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循环肿瘤细胞(CTC)与恶性肿瘤的发生发展密切相关.目前检测CTC的方法有逆转录聚合酶链反应、免疫磁珠富集检测法等.检测CTC有助于发现早期肿瘤患者的微转移、重新确定临床分期,监测术后或者放化疗后患者肿瘤复发与转移,评估预后,选择个体化的治疗策略. 相似文献
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循环肿瘤细胞的研究进展 总被引:1,自引:0,他引:1
肿瘤细胞的脱落、侵袭并进入血液循环是实现肿瘤转移的最初阶段,并为最终形成临床转移灶提供了可能,深入研究循环肿瘤细胞有助于对肿瘤转移机制的了解,可为抗转移治疗提供依据:全文综述循环肿瘤细胞的临床意义及检测方法。 相似文献
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肿瘤转移是导致肿瘤患者死亡的主要原因之一,相同的治疗方案在同一肿瘤患者之间的疗效差异很大,造成这一现象的原因是恶性肿瘤之间的分子分型存在差异。随着精准医疗时代的到来,循环肿瘤细胞(CTC)检测技术应运而生,人类对恶性肿瘤的检测达到单细胞水平。与传统影像学检查、病理学检查及肿瘤标志物等相比,具有无创、多次、实时获取及整体性等优点;在疗效评估、个体化治疗、预后监测、肿瘤筛查等方面具有独特优势。作者概述常见CTC检测技术的特点及其临床应用现状,为临床提供参考。 相似文献
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目的:评价hMAM和CK19 mRNA联合检测早期乳腺癌循环肿瘤细胞的临床价值.方法:采用RT-PCR检测早期乳腺癌患者CK19、hMAM mRNA阳性循环肿瘤细胞.结果:hMAM和CK19 mRNA联合检测早期乳腺癌患者循环肿瘤细胞阳性率(52.0%)均高于良性乳腺疾病患者(16.7%)和健康体检者(5.0%), P值分别为0.004和0.000;阳性率与癌组织HER-2过表达相关,P=0.049.联合检测的敏感度为57.5%,特异度为88.6%.26例联合检测阳性患者,13例随访期出现转移复发,P=0.001;中位无瘤生存期明显降低,P=0.000.结论:hMAM和CK19 mRNA是一组敏感度和特异度较好的诊断早期乳腺癌患者循环肿瘤细胞的基因标志,可能作为早期乳腺癌术后监测转移复发辅助指标. 相似文献
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乳腺癌循环肿瘤细胞检测方法的研究进展 总被引:1,自引:1,他引:0
目的:对乳腺癌循环肿瘤细胞(CTC)检测方法进行简要总结和评述.方法:以乳腺肿瘤和CTC为关键词,检索1995-01-2010-05 PubMed、MEDLINE、EMBASE、Science Direct、Springer、CNKI和维普数据库的相关文献.纳入标准:关于CTC检测方法的文献.根据纳入标准符合分析文献39篇.结果:伴随近年生物学技术的飞速发展,CTC的检测敏感性和特异性显著提高.目前,CTC检测方法多由富集分离和标记鉴定两部分组成.Cell Search系统和实时定量逆转录聚合酶链反应法是目前最常用的CTC检测方法,前者特异性较好、可获取形态学信息并可计数,后者敏感性更高.结论:CTC检测方法众多,但尚缺乏公认的检测标志和标准的检测流程.进一步提高CTC的检测效率有助于加深对其应用价值的认识. 相似文献
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Detection rate and prognostic value of circulating tumor cells and circulating tumor DNA in metastatic uveal melanoma 下载免费PDF全文
François‐Clément Bidard Jordan Madic Pascale Mariani Sophie Piperno‐Neumann Aurore Rampanou Vincent Servois Nathalie Cassoux Laurence Desjardins Maud Milder Isabelle Vaucher Jean‐Yves Pierga Ronald Lebofsky Olivier Lantz 《International journal of cancer. Journal international du cancer》2014,134(5):1207-1213
Circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) have been recently investigated in several cancer types, but their respective clinical significance remains to be determined. In our prospective study, we compared the detection rate and the prognostic value of these two circulating biomarkers in patients with metastatic uveal melanoma. GNAQ/GNA11 mutations were characterized in archived tumor tissue. Using a highly sensitive and mutation‐specific bidirectional pyrophosphorolysis‐activated polymerization (bi‐PAP) technique, GNAQ c.626A>T, GNAQ c.626A>C and GNA11 c.626A>T copy numbers were quantified in plasma from 12 mL of blood. CTCs were detected at the