ACTIVATION STATES AS ASSESSED BY VERBAL REPORT AND FOUR PSYCHOPHYSIOLOGICAL VARIABLES

The present research was part of a program aimed at examination of the validity of controlled verbal reports of various activation states. A difference score design was used in which four psychophysiological measures and verbal ratings of various activation states were obtained in a baseline and an activation period from 41 female subjects. Verbal reports were then correlated with individual physiological measures and composites or indices of physiological measures. Specifically, two kinds of physiological index were employed, one in which the subject's physiological change score was represented by the single system showing the greatest change, and a second index weighted equally by all four physiological measures. The physiological index using the single system showing the greatest activation yielded slightly greater correlations with verbal report than the other index. Skin conductance and heart rate, the best combination of the four physiological systems measured, correlated as high as .62 with verbal report. The results were interpreted as demonstrating the usefulness and validity of controlled self report and the relative superiority of skin conductance and heart rate among other physiological systems in correlations with verbal report.     

The timeline followback reports of psychoactive substance use by drug-abusing patients: psychometric properties

The Timeline Followback (TLFB; L. C. Sobell & M. B. Sobell, 1996) interview, which uses a calendar method developed to evaluate daily patterns and frequency of drinking behavior over a specified time period, has well-established reliability and validity for assessing alcohol consumption. Although several investigators have used the TLFB to evaluate drug-using behavior, few studies have examined the psychometric properties of the interview for this purpose. The authors conducted TLFB interviews with a sample of adult drug-abusing patients seeking treatment for substance abuse (n = 113) at baseline, posttreatment, and quarterly thereafter for 12 months. It was found that the patients' reports about their drug consumption using this method generally had high (a) retest reliability, (b) convergent and discriminant validity with other measures, (c) agreement with collateral informants' reports of patients' substance use, and (d) agreement with results from patients' urine assays.     

Effects of cognitive behavioural therapy on verbal learning and memory in major depression: Results of a randomized controlled trial

Major depression (MD) is often accompanied by deficits in cognitive functioning. Cognitive behavioural therapy (CBT) has beneficial effects on MD. The aim of this study was to examine whether CBT affects verbal learning and memory in patients with MD and whether CBT that emphasizes exercise during behavioural activation has additional effects on verbal performance. Ninety‐eight patients with MD were randomly assigned to CBT emphasizing either exercise during behavioural activation (CBT‐E) or CBT emphasizing pleasurable low‐energy activities (CBT‐C). A passive waiting list control group was also involved (WL). Thirty nondepressed age‐ and sex‐matched controls were included to examine potential verbal learning and memory alterations in MD at baseline. Neuropsychological measures were assessed at baseline and after 16 weeks of CBT and waiting time, respectively. Patients with MD demonstrated worse cognitive performance than healthy controls in verbal learning, recognition, and memory at baseline. After treatment, we found no improvements concerning verbal learning and memory performance compared with WL, with the exception of recognition memory. No differences were found between CBT conditions. Psychological treatments such as CBT seem to have limited influence on memory functions. Concerning recognition memory, our results contradict, in part, previous assumptions that cognitive impairments persists despite depressive symptom reduction.     

A longitudinal study of cognition change during early menopausal transition in a rural community

OBJECTIVE: To characterize changes in cognition that occur during the hormonal transitions of menopause. METHOD: We conducted a longitudinal population-based study in Kinmen, Taiwan, recruiting all women age 40-54 years who were premenopausal and without a history of hormone replacement therapy (HRT) or hysterectomy. The cognitive measures used to assess function included the Auditory-Verbal Learning Test, visual memory, verbal fluency, Trail Making Test and digit span. RESULTS: A total of 694 eligible women participated in the baseline study, and 573 women (83%) completed follow-up 18 months later. After excluding 78 women who received hysterectomy or HRT, the final sample was composed of 495 subjects, of whom 114 (23%) progressed to perimenopause during follow-up. Women who remained premenopausal were younger than those who became perimenopausal (44.7 +/- 2.3 years versus 47.1 +/- 3.0 years, p < 0.01). All follow-up cognitive scores in women who entered perimenopause were slightly better than baseline measures except for Rey Auditory-Verbal Learning Test, which decreased by 0.23 (S.D. = 2.9, p = 0.3). At follow-up, cognitive function except for verbal fluency did not differ significantly between women who stayed premenopausal and those became perimenopausal after controlling for age, education, and baseline cognitive scores. Women who entered perimenopause have an average of 1.3 items (S.D. = 0.4) less in verbal fluency measures as compared with their premenopausal peers at the follow-up period. CONCLUSIONS: The menopausal transition might not accompany significant cognitive decline except for verbal fluency.     

