注射用丹参多酚酸盐治疗冠心病心绞痛的疗效观察

目的对注射用丹参多酚酸盐治疗冠心病心绞痛患者的治疗效果进行观察分析。方法随机选择94例冠心病心绞痛患者的临床资料,分为对照组和研究组,各47例,对照组给予常规疗法,研究组应用注射用丹参多酚酸盐治疗。结果研究组总临床有效率、硝酸甘油用量、心绞痛持续时间、发作次数均指标与对照组对比(P0.05)。结论治疗冠心病心绞痛患者应用注射用丹参多酚酸盐,能提高治疗有效率,缩短心绞痛持续时间,减少心绞痛发作次数,值得临床推广。     

丹参多酚酸盐在冠心病心绞痛患者中的应用及对血脂和炎性因子的影响效果

目的:研究与分析丹参多酚酸盐在冠心病心绞痛患者中的应用及其对血脂及炎性因子的影响效果.方法:特选取自2015年2月起至2016年12月经我院收治的冠心病心绞痛患者102例,并按数字表法随机分为试验组与对照组,每组均51例.予以对照组常规抗心绞痛西药治疗,试验组则在此基础上加以使用丹参多酚酸盐中药治疗.对比两组治疗前后血脂、炎性因子水平、心绞痛发作次数及每次持续时间.结果:经过治疗后,两组血脂及炎性因子水平均呈下降趋势,且试验组TG、TC、HDL-C、LDL-C、IL-6、TNF-α、hs-CRP等下降程度均明显优于对照组;试验组心绞痛发作次数(0.86±0.38)次、持续时间(3.43±1.08)( min/次)等均明显低于对照组心绞痛发作次数、持续时间,差异有统计学意义(P＜0.05).结论:对冠心病心绞痛患者使用丹参多酚酸盐进行治疗后,可有效降低其血液中的血脂及炎性因子水平,作用效果较优.     

注射用丹参多酚酸盐联合替格瑞洛治疗不稳定型心绞痛患者疗效观察

目的:研究注射用丹参多酚酸盐联合替格瑞洛治疗不稳定型心绞痛(UAP)患者的临床疗效。方法:选取我院所收治的68例UAP患者,按照随机抽签法分为对照组和观察组,每组34例,对照组采用替格瑞洛治疗,观察组采用注射用丹参多酚酸盐联合替格瑞洛治疗,治疗后观察两组的心绞痛持续时间、发作次数,心电图改善疗效和临床疗效。结果:治疗后观察组与对照组相比,心绞痛持续时间缩短、发作次数减少(P<0.05);治疗后观察组心电图改善疗效及临床疗效高于对照组(P<0.05)。结论:注射用丹参多酚酸盐联合替格瑞洛治疗UAP患者,能有效缩短心绞痛发作持续时间,减少心绞痛发作次数,改善患者心电图和临床疗效。     

酒石酸美托洛尔治疗扩张型心肌病的临床疗效

目的探讨酒石酸美托洛尔治疗扩张型心肌病的临床疗效。方法选取我院2018年3月～2019年3月收治的66例患者,在保证随机、合理、公正的前提下,将66例患者分为对照组和研究组,各33例,对照组患者接受常规治疗,观察组患者接受酒石酸美托洛尔治疗,比较两组患者治疗后LVESd(左室收缩末内径)、LVEF(左室射血分数)、LVEDd(左室舒张末期内径)血压水平及心率情况。结果治疗前,两组患者的LVESd、LVEF、LVEDd、收缩压、舒张压及心率比较,差异无统计学意义(P0.05);治疗后,观察组LVESd、LVEDd、收缩压、舒张压及心率明显低于对照组,LVEF高于对照组,差异有统计学意义(P0.05)。结论酒石酸美托洛尔治疗扩张型心肌病,能有效改善患者的心功能,降低心肌损伤,值得临床推广。     

丹参多酚酸盐注射液与丹参注射液在冠心病治疗中疗效和安全性对比

目的:探讨丹参多酚酸盐注射液与丹参注射液治疗冠心病的效果。方法:选取稳定型心绞痛患者140例,根据随机数字表法分为观察组和对照组,各70例。观察组静脉滴注丹参多酚酸盐进行治疗,对照组应用丹参进行治疗,观察两组治疗效果。结果:1两组患者治疗后心绞痛发作次数和硝酸甘油用量明显低于治疗前,总运动代谢当量、心绞痛诱发时间和ST段压低1 mm时间差异明显高于对照组,差异具有统计学意义(P0.05);两组对比,观察组心绞痛发作次数和硝酸甘油用量明显低于对照组,差异有统计学意义(P0.05)。两组间总运动代谢当量、心绞痛诱发时间和ST段压低1 mm时间差异无统计学意义(P0.05)。2观察组总不良反应发生率为2.9%,明显低于对照组12.9%(P0.05)。结论:丹参多酚酸盐注射液治疗冠心病效果更好、更安全,值得在临床上推广应用。     

丹参川芎汤辨证治疗老年气阴两虚血瘀型冠心病的临床疗效分析

[目的]探讨分析丹参川芎汤辨证治疗老年气阴两虚血瘀型冠心痛的临床疗效.[方法]将我院自2009年2月至2012年2月收治的气阴两虚血瘀型老年冠心病患者84例分为两组,对照组40例给予复方丹参滴丸,治疗组44例给予丹参川芎汤,观察两组的疗效及心绞痛发作次数、持续时间、硝酸甘油用量.[结果]治疗组患者的心绞痛疗效、中医证候疗效93.18％、90.91％均明显优于对照组77.5％、72.5％(P＜0.05);治疗后两组患者的心绞痛发作次数、持续时间、硝酸甘油用量均明显低于治疗前(P＜0.05),但治疗组患者低于对照组(P＜0.05).[结论]丹参川芎汤辨证治疗老年气阴两虚血瘀型冠心病的疗效确切,能明显减少心绞痛的发作次数及持续时间.     

