共查询到20条相似文献,搜索用时 46 毫秒
1.
Higher serotonin transporter availability in early‐onset obsessive–compulsive disorder patients undergoing escitalopram treatment: A [11C]DASB PET study 下载免费PDF全文
Junhee Lee Bo‐Hyung Kim Euitae Kim Oliver D. Howes Kang Ik Kevin Cho Youngwoo Bryan Yoon Jun Soo Kwon 《Human psychopharmacology》2018,33(1)
Objective
Early‐onset obsessive–compulsive disorder (EOCD) and late‐onset obsessive–compulsive disorder (LOCD) are distinct subtypes of obsessive–compulsive disorder (OCD). OCD patients are treated with serotonin reuptake inhibitors, but the difference in serotonin transporter (SERT) availability between medicated EOCD and LOCD is unexplored yet.Methods
Six EOCD and 6 LOCD patients were enrolled. They underwent serial [11C]DASB positron emission tomography scans during maintenance therapy with escitalopram, and their plasma concentration of escitalopram was measured simultaneously with the scan. Then, the drug‐free binding potential of SERT was calculated by pharmacokinetic–pharmacodynamic modelling.Results
In comparison with LOCD patients, SERT availability was significantly higher in the putamen of EOCD patients (U = 4, p = .026), but not in the caudate nucleus (U = 14, p = .589), thalamus (U = 16, p = .818), and dorsal raphe nucleus (U = 7, p = .093). Binding potential of putamen showed a negative correlation (r = ?.580, p = .048) with age of onset of the disease, but not with the Yale–Brown Obsessive Compulsive Scale scores.Conclusions
These findings indicate that the earlier the age of onset of OCD, the less serotonergic pathology there is and that this difference remains even after long‐term serotonin reuptake inhibitor treatment. Clinically, it might suggest that nonserotonergic treatments would be a better option for EOCD patients. 相似文献2.
Association between PLA2G12A polymorphism and patients with schizophrenia in a southern Chinese Han population 下载免费PDF全文
Li Hui Xiao Li Yin Jie Chen Hong Liang Zhu Guang Ya Zhang Xiao Qiong Wang Jia Hong Liu Cheng Zhu Dong Wu Xu Xin Yu Guang Zhong Yin 《Human psychopharmacology》2018,33(2)
Background
Elevated phospholipase A2 (PLA2) activity is reported to be involved in the development of schizophrenia. Further study revealed an association between PLA2 groups XIIA (PLA2G12A) polymorphism and patients with schizophrenia in a northeast Chinese Han population.Objective
This study will further examine whether PLA2G12A rs3087494 polymorphism is associated with patients with schizophrenia in a southern Chinese Han population.Methods
This polymorphism was genotyped in 438 patients with schizophrenia (diagnosed according to Diagnostic and Statistical Manual of Mental Disorders‐IV) and 876 healthy controls using a case–control design. Demographic and clinical data were collected in all subjects.Results
The allele and genotype frequencies of PLA2G12A rs3087494 polymorphism significantly differed between groups (both, p < .001). These differences still were significant by adjusting for sex and age. However, there was no difference in age at onset among 3 genotype groups in patients with schizophrenia by adjusting for the variables (F = 0.22, p = .80). Stepwise multivariate regression analysis showed that this polymorphism was not associated with age at onset in patients with schizophrenia (β = .008, t = .07, p = .94).Conclusions
Our results indicated that even though PLA2G12A rs3087494 polymorphism did not influence age at onset in patients with schizophrenia, it may play an important role in the susceptibility to schizophrenia in a southern Chinese Han population. 相似文献3.
Suohui Zhang Guangjiong Qin Yan Wu Yunhua Gao Yuqin Qiu Fang Li Bai Xu 《Pharmaceutical research》2011,28(1):117-123
Purpose
In vitro and in vivo permeation studies were conducted to evaluate the characteristic of percutaneous administration of high hydrophilic drug L-carnitine (LC) by Functional MicroArray (FMA) painless intradermal delivery system. 相似文献4.
Li Peng Naghma Khan Farrukh Afaq Chuangxing Ye Hasan Mukhtar 《Pharmaceutical research》2010,27(6):1128-1137
Purpose
We evaluated the chemotherapeutic effect of water extract of white cocoa tea (WCTE) against human prostate cancer (PCa) in vitro and in vivo. 相似文献5.
Migalska K Morrow DI Garland MJ Thakur R Woolfson AD Donnelly RF 《Pharmaceutical research》2011,28(8):1919-1930
Purpose
To assess the feasibility of transdermal macromolecule delivery using novel laser-engineered dissolving microneedles (MNs) prepared from aqueous blends of 20% w/w poly(methylvinylether maleic anhydride) (PMVE/MA) in vitro and in vivo. 相似文献6.