Cultural diversity in patient participation: the influence of patients' characteristics and doctors' communicative behaviour

OBJECTIVE: The primary goal of this study was to examine the extent to which patient participation during medical visits is influenced by patients' ethnic background, patients' culture-related characteristics (e.g. acculturation, locus of control, cultural views) and features of doctors' communicative behaviour. Furthermore, the mutual influence between patients' participatory behaviour and doctors' communicative behaviour was investigated. An additional goal was to identify the independent contribution of these variables to the degree of patient satisfaction and mutual understanding between GP and patient. METHODS: Communicative behaviour of patients (n=103) and GPs (n=29) was analysed with Roter's Interaction Analysis System, frequency of patient questions and patients' assertive utterances (e.g. making requests, suggesting alternative treatment options). Additional data were gathered using GP and patient questionnaires after the consultations. RESULTS: Results show that non-Western ethnic minority patients display less participatory behaviour during medical consultations than Dutch patients. GPs' affective verbal behaviour had most effect on degree of patient participation and patient satisfaction. Regression analyses indicate a significant mutual influence between patients' verbal behaviour and GPs' verbal behaviour. CONCLUSION: Overall, results of this study show some important differences between Dutch and non-Western ethnic minority patients in degree of patient participation. Furthermore, our results indicate that patient participation encompasses several aspects that are not necessarily interrelated. PRACTICE IMPLICATIONS: The necessity for continued education of GPs' communicative skills, particularly when dealing with non-Western ethnic minority patients, is reflected in the strong influence of GP's affective verbal behaviour on both patient participation and their satisfaction with the medical encounter.     

Restructuring mood in cyclothymia using cognitive behavior therapy: an intensive time-sampling study

Hypotheses predicting how cognitive behavioral therapy (CBT) would change the daily pattern of mood and sleep in a patient with cyclothymia were formulated based on circadian processes. Using a prospective single-case experimental design, the patient provided mood ratings every 4 hours and sleep reports daily for 49 weeks, including a 4-week baseline, a 20-session CBT intervention, and a follow-up period. Improvements in mood during and after therapy were accounted for by reduced daily mood variability and extended sleep. The patient's energy at different times of day was explained by adjusting the endogenous rhythm in a mathematical circadian model. Treatment of cyclothymia and related bipolar disorders may be enhanced by integrating understanding of circadian mood regulation into CBT treatment.     

Neurophysiological evidence for the validity of verbal strategy reports in mental arithmetic

Behavioral research has shown that arithmetic problems (e.g., 6 + 2=) are solved with various strategies, which can be inferred from the size of the presented problems or from trial-by-trial verbal strategy reports. The validity of these verbal strategy reports, however, has been repeatedly questioned. In the present electroencephalography study, we compared the association of both approaches with the oscillatory brain responses during arithmetic problem solving. Nineteen adults solved small and large addition and subtraction problems and indicated the applied strategy (fact retrieval vs. procedure use) on a trial-by-trial basis by means of verbal strategy reports. Analysis of event-related (de-)synchronization (ERS/ERD) in theta and alpha frequencies revealed a general convergence of verbal strategy reports and the problem size approach, with fact retrieval being accompanied by higher left-hemispheric theta ERS, and procedural strategies being reflected in higher widespread ERD in the lower alpha band and bilateral parietooccipital ERD in the upper alpha band. A direct comparison of the neurophysiological data from both approaches suggests a higher sensitivity of verbal strategy reports to problem solving strategies applied in mental arithmetic, particularly for large problems. Taken together, the current data provide the first neurophysiological evidence for the validity of verbal strategy reports.     

Families coping with schizophrenia: coping styles, their origins and correlates

An analysis of the coping styles adopted by relatives of schizophrenic patients has been identified by many reviewers as essential to an understanding of the complex interactions between patient and caregiver and to the origins of relatives' expressed emotion (EE). This study reports a taxonomy of coping behaviour derived from interviews with relatives of schizophrenic patients. It was found that relatives adopted broad styles of coping across all areas of patients' behaviour change. Relationships were uncovered between the styles and (a) relatives perceived control, burden and stress, (b) patients' social functioning, severity of behavioural disturbance and progress of the illness. It is suggested that advising relatives of changes in their coping styles in the course of family intervention must be tempered by an understanding of their origins in patients' behaviour. Further research is recommended to identify the coping styles associated with the high EE/low EE research classification.     