注射用血塞通冻干粉针剂联合倍他乐克对急诊冠心病心绞痛患者心绞痛发作频次、持续时间及心功能影响

目的 ：探讨注射用血塞通冻干粉针剂联合倍他乐克对急诊冠心病心绞痛患者心绞痛发作频次、持续时间及心功能影响。方法：回顾性纳入本院2019年10月～2021年10月收治的76名急诊冠心病心绞痛患者为研究对象，其中2019年10月～2020年10月的采用倍他乐克等常规基础药物治疗的38例患者为对照组，2020年11月～2021年10月的在对照组基础上增加使用血塞通冻干粉针剂的38例患者为观察组。对比两组心绞痛发作频次、持续时间及心功能相关指标。结果：(1)两组治疗前的心绞痛发作频次及持续时间均接近（P>0.05）；治疗后，两组心绞痛发作频次及时间均降低，且观察组心绞痛发作频次及持续时间均低于对照组（P<0.05）；(2)治疗前两组左室舒张末期内径（LVEDD）、左室收缩末期内径（LVESD）、左室射血分数（LVEF）等数据均接近（P>0.05）；治疗后，观察组LVEF高于对照组（P<0.05）,LVEDD和LVESD均较对照组低（P<0.05）。结论：注射用血塞通冻干粉针剂联合倍他乐克治疗急诊冠心病心绞痛疗效明显，可减少发作频次，缩短持续时间，促进心功能的恢复，...     

丹参多酚酸盐联合美托洛尔缓释片治疗冠心病不稳定心绞痛的临床研究

目的:探讨丹参多酚与美托洛尔治疗不稳定心绞痛的疗效.方法:收集该院冠心病不稳定心绞痛的患者,随机分为研究组和对照组.对照组接受常规治疗与美托洛尔缓释片,研究组在对照组治疗基础上加用丹参多酚酸盐.对比(1)两组治疗前后每周心绞痛发作次数.(2)两组心绞痛治疗疗效.结果:(1)两组治疗前每周心绞痛发作次数比较无差异(P>0.05);两组治疗后每周心绞痛发作次数比较有差异(P<0.05).(2)两组治疗后每周心绞痛发作次数比较有差异(P<0.05).结论:本文认为丹参多酚与美托洛尔治疗不稳定心绞痛疗效肯定,可以减少每周心绞痛发作次数.     

丹参多酚酸盐联合曲美他嗪治疗冠心病心绞痛的疗效及安全性分析

目的：探讨丹参多酚酸盐联合曲美他嗪治疗冠心病心绞痛的临床疗效及安全性，为临床进一步治疗冠心病心绞痛提供参考。方法：选取2016年1月至2017年1月我院80例冠心病心绞痛患者，随机分为对照组（硝酸甘油等常规治疗）和观察组（丹参多酚酸盐联合曲美他嗪治疗），每组各40例，比较两组治疗的临床疗效，每天发作次数、每次发作持续时间、硝酸甘油用量以及治疗前后生活质量评分及治疗期间不良反应。结果：观察组临床症状治疗及心电图治疗的总有效率均明显增高，差异有统计学意义（P<0.05）；与对照组相比，观察组治疗后每天发作次数、每次发作持续时间、硝酸甘油用量均明显减少，差异有统计学意义（P<0.05）；与对照组相比，观察组治疗后生活质量评分升高，差异有统计学意义（P<0.05）；治疗期间两组都没有出现严重不良反应。结论：丹参多酚酸盐联合曲美他嗪治疗冠心病心绞痛，能够明显提升临床疗效，改善患者生活质量，具有治疗安全性。     

丹参多酚酸盐治疗冠心病心绞痛的临床疗效及对患者生活质量的影响

目的 评价丹参多酚酸盐治疗冠心病心绞痛的疗效及对患者生活质量的影响.方法 将120例冠心病心绞痛患者分为试验组和对照组,各60例.入院后均给予常规基础治疗,对照组患者给予丹红注射液治疗,试验组患者给予丹参多酚酸盐治疗.观察两组患者疗效、主要供血冠状动脉的血流情况的改善情况和生活质量状况.结果 治疗后,试验组总有效率(96.67％)高于对照组(78.33％,P＜0.05);两组患者治疗后左心室前降支的血流参数明显改善,且试验组患者的左心室供血动脉前降支的血流参数改善情况优于对照组患者(均P＜0.05);试验组患者治疗后生活质量评分高于对照组患者(P＜0.05).结论 丹参多酚酸盐治疗冠心病心绞痛疗效显著,良好改善患者的血流状况和有效提高了患者的生活质量,适合临床推广应用.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.