妊娠期高血压疾病危险因素及妊娠结局分析

目的调查分析台州市妊娠妇女高血压疾病患病率、影响因素及妊娠结局。方法回顾性分析2017年1月-2019年6月台州市妊娠妇女4 875例临床资料,统计高血压疾病患病率,采用多因素非条件Logistic回归分析法分析妊娠妇女高血压疾病发生的影响因素并调查妊娠结局。结果 4 875例妊娠妇女中共有182例合并高血压疾病,发病率3.73%,其中妊娠期高血压43例,轻度子痫前期40例,重度子痫前期99例。单因素分析合并高血压疾病组与未合并高血压疾病组在年龄、体质指数、月收入、文化程度、有无高血压家族史、有无孕期并发症、是否为双胎或多胎、有无负性情绪方面对比差异有统计学意义(P0.05)。多因素Logistic回归分析体质指数、高血压家族史、孕期并发症、负性情绪均是影响台州市妊娠妇女高血压疾病发生的危险因素。合并高血压疾病组低体质量儿、胎儿窘迫、新生儿窒息、围生儿死亡比例明显高于未合并高血压疾病组,差异均有统计学意义(P0.05),两组胎儿畸形比例比较差异无统计学意义(P0.05)。结论体质指数、高血压家族史、孕期并发症、负性情绪均是影响台州市妊娠妇女高血压疾病发生的危险因素,合并高血压疾病会影响妊娠结局,应积极干预上述危险因素,进一步降低本地区妊娠妇女高血压疾病患病率。     

2007-2016年西宁地区妊娠期高血压疾病发病情况、危险因素及妊娠结局的调查

目的探讨2007-2016年西宁地区妊娠期高血压疾病(HDCP)的发病情况、危险因素及妊娠结局,了解西宁地区该疾病发病趋势,为临床进行健康宣教提供理论依据。方法回顾性分析2007年1月-2016年12月青海省人民医院24 599例妊娠孕妇临床资料,分析HDCP发病情况、HDCP的危险因素及对妊娠结局的影响。结果 HDCP发病率为3.61%,且发病率呈逐年增高趋势(P<0.05)。其中重度子痫前期发病率呈逐年升高趋势(P<0.05),轻度妊娠期高血压发病率近10年无明显变化(P>0.05)。对孕妇年龄、BMI、月收入、产次、流产史、文化程度、高血压家族史、孕期并发症、负面情绪、不良生活方式及双胎或多胎进行单因素分析,发现年龄、BMI、月收入、文化程度、高血压家族史、孕期并发症、负面情绪为妊娠期发生高血压疾病的危险因素(P<0.05)。对差异有统计学意义的单因素进行Logistic回归分析,发现BMI、文化程度、高血压家族史及负面情绪为妊娠期发生高血压疾病的独立危险因素(P<0.05)。伴有妊娠期高血压的孕妇发生低体重儿、胎儿窘迫、新生儿窒息、围生儿死亡的风险明显高于无妊娠期高血压孕妇(P<0.05)。结论西宁地区近10年HDCP发病率呈逐年增高趋势,且发病程度加重。妊娠期肥胖、文化程度低、高血压家族史及有负面情绪为发生HDCP的独立危险因素。妊娠期高血压可影响妊娠结局,应重视对HDCP的预防及保健。     

子痫前期发病的高危因素分析

目的探讨子痫前期(PE)发病的高危因素及其对策措施。方法回顾性选取该院84例PE病例作为子痫前期组,同时随机抽取168例未发生PE的孕妇作为对照组;回顾性收集影响PE发病的潜在危险因素,采用单因素比较法和多因素Logistic回归法分别筛选PE发病的高危因素。结果多因素Logistic回归分析结果显示,影响PE发病的因素包括年龄、孕前BMI、高血压家族史、妊娠期高血压疾病、妊娠期合并肾炎及妊娠合并营养不良。结论 PE发病的高危因素包括高龄、孕前超重或肥胖、高血压家族史、妊娠期高血压疾病、妊娠期合并肾炎及妊娠合并营养不良等,应针对这些高危因素,早期采取干预措施,改善母婴妊娠结局。     