Lack of Correlation Between Frontalis EMG and Either Neck EMG or Verbal Ratings of Tension

Eight normal subjects were trained with the aid of EMG feedback to successively increase and decrease the activity of the frontalis muscle on 5 consecutive days. Along with the activity of the frontalis, sternomastoid EMG was recorded from 4 subjects and EMG from both the semispinalis and splenius capitus was recorded from the other 4 subjects. Estimates of the degree of subjective tension or relaxation were obtained following Baseline, Increase Frontalis, and Decrease Frontalis periods on each treatment day. Frontalis EMG activity showed significant increases and decreases relative to baseline levels during appropriate periods. Sternomastoid EMG did not change significantly during either Increase Frontalis or Decrease Frontalis periods. Semispinalis/splenius EMG activity also did not change during Increase Frontalis periods, but increased significantly during Decrease Frontalis periods. Subjects’estimates of subjective tension increased above baseline during increases in frontalis EMG activity, but did not change significantly during decreases in frontalis EMG. These data support the findings of Alexander that changes in frontalis EMG neither generalize to other somatic muscles nor correlate with verbal reports of cognitive tension or relaxation.     

Undetectable cerebrospinal fluid HIV RNA and beta-2 microglobulin do not indicate inactive AIDS dementia complex in highly active antiretroviral therapy-treated patients

OBJECTIVE: To assess whether nonelevated cerebrospinal fluid (CSF) markers could delineate inactive AIDS dementia complex (ADC) in patients receiving highly active antiretroviral therapy (HAART), using neuropsychologic performance change as an indicator of ADC stability. METHODS: We used data from the abacavir (ABC) ADC trial (n = 78) and examined the patients' neuropsychologic performance change with the Reliable Change Index according to 3 cutoff groups: (1) CSF viral load (VL) <100 copies/mL, (2) CSF beta-2 microglobulin (beta2m) <2.2 mg/L, and (3) CSF VL and CSF beta2m below cutoffs. RESULTS: CSF marker cutoff groups did not define neuropsychologic change. Linear regression showed that only CSF VL was a weak predictor of neuropsychologic performance change. CONCLUSION: HAART-treated ADC patients with baseline CSF markers of viral and immunologic inactivity did not necessarily have inactive ADC when followed over 12 weeks. More sensitive CSF markers to judge the activity of ADC are urgently needed, whereas the interpretation of these markers should be considered with caution in HAART-treated ADC patients.     

The influence of outcome measures in assessing client change and treatment decisions

This study investigated the influence that information in the form of outcome measures and client verbal reports can have on treatment decisions and clinician judgment of client change. A random national sample of psychologists (N=810, 45% response rate) were given clinical vignettes and asked questions regarding their view of client progress and subsequent treatment decisions. Despite clinicians reporting that verbal report is more influential in their actual clinical practice than outcome measure information, both sources of information had an equal impact on judgments of client change. Negative information (from either source) influenced clinicians more than positive information. Outcome measure information indicating client deterioration led more clinicians to choose to alter treatment than client verbal report of deterioration. Information indicating client improvement led some clinicians to continue treatment in the same manner as they had been. Insight-oriented therapists were more likely to continue treatment-as-usual than were cognitive-behavioral therapists.     

Isoflavones and cognitive function in older women: the SOy and Postmenopausal Health In Aging (SOPHIA) Study

OBJECTIVE: This study examines the effects of a dietary supplement of isoflavones on cognitive function in postmenopausal women. DESIGN: Participants for this 6-month, double-blind, randomized, placebo-controlled clinical trial were women who were in good health, were postmenopausal at least 2 years, and were not using estrogen replacement therapy. Between July 24, 2000, and October 31, 2000, 56 women aged 55 to 74 years were randomized; 2 in the placebo group and 1 in the active treatment group did not complete the 6-month evaluation, and none withdrew because of adverse effects. Women randomized to active treatment (n = 27) took two pills per day, each containing 55 mg of soy-extracted isoflavones (110 mg total isoflavones per day; Healthy Woman: Soy Menopause Supplement, Personal Products Company, McNeil-PPC Inc., Skillman, NJ, USA). Women assigned to placebo (n = 26) took two identical-appearing pills per day containing inert ingredients. Cognitive function tests administered at baseline and follow-up included the following: Trails A and B, category fluency, and logical memory and recall (a paragraph recall test assessing immediate and delayed verbal memory). RESULTS: At baseline, all women were cognitively intact; there were no significant differences by treatment assignment in age, education, depressed mood, or cognitive function (all P values > 0.10). Compliance was 98% and 97%, respectively, in the placebo and treatment groups; all women took at least 85% of their pills. The women in the treatment group did consistently better, both as compared with their own baseline scores and as compared with the placebo group responses at 6 months. Comparisons of percentage change in cognitive function between baseline and follow-up showed greater improvement in category fluency for women on active treatment as compared with the case of those on placebo (P = 0.02) and showed (nonsignificantly) greater improvement on the two other tests of verbal memory and Trails B. CONCLUSION: These results suggest that isoflavone supplementation has a favorable effect on cognitive function, particularly verbal memory, in postmenopausal women.     

