邵先舫教授辨证治疗膝骨关节炎临床经验

总结邵先舫教授辨证治疗膝骨关节炎的临床经验.邵教授认为膝骨关节炎主要病因为年老体虚、劳倦内伤、饮食不节、外邪入侵等;病机关键以肝肾不足、气血亏虚为本,以风、寒、湿、热、瘀、痰为标;治疗上以标本同治为纲,并结合中医辨证,提出调补肝肾、健脾益气、祛风胜湿、清热除湿、活血化瘀、搜风除痰六大治法,此外,还主张内外兼治,使气畅血...     

周亨德教授辨治溃疡性结肠炎缓解期经验

[目的]总结周亨德教授诊疗溃疡性结肠炎(ulcerative colitis,UC)缓解期的临床经验和学术观点。[方法]通过复习相关中医文献,跟师临诊及整理医案,总结周教授对UC缓解期病因病机、辨证分型的认识,以及治疗思路和用药特色,并列举验案一则加以佐证。[结果]周教授认为,UC缓解期多为虚证或虚中夹实证,脾气亏虚为发病之本,湿、热、瘀、滞为发病之标。虚证可分为脾气亏虚、脾阳不足两型,以益气健脾、温阳健脾为治则,脾气亏虚型选用参苓白术散加减,脾阳不足型选用理中汤加减;虚中夹实者在上述证型基础上分别选用疏肝理气、消食导滞、清热燥湿、活血化瘀之品,强调适时调养胃阴,以防燥湿太过。所举验案中患者辨证为脾气亏虚,经过益气健脾燥湿、疏肝行气导滞等治疗后,收效良好。[结论]周教授认为UC缓解期多为本虚证或本虚标实证,以脾气亏虚为本,湿邪为标,健脾化湿应贯穿整个治疗过程,其临床经验值得传承推广。     

张斌霞教授辨证治疗失眠经验

介绍张斌霞教授辨证治疗失眠的临床经验.张教授认为,情志刺激、劳倦本虚为失眠的主要病因,本病乃本虚标实之证,正气不足、气阴两虚为致病之本,虚热内伏、瘀血内阻为发病之标;临证治疗以健脾养心、益气养阴为根本大法,配合清泄虚热、活血化瘀,强调清补兼施,并将活血化瘀之法贯穿于失眠治疗的始终,以自拟方益气滋阴安眠汤作为治疗失眠的基...     

路志正教授治疗白塞病临床经验管窥

白塞病临床治疗棘手,疗效欠佳,严重危害患者的身心健康。路志正教授认为该病属于中医学之＂狐惑病＂范畴,发病与肝、脾关系密切,涉及心、肾、肺诸脏,病因病机为肝郁化火,气阴两伤,脾虚失运,湿毒熏蒸脏腑,病机错综复杂,涉及多个脏腑,同时或先后发病,五脏相因,湿毒为患,为本虚标实,虚实夹杂之证;治疗强调辨病辨证相结合,以益气养阴、疏肝健脾、化湿解毒为法,以甘草泻心汤为主方,圆机活法,内服外用并行,内外同治,始克有济,使病情缓解向愈。     

克罗恩病病因病机探析

提出克罗恩病可从肠痈论治,将克罗恩病的病因归纳为外感六淫疫毒之邪、情志失调、饮食不节、久病体虚等,其发病主要以湿热蕴结为由,以瘀血阻滞为标,以脾肾亏虚为本,以痰瘀互结为变。克罗恩病多属本虚标实、虚实夹杂之证,在对该病本虚的认识基础上,更应重视湿、热、痰、瘀在疾病发生发展过程中的作用。治疗时应紧抓病因病机,早期以清热利湿、活血散瘀、疏理气机为主,后期在祛痰化瘀的基础上注重健脾益气扶正、补脾益肾固本。     

王小琴治疗肾性蛋白尿经验

蛋白尿为慢性肾脏病的典型症状之一,与慢性肾脏病的预后及转归关系密切。王小琴教授认为蛋白尿的中医病因病机不外乎本虚标实,本虚主要责之于肺脾肾,以肾为中心;同时风、湿、瘀之邪为标。治疗上以滋肾固精健脾为主,兼以益气祛风除湿、活血化瘀通络。提倡扶正祛邪、标本兼顾,善用经方名方灵活辨证加减,临床疗效显著。     

特发性肺纤维化中西医发病机制研究进展

1 中医对IPF发生发展的病机认识 对IP F中医病机的认识,各家不尽相同,但总以气血津液辨证理论为切入点,并以本虚标实立论,但本虚、标实具体所指及其病机阐释角度有异. 目前专家学者多将气血津液辨证与脏腑辨证相结合,认为IP F以肺脾肾之气阴亏虚为本、痰瘀夹邪(寒、热、湿、毒等)为标.     

王新陆教授从血浊论治冠心病浅析

王新陆教授在长期的临床实践和理论研究中提出"血浊"理论，为中医治疗冠心病提供了新的辨证思路和理论支持，认为冠心病的发病机制当分为3个过程：即正气亏虚当为发病之本，血浊不清为致病之渐，痰瘀痹阻当为发病之标，而气滞、寒凝、过劳等多为病情加重的诱发因素。其病理性质当为本虚标实证。对于冠心病的治疗，提出了"治本不忘其虚，治渐不离其浊，治标不外痰瘀"的治疗大法，同时强调针对患者的体质、诱发因素等方面，辨证求因，审因论治。上述理论的提出，为中医治疗冠心病提供了新的辨证思路和理论支持，使疾病治疗的重心大大前移。     

刘苓霜辨证治疗肾癌经验

刘苓霜主任医师认为肾癌发病多由肾气不足,水湿不化,湿毒内生,结于腰府;或感受外邪,湿热毒蕴结水道,导致气滞血瘀,日久形成有形之块,其病位主要在肾,可涉及脾胃、肺、肝、心等脏器,其病机以正虚、脏腑功能失调为本,湿热毒瘀互结为标,为虚实夹杂之证,本虚主要表现在肝肾阴虚,脾肾两虚;标实主要表现在湿、热、毒、瘀互结,治疗当先遵循扶正为主、祛邪为辅、扶正与祛邪有机结合的原则,扶正以健脾益肾为主,而祛邪则以清热、祛湿、解毒、化瘀为主,两者相辅相成,互为表里,"扶正抗癌"的学术思想贯穿治疗始终。     

刘苓霜辨证治疗肾癌经验

刘苓霜主任医师认为肾癌发病多由肾气不足,水湿不化,湿毒内生,结于腰府;或感受外邪,湿热毒蕴结水道,导致气滞血瘀,日久形成有形之块,其病位主要在肾,可涉及脾胃、肺、肝、心等脏器,其病机以正虚、脏腑功能失调为本,湿热毒瘀互结为标,为虚实夹杂之证,本虚主要表现在肝肾阴虚,脾肾两虚;标实主要表现在湿、热、毒、瘀互结,治疗当先遵循扶正为主、祛邪为辅、扶正与祛邪有机结合的原则,扶正以健脾益肾为主,而祛邪则以清热、祛湿、解毒、化瘀为主,两者相辅相成,互为表里,"扶正抗癌"的学术思想贯穿治疗始终。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Electro-Acupuncture Combined with the Trigger Point Needle-Embedding for Treatment of Primary Trigeminal Neuralgia in 31 Cases

In recent years, the author of this essay has applied electro-acupuncture combined with the trigger point needle-embedding for treatment of primary trigeminal neuralgia in 31 cases, yielding satis- factory results as reported in the following.     

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.endometria from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.     

Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

Prof. SHI Da-zhuo, Ph.D., male, was born on March 20, 1960. Prof. SHI entered the Ph.D. program in 1990 at the China Academy of Chinese Medical Sciences under the supervision of Prof. CHEN Ke-ji, majoring in the treatment of cardiovascular diseases. After receiving his Ph.D. degree in 1993, Prof. SHI started working at the Cardiovascular Center in Xiyuan Hospital affiliated to China Academy of Chinese Medical sciences.     

Persist in and Carry Forward the Integrative Medical Research——Speech at the 6th National General Congress of Chinese Association of Integrative Medicine by Academician CHEN Zhu,Minister of Ministry of Health

The 6th National General Congress of Chinese Association of Integrative Medicine （CALM） was convened at 19-20, April 2008 in Beijing. Academician CHEN Zhu, the minister of Ministry of Health indicated at the congress that the integration of Chinese and Western medicine is very well in keeping with the situation of our country and the general rule of development in medical science; and as a good integration of Chinese medicine and Western medicine, it is mutually beneficial and advantageous to both of them. Seeing the creativity shown in integrative medical investigation in theoretic and methodological sides, we should and must persist in and develop it.