stomatitis could be divided into atrophic and hyperplastic types. The former showed a smooth and atrophic mucosa. The latter showed a large number of exophytic projections which were composed of marked acanthosis and submucosal fibrosis, and was further subdivided into granular and papillary subtype according to the size of projections. In the present study, there were six cases of the atrophic type, and eleven cases of the hyperplastic type (consisting of seven granular and four papillary subtypes). The hyperplastic type was more frequently observed in patients with partial dentures compared with complete dentures and was associated frequently with ill fitting of the denture base as well as agglutination of denture plaque. Cytoimmunological study revealed that there was a pronounced increase of plasma cells, especially IgG- and IgA-producing cells, and a moderate increase of lymphocytes as well as mast cells in both types of denture stomatitis. Mast cells were always noted in the area with marked plasma cell infiltration, suggesting an intimate relation between both cells. These findings suggest that the immunological reactions play some role in the pathogenesis of denture stomatitis.     

Glycaemic disorders in denture stomatitis

The prevalence of glycaemic disorders was investigated in native Upper-Austrians with Candida-associated denture stomatitis. All patients with previously unknown diabetes mellitus were subjected to an oral glucose tolerance test (OGTT) and as a result diabetes was diagnosed in 13% of the patients over 50 years of age. Thirty-five percent of all inspected patients over 50 years of age with denture stomatitis had type 2 diabetes mellitus and 36% had impaired glucose tolerance (IGT). The correlation between Candida-associated denture stomatitis and diabetes mellitus indicates a means for the early diagnosis of diabetes. Hyperglycaemia could not be a predisposition to denture stomatitis, since all patients with denture stomatitis in the age-bracket 26-50 years were without diabetes and only very few of the older patients with diabetes were obese. The correlation between Candica-associated denture stomatitis and type 2 diabetes mellitus could be traced back to a reduced resistance to Candida that preceded the diabetes.     

Gastroenterological drugs and denture stomatitis

The aim of this study was to investigate the medical and dental variables related to the presence of denture stomatitis. The study population was comprised of 106 elderly people (82 women, 24 men; mean age, 81.3 years) using a maxillary complete denture and living in a geriatric nursing home in Oulu, Finland. The following variables were used in the analysis: medical diagnoses, which could have a possible biological association with stomatitis; daily use of drugs; ability to cope with everyday life; oral hygiene; and the condition of the denture. The prevalence of stomatitis was 52% among residents wearing complete dentures. Patients receiving gastroenterological drugs had less stomatitis (p = 0.01, chi-square). The results suggest a preliminary finding that older adults using gastroenterological drugs had less stomatitis .     

Leucocyte function in denture stomatitis

As part of a wider series of experiments to study the aetiological significance in denture stomatitis, 30 patients and 30 age- and sex-matched controls were subjected to in vitro antigenic challenge. No abnormality of leucocyte transformation or migration-inhibition factor production could be demonstrated.     

In situ characterization of the inflammatory cell infiltrates of hyperplastic denture stomatitis

Cryostat sections from 14 surgical specimens were examined to determine whether selected factors of the immune response related to histopathological reactions are present in the palatal mucosa affected by hyperplastic denture stomatitis. By means of various immunological techniques the presence of IgG, IgA, IgM, complement factor C3c, receptors for the Fc region of IgG (FcR) and for complement factor C3b (C3bR), T lymphocytes, and macrophages were studied. The inflammatory infiltrate was mainly located in the papillary part of the lamina propria. IgG, IgA, and IgM appeared both in plasma cells and intercellularly. FcR, C3bR, and T lymphocytes were present in the areas with inflammatory cell infiltrate. Macrophages were found in the papillary part of the lamina propria and within the epithelium. The immunological response in the mucosa affected by denture stomatitis was in many respects similar to that of marginal and apical periodontitis. We conclude that hyperplastic denture stomatitis is a complex inflammatory lesion showing elements of both humoral and cellular immune responses.