子痫前期发病高危因素及其对妊娠结局的影响分析

目的探讨子痫前期(PE)发病的高危因素及其对母婴妊娠结局的影响。方法回顾性收集1 080例子痫前期孕妇作为子痫前期组,随机选取540例未发生子痫前期的孕妇作为对照组;采用单因素χ2检验和多因素Logistic回归法筛选子痫前期发病的高危因素,比较两组母婴妊娠并发症的差异。结果多因素结果显示,影响子痫前期发病的危险因素包括高龄(OR=3.418)、妊娠期超重(OR=4.406)、高血压家族史(OR=2.989)、妊娠期高血压疾病(OR=6.234)、妊娠期糖尿病或肾病(OR=3.235)、营养不良(OR=2.550)等。子痫前期组的胎儿窘迫、胎膜早破、产后出血、剖宫产、新生儿窒息、低出生体质量儿等发生率均高于对照组,差异有统计学意义(P0.05)。结论子痫前期发病的高危因素包括高龄、妊娠期超重或肥胖、高血压家族史、妊娠期高血压疾病、妊娠期糖尿病或肾病、营养不良等,子痫前期容易产生妊娠并发症,应早期采取干预措施改善母婴妊娠结局。     

妊娠期高血压疾病危险因素分析

目的:探讨妊娠期高血压发病的危险因素及对与孕产妇及新生儿结局的影响.方法:通过问卷调查及病例分析等方法对我所产前门诊确诊的109例妊娠期高血压孕产妇的发病孕周、蛋白尿的程度、疾病的进展程度与妊娠结局的关联进行评估分析.结果:①患者出现蛋白尿程度及出现时间与患者疾病的发病程度相关,②发病孕周与患者不良妊娠结局有明显的相关性(P<0.05),而与胎儿及新生儿的不良妊娠结局无明显的相关性(P>0.05).结论:妊娠期高血压疾病的患者严格控制其疾病的发展,并对有蛋白尿患者进行及时的纠正,严格控制并发症的发生,在尽可能的情况下延长孕周,可以大大减少孕产妇及围生儿发生不良妊娠结局     

妊娠期高血压相关影响因素分析

目的:探讨妊娠期高血压疾病的危险因素,为降低妊娠期高血压提供依据。方法:回顾性分析127例妊娠期高血压疾病患者的临床资料,采用多元logistic回归分析其危险因素;比较127例患者(研究组)和100例健康产妇(对照组)的母婴结局差异。结果:多元logistic分析显示影响妊娠期高血压疾病的危险因素有妊娠期高血压家族史(OR=1.86,95%CI 1.45~2.39)、妊娠期负性事件(OR=1.93,95%CI 1.55~2.39)和负性情绪(OR=1.86,95%CI 1.45~2.39),而定期产检(OR=0.46,95%CI 0.30~0.69)和服用叶酸(OR=0.31,95%CI 0.24~0.40)可以降低妊娠期高血压疾病发生风险。结论:妊娠期高血压疾病其发病率与多种因素有关,应提高产检率、加强妊娠期营养、调节心理情绪等进行干预。     

妊娠期糖尿病的相关危险因素分析及其对母婴结局的影响

目的探究妊娠期糖尿病(GDM)发病的相关危险因素,并分析其对母婴结局的影响。方法选取2015年6月-2017年6月晋中市第二人民医院产科收治的围生期孕妇1133例为研究对象,其中183例GDM患者为GDM组,950例健康产妇为对照组。收集对比两组产妇一般临床资料,并比较两组妊娠结局和新生儿结局的差异。结果单因素分析结果显示,年龄≥35岁、受教育程度高、有糖尿病家族史及高血压病史、妊娠前超重、日运动时间≤1 h、妊娠期营养过度与GDM发病相关(P0.05);而孕次、吸烟史及高胆固醇血症与GDM发病无关(P0.05)。多因素Logistic回归分析结果显示,年龄≥35岁、糖尿病家族史、日运动时间≤1 h、妊娠期营养过度是GDM的独立危险因素(P0.05)。GDM组剖宫产、羊水量异常、产后出血、子痫前期、胎膜早破、胎盘早剥、早产及酮症酸中毒发生率显著高于对照组,差异有统计学意义(P0.05)。GDM组新生儿窒息、新生儿低血糖、低体质量儿、巨大儿、新生儿高胆红素血症及新生儿畸形发生率显著高于对照组,差异有统计学意义(P0.05)。结论年龄、糖尿病家族史、日运动时间、妊娠期营养过度是GDM发生的独立危险因素,医护人员在工作中准确筛查高危妊娠期妇女,并采取相应的治疗措施,做到早发现、早治疗,最大限度的改善母婴结局。     

