桂枝茯苓胶囊治疗药物流产后出血52例疗效观察

目的：观察桂枝茯苓胶囊治疗药物流产后阴道出血的效果。方法：将门诊自愿要求药物流产的早孕妇女104人随机分为治疗组52例，对照组52例。采用相同的服药方法和剂量进行药物流产，在胚胎组织排出后，治疗组服用桂枝茯苓胶囊，3粒/次，tid；对照组口服安络血5mg、止血敏0．5g，tid，共5d。结果：治疗组在出血时间、出血量等方面均明优于对照组。结论：桂枝茯苓胶囊可减少药物流产后阴道出血量，缩短出血时间。     

桂枝茯苓胶囊用于药流后的临床观察附:240例病例报告

目的观察桂枝茯苓胶囊在药物流产中的临床疗效.方法将240例停经49天以内的早孕者按药流顺序随机分为治疗组和对照组各120例,两组在药流的同时,治疗组加服桂枝茯苓胶囊.结果治疗组阴道出血量明显少于对照组(P＜0.05),阴道出血持续时间明显缩短(P＜0.05),而完全流产率高于对照组(P＜0.05).结论桂枝茯苓胶囊能减少药流后出血量,缩短出血时间,提高完全流产率.     

桂枝茯苓胶囊缩短药物流产后阴道出血的观察

目的 :观察桂枝茯苓胶囊缩短药物终止孕 4 9d内妊娠后的阴道出血情况。方法 :对 98例孕 4 9d内要求药物流产的健康妇女 ,根据药物流产后的不同处理分为清宫组、对照组、治疗组 ,对治疗组流产后加服桂枝茯苓胶囊 ,与对照组 ,清宫组比较 ,观察药物流产后阴道出血量及时间。结果 :治疗组服用桂枝茯苓胶囊后 ,阴道出血时间与清宫组接近 ,与对照组相比平均缩短约有 4d左右。有显著性差别 (P <0 .0 0 1) ,出血量也较对照组少。结论 :桂枝茯苓胶囊在药物终止早孕 4 9d内 ,对缩短流产后阴道出血时间减少出血有一定作用 ,值得推广。     

桂枝茯苓丸治疗药物流产后阴道出血临床分析

目的:回顾性分析桂枝茯苓丸在治疗药物流产(简称药流)后阴道出血的作用.方法:选择2000年1月至2004年1月门诊药流后的妇女226例,将其随机分成两组,前组加服桂枝茯苓丸,后组加服生化汤丸,观察两组用药后阴道出血情况.结果:前组阴道出血量少于后组,阴道出血时间短于后组,两组差异显著(P＜0.01).结论:桂枝茯苓丸可减少药流后阴道出血量,缩短阴道出血时间,提高药流成功率.     

桂枝茯苓胶囊配合药物流产临床观察

目的:缩短药物流产后阴道出血时间,提高完全流产率。方法:选择无药物流产禁忌证者180例,随机分成治疗组与对照组各90例。治疗组在胚囊排出后服用桂枝茯苓胶囊7～14d,对照组不用药。分别在药物流产后第7天、第14天门诊随访检查及B超监测宫腔内情况。结果:治疗组阴道出血量明显低于对照组;阴道出血持续时间比对照组明显缩短;治疗组完全流产率高于对照组。结论:桂枝茯苓胶囊配合治疗药物流产在缩短阴道出血时间、减少阴道出血量、提高完全流产率方面疗效显著。     

桂枝茯苓胶囊配合药物流产临床观察

目的：缩短药物流产后阴道出血时间,提高完全流产率。方法：选择无药物流产禁忌证者180例,随机分成治疗组与对照组各90例。治疗组在胚囊排出后服用桂枝茯苓胶囊7～14d,对照组不用药。分别在药物流产后第7天、第14天门诊随访检查及B超监测宫腔内情况。结果：治疗组阴道出血量明显低于对照组;阴道出血持续时间比对照组明显缩短;治疗组完全流产率高于对照组。结论：桂枝茯苓胶囊配合治疗药物流产在缩短阴道出血时间、减少阴道出血量、提高完全流产率方面疗效显著。     

桂枝茯苓胶囊在药物流产中的应用效果观察

目的观察桂枝茯苓胶囊在药物流产的应用效果。方法将早孕健康妇女262例随机分两组,常规服用米非司酮与米索前列醇．治疗组于服米索前列醇2h后始服桂枝茯苓胶囊3粒,1日3次,饭后服,连服5天,观察两组流产效果、药流后阴道出血量及阴道出血时间。结果治疗组完全流产率为98.28％,对照组为90.45％,两组流产效果差异有显著性,治疗组阴道出血量减少出血时间短,与对照组相比差异有非常显著性。结论桂枝茯苓胶囊可提高药流效果,减少阴道出血量及缩短阴道出血时间,可在药流中推广应用。     

桂枝茯苓丸治疗药物流产后阴道出血临床分析

目的:回顾性分析桂枝茯苓丸在治疗药物流产(简称药流)后阴道出血的作用。方法:选择2000年1月至2004年1月门诊药流后的妇女226例,将其随机分成两组,前组加服桂枝茯苓丸,后组加服生化汤丸,观察两组用药后阴道出血情况。结果:前组阴道出血量少于后组,阴道出血时间短于后组,两组差异显著(P<0.01)。结论:桂枝茯苓丸可减少药流后阴道出血量,缩短阴道出血时间,提高药流成功率。     

桂枝茯苓胶囊在药物流产中的应用效果观察

目的观察桂枝茯苓胶囊在药物流产的应用效果。方法将早孕健康妇女483例随机分两组，常规服用米非司酮与米索前列醇，治疗组于服米索前列醇1h后始服桂枝茯苓胶囊3粒，1日3次，饭后服，连服5天，观察两组流产效果、药流后阴道出血量及阴道出血时间。结果治疗组完全流产率为96．67％，对照组为90．53％，两组流产效果差异有显著性，治疗组阴道出血量减少，出血时间短，与对照组相比差异有非常显著性。结论桂枝茯苓胶囊可提高药流效果。减少阴道出血量及出血时间，可在药流中推广应用。     

桂枝茯苓胶囊配合药物流产90例临床观察

目的:观察桂枝茯苓胶囊配合药物流产的疗效. 方法:将180例早孕妇女随机分为2组,每组90例,均口服米非司酮配伍米索前列醇片终止旱孕,治疗组于服药第1日加服桂枝茯苓胶囊. 结果:治疗组完全流产95.56%,孕囊排出时间68±9.78小时,阴道出血时间超过14天者占5.56%;对照组完全流产率87.78%,孕囊排出时间75±6.32小时,阴道出血时间超过14天者占21.11%,3项指标比较,差异有显著性意义(P<0.05). 结论:桂枝茯苓胶囊配合药物流产可提高完全流产率,缩短阴道出血时间.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.