same time in 7.5 mL of blood by the CellSearch® technique. Patient characteristics and outcome were prospectively collected. CTCs (≥1) were detected in 12 of the 40 included patients (30%, range 1–20). Among the 26 patients with known detectable mutations, ctDNA was detected and quantified in 22 (84%, range 4–11,421 copies/mL). CTC count and ctDNA levels were associated with the presence of miliary hepatic metastasis (p = 0.004 and 0.03, respectively), with metastasis volume (p = 0.005 and 0.004) and with each other (p < 0.0001). CTC count and ctDNA levels were both strongly associated with progression‐free survival (p = 0.003 and 0.001) and overall survival (p = 0.0009 and <0.0001). In multivariate analyses, ctDNA appeared to be a better prognostic marker than CTC. In conclusion, ctDNA and CTC are correlated and both have poor prognostic significance. CTC detection can be performed in every patient but, in patients with detectable mutations, ctDNA was more frequently detected than CTC and has possibly more prognostic value. 相似文献
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循环肿瘤细胞(CTC)对于监测肿瘤复发及判断预后具有重要意义.纳米技术为检测CTC提供了良好的平台,使CTC的应用具有广阔的发展前景.同时,利用纳米技术设计杀灭CTC的纳米装置在清除CTC方面有广阔的应用前景,为肿瘤治疗提供了新的研究方向. 相似文献
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Haizhen Wang Yannis Hara Xingtong Liu James M. Reuben Yongzhuang Xie Huaxi Xu Guojun Bu Yihua Pei Vineet Gupta Xiangwei Wu 《Oncotarget》2015,6(29):27304-27311
Circulating tumor cells (CTCs) are in limited numbers and heterogeneous, making their detection, isolation, and enumeration a major challenge. To overcome these difficulties, we developed a novel method to detect and enumerate CTCs with invasive property. Our assay consists of three simple steps: enrichment, Matrigel invasion assay, and immunostaining. We have validated this method using mouse xenograft tumor models and confirmed its utility in human cancer patients. Our method does not require special equipment and antigen expression for CTC selection, is less likely to be affected by the heterogeneity of the CTCs, and could be applicable to virtually all cancers. Most important, our method enumerates invasive CTCs, which may allow more accurate correlations with clinical outcome and treatment response compared with other CTC detection methods. 相似文献
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血小板可与循环中的肿瘤细胞相互作用形成血小板一瘤栓,帮助肿瘤细胞逃脱免疫系统的攻击。活化的血小板还可释放多种生物活性因子,促进肿瘤细胞的侵袭和生长,诱导肿瘤新血管生成。血小板与肿瘤转移关系的研究,对阐明肿瘤侵袭与转移的机制,建立抗肿瘤转移治疗的新方法具有重要价值。 相似文献
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近期的干细胞研究提示门静脉癌栓(PVTT)可能与肝癌干细胞在门静脉微环境诱导下的定向转移有关,肝癌干细胞脱离原发病灶,外渗到细胞外基质,促进血管的生成或细胞内渗,从而进入循环系统,逃避宿主的防御机制,通过趋化作用迁移到特定的门静脉内皮黏附,归巢到特定的微环境,形成门静脉癌栓. 相似文献