高龄女性妊娠期高血压疾病对妊娠结局的影响分析

目的 分析高龄产妇并发妊娠期高血压对妊娠结局的影响.方法 选取广东省中山市人民医院产科2014年5月至2016年5月收治的并发妊娠期高血压疾病(GHD)的高龄孕产妇40例,同时选择同期年龄＜35岁的孕产妇40例GHD作为对照组,对两组产妇的产科并发症发生情况、围产儿结局进行统计分析.结果 高龄组子痫前期及子痫、早产发生率均显著高于低龄组(x2值分别为7.680、4.114,均P＜0.05),两组妊娠高血压心脏病、HELLP综合征、胎盘早剥、产后出血发生率均无显著性差异(x2值分别为1.053、0.392、1.053,均P＞0.05).高龄组产妇生长受限发生率显著高于低龄组(x2=3.914,P＜0.05),两组胎儿窘迫、新生儿窒息、新生儿畸形、围产儿死亡发生率均无显著性差异(x2值分别为0.721、1.053,均P＞0.05).结论 高龄产妇较低龄产妇并发妊娠期高血压疾病时易发生不良妊娠结局,临床需要重视.     

妊娠高血压疾病危险因素的病例对照研究

目的 筛选妊娠高血压发病危险的主要母体因素,为有效地防治妊高征提供科学依据.方法 采用1:1配比的病例-对照研究方法,对妊高征的可能危险因素进行条件Logistic 回归分析.结果 影响妊娠期高血压疾病发生的危险母体因素主要有:妊娠年龄、家庭收入状况、文化程度、产次、孕期情绪状况、妊高征家族史、双胎或多胎妊娠、血清钙离子浓度.胎儿性别也与它的发生有一定关系.结论 对于妊娠年龄高、家庭收入状况和文化程度低、孕期不良情绪、妊高征家族史、双胎或多胎妊娠等孕妇要加强监测,早期发现妊娠期高血压疾病,早治疗,尽可能避免因此带来的不良结局.同时对高危人群补充钙剂或摄入充足含钙食物,可安全有效地预防妊娠期高血压疾病.     

妊娠期肝内胆汁淤积症对围生儿不良结局的影响及高危因素分析

目的探讨妊娠期肝内胆汁淤积症(ICP)对围生儿不良结局的影响,并分析ICP围生儿不良结局的高危因素。方法选择上海市嘉定区妇幼保健院2010年1月-2015年12月收治的200例ICP患者为观察组,同期入院的正常孕妇200例为对照组。收集两组围生儿结局资料和孕妇的临床资料。结果观察组围生儿早产、胎儿宫内窘迫、新生儿窒息、死胎的发生率均高于对照组(P0.05)。单因素分析结果显示:ICP的发病时间、合并乙肝、妊娠期糖尿病(GDM)、妊娠期高血压疾病、ICP家族史、谷丙转氨酶、总胆汁酸、总胆红素、直接胆红素和ICP围生儿不良结局有关(P0.05);孕妇年龄、孕次、产次、分娩方式、皮肤瘙痒和ICP围生儿不良结局无关(P0.05)。Logistic回归分析结果显示,ICP的发病时间、妊娠期高血压疾病、GDM、高总胆汁酸是ICP围生儿不良结局的独立危险因素(P0.05)。结论 ICP增加围产儿不良结局,发病时间、妊娠期高血压疾病、GDM、高总胆汁酸是围生儿不良结局的高危因素。     

Impact of preeclampsia and gestational hypertension on birth weight by gestational age

The predominant etiologic theory of preeclampsia is that reduced uteroplacental perfusion is the unique pathogenic process in the development of preeclampsia. Decreased uteroplacental blood flow would result in lower birth weights. To date, no study has assessed the effect of preeclampsia on birth weight by gestational age. Thus, the authors conducted a retrospective cohort study based on 97,270 pregnancies that resulted in delivery between 1991 and 1996 at 35 hospitals in northern and central Alberta, Canada. Differences in mean birth weight between women with preeclampsia and normotensive women ranged from -547.5 g to 239.5 g for gestational age categories ranging from < or = 32 weeks to > or = 2 weeks. The birth weights were statistically significantly lower among mothers with preeclampsia who delivered at < or = 37 weeks, with an average difference of -352.5 g. However, the birth weights were not lower among preeclamptic mothers who delivered after 37 weeks (average difference of 49.0 g). In Alberta, 61.2% of preeclamptic patients gave birth after 37 weeks of gestation. The authors conclude that babies born to mothers with preeclampsia at term have fetal growth similar to that of babies born to normotensive mothers. This finding does not endorse the currently held theory that reduced uteroplacental perfusion is the unique pathophysiologic process in preeclampsia.     