Elena Soto Sebastian Haertter Michael Koenen-Bergmann Alexander Staab Iñaki F. Trocóniz 《Pharmaceutical research》2010,27(2):340-349
Purpose
To establish an in vitro-in vivo level A correlation (IVIVC) for pramipexole slow-release formulations. 相似文献7.
Karlgren M Ahlin G Bergström CA Svensson R Palm J Artursson P 《Pharmaceutical research》2012,29(2):411-426
Purpose
To establish in vitro and in silico models that predict clinical drug–drug interactions (DDIs) with the OATP1B1 (SLCO1B1) transporter. 相似文献8.
Chen B Zhang W Gu Z Li J Zhang Y Cai W 《European journal of clinical pharmacology》2011,67(6):601-612
Purpose
To establish the population pharmacokinetic (PPK) model of cyclosporine (CsA) in Chinese renal transplant recipients and evaluate the influence of various indexes including CYP3A5 and MDR1 genetic polymorphism on pharmacokinetic parameters. 相似文献9.
Braida D Donzelli A Martucci R Capurro V Busnelli M Chini B Sala M 《Psychopharmacology》2012,220(2):319-330
Rationale
Oxytocin (OT) and arginine-vasopressin (AVP) regulate social behavior in mammals. Zebrafish (Danio rerio) allows higher throughput and ease in studying human brain disorders. 相似文献10.
Qun Liu Andrew Michael Rauth Jiang Liu Karlo Babakhanian Xinyue Wang Reina Bendayan Xiao Yu Wu 《Pharmaceutical research》2009,26(10):2343-2357
Purpose
This work focused on the characterization and in vitro/in vivo evaluation of an alginate/chitosan microsphere (ACMS) formulation of glucose oxidase (GOX) for the locoregional delivery of reactive oxygen species for the treatment of solid tumors. 相似文献11.
Ravi Chari Kavita Jerath Advait V. Badkar Devendra S. Kalonia 《Pharmaceutical research》2009,26(12):2607-2618
Purpose
To explain the differences in protein-protein interactions (PPI) of concentrated versus dilute formulations of a model antibody. 相似文献12.
Denora N Laquintana V Trapani A Suzuki H Sawada M Trapani G 《Pharmaceutical research》2011,28(11):2820-2832
Purpose
To evaluate the utility of new Translocator protein 18 kDa (TSPO)-targeted fluorescent probes for in vivo molecular imaging of activated microglia. 相似文献13.
Objective
Ipomoea genus is an excellent source of lysergol which is used as a hypotensive and psychrotopic analgesic. Microwave-assisted extraction (MAE) was employed to extract lysergol from Ipomoea seeds, and response surface methodology (RSM) was applied to predict optimum conditions for extraction. 相似文献14.
Saijie Zhu Minghuang Hong Lihong Zhang Guotao Tang Yanyan Jiang Yuanying Pei 《Pharmaceutical research》2010,27(1):161-174
Purpose
To investigate the effects of PEGylation degree and drug conjugation style on the in vitro and in vivo behavior of PEGylated polyamidoamine (PAMAM) dendrimers-based drug delivery system. 相似文献15.
Saito S Hasegawa J Kobayashi N Kishi N Uchiyama S Fukui K 《Pharmaceutical research》2012,29(2):397-410
Purpose
To investigate relationship between second virial coefficient B 2 and viscosity and aggregation propensity of highly concentrated monoclonal antibody (MAbs) solutions. 相似文献16.
Purpose
To develop a population pharmacokinetic (PK) model which allowed the simultaneous modeling of trans-resveratrol and its glucuronide and sulfate conjugates. 相似文献17.
Xiang X Vakkilainen J Backman JT Neuvonen PJ Niemi M 《European journal of clinical pharmacology》2011,67(11):1159-1167
Purpose
To investigate possible effects of the SLCO1B1 polymorphism on the pharmacokinetics of ursodeoxycholic acid (UDCA) and its metabolites in healthy volunteers. 相似文献18.
Pengcheng Zhang Luojuan Hu Yucai Wang Jun Wang Linyin Feng Yaping Li 《Pharmaceutical research》2010,27(12):2657-2669
Purpose
The purpose of this work was to investigate the potential of poly(ε-caprolactone)-block-poly(ethyl ethylene phosphate) (PCL-PEEP) micelles for brain-targeting drug delivery. 相似文献19.
Purpose
To study crystal growth rates of amorphous griseofulvin (GSF) below its glass transition temperature (T g) and the effect of surface crystallization on the overall crystallization kinetics of amorphous GSF. 相似文献20.
Ghassemi AH van Steenbergen MJ Barendregt A Talsma H Kok RJ van Nostrum CF Crommelin DJ Hennink WE 《Pharmaceutical research》2012,29(1):110-120