Estrogen therapy selectively enhances prefrontal cognitive processes: a randomized, double-blind, placebo-controlled study with functional magnetic resonance imaging in perimenopausal and recently postmenopausal women

OBJECTIVE: Estrogen therapy (ET) seems to differentially effect cognitive processes in younger versus older postmenopausal women, suggesting a window of opportunity when ET is most beneficial. Cognitive improvement in younger postmenopausal women has been attributed to ET's influence on hot flushes and sleep, but empiric examination of the mediating role of menopause symptoms versus direct effects of ET on the brain is limited. DESIGN: In a double-blind trial, 52 women were randomly assigned to estradiol 0.05 mg/day (n = 26) or placebo transdermal patches (n = 26) for 12 weeks. Women completed tests of memory, learning, and executive functioning, and hot flush and sleep assessments at baseline and study end. A subset of women (five ET treated, six placebo treated) also underwent blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) studies. RESULTS: Nondepressed perimenopausal and postmenopausal women were studied. The majority had hot flushes and sleep impairment. Compared with placebo, ET selectively reduced errors of perseveration during verbal recall (P = 0.03), a frontal system-mediated function, but did not influence other cognitive processes. Women with baseline hot flushes had greater cognitive benefit with ET (P < 0.05). Cognitive benefit was not associated with sleep problems or its improvement. Measures of fMRI BOLD activation during tests of verbal and spatial working memory showed significant increases in frontal system activity with ET (P < 0.001). CONCLUSIONS: Estrogen therapy selectively improves executive functioning as demonstrated by reduced perseverative errors and prefrontal cortex activation during verbal recall tasks. Cognitive improvement with ET is associated with hot flushes, but not with sleep, suggesting that ET has a direct central nervous system effect, rather than an indirect effect mediated through improvement of sleep.     

评价和奖赏对场依存、场独立儿童语言创造力的影响

目的：考察外部诱因对场依存(FD)、场独立(FI)儿童语言创造力的影响。方法：114名10-11．5岁的FD和FI被试在期待评价、契约式奖赏的诱因出现前后分别写故事，用主观评判法在6个指标上评估其语言创造力。结果：期待评价时，FD被试的创造性、想象力、构思新颖性得分显著提高，FI被试无显著变化；期待奖赏时，FI被试的想象力、修辞技巧、美感分数显著下降，FD被试无显著变化；创造力基线水平上，FD被试的美感得分显著低于FI被试；FD被试的智力成绩显著低于FI被试。结论：FD和FI被试对相同外部诱因的反应有差异，且在语言创造力基线和智力水平上也有差异。     

Physician facilitation of patient involvement in care: correspondence between patient and observer reports

The authors surveyed 128 patients with type 2 diabetes mellitus (1) to evaluate the congruence between patients' and observers' perceptions of physicians' facilitation of patients' involvement in care and (2) to identify which physician behaviors were most closely related to patients' perceptions that their doctors encouraged them to be involved in their care. The patients reported the degree to which they perceived that their physicians encouraged their involvement in the medical care process. Raters blind to the study hypotheses coded audiotapes of the physician-patient interactions. Pearson's r and simultaneous multiple regression used to address the study questions indicated a small to moderate, but statistically significant, association between patients' perceptions and observers' reports concerning the physicians' levels of facilitation. Open-ended questions, responding to patient questions, and offering fewer alternatives were all associated with the patients' positive reports of physician facilitation.     

In vivo effect of celecoxib and tenoxicam on oxidant/ anti-oxidant status of patients with knee osteoarthritis

The aim of this study was to compare the in vivo effects on free radical metabolism of 2 non-steroidal anti-inflammatory drugs (NSAIDs): tenoxicam, an oxicam preferentially cyclooxygenase-1 (COX-1) inhibitor, and celecoxib, a sulfonamide selective COX-2 inhibitor. The serum levels of oxidative stress-related enzymes (ie, xanthine oxidase (XO), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px)), of a lipid peroxidation marker (malondialdehyde (MDA)), and of nitric oxide (NO) in patients with knee osteoarthritis were studied at baseline and after a 4-wk course of treatment with celecoxib (n = 11) and tenoxicam (n = 12). Celecoxib-treated patients had significant decrease in nitrite levels (p = 0.043), whereas SOD, XO, GSH-Px enzyme activities, and MDA levels did not change significantly compared to baseline. Tenoxicam-treated patients had significant decrease in nitrite levels (p = 0.036) and XO activity (p = 0.01), but their SOD, GSH-Px enzyme activities, and MDA levels were unchanged from baseline. There was significant correlation between the patients' (n = 23) Western Ontario and McMaster Universities (WOMAC) LK3.0 Osteoarthritis Index, WOMAC-pain scores, and MDA levels (r = 0.50, p = 0.014) and the patients' WOMAC-stiffness scores and XO enzyme activity (r = 0.46, p = 0.027) at baseline. Significant improvement was found in pain-VAS, patients' global assessment, and WOMAC pain, stiffness, and physical function scores in celecoxib and tenoxicam-treated groups. In summary, our study revealed that tenoxicam may have antioxidant effects, and that celecoxib and tenoxicam may reduce nitrite levels, indicating an alteration of NO pathways.     

Language change in child psychotherapy: a meta-analytic review.

Eighteen child therapy outcome studies, containing 26 treatment/control comparisons on at least one language measure, were evaluated. Four questions were addressed: (a) Does child therapy positively impact children's language proficiencies, and are its effects comparable to those obtained on nonlanguage outcome measures? (b) Do outcome effects vary across individual versus group treatment? (c) Does the type of emphasis on verbal process in treatment affect the degree of gain in the children's language proficiencies at outcome? and (d) Do effect sizes on language measures differ depending on type of presenting problem? Results indicate that child therapy has a significant positive impact on children's language proficiencies and that individual is superior to group treatment. Several trends emerged suggesting relationships between the magnitude of language change and type of emphasis on verbal processes in therapy and the childs' presenting problems. Further research on language variables is recommended.     

Substitute decision-making: measuring individually mediated sources of uncertainty

One aspect of O'Connor's Decisional Conflict Scale [O'Connor, A.M., Validation of a decisional conflict scale, Med. Decis. Making 15 (1995) 25-30] is the assessment of selected factors (perceived lack of information, undue social pressure, lack of support from others, and lack of clarity about personal values) that are believed to contribute to decisional uncertainty. This study explored the appropriateness of this uncertainty measure in the substitute decision-making context. Forty-nine mothers deciding on gastrostomy tube insertion for their children completed the scale, and also provided verbal reports about the contributory factors. For each of the four factors, relatively high-, moderate-, and low-scoring sub-groups were identified; then the associated verbal reports were examined for across-sub-group differences. Differences in verbal reports about information (chi 2 = 6.990, P = 0.0082), perceived pressure (chi 2 = 8.377, P = 0.0038), social support (chi 2 = 5.573, P = 0.0182), and perceived gains and losses (chi 2 = 3.85, P = 0.0499; chi 2 = 5.76, P = 0.0164) were observed, implying consistency between quantitative scores and verbal reports. This quantitative/qualitative hybrid approach may be clinically useful for assessing individually mediated factors contributing to decision uncertainty, and for evaluating therapeutic interventions in other substitute decision-making contexts.     

Verbal victimization and changes in hopelessness among elementary school children

Hopelessness is a known risk factor for a number of negative outcomes including suicide attempts and deaths. However, little is known about how hopelessness may develop. The goal of this study was to examine the impact of verbal victimization on changes in children's levels of hopelessness. Participants were 448 fourth- and fifth-grade children who were assessed twice, 6 months apart. As hypothesized, reports of verbal victimization occurring during the follow-up period predicted residual change in children's levels of hopelessness. This relation was maintained even after statistically controlling for children's depressive symptoms. Together, these findings suggest that verbal victimization is associated with a greater risk for developing hopelessness in elementary school children, an effect that appears at least partially independent of concurrent depressive symptoms.     

A meta-analytic review of verbal fluency performance in patients with traumatic brain injury

A meta-analysis of 30 studies with 1,269 participants was conducted to investigate the sensitivity of tests of verbal fluency to the presence of traumatic brain injury (TBI). As has been found for patients with focal frontal lobe injuries (but not for patients with focal temporal lobe lesions), TBI patients were comparably impaired on tests of phonemic and semantic fluency. The phonemic fluency deficit could not be accounted for by patients' level of premorbid or current verbal IQ and was also substantially (although not significantly) in excess of the deficit on a measure of psychomotor speed. Phonemic fluency was also significantly more sensitive to the presence of TBI than was the Wisconsin Card Sorting Test.