妊娠20周前体重增长与妊娠期高血压关系的研究

目的：探讨妊娠20周前的体重增长与妊娠期高血压发生风险的关系。方法对自2013年1月至2013年4月在北京妇产医院进行常规产前检查并在本院分娩的1263例孕妇进行前瞻性巢式病例对照研究,病例组为发生妊娠期高血压的孕妇,对照组为血压正常的孕妇。收集年龄、身高、孕前体重、分娩前体重、妊娠期体重记录、高血压家族史、孕次、产次等资料,统计学方法采用t检验、χ2检验及多因素logistic回归分析。结果病例组的孕期总增重（17．94．5kg）高于对照组（16．44．4kg）,t＝2．54,P＝0．01;病例组的妊娠20周前体重增长（6．12．8 kg）也高于对照组（5．03．1kg）,t＝2．72, P＝0．01。按孕前体质量指数（BMI）分组后,对于BMI＜24 kg／m2的孕妇,病例组的孕期总增重和妊娠20周前的体重增长仍明显高于对照组（P＜0．05）;对于BMI≥24 kg／m2的孕妇,病例组的孕期总增重明显高于对照组（P＜0．05）,而妊娠20周前的体重增长与对照组相比虽然有增高趋势,但差异无统计学意义（P＞0．05）。控制年龄、孕前BMI、孕次、产次、高血压家族史、测量体重时的孕周等混杂因素后,妊娠20周前的体重增长每增加1kg,发生妊娠期高血压的风险增加12．5％（95％可信区间为1．038～1．220,P＝0．004）。结论妊娠20周前的体重增长是妊娠期高血压的危险因素,控制妊娠20周前的体重增长对于预防妊娠期高血压可能具有重要意义,尤其是对于孕前BMI＜24 kg／m2的孕妇。     

孕前体质指数及妊娠期体重增长与妊娠期糖尿病及高血压的关系

目的 研究孕前体质指数(pBMI)及妊娠期体重增长(GWG)与产妇患妊娠期糖尿病及高血压的关系.方法 回顾性分析2011年2月至2012年2月行常规产前检查并住院分娩的产妇1240例,记录pBMI、GWG、第24～ 28孕周的空腹血糖及血压水平.采用相关性分析及Logistic回归分析的方法研究pBMI及GWG与妊娠期糖尿病及高血压的关系.结果 根据pBMI分组,轻体重组260例,正常体重组917例,超重组36例,肥胖组27例.根据GWG分组,低度增长组104例,正常增长组758例,中度增长组249例,高度增长组129例.pBMI与GWG呈负相关(r=-0.646,P＜0.01).以正常体重组为参照,超重组妊娠期糖尿病发病率为11.11％(4/36),OR值为4.120,P＜0.05;肥胖组妊娠期糖尿病发病率为18.52％(5/27),OR值为7.492,P＜0.05;肥胖组妊娠期高血压发病率为11.11％(3/27),OR值为6.243,P＜0.05.以正常增长组为参照,低度增长组妊娠期糖尿病发病率为15.38％(16/104),OR值为9.006,P＜0.05;低度增长组妊娠期高血压发病率为4.81％(5/104),OR值为3.140,P＜0.05;高度增长组妊娠期高血压发病率为4.65％(6/129),OR值为3.033,P＜0.05.各组空腹血糖及血压水平比较差异无统计学意义(P＞0.05).结论 pBMI与GWG呈负相关,pBMI偏高及GWG偏低均是患妊娠期糖尿病及高血压的危险因素.     

Association between gestational diabetes and pregnancy-induced hypertension

Gestational diabetes and pregnancy-induced hypertension are common, and their relation is not well understood. The authors conducted a population-based case-control study using 1992-1998 Washington State birth certificate and hospital discharge records to investigate this relation. Consecutive cases of pregnancy-induced hypertension were divided into four groups based on International Classification of Diseases, Ninth Revision codes: eclampsia (n=154), severe preeclampsia (n=1,180), mild preeclampsia (n=5,468), and gestational hypertension (n=8,943). Cases were compared with controls who did not have pregnancy-induced hypertension (n=47,237). Gestational diabetes was more common in each case group (3.9% in eclamptics, 4.5% in severe preeclamptics, and 4.4% in both mild preeclamptics and those with gestational hypertension) than in controls (2.7%). After adjustment for body mass index, age, ethnicity, parity, and prenatal care, gestational diabetes was associated with increased risk of severe preeclampsia (odds ratio (OR)=1.5, 95% confidence interval (CI): 1.1, 2.1), mild preeclampsia (OR=1.5, 95% CI: 1.3, 1.8), and gestational hypertension (OR=1.4, 95% CI: 1.2, 1.6). Gestational diabetes was more strongly associated with pregnancy-induced hypertension among women who received less prenatal care (OR=4.2 for eclampsia and OR=3.1 for severe preeclampsia, p<0.05 for both) and among Black women (OR for eclampsia and preeclampsia together=3.9, p<0.05).     

Impact of pregnancy-induced hypertension on birthweight by gestational age

Few studies to date have examined the effect of severe pre-eclampsia, pre-eclampsia, and gestational hypertension on birthweight according to gestational age. We conducted a population-based retrospective cohort study of 16,936 pregnant women in Suzhou, China. Analysis of variance and multivariable linear regression were performed to compare the mean birthweights of babies born to mothers with gestational hypertension, pre-eclampsia, and severe pre-eclampsia with birthweights of infants born to mothers with normal blood pressure at each week of gestation. The differences in mean birthweight between women with severe pre-eclampsia and women with normal blood pressure ranged between -467.7 g and 189.1 g. The birthweights were statistically significantly lower in women with severe pre-eclampsia than in women with normal blood pressure for gestational age categories < or = 35 and 36 weeks. However, after adjustment for confounding variables, the birthweights were not statistically significantly different in women with severe pre-eclampsia when compared with women with normal blood pressure even at < or = 35 and 36 weeks. The differences in mean birthweight between women with pre-eclampsia and women with normal blood pressure ranged between -132.2 g and 174.6 g. These differences were not statistically significant, before or after adjusting for confounding variables. There were no differences in mean birthweight between women with gestational hypertension and women with normal blood pressure. Further analysis suggested that pre-eclampsia and gestational hypertension were associated with increased rates of both small-for-gestational-age and large-for-gestational-age infants. The majority of the babies born to mothers with different types of pregnancy-induced hypertension were appropriate-for-gestational-age or even large-for-gestational-age. In this Chinese population, most babies born to mothers with severe pre-eclampsia or pre-eclampsia and gestational hypertension had similar fetal growth to those born to normotensive mothers.     

Racial differences in gestational weight gain and pregnancy-related hypertension

PurposeThe aim of the study was to examine racial differences in gestational weight gain (GWG) and pregnancy-related hypertension.MethodsLogistic regression models tested racial differences in adequacy of GWG and pregnancy-induced hypertension in all singleton live births from the South Carolina 2004–2006 birth certificates.ResultsCompared with white women, black and Hispanic women had 16%–46% lower odds of gaining weight above the recommendations. However, the odds of inadequate GWG was ∼50% higher in black and Hispanic women with a pregnancy body mass index (BMI) less than 25 kg/m². Furthermore, compared with women with adequate GWG, women with excessive GWG had higher odds of pregnancy-related hypertension (underweight: 2.35, 95% confidence interval [CI; 1.66, 3.32]; normal: 2.05, 95% CI [1.84, 2.27]; overweight: 1.93, 95% CI [1.64, 2.27]; obese: 1.46, 95% CI [1.30, 1.63]). Among women with a BMI less than 25 kg/m², black women had higher odds of pregnancy-related hypertension than white women (underweight: 1.64, 95% CI [1.14, 2.36]; normal weight: 1.28, 95% CI [1.15, 1.42]), whereas among women with a BMI less than 25 kg/m², Hispanic women had 40% lower odds.ConclusionsPrograms are needed to curb excessive GWG in all racial groups and to help some sub-groups ensure adequate GWG. Maternal obesity and GWG are two factors that should be used in combination to reduce racial differences in pregnancy-related hypertension.     

Methylenetetrahydrofolate reductase polymorphisms and the risk of gestational hypertension

BACKGROUND: Evidence on the association of 5,10 methylentetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in women with gestational hypertension is inconsistent. It is also unknown whether the fetal genotype is relevant, or whether folic acid supplementation modifies this association. METHODS: The study population was composed of U.S. and Canadian white women with nonmalformed infants participating in the Slone Epidemiology Center Birth Defects Study between 1993 and 2000. Women were interviewed within 6 months after delivery regarding multivitamin use in pregnancy and the occurrence of gestational hypertension, among other factors. DNA was extracted from cheek swabs and gene alleles determined by restriction fragment length polymorphism analysis. We compared the prevalence of the 677TT/CT and 1298CC/AC genotypes between cases with gestational hypertension (54 mothers and their 51 offspring) and controls (100 mothers and their 99 offspring). We also estimated odds ratios (ORs) and 95% confidence intervals (CIs) using conditional logistic regression to control for geographic region and calendar year. RESULTS: The T allele was present in 69% of women with gestational hypertension versus 57% of control women (compared with 677CC, OR = 1.9; 95% CI = 0.9-4.0). The offspring of case and control women had a 677TT/CT genotype prevalence of 68% and 47%, respectively (2.4; 1.1-5.0). Among women supplemented with folic acid during the first 5 months of pregnancy, the ORs for maternal and fetal 677TT/CT genotypes were 0.9 (0.3-2.5) and 2.1 (0.7-6.0), respectively. Neither maternal nor fetal 1298CC/AC genotypes were associated with an increased risk of gestational hypertension. CONCLUSION: Maternal and fetal MTHFR C677T polymorphism may be associated with a moderately increased risk of gestational hypertension, and there is a suggestion that this association may be diminished among women receiving folate supplementation during pregnancy.     

运动、饮食综合干预对妊娠期糖尿病合并妊娠期高血压孕妇影响观察

目的 探究运动、饮食综合干预对妊娠期糖尿病合并妊高症（GDM-PIH）孕妇母子结局及临床疗效的影响。方法 选取我院2016年1月到2017年9月间收治的152例妊娠期糖尿病合并妊高症患者,随机分为对照组和观察组,每组各76例。对照组进行常规降糖降压治疗,观察组采用运动、饮食综合干预。比较两组患者血糖血压控制情况、Mg2+、内脂素水平、缺血缺氧损伤指标、血管新生因子水平和两组母子结局。结果 治疗前,对照组和观察组收缩压、舒张压、平均动脉压、空腹血糖、口服葡萄糖耐量试验（OGGT2h）血糖、Mg2+、内脂素水平差异无统计学意义（P>0.05）。治疗后,与对照组比较,观察组收缩压［136.74±11.26比148.62±11.56 mmHg］、舒张压［86.45±8.31比92.44±8.52 mmHg］、平均动脉压［100.24±9.13比110.28±9.36 mmHg］、空腹血糖、OGGT2h血糖、内脂素［18.22±4.37比23.25±4.88 μg/L］、缺氧诱导因子-1α（hypoxia inducible factor-1α,HIF-1α）［40.26±5.89比84.25±9.46 pg/L］、一氧化氮、内皮素-1、丙二醛、Caspase-3蛋白［5.58±1.87比12.46±2.32 pg/L］、Bax［9.42±1.25 比24.25±3.56 pg/L］、可溶性人血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)受体（sFlt-1）［（51.24±6.25比82.34±9.26） pg/L］水平降低;Mg2+、碱性成纤维生长因子、转化生长因子β1（transforming growth factor-β,TGFβ1）［110.12±11.13 比74.44±9.25 μg/L］、促血管生长素-2（angiogenin -2,Ang-2）［68.65±7.21 比45.97±6.33 pg/L］、肝细胞生长因子（Hepatocyte Growth Factor ,HGF）［80.12±8.32 比56.98±5.99 mg/L］、VEGF［207.61±24.15比115.54±15.22 mg/L］水平升高,不良妊娠结局［（15.79% 比42.11%）］、不良胎儿结局［（26.32% 比50.00%）］降低,差异有统计学意义（P<0.05）。结论 运动、饮食综合干预能有效控制患者病情,平衡患者缺血缺氧损伤指标、降低血管新生因子水平,从而改善GDM-PIH患者的母子结局,值得